the tragic story of paolo and francesca was the subject

... positions and sequences used to amplify pri-miR9-1, 9-2 and 9-3. Arrows indicate the position and orientation of the primers. Bold font represents the sequence of mature miR9* and italic fonts the ... sense and antisense strands of the piRNA hairpin are involved in formation of the piR- NA-interacting complex (piRC) and function in the transcriptional gene silencing of retrotransposons and genetic ... P19 cells; the white bar represents mature miR9 and the black bar mature miR9*, and the line with a triangular head indicates the ratio (numerical values shown on the top of bar) of mature miR9...

Ngày tải lên: 18/02/2014, 17:20

... including funds of funds, except for France, Germany and Italy for which the funds of funds data are included in the other fund categories; (3) net sales of non-UCITS are included in "other" ... D D o o m m i i c c i i l l i i a a t t i i o o n n The combined assets of the investment fund market in Europe, i.e. the market for UCITS and non- UCITS, edged slightly lower in the second quarter of 2011 by 0.1 percent to stand at EUR ... this segment of the business accounted for just over 73 percent of the fund market at end June 2011, with the remaining 27 percent composed of non-UCITS. Table 7. Net Assets of the European...

Ngày tải lên: 07/03/2014, 16:20

... -8.5% -296 -12.6% -459 Total (incl. Ireland & Netherlands) 35,766 -1.0% -346 -0.9% -340 (1) No full data breakdown is available for Ireland and the Netherlands; (2) end June 2012 compared to ... of 2012 and Results for the First Half of 2012 This report was prepared by Bernard Delbecque, Director of Economics and Research EFAMA The European Fund and Asset Management ... (EUR 1 billion). Luxembourg and Ireland attracted net inflows of EUR 22 billion and EUR 17 billion, respectively, into bond funds during the quarter. On the other hand, money market funds in...

Ngày tải lên: 07/03/2014, 16:20

... collected and treated as detailed in Materials and methods. An equation containing the sum of three exponentials was fit to the data. The R 2 forthefitwasbetterthan 0.998; the fit is shown as the solid ... the time course of the absorb- ance change at 443 nm. The difference between the steady state values of the 276 K sample and the totally reduced sample at 276 K are clearly much larger than the ... temperature in the cuvette was monitored during the assay with a T-type thermo- couple and was constant within ± 0.1 K over the course of the measurement. The rate constant on the ordinate is a turnover...

Ngày tải lên: 31/03/2014, 07:20

Ngày tải lên: 09/04/2014, 16:38

Ngày tải lên: 17/01/2014, 03:20

... occupation of Richard Bright and Thomas Daniel and then Co-partners trading under the Firm of the Bristol Copper Company but then the property of the said James Ford on[Pg 13] the South part and extending ... £3,000. There is still evidence in the building of the occupation of the Inland Revenue staff, iron gates and spiked barriers in the first floor passage to cut off their rooms from the Post Office ... business of the Bath Post Office,[Pg 46] and of his cross post contracts, and the other on the house in which John Palmer was born. Soon after noon on the eventful day, the Bath postmen's band,...

Ngày tải lên: 17/02/2014, 02:20

... ligand binding. The loop region of the upper domain moves towards the active site of the enzyme, thus shielding the substrates (and ligands) from bulk solvent. A detailed thermodynamic study of ... 1UAE [11]), conformation. The thiol group of C115 is highlighted in green and the nitrogen atoms of R120 and K22 in blue. The open form of MurA is unliganded (A) and the closed conformation (B) ... importance of R120 for the formation of the covalent fosfomycin adduct, we construc- ted the K22V/R120V and K22V/R120K double mutants (see Materials and methods) and repeated the analysis of adduct...

Ngày tải lên: 19/02/2014, 13:20

... with BamHI and NotI, and ligated into the same sites of the pQTev vector to yield the plasmid pQTev-dptF. The integrity of the plasmid was confirmed by sequencing. The resulting plasmid was used ... features is of consider- able importance for the development of selective potent drugs. The biosynthesis of the peptide core of these acidic lipopeptides via nonribosomal peptide synthetases (NRPSs) ... recognized by the C domain of the initiation module of dapto- mycin. That DptE and DptF are involved in the lipidation process of daptomycin was first shown by Miao et al. [1]. In their work, the daptomycin...

Ngày tải lên: 07/03/2014, 04:20

... adduct detected by the ESR spec- trometer. The typical ESR signal of DMPO-OOH ⁄ DMPO- OH was observed. The OH and O 2 -scavenging activity was calculated on the basis of decreases in the DMPO-OH or DMPO-OOH ... Maastricht University, the Netherlands Colorectal cancer is the third most commonly diagnosed cancer in the world and is one of the major causes of cancer-associated mortality in the USA [1,2]. Epidemio- logical ... treatment and the degree of polymerization related to the bioavailability in the colon. Procyanidins and monomeric catechins (Fig. 1) are the main active polyphenols in grape and pine bark. The difference...

Ngày tải lên: 07/03/2014, 05:20

... the c-phosphate of the bound nucleotide across the dimer [15] and the aromatic residue of the A-loop stacks against the adenine moiety of bound nucleotide and provides further stabilization and specificity ... cleavage of the c-phosphate does occur in the NBD with the mutation at the IC [36,38,39]. More- over, these and other studies suggest that the IC residues are involved in the formation of the NBD dimer, ... motifs: the Walker A and B motifs, the signature or LSGGQ motif and the A-, D-, H- and Q-loops. These motifs are positioned around the bound nucleotide and help to position and maintain it in the...

Ngày tải lên: 07/03/2014, 06:20

... 5. The Secretary of Energy and the Director of the Na- tional Science Foundation, working with the White House Office of Science and Technology Policy and the Office of Management and Budget and ... suggests that these impending discoveries may transform our understanding of the origin of matter and energy and the ongoing evolution of the universe. The limitations of the Standard Model are ... exciting periods in the history of physics. One of the great scientific achievements of the 20th century was the develop- ment of the Standard Model of elementary particle physics, which describes the relationships...

Ngày tải lên: 14/03/2014, 10:20

... 81% in the SH-SY5Y cells (Fig. 1A). Neither ASO significantly affected the level of the mRNA for the other ADAM, confirming the specificity of these ASOs [19]. The ASOs reduced the level of their ... in the presence or absence of APMA. In the majority of cases there was little difference between the effect of inhibitors on the constitutive shedding of ACE and the APMA-induced shedding of ... increase in the shedding of APP upon incubation of the cells with APMA, the shedding of ACE was increased several-fold. The soluble form of ACE shed upon APMA stimulation was cleaved at the same...

Ngày tải lên: 30/03/2014, 14:20

... absorbance properties of the chromophore without affecting the coordination number or the spin state of the haem-iron, and the quenching of the 1 H-NMR relaxivity. Values of K d for ibuprofen and warfarin ... 10 28 M and n ẳ 1.0 ^ 0.1, in the absence of drugs, and K d ẳ 1.5 ^ 0.2 10 27 M and n ẳ 1.0 ^ 0.1, in the presence of ibuprofen and warfarin. The haem concentration was 1.0 Â 10 27 M. The electronic ... constant (K d ) and of the Hill coefficient (n ) for haem binding to HSA, in the absence and presence of ibuprofen and warfarin. The K d value for ferric haem binding to HSA, in the absence of drugs,...

Ngày tải lên: 31/03/2014, 23:20

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