the yin and yang of two big balance sheets

... and S E Radford The Yin and Yang of protein folding Fig A schematic energy landscape for protein folding and aggregation The surface shows the multitude of conformations ‘funneling’ towards the ... in general, fold to the native state on a sub-second timescale and have been the focus of many experimental and theoretical studies of folding [5] The folding landscape of these proteins is usually ... correct folding 5966 of proteins on one hand, and the rapid degradation of mutated or misfolded polypeptides on the other [32,33] (Fig 2) The folding of newly synthesized proteins to their native conformations...

Ngày tải lên: 23/03/2014, 11:20

... RNAPII staining is shown on the left and an overlay of the RNAPII staining showing the contributions of the genes is on the right The side panels show the enlarged images of colocalizing FISH signals, ... (c) Loops of chromatin may extend away from the core of the territory (d) As G1 phase is established and nucleoli form, loops of NOR-containing chromatin co-associate with the other components of the ... Air and Kcnq1ot1, which range in size from 17 to 108 kb The most studied of these lncRNAs is Xist Transcription of Xist [43,44] from one of the two X chromosomes results in the inactivation of...

Ngày tải lên: 09/08/2014, 20:21

... function reported in the present study as the Yin and Yang actions of ginseng This concept was considered as an extension of the Yin and Yang actions of ginseng proposed by other investigators ... effects and similarity in the yield (% extractive of 41.4 and 35.3) and potency of the AQ and ALC extracts (Figure and 2), we consider the extract-specific inhibitory and stimulatory effect on ... molecular weights of Fractions I and III were about 73,000 and 37,000 Da respectively; and their yield accounted for 28% and 40% by dry weight of the AQ extract respectively Since PS of ginseng possesses...

Ngày tải lên: 13/08/2014, 14:20

... rather to the maintenance of the enzyme’s tertiary structure Molecular basis of the deficiency of human mutant a-Gal A enzymes Fig Structure of the a-Gal A monomer (A) and location of Fabry disease ... including the heart, kidneys, and brain (the main organs affected by Fabry disease in man), they are an excellent biochemical animal model for in vivo proofof-concept, and allow the pharmacokinetics of ... 32–330), and a C-terminal domain (residues 331– 429) containing eight antiparallel b strands on two sheets in a b sandwich (Fig 1A) [28] The first domain contains the active-site formed by the C-terminal...

Ngày tải lên: 30/03/2014, 03:20

... insure they have a comprehensive understanding of the interpretation of responses during the chart-stimulated recall Their orientation will consist of training on the theory and methods of chart-stimulated ... within their practice and requires chart audits and observations Stage focuses on the client and requires evaluation of the efficiency, effectiveness, adequacy and appropriateness of care and its ... highlighted the need to better understand the mediators of knowledge transfer, and previous work has established that a variety of factors may influence the effects of KT [38,39] However, the mediators...

Ngày tải lên: 11/08/2014, 05:22

... 2641 these spots This led to the identication of two new thioredoxin h isoforms, designated HvTrxh1 and HvTrxh2 From MALDI-TOF peptide mass mapping data, it is probable that the two spots of higher ... observed The relative intensity of the two HvTrxh1 spots from the different tissues varies (Fig 1), suggesting that the degree of modication giving rise to the two spots differs among these tissues ... initials and isoforms by italicised sux Accession numbers are given in Materials and methods The identity of the residue corresponding to R101 in HvTrxh1 is given for each of the circled clusters The...

Ngày tải lên: 23/03/2014, 17:22

... in the central, mantle and the peripheral regions by their cellular composition The regional distribution and relative frequency of endocrine cells in the principal islets of two species of teleostean ... Insulin is synthesized in the B cells of the pancreatic islets and regulates the serum glucose levels (Hsu and Crump, 1989) The regional distribution and relative frequency of the insulin-immunoreactive ... the pancreas of the channel catfish and the lungfish (McNeill et al., 1984; Hansen et al., 1987) In the present study, the regional distribution and relative frequency of endocrine cells in the...

Ngày tải lên: 07/08/2014, 14:23

... citatsomreht a ot detcennoc )nedewS ,aicamrahP( tinu IIrohpitluM eht ni demrofrep saw sisylana citerohportcele ehT la te gnisucof cirtceleosi lacitylanA snoitacifidom thgils htiw ]42[ nibwoT fo dohtem ... ,BKL( rettolb yrd-imes tolBavoN a gnisu demrofrep saw sisylana tolbonummI la te gnittolbonummI ]31[ ilmmeaL yb debircsed snoitidnoc eht ot gnidrocca demrofrep saw siserohportcele dna ,selpmas ,sleg ... noitaraperP )ASU ,daRoiB( lleC balS-lauD II naetorP -iniM eht ni demrofrep saw sisylana citerohportcelE EGAP-SDS ]3[ dohtem drofdarB eht yb detamitse saw sPLG eht fo tnetnoc nietorp ehT fo sPLG...

Ngày tải lên: 07/08/2014, 20:23

... populations and the two European oak species Q petraea (Matt) and Q robur L Levels of tannins in the heartwood of these two species have been reported to be greater than those found in the heartwood of ... logs and cutting of bolts, two staves were removed and used for this study These staves were cut from the outer heartwood, near the base of north and south facing sides of the bole Therefore, for ... Tronçais, the other in the Limousin region of France From each of these clear felled sites 20 randomly selected trees, of suitable quality for cooperage, were chosen During the splitting of logs and...

