Tài liệu hạn chế xem trước, để xem đầy đủ mời bạn chọn Tải xuống
1
/ 25 trang
THÔNG TIN TÀI LIỆU
Thông tin cơ bản
Định dạng
Số trang
25
Dung lượng
127,67 KB
Nội dung
Chapter References CHAPTER REFERENCES Alemany, R., D Meyer Zu Heringdorf, et al (1999) "Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase." J Biol Chem 274(7): 3994-9 Ammit, A J., A T Hastie, et al (2001) "Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma." Faseb J 15(7): 1212-4 Ancellin, N., C Colmont, et al (2002) "Extracellular export of sphingosine kinase-1 enzyme Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation." J Biol Chem 277(8): 6667-75 Argraves, K M., B A Wilkerson, et al (2004) "Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis." J Biol Chem 279(48): 50580-90 Ashjian, P H., A S Elbarbary, et al (2003) "In vitro differentiation of human processed lipoaspirate cells into early neural progenitors." Plast Reconstr Surg 111(6): 1922-31 Auge, N., M Nikolova-Karakashian, et al (1999) "Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase." J Biol Chem 274(31): 21533-8 Auge, N., A Negre-Salvayre, et al (2000) “Sphingomyelin metabolites in vascular cell signaling and atherogenesis.” Prog Lipid Res 39:207–229 Bacou, F., R B el Andalousi, et al (2004) "Transplantation of adipose tissue-derived stromal cells increases mass and functional capacity of damaged skeletal muscle." Cell Transplant 13(2): 103-11 Bai Aiping, G Patrick Meier, et al (2004) “Prodrug modification increases D609 chemical stability and cytotoxicity agaist U937 leukemia cells” JPET Fast Forward 309:1051-9 Baumruker, T and E E Prieschl (2002) "Sphingolipids and the regulation of the immune response." Semin Immunol 14(1): 57-63 Behfar, A and A Terzic (2007) "Optimizing adult mesenchymal stem cells for heart repair." J Mol Cell Cardiol 42(2): 283-4 Benoit, D S and K S Anseth (2005) "Heparin functionalized PEG gels that modulate protein adsorption for hMSC adhesion and differentiation." Acta Biomater 1(4): 461-70 158 Chapter References Benvenuti, S., R Saccardi, et al (2006) "Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related gene seladin-1." Exp Cell Res 312(13): 2592-604 Bernatchez, P N., F Tremblay, et al (2003) "Sphingosine 1-phosphate effect on endothelial cell PAF synthesis: role in cellular migration." J Cell Biochem 90(4): 719-31 Biddulph, D M., M M Dozier, et al (2000) "Inhibition of prostaglandin synthesis reduces cyclic AMP levels and inhibits chondrogenesis in cultured chick limb mesenchyme." Methods Cell Sci 22(1): 9-16 Bielby, R., E Jones, et al (2007) "The role of mesenchymal stem cells in maintenance and repair of bone." Injury 38 Suppl 1: S26-32 Bielawska, A., Szulc, Z., and Hannun, Y (2000) "A Synthesis of key precursors of radiolabeled sphingolipids." Methods Enzymol., 311: 518-535 Billich A, Bornancin F, et al (2003) "Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases" J Biol Chem 278 (48): 47408–15 Blakolmer, K., K Jaskiewicz, et al (1995) "Hematopoietic stem cell markers are expressed by ductal plate and bile duct cells in developing human liver." Hepatology 21(6): 1510-6 Brinkmann, V Michael D Davis, et al (2002) “The immune modulator, FTY720, targets sphingosine 1-phosphate receptors.” J Biol Chem 277, 21453-21457 Bruder, S P., N Jaiswal, et al (1997) "Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation." J Cell Biochem 64(2): 278-94 Bussolati, B., S Bruno, et al (2005) "Isolation of renal progenitor cells from adult human kidney." Am J Pathol 166(2): 545-55 Cao, Tong, Boon Chin Henga, et al (2005) “Osteogenic differentiation within intact human embryoid bodies result in a marked increase in osteocalcin secretion after 12 days of in vitro culture, and formation of morphologically distinct nodule-like structures” Tissue and Cell 37:325-34 Chastain, S R., A K Kundu, et al (2006) "Adhesion of mesenchymal stem cells to polymer scaffolds occurs via distinct ECM