the role of wt1 in development and disease
Tài liệu Investigating the Role of Poultry in Livelihoods and the Impact of Avian Flu on Livelihoods Outcomes in Africa docx
... et al 2008; Aning, Turkson, and Asuming-Brempong 2008; Obi, Oparinde, and Maina 2008; Omiti and Okuthe 2008) Therefore, information regarding the role of poultry in the livelihoods of small-scale ... culled No information is available on the costs of culling, diagnostic testing of samples, cleaning and disinfection, and other administrative costs (Obi, Oparinde, and Maina 2008) Regarding the impacts ... detail the role of poultry (both as a source of income and as an asset) in the entirety of the households’ income and asset portfolios Regarding the sources of data used in this study, for the West...
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Báo cáo khoa học: Caenorhabditis elegans metallothionein isoform specificity – metal binding abilities and the role of histidine in CeMT1 and CeMT2 potx
... some hint of partial participation in a subset of the metal complexes present in our preparations The role of histidine in metal ion coordination in MTs is a subject that has gathered increasing ... greatly in terms of the number of other less likely modifiable residues (Lys, Tyr, Ser and Thr) and cysteines remain inaccessible due to the binding of metal ions Of special significance is the result ... the data suggest the contribution of three out of four histidines (probably excluding the C-terminal histidine) in the coordination of the seventh M(II) ion, precisely the Zn(II) of Cd6Zn1–CeMT1...
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AUTISM SPECTRUM DISORDERS: THE ROLE OF GENETICS IN DIAGNOSIS AND TREATMENT pot
... that code for proteins from the family of neurexins and neuroligins that play, in turn, a role in the development and functioning of synaptic and in particular glutamatergic and GABA-ergic networks ... stop resulting in the absence of the FMR1 protein This results in intellectual disability and other symptoms of the Fragile X syndrome among men, and in >50% of the women who are carriers of a full ... groups The findings of this study reveal that the PDD-NOS group had a high number of features in common with the autism and the ADHD groups, in terms of presenting and/ or reported symptoms and developmental...
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Báo cáo y học: "The role of leptin in innate and adaptive immune responses" doc
... the main binding site for leptin on the Ob-R The Ig-like and the FN-III domains are critically involved in Ob-R activation The role of CRH1 remains to be determined [111,112] FNIII, fibronectin ... adipocytokines have been observed in a variety of inflammatory conditions (reviewed in [27]) and, in particular, the role of leptin in immune responses and inflammation has lately become increasingly ... in leptin-deficiency The role of leptin in experimental models of arthritis A potential role of leptin has been recently investigated in several models of arthritis depending on acquired or innate...
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A transmembrane mutation in FcgRIIb reveals the role of ceramide in phagocytosis and autoimmunity
... 1.8) The lipid moiety can vary in terms of chain length of the fatty acids and in the degree of saturation and hydroxylation of the sphingoid base Also, variations in the type, number and linkage ... promoting phagocytosis, the release of various inflammatory cytokines and the production of reactive oxygen species The inhibitory receptor on the other hand serves to regulate the threshold of the ... and clearance of infectious targets and contributes to the maintenance of tissue homeostasis, control of immune responses and the resolution of inflammation The understanding of the phagocytic...
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The Role of Deployments in Competency Development - Experience from Prince Sultan Air Base and Eskan Village in Saudi Arabia potx
... pertaining to the nature and extent of airmen development occurring within the Training, Exercise, and Deployment (TED) arena Specifically, they asked whether officers learn enough during contingency ... which they learned a specific competency or skill They then indicated the single “best” learning environment for the skill or competency in question Settings included initial training, on -the- job ... examination of how to track that learning The research summarized here responds to that query and, in doing so, sheds light on the learning of enlisted personnel vis-à-vis the learning of officers...