Ngày tải lên: 08/08/2014, 18:21

... and five orders, finds acceptance as food by the locals Out of the 81 species, are representatives of the Odonata, 17 of the Orthoptera, 16 of the Hemiptera, 15 of the Hymenoptera and 24 of the ... stages of insects taken are quite similar between the two tribes However, the total number of species consumed by the Nyishi Bangni of the East Kameng district is higher than that of the Galo of the ... rainfall of 3000 mm and temperatures ranging from 5°C in the month of December to 38°C in the month of July The total population of the district, which is inhabited by not only members of the Galo,...

Ngày tải lên: 10/08/2014, 09:21

... regarding the effects of a shunt not at the atrial level but from the pulmonary artery to the left atrium The purpose of this study was to examine the effects of right ventricle overload of two different ... proximal and distal directly rather than to introduce a Page of 10 catheter Swan Ganz through the tricuspid valve because of the enhanced stability and reproducibility of the pressure and volumetric ... (proximally of the banding) The other side of the graft was connected end to side with the left auriculum for group No (Figure 3) We have chosen to introduce the 14-G hypodermic needle into the left...

Ngày tải lên: 10/08/2014, 09:22

... participated in the design of the study, carried out parts of the study, wrote the manuscript, and contributed equally to this study; LS and DY carried out parts of the study and contributed ... range, 42-153) For the patients still participating in the study at the time of data cutoff, everolimus exposures were 209 and 230 days for the patients with RCC and 243 days for the patient with ... before the first dose of everolimus (baseline), weekly for the first weeks, every other week for the second and third month, and monthly thereafter A safety follow-up was conducted 28 days after the...

Ngày tải lên: 10/08/2014, 21:23

... terms of the audience’s perception of the offensive act Therefore, the appropriateness of a response depends upon the exigence of the situation The definition of effectiveness also establishes the ... whether the recipients of the accounts were offended or not (appropriateness) and whether the recipients were persuaded to restore the face of the transgressor (effectiveness)” (p 157) These two ... account the point of view of the audience Burns and Bruner (2000) did offer some suggestions in order to improve the theory of image repair First, they suggested that the researcher expands the frame...

Ngày tải lên: 24/08/2014, 10:40

... depends on the magnitude of the field B(r) = |B(r)| Depending on the sign of gF mF , the particle experiences a magnetic force, either towards the minima of the field or to the maxima of the field ... states P3/2 and P1/2 respectively Thus the two terms in the bracket represent the contributions of the D2 and the D1 line to the total dipole potential The optical dipole trap depth in terms of temperature ... (MMOT) and Magnetic Trap (MT), to cool and store the atoms 2.1 Laser cooling and trapping The laser cooling and trapping rely on the interaction of the atoms with the laser light field The light...

Ngày tải lên: 08/09/2015, 15:07

... out of the data set—at least, under the Bayesian and correlational-type theories of the moment.” The Promise and Peril of Big Data But this sort of theory-formation is fairly crude in light of the ... practice, the theory and the data reinforce each other It’s not a question of data correlations versus theory The use of data for correlations allows one to test theories and refine them.” That ... “dumb dust”—grains of salt and sand—scientists put the grains on the top of a plate to show how they respond when the frequency of audio signals directed at the bottom of the plate is manipulated...

Ngày tải lên: 13/09/2016, 12:01

... side of the figure shows the copying scheme where log space is generated by reading the section of disk after the end of the log and rewriting the active blocks of that section along with the new ... relative importance of the various kinds of data written to disk, both in terms of how much of the live blocks they occupy on disk and in terms of how much of the data written to the log they represent ... chooses the segments with the highest ratio of benefit to cost The benefit has two components: the amount of free space that will be reclaimed and the amount of time the space is likely to stay free The...

Ngày tải lên: 12/09/2012, 15:05

... very specialized audience State -of -the- art researchers need this kind of detailed mathematics to understand the theoretical implications of the work A basic premise of this book is that most practical ... Multiplexing There are approximately one billion telephones in the world At the press of a few buttons, switching networks allow any one of these to be connected to any other in only a few seconds The ... word in the incoming audio signal is isolated and then analyzed to identify the type of excitation and resonate frequencies These parameters are then compared with previous examples of spoken...

Ngày tải lên: 13/09/2012, 09:49

... patterns Whether these are activated depends on the social demands placed on the individual by the way of life of their community These determine the situational contexts evocative of the social ... if the above definitions of the two terms and the distinctions drawn between them were of interest and perhaps of some clinical value, they would hardly be meaningful so far as research and theory ... see the rise of psychology and the application of its psychometric methods to the study of social phobia The first scale for the measurement of social anxiety À the psychological construct at the...

Ngày tải lên: 21/09/2012, 10:54

... referral) may depend on the nature of the condition, whether the referral is for reasons of diagnosis and/ or treatment, the preference of the provider, and the relationship between the providers Medical ... situation, that the point of referral may depend on the familiarity or relationship between the providers, and that the nature of the referral (e.g., amount and type of information accompanying the referral) ... group composed of both chiropractic and medical professionals The goals of the focus group were to explore the attitudes and experiences of medical and chiropractic clinicians regarding their patients...

Ngày tải lên: 25/10/2012, 10:06

... Department of State A few of the groups on the official list, however, are guerrilla organizations These include the FARC, the LTTE, and the PKK To be sure, the FARC, the LTTE, and the PKK engage ... communications, and so forth Whereas the skills of the elite terrorist commandos of the 1960s and 1970s were often limited to what they learned in training camp, the terrorists of the 1990s who ... justification for their killing of other Jews was that these killings demonstrated the consequences of the immorality of collaborating with the Roman invaders, and that the Romans could not protect their...

Ngày tải lên: 07/11/2012, 14:21