ligands and controls their osteogenic differentiation." J Biomed Mater Res A 78(1): 73-85 Chen, X L., J Y Grey, et al (2004) "Sphingosine kinase-1 mediates TNF-alphainduced MCP-1 gene expression in endothelial cells: upregulation by oscillatory flow." Am J Physiol Heart Circ Physiol 287(4): H1452-8 159 Chapter References Chen, Y., F Y Teng, et al (2006) "Coaxing bone marrow stromal mesenchymal stem cells towards neuronal differentiation: progress and uncertainties." Cell Mol Life Sci 63(14): 1649-57 Cheng, Su-Li, Jian-Su Shao, et al (2003) “Msx2 Promotes Osteogenesis and Suppresses Adipogenic Differentiation of Multipotent Mesenchymal Progenitors” J Biol Chem., 278(46):45969-77 Chiba, K., Y Yanagawa, et al (1998) "FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats I FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing." J Immunol 160(10): 5037-44 Chiou, M., Y Xu, et al (2006) "Mitogenic and chondrogenic effects of fibroblast growth factor-2 in adipose-derived mesenchymal cells." Biochem Biophys Res Commun 343(2): 644-52 Choi, O H., J H Kim, et al (1996) "Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor." Nature 380(6575): 634-6 Chun, Jerold, Edward J Goetzl, et al (2002) “Lysophospholipid Receptor Nomenclature.” International Union of Pharmacology 54(2): 265-269 Cipriani, P., S Guiducci, et al (2007) "Impairment of endothelial cell differentiation from bone marrow-derived mesenchymal stem cells: new insight into the pathogenesis of systemic sclerosis." Arthritis Rheum 56(6): 1994-2004 Clark, B R and A Keating (1995) "Biology of bone marrow stroma." Ann N Y Acad Sci 770: 70-8 Conget, P A and J J Minguell (1999) "Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells." J Cell Physiol 181(1): 67-73 Corcione, A., F Benvenuto, et al (2006) "Human mesenchymal stem cells modulate Bcell functions." Blood 107(1): 367-72 Cousin, B., M Andre, et al (2003) "Reconstitution of lethally irradiated mice by cells isolated from adipose tissue." Biochem Biophys Res Commun 301(4): 1016-22 Cowan, C M., Y Y Shi, et al (2004) "Adipose-derived adult stromal cells heal criticalsize mouse calvarial defects." Nat Biotechnol 22(5): 560-7 Crews, C M., A Alessandrini, et al (1992) "The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product." Science 258(5081): 478-80 160 Chapter References Cummings, R J., N L Parinandi, et al (2002) "Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells." J Biol Chem 277(33): 30227-35 Cuvillier, O., G Pirianov, et al (1996) "Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate." Nature 381(6585): 800-3 Cuvillier, O., D S Rosenthal, et al (1998) "Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes." J Biol Chem 273(5): 2910-6 Dekel, B., S Metsuyanim, et al (2006) "Multiple imprinted and stemness genes provide a link between normal and tumor progenitor cells of the developing human kidney." Cancer Res 66(12): 6040-9 Desai, NN, H Zhang et al (1992) “Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation.” J Biol Chem 267: 23122-23128 Deutschman, D H., J S Carstens, et al (2003) "Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate." Am Heart J 146(1): 62-8 Dimarakis, I and N Levicar (2006) "Cell culture medium composition and translational adult bone marrow-derived stem cell research." Stem Cells 24(5): 1407-8 Djouad, F., D Mrugala, et al (2006) "Engineered mesenchymal stem cells for cartilage repair." Regen Med 1(4): 529-37 Donati, Chiara, Francesca Cencetti, et al (2007) “Sphingosine 1-phosphate mediates proliferation and survival of mesoangioblasts.” Stem cells 25(7):1713-1719 Dragoo, J L., J Y Choi, et al (2003) "Bone induction by BMP-2 transduced stem cells derived from human fat." J Orthop Res 21(4): 622-9 Drouet, M., F Mourcin, et al (2005) "Mesenchymal stem cells rescue CD34+ cells from radiation-induced apoptosis and sustain hematopoietic reconstitution after coculture and cografting in lethally irradiated