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Báo cáo khoa học: "The role of body mass index and diabetes in the development of acute organ failure and subsequent mortality in an observational cohor" doc
... independent variable in the analysis and could not explain the results even though the infection rate and the duration of mechanical ventilation were not increased in the obese group Studies of critically ... determine the role of DM in modifying the effect of obesity Materials and methods Study population The Atherosclerosis Risk in Communities (ARIC) study is a prospective, population-based study of the ... analytic cohort Outcome variables The primary outcomes of interest were the risk of the development of acute organ failure within three years of the baseline examination, in- hospital mortality related...
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Evaluation of the role of autophagy in fungal development and pathogenesis 2
... 13 and maintence of intracellular membrane compartments and their resident proteins in eukaryotic cells Endosomes also play a role in cellular signaling The G protein signaling occurring on the ... analysis The replacement of ATG8 and the single-copy integration of the genomic ATG8 locus were confirmed by Southern blotting (Fig 3B) Two independent strains in each instance were then characterized ... placed on induction medium plates containing 200 µM Acetosyringone, 60 µg/mL Streptomycin and 100 µg/mL Ampicillin Air-dry the liquid on the filter in the laminar flow hood Incubate the mixture...
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Evaluation of the role of autophagy in fungal development and pathogenesis 3
... from the wild type in terms of its capacity to breach the host surface and cause disease (Fig 6A and B) Interestingly, and unlike the atg8Δ, the gph1Δ atg8Δ strain elicited a slight induction of ... OP-2 strains The indicated strains were initially grown in the dark for days and then subjected to constant illumination to induce conidiation At the specified time-points post induction, the fungal ... regulation of conidiation, and to elucidate the exact physiological role of autophagy in the process of asexual development in Magnaporthe A key finding was the remarkable suppression of atg8Δ...
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Evaluation of the role of autophagy in fungal development and pathogenesis
... Yun long and Selvarai Poonguzhali, for making our lab a most pleasant and stimulating working environment The TLL community, especially the sequencing lab and the microscopy and imaging facility ... selective, depending on the specific biological circumstance and/ or the specific inducer involved Autophagy was first identified and characterized in yeast and in animal cells In recent years, ... differentiation and conidiation in Magnaporthe 49 3.2.4 Post-translational processing and Atg8p targeting to autophagosomes in Magnaporthe 53 3.2.5 Induction and subcellular...
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Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 2
... aldehyde 1, and using the synthetic route shown in Scheme 1, six analogues of sphingosine were synthesized In the first step, acetylides of various chain lengths, obtained from the treatment of alkynes ... change Within the linear range of the assay (~5-25μg/mL), the more protein present, the more the Coomassie Blue binds changing the absorbance of the sample After getting cell lysates from the CHO ... was not in the final list and not being tested further, is mainly because the yield of compound 2a3 is really low (~7%) Therefore, obtaining compound 3a3 requied a large amount of the starting material-Garner’s...
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Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 3
... inhibitor candidate, in terms of the ability to penetrate into the cells and inhibit the endogenous SPHK1 and the good yield obtained from the chemical synthesis procedure Therefore, in this chapter, ... 3.2.3.1.2.2 Immunostaining of Osteocalcin, Osteopontin, and osteonectin The expression of osteocalcin, osteopontin, and osteonectin was measured by immunostaining after 28 days of culture with or ... staining in each sample was quantified by dissolving the staining with 100% of isopropanol and detecting the absorbance at 500nm 3.1.3.3 Fluorescence Immunostaining Fluorescence immunostaining...
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Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 4
... cultured in 6-well plates were washed twice with 1x PBS and starved in serum-free DMEM for half an hour 1μM S1P was then added into the wells and incubated at 37°C for 5min, 10min, 30min, and 60min ... with iκB, and the phosphorylation of iκBα would cause the release and the activation of NF-κB The activated NF-κB can then translocate into the nucleus and trigger gene expression Due to the limited ... Osteogenic and Adipogenic Induction Culture) Cells were cultured for a total of 28 days, then fixed and stained with Alizarin Red S The Alizarin Red S Staining quantification results are shown in Figure...
