the unfolding of consciousness

... [31], the resonance decay (i.e. loss of intensity) of reduced a-lactalbumin in the absence of aB-crystallin arises from aggregation of the molten globule state of this protein. In the presence of ... concen- tration of proteins, the main group of which is the crystallins, the higher-order structural arrangement of which enables the refraction of light to ensure proper vision. The principal ... this flexible region plays in the structure of the protein and its importance in maintaining the structural integrity of the well-ordered domain core of the protein (e.g. the C-terminal a-crystallin...

Ngày tải lên: 16/03/2014, 18:20

... of cortex and their targets in the front that project back to the upper stages of the ventral pathway (possibly involving stages of the tha- lamus, such as the pulvinar [130] , as well as the ... consist of a matrix of many hundredth thousandths of voxels for each subject and for each condition. Each of these voxels BACKGROUND The human brain is approximately 2% of the weight of the ... integrated view of the organism; the set whose cross-regional activity generates the representation of the object; and the set which is responsible for interrelating the two others. The object...

Ngày tải lên: 03/04/2014, 12:07

... duration of the relationship between the father and mother. If the relationship is brief, Haig observes, chances are that any other children borne by the woman will bear the genes of another man. The ... metric tons of lead have been placed on the northern side of the towerÕs base. The weights have pushed down the foundation under the northern wall, thereby straight- ening the tower a couple of centimeters. ... rates. In other words, the fetal strategy is paying oÝ. This hypothetical drama is further complicated by the role of the father, whose genetic interests, again, diverge from those of the mother....

Ngày tải lên: 12/05/2014, 15:03

... structure of the neutral protease from Bacillus stearothermo- philus, including the position of the disulfide bridge in mutant G8C ⁄ N60C. The model was created on the basis of the X-ray structure of thermolysin ... kJÆmol )1 through the introduction of the disulfide bridge (at 5mm CaCl 2 and 25 ° C) is obtained. The influence of calcium ions on the unfolding kinetics The influence of the calcium ion concentration on unfolding ... concentra- tion, the addition of calcium ions is able to change the unfolding rate constant over four orders of magni- tude. The addition of EDTA resulted in a further increase of the unfolding rate,...

Ngày tải lên: 19/02/2014, 17:20

... Unified Quest), on the topic of the long war, all of which have high- lighted the difficulty of producing a single term capable of describing the complex nature of the situation facing the United States. ... (PSYOPS). As the numbers grow, 2 Unfolding the Future of the Long War consider it as the confluence of three sets of problems: those related to the ideologies espoused by key adversaries in the conflict, ... by agencies other than the Army, but it has often been fulfilled by the Army. Broad Observations From the consideration of the implications of the proposed trajec- tories for the United States,...

Ngày tải lên: 06/03/2014, 20:20

... enhances the rate due to the release of the sixth axial ligand from the heme-iron which allows for the peroxide anion to bind. At pH 4.5 the mid-point of the unfolding transition (C m ) for the M100K ... with the unfolding data accumulated in this study which show that the early unfolding of the M100K variant involves the breaking of the Lys-N f -iron bond coupled with the dynamic process of ligand ... amounts of guanidinium hydrochloride (GdmHCl) the protein unfolds resulting in the perturbation of a number of electronic absorption bands and the appearance in the spectrum of new ones. One of these,...

Ngày tải lên: 07/03/2014, 17:20

... substitution on the destabilization of secondary structure that leads to the large perturbation of the stability of the protein tertiary structure (although there is about 7% difference of thermal energy ... lower than that of the wild-type protein. The thermodynamic parameters of the glycine susti- tution mutants also differed greatly from the wild-type protein. The T m values of these mutants ranged ... each state less than 5 kcalÆmol [1]. Therefore, the measured energy of thermal unfolding mainly contributes to the conversion of N to D. For wild-type SNase, the unfolding energy needed is about...