baboons: is autologous stem cell therapy in nuclear accident settings hype or reality?" Bone Marrow Transplant 35(12): 1201-9 Duan, H F., C T Wu, et al (2004) "Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells." Exp Cell Res 298(2): 593-601 Edsall, L C., G G Pirianov, et al (1997) "Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation." J Neurosci 17(18): 6952-60 161 Chapter References Edsall, Lisa C, James R Van Brocklyn, et al (1998) “N,N-Dimethylsphingosine Is a Potent Competitive Inhibitor of Sphingosine Kinase but Not of Protein Kinase C: Modulation of Cellular Levels of Sphingosine 1-Phosphate and Ceramide.” Biochemistry, 37 (37), 12892 -12898 English, D., Z Welch, et al (2000) "Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis." Faseb J 14(14): 2255-65 Enlund, F., L Samuelsson, et al (1999) "Analysis of three suggested psoriasis susceptibility loci in a large Swedish set of families: confirmation of linkage to chromosome 6p (HLA region), and to 17q, but not to 4q." Hum Hered 49(1): 2-8 Erickson, G R., J M Gimble, et al (2002) "Chondrogenic potential of adipose tissuederived stromal cells in vitro and in vivo." Biochem Biophys Res Commun 290(2): 763-9 Farquharson, C., J L Berry, et al (1998) "Ascorbic acid-induced chondrocyte terminal differentiation: the role of the extracellular matrix and 1,25-dihydroxyvitamin D." Eur J Cell Biol 76(2): 110-8 Frankish, H (2001) "Researchers turn human stem cells into heart tissue." Lancet 358(9280): 475 French, K J., R S Schrecengost, et al (2003) "Discovery and evaluation of inhibitors of human sphingosine kinase." Cancer Res 63(18): 5962-9 Friedenstein, A J., K V Petrakova, et al (1968) "Heterotopic of bone marrow.Analysis of precursor cells for osteogenic and hematopoietic tissues." Transplantation 6(2): 230-47 Fukuda, K and J Fujita (2005) "Mesenchymal, but not hematopoietic, stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction in mice." Kidney Int 68(5): 1940-3 Garner, P., Park, J M., and Malecki, E (1988) "A stereodivergent synthesis of Derythro-sphingosine and D-threo-sphingosine from L-serine." J Org Chem., 53: 43954398 Gaustad, K G., A C Boquest, et al (2004) "Differentiation of human adipose tissue stem cells using extracts of rat cardiomyocytes." Biochem Biophys Res Commun 314(2): 420-7 Gearhart, J (1998) "New potential for human embryonic stem cells." Science 282(5391): 1061-2 162 Chapter References Geoffroy, K., N Wiernsperger, et al (2004) "Bimodal effect of advanced glycation end products on mesangial cell proliferation is mediated by neutral ceramidase regulation and endogenous sphingolipids." J Biol Chem 279(33): 34343-52 Gerstenfeld, L C., T J Cho, et al (2001) "Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling." Cells Tissues Organs 169(3): 285-94 Ghen, M J., R Roshan, et al (2006) "Potential clinical applications using stem cells derived from human umbilical cord blood." Reprod Biomed Online 13(4): 562-72 Ghosh, TK, Bian J, et al (1990) “Intracellular calcium release mediated by sphingosine derivatives generated in cells.” Science, 248: 1653-1656 Gimble, J M., S Zvonic, et al (2006) "Playing with bone and fat." J Cell Biochem 98(2): 251-66 Giordano, A., U Galderisi, et al (2007) "From the laboratory bench to the patient's bedside: an update on clinical trials with mesenchymal stem cells." J Cell Physiol 211(1): 27-35 Gordon, E M., M Skotzko, et al (1997) "Capture and expansion of bone marrowderived mesenchymal progenitor cells with a transforming growth factor-beta1-von Willebrand's factor fusion protein for retrovirus-mediated delivery of coagulation factor IX." Hum Gene Ther 8(11): 1385-94 Grigoriadis, A E., J N Heersche, et al (1988) "Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone." J Cell Biol 106(6): 2139-51 Hait, Nitai C., Andrea Bellamy, et al (2007) “Sphingosine kinase type activation by ERK-mediated phosphorylation.” J Bio Chem 282(16):12058-65 Hait, Nitai