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Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 5
... differentiation in most of the cases, while at higher amounts (1μM DMS and 5μM CP6) showed to inhibit the osteogenic differentiation in most of the experiments Interestingly, in human BM- and AD- MSCs ... potential for the use of SPHK inhibitors in preconditioning stem cells before transplanting them into the body, by committing stem cells along specific differentiation path More work, including in vivo ... Conclusion and Future Work being one of the most potent and specific SPHK1 inhibitors (chapter 2), DMS was continuously used as a reference inhibitor It is interesting to note that CP6 and DMS affected...
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Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 6
... (1998) “N,N-Dimethylsphingosine Is a Potent Competitive Inhibitor of Sphingosine Kinase but Not of Protein Kinase C: Modulation of Cellular Levels of Sphingosine 1-Phosphate and Ceramide.” Biochemistry, ... “Characterization of N, N-dimethyl-derythro-sphingosine-induced apoptosis and signaling in U937 cells: independence of sphingosine kinase inhibition.” Prostaglandins & Other Lipid Mediators 86(1-4):18-25 Kimura, ... sphingosine kinase." J Biol Chem 279(43): 44802-11 164 Chapter References Igarashi, Y and S Hakomori (1989) "Enzymatic synthesis of N,N-dimethyl-sphingosine: demonstration of the sphingosine:...
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Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation
... this increasing need for more MSCs is one of the main motivations of the present study, in particular, in studying the role of S1P in adult stem cell proliferation Another major motivation is the ... effects of S1P by inhibiting proliferation and secretion of cytokines, while enhancing secretion of the suppressive cytokine Interleukin-10 (IL-10) S1PR5 is the most recent member in S1PRs family and ... include using SPHK inhibitors to inhibit endogenous SPHK directly, or inhibiting the phosphorylated product S1P directly One of the successful attempts of inhibiting S1P is the development of the monoclonal...
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The role of microRNAs in embryonic stem cell development and differentiation
... Seng, Huibin, Yin Loon, Minh, Sandy, Phil and all other past and present members of Bing’s lab, thank you for your friendship, and for making the lab such a stimulating and fun place to work in I ... putative minimal promoter The number and precise sequences of the pre-microRNAs, their distance from the promoter and the polyadenylation sites, the regions flanking the hairpins, and the types, ... it finds putative microRNA binding sites in the sequence of interest before identifying the targeting microRNA In a luciferase reporter screen, average repressions of 30% or more for 168 of 226...
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Circuit theory of finance and the role of incentives in financial sector reform
... profitability is declining The internalization of information within the same institution may thus enhance intra-circuit and inter-circuit stability by reducing the incentive to overfinancing The ... searching, inspecting, testing, evaluating, interpreting and judging are parts of the production process of information; disseminating information to the general public through reports or advertising ... placing money with investment financial institutions in the capital market, and hold the remaining share in noninterest bearing, short-term bank deposits (eq 7) The share of savings going to the...
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The role of language in adult education and poverty reduction in Botswan
... Botswana maintains the hegemony and the gap between the poor and the rich, the major and minority groups In order to redress poverty the adult education program needs to be aware of the social ... knowledge of the minority and poor people and use them to mobilize the poor and minorities who are struggling for the betterment of their conditions It could mobilize the so called minorities ... oppose their status and challenge the hegemony of the majority communities in Botswana 31 In most parts of the world, education is for the most part the preserve of the few (elites) The choice of...
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Tài liệu Egypt''''s Water Warriors : Water Pollution in Egypt and the Role of NGOs in Reaching Integrated Management ppt
... chemical and microbiological properties of groundwater in Saint Katherine, South Sinai, Egypt and exploring the diversity, occurrence and distribution of fungal taxa in groundwater in South Sainai, ... to the natural protectorate law and the decision of the Prime Minister regulating to activities inside the protectorates in addition to the inefficiency of the biological treatment project of ... Azeem was one of a few Media reported the progress in increasing interest.[19],[20].to investigate the amount and seriousness of pollution caused by factories dumping their waste in the Egyptian...
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