Ngày tải lên: 07/03/2014, 21:20

... accurately describes the dissociation /unfolding process of d 2 -crystallin. Another possible origin of the discrepancy between the results of Sampaleanu et al. [30] may be the denaturation time used in these ... demonstrate the formation of dimers during the dissociation step (Fig. 1). These results are in agreement with the double dimer structure of the tetra- meric d 2 -crystallin. The crystal structure of the ... proposed a minimum model for the dissociation /unfolding of the tetrameric duck d 2 -crystallin in the presence of GdnHCl. The dissociation step involves dissociation of tetramer to monomers. However,...

Ngày tải lên: 08/03/2014, 08:20

... iden- tified as the major and the minor forms of the holo- ACP structure, on the basis of their percentage contri- butions (65% and 35%, respectively) to the overall structure of the protein. The structures ... with the LEM of protein unfolding [29]. It is apparent from the solution denaturation studies that the holo form of the protein has greater stability than the apo form. The differences in the unfolding thermodynamic ... estimated on the basis of the linear regression of the fraction number of the molecular mass markers cytochrome c (CyC), carbonic anhydrase (CA), and BSA. From the calibration curve of the sucrose...

Ngày tải lên: 16/03/2014, 10:20

... studied the effect of the mutations on the thermodynamic and kinetic stability. The similarity of the impact on both the thermodynamic and kinetic stabilities suggests a predominant effect on the ... disturbance of the formation of a hydrophobic cluster [42]. Nevertheless, the decrease in the thermodynamic stability is m ainly c ause d by t he faster unfolding resulting from destabilization of the ... validity of the concept of t he unfolding region. Acknowledgements We are grateful to Professor R. T. Raines (University of Wisconsin, Madison, WI, USA) for the gift of the plasmid pBXR, to Professor G....

Ngày tải lên: 16/03/2014, 18:20

... responsible for the higher stability of the wild-type protein compared to the mutant. Thus, the value of 1.8 kJÆmol )1 could be taken as being the maximum cost of the disruption of the K13-E34 salt bridge ... 4.00. Nevertheless, there is no commonly held view in the literature on the energetic advantages of solvent-exposed salt bridges as the disruption of a salt bridge by the substitution of one of the ... will coincide within the limits of experimental accuracy and therefore the heat-capacity change on unfolding will be the same for the wild-type and the mutant protein. The quality of the multiple-curve...

Ngày tải lên: 23/03/2014, 12:20

... a con sequence, the stability of the apoprotein in high salt is greater than the s tability of the holoprotein. Phosphate increases the slope in the transition region of the unfolding curve for ... dissociation of FMN. The rate of unfolding of apo¯avodoxin depends on the urea concentration, while the reaction with the holo- protein is independent of urea. The rates decrease in high salt with the ... ¯ avodoxin, differences in the m echa- nisms of unfolding of the two proteins might be under- standable. The conformations of the two loops of protein that envelop the FMN are different in t...

Ngày tải lên: 31/03/2014, 15:20

... strategy. Neither M nor M ∗ is conscious in and of itself, independently of the other state. It is their coming together in the right way that yields consciousness. 58 Versions of the HOMT differ ... apart H 2 O and the other stuff and are unaware of the differences in the molecular com- position of the watery stuff in their envi- ronment, the representational contents of their respective ... longer focused on the sky, but rather on the experience thereof. What are you aware of? It seems that you are still aware of the blueness of the sky. Certainly you are not aware of some second blueness,...

Ngày tải lên: 03/04/2014, 12:10

... educa- tion. The average levels of health consciousness were also compared across the categories of diners as well as the proportion of people who responded that taste or health was the mos t important ... symbolic calorie label can further reduce the caloric intake of even the most health conscious patrons. Finally, calorie labels were more likely to influence the selection of the main entrée as opposed ... USA Full list of author information is available at the end of the article © 2013 Ellison et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons...

Ngày tải lên: 08/04/2014, 18:33

Ngày tải lên: 05/06/2014, 11:32