C, Sukumar Sarkar, et al (2005) “ Role of Sphingosine Kinase in cell migration toward epidermal growth factor.” J Biol Chem., 280(33):29462-9 Hanafusa, N., Y Yatomi, et al (2002) "Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells." Nephrol Dial Transplant 17(4): 580-6 Hannun, Y A (1994) "The sphingomyelin cycle and the second messenger function of ceramide." J Biol Chem 269(5): 3125-8 Harada, J., M Foley, et al (2004) "Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells." J Neurochem 88(4): 1026-39 163 Chapter References Harmand, M F., M Thomasset, et al (1984) "In vitro stimulation of articular chondrocyte differentiated function by 1,25-dihydroxycholecalciferol or 24R,25dihydroxycholecalciferol." J Cell Physiol 119(3): 359-65 Heller, R A and M Kronke (1994) "Tumor necrosis factor receptor-mediated signaling pathways." J Cell Biol 126(1): 5-9 Heng, BC, T Cao, et al (2004) “Strategies for directing the differentiation of stem cells into the osteogenic lineage in vitro.” J Bone Miner Res 19:1379–1394 Hentze, H, Graichen R, et al (2007) “Cell therapy and the safety of embryonic stem cellderived grafts.” Trends Biotechno 25:24-32 Herold, P (1988) "Synthesis of D-erythro- and D-threo-sphingosine derivatives from Lserine." Helv Chim Acta, 71: 354-362 Herbertson, A and J E Aubin (1995) "Dexamethasone alters the subpopulation makeup of rat bone marrow stromal cell cultures." J Bone Miner Res 10(2): 285-94 Hicok, K C., T V Du Laney, et al (2004) "Human adipose-derived adult stem cells produce osteoid in vivo." Tissue Eng 10(3-4): 371-80 Hla, T (2004) "Physiological and pathological actions of sphingosine 1-phosphate." Semin Cell Dev Biol 15(5): 513-20 Hla, T and T Maciag (1990) "An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors." J Biol Chem 265(16): 9308-13 Hong, G., L M Baudhuin, et al (1999) "Sphingosine-1-phosphate modulates growth and adhesion of ovarian cancer cells." FEBS Lett 460(3): 513-8 Huang, J I., S R Beanes, et al (2002) "Rat extramedullary adipose tissue as a source of osteochondrogenic progenitor cells." Plast Reconstr Surg 109(3): 1033-41; discussion 1042-3 Huang, S and L W Terstappen (1992) "Formation of haematopoietic microenvironment and haematopoietic stem cells from single human bone marrow stem cells." Nature 360(6406): 745-9 Hwang, N S., S Varghese, et al (2007) "Morphogenetic signals from chondrocytes promote chondrogenic and osteogenic differentiation of mesenchymal stem cells." J Cell Physiol 212(2): 281-4 Ibrahim, F B., S J Pang, and A J Melendez (2004) "Anaphylatoxin signaling in human neutrophils A key role for sphingosine kinase." J Biol Chem 279(43): 44802-11 164 Chapter References Igarashi, Y and S Hakomori (1989) "Enzymatic synthesis of N,N-dimethyl-sphingosine: demonstration of the sphingosine: N-methyltransferase in mouse brain." Biochem Biophys Res Commun 164(3): 1411-6 Igarashi, Y., S Hakomori, et al (1989) "Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities." Biochemistry 28(17): 6796-800 Ikeda, H., Y Yatomi, et al (2000) "Biological activities of novel lipid mediator sphingosine 1-phosphate in rat hepatic stellate cells." Am J Physiol Gastrointest Liver Physiol 279(2): G304-10 Im, G I., N H Jung, et al (2006) "Chondrogenic differentiation of mesenchymal stem cells isolated from patients in late adulthood: the optimal conditions of growth factors." Tissue Eng 12(3): 527-36 Im, Dong-Soon, Christopher E Heise, et al (2000) “Characterization of a novel sphingosine 1-phosphate Receptor, Edg-8.” Biol Chem, 275(19):14281-14286 Isakova, I A., K Baker, et al (2006) "Preclinical evaluation of adult stem cell engraftment and toxicity in the CNS of rhesus macaques." Mol Ther 13(6): 1173-84 Ishii, I., B Friedman, et al (2001) "Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3." J Biol Chem 276(36): 33697-704 Ishii, Isao, Xiaoqin Ye, et al (2002) “Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3” J Biol Chem., 277(28):25152-9 Jailard, C., S Harrison, et al (2005) “Edg8/S1P5: An oligodendroglial receptor with dual function on process retraction and cell survival.” J NeuroSci 25(6):1459-69 Jaiswal, Rama K., Neelam Jaiswal, et al (2000) “Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase.” J Biol Chem., 275(13):9645-52 Jian, H., X Shen, et al (2006) "Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells." Genes Dev 20(6): 666-74 Jin, Zhu-Qiu, Joel S Karliner (2006) “Low dose N,N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCε dependent mechanism.” Cardiovascular Res 71:725-34 165 Chapter References Joannides, A., P Gaughwin, et al (2004) "Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells." Lancet 364(9429): 172-8 Johansson, C B., M Svensson, et al (1999) "Neural stem cells in the adult human brain." Exp Cell Res 253(2): 733-6 Johnstone, B., T M Hering, et al (1998) "In vitro chondrogenesis of bone marrowderived mesenchymal progenitor cells." Exp Cell Res 238(1): 265-72 Jolly, P S., M Bektas, et al (2004) "Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis." J Exp Med 199(7): 959-70 Kakudo, N., A Shimotsuma, et al (2007) "Fibroblast growth factor-2 stimulates adipogenic differentiation of human adipose-derived stem cells." Biochem Biophys Res Commun 359(2): 239-44 Kaiser, E., Tam, J P., et al (1988) "Chlorotrimethylsilane-phenol as a mild deprotection reagent for the tert-butyl based protecting groups in peptide synthesis.” Tetrahedron Lett., 29: 303-306 Kang, Y J., E S Jeon, et al (2005) "Role of c-Jun N-terminal kinase in the PDGFinduced proliferation and migration of human adipose tissue-derived mesenchymal stem cells." J Cell Biochem 95(6): 1135-45 Katsuma, S., Y Hada, et al (2003) "Transcriptional profiling of gene expression patterns during sphingosine 1-phosphate-induced mesangial cell proliferation." Biochem Biophys Res Commun 300(2): 577-84 Katsuma, S., Y Hada, et al (2002) "Signalling mechanisms in sphingosine 1-phosphatepromoted mesangial cell proliferation." Genes Cells 7(12): 1217-30 Kee, T H., P Vit, et al (2005) "Sphingosine kinase signalling in immune cells." Clin Exp Pharmacol Physiol 32(3): 153-61 Khovidhunkit, Weerapan, MinSun Kim, et al (2004) “Effects of Infection and Inflammation on Lipid and Lipoprotein Metabolism: Mechanisms and Consequences to the Host” J Lipid Res 45(7):1169-96 Kilian, O., I Flesch, et al (2004) "Effects of platelet growth factors on human mesenchymal stem cells and human endothelial cells in vitro." Eur J Med Res 9(7): 33744 166 Chapter References Kim, S S., J M Choi, et al (2005) "cAMP induces neuronal differentiation of mesenchymal stem cells via activation of extracellular signal-regulated kinase/MAPK." Neuroreport 16(12): 1357-61 Kim, Jin-Wook, Yong-Woo Kim, et al (2005) “Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases.” Bioorganic & Medicinal Chemistry 13: 3475-3485 Kim, Ji Young, Kristin S Tillison, et al (2007) “Differentiation-dependent expression of adhfel in adipogenesis.” Arch Biochem Biophys 464(1):100-111 Kim, Hyo-Lim, Santosh J Sacket, et al (2008) “Charaterization of N,N-dimethyl-Derythro-sphingosine-induced apoptosis and signaling in U937 cells: Independece of sphingosine kinase inhibition.” Prostaglandins & other lipid Mediators 86: 18-25 Kim, Hyo-Lim, Santosh J Sacket, et al (2008) “Characterization of N, N-dimethyl-derythro-sphingosine-induced apoptosis and signaling in U937 cells: independence of sphingosine kinase inhibition.” Prostaglandins & Other Lipid Mediators 86(1-4):18-25 Kimura, T., T Watanabe, et al (2000) "Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3." Biochem J 348 Pt 1: 71-6 Kimura, T., K Sato, et al (2001) “Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells.” J Biol Chem 276:31780–31785 King, C C., Zenke, F T., et al (2000) “Sphingosine is a novel activator of 3phosphoinositide-dependent kinase 1.” J Biol Chem., 275: 18108-18113 Kluk, M J and T Hla (2001) "Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration." Circ Res 89(6): 496-502 Kluk, Michael J and Timothy Hla (2002) “Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors.” Biochimica et Biophysica Acta 1582:72-80 Koda, Masahiro, Takashi Murate et al (2005) “Sphingosine kinase is involved in dibutyryl cyclic AMP-induced granulocytic differentiation through the upregulation of extracellular signal-regulated kinase, but not p38 MAP kinase, in HL60 cells” Biochimica et Biophysica Acta 1733:101– 10 Kogler, G., S Sensken, et al (2006) "Comparative generation and characterization of pluripotent unrestricted somatic stem cells with mesenchymal stem cells from human cord blood." Exp Hematol 34(11): 1589-95 167 Chapter References Kohama, T., A Olivera, et al (1998) "Molecular cloning and functional characterization of murine sphingosine kinase." J Biol Chem 273(37): 23722-8 Kohsaki, M., B Yanes, et al (1981) "Non-frozen preservation of committed hematopoietic stem cells from normal human bone marrow." Stem Cells 1(2): 111-23 Kolesnick, R and D W Golde (1994) "The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling." Cell 77(3): 325-8 Kono, K., Tanaka, M., et al (2000a) “B-535a, b and c, new sphingosine kinase inhibitors, produced by a marine bacterium; taxonomy, fermentation, isolation, physico-chemical properties and structure determination.” J Antibiot (Tokyo), 53: 753-758 Kono, K., Tanaka, M., et al (2000b) “Characterization of B-5354c, a new sphingosine kinase inhibitor, produced by a marine bacterium.” J Antibiot (Tokyo), 53: 759-764 Kono, K., Tanaka, M., et al (2001) “S-15183a and b, new sphingosine kinase inhibitors, produced by a fungus.” J Antibiot (Tokyo), 54: 415-420 Krampera, M., G Pizzolo, et al (2006) "Mesenchymal stem cells for bone, cartilage, tendon and skeletal muscle repair." Bone 39(4): 678-83 Kratchmarova, I., B Blagoev, et al (2005) "Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation." Science 308(5727): 1472-7 Kronenwett, R., S Martin, et al (2000) "The role of cytokines and adhesion molecules for mobilization of peripheral blood stem cells." Stem Cells 18(5): 320-30 Kukekov, V G., E D Laywell, et al (1999) "Multipotent stem/progenitor cells with similar properties arise from two neurogenic regions of adult human brain." Exp Neurol 156(2): 333-44 Kumar, S., G Mahendra, et al (2004) "Osteogenic differentiation of recombinant adenoassociated virus 2-transduced murine mesenchymal stem cells and development of an immunocompetent mouse model for ex vivo osteoporosis gene therapy." Hum Gene Ther 15(12): 1197-206 Kundu, A K and A J Putnam (2006) "Vitronectin and collagen I differentially regulate osteogenesis in mesenchymal stem cells." Biochem Biophys Res Commun 347(1): 34757 Kuno, Yuko, Teruaki Nishiuma, et al (2007) “Sphingosine kinase regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta1.” Am J Respir Cell Mol Biol Vol 37: 395-404, 2007 168 Chapter References Kuokkanen, S., M Gschwend, et al (1997) "Genomewide scan of multiple sclerosis in Finnish multiplex families." Am J Hum Genet 61(6): 1379-87 Kupperman, E., S An, et al (2000) "A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development." Nature 406(6792): 192-5 Latif, N., P Sarathchandra, et al (2007) "Characterization of structural and signaling molecules by human valve interstitial cells and comparison to human mesenchymal stem cells." J Heart Valve Dis 16(1): 56-66 Lee, I C., J H Wang, et al (2007) "The differentiation of mesenchymal stem cells by mechanical stress or/and co-culture system." Biochem Biophys Res Commun 352(1): 147-52 Lee, M J., S Thangada, et al (1999) "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate." Cell 99(3): 301-12 Lee, M J., S Thangada, et al (2001) "Akt-mediated phosphorylation of the G proteincoupled receptor EDG-1 is required for endothelial cell chemotaxis." Mol Cell 8(3): 693704 Lee, R H., B Kim, et al (2004) "Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue." Cell Physiol Biochem 14(4-6): 311-24 Lee, Eun-Hee, Yun-Kyung Lee, et al (2006) “Dimethylsphingosine regulates intracellular pH and Ca2+ in human monocytes.” J Pharma Sci 100 (4): 289-296 Leong Tai Wei David (2006a) "Characterization of human adipose derived adult multipotent precursor cells" (NUS PhD thesis) Leong, D T., A Gupta, et al (2007) "Absolute quantification of gene expression in biomaterials research using real-time PCR." Biomaterials 28(2): 203-10 Leong, Natalie L., Jie Jiang et al (2006b) “Polymer-Ceramic composite scaffold induces osteogenic differentiation of human mesenchymal stem cells.” EMBS Annual International Conference New York City, USA, Aug 30-Sept 3, 2006 Levenstein, M E., T E Ludwig, et al (2006) "Basic fibroblast growth factor support of human embryonic stem cell self-renewal." Stem Cells 24(3): 568-74 Levesque, J P., Y Takamatsu, et al (2001) "Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor." Blood 98(5): 1289-97 169 Chapter References Li, X., X Yu, et al (2007) "Bone marrow mesenchymal stem cells differentiate into functional cardiac phenotypes by cardiac microenvironment." J Mol Cell Cardiol 42(2): 295-303 Li, Z Y., L Chen, et al (2007) "Odontogenic potential of bone marrow mesenchymal stem cells." J Oral Maxillofac Surg 65(3): 494-500 Limaye, V., X Li, et al (2005) "Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members." Blood 105(8): 3169-77 Liu, H., D Chakravarty, et al (2002) "Sphingosine kinases: a novel family of lipid kinases." Prog Nucleic Acid Res Mol Biol 71: 493-511 Liu, H., M Sugiura, et al (2000) "Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type isoform." J Biol Chem 275(26): 19513-20 Liu, Y., R Wada, et al (2000) "Edg-1, the G protein-coupled receptor for sphingosine1-phosphate, is essential for vascular maturation." J Clin Invest 106(8): 951-61 Lucarelli, E., A Beccheroni, et al (2003) "Platelet-derived growth factors enhance proliferation of human stromal stem cells." Biomaterials 24(18): 3095-100 Luyten, F P (2004) "Mesenchymal stem cells in osteoarthritis." Curr Opin Rheumatol 16(5): 599-603 Lyncha, Kevin R., Timothy L Macdonaldb (2001) “Structure activity relationships of lysophospholipid mediators” Prostaglandins & other Lipid Mediators 64: 33–45 McDonald, O B., Hannun, Y A., et al (1991) “Activation of casein kinases II by sphingosine.” J Biol Chem., 266: 21773-21776 Mackay, A M., S C Beck, et al (1998) "Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow." Tissue Eng 4(4): 415-28 Mackenzie, T C and A W Flake (2001) "Human mesenchymal stem cells persist, demonstrate site-specific multipotential differentiation, and are present in sites of wound healing and tissue regeneration after transplantation into fetal sheep." Blood Cells Mol Dis 27(3): 601-4 MacLennan, AJ, Devlin BK, et al (2000) “Antisense Studies in PC12 Cells Suggest a Role for H218, a Sphingosine 1-Phosphate Receptor, in Growth-Factor-Induced Cell-Cell Interaction and Neurite Outgrowth.” Dev Neurosci 22:283-295 170 Chapter References MacLennan, A J., P R Carney, et al (2001) "An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate receptor in neuronal excitability." Eur J Neurosci 14(2): 203-9 Madry, H., R Padera, et al (2002) "Gene transfer of a human insulin-like growth factor I cDNA enhances tissue engineering of cartilage." Hum Gene Ther 13(13): 1621-30 Malek, R L., R E Toman, et al (2001) "Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors." J Biol Chem 276(8): 5692-9 Mandala, S., Richard Hajdu, et al (2002) “Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.” Science 296, 346-349 Mansoor, M, and A.J Melendez (2008) “Recent trials for FTY720 (fingolimod): a new generation of immunomodulators structurally similar to sphingosine” Rev Recent Clin Trials 3(1):62-9 Mastrogiacomo, M., R Cancedda, et al (2001) "Effect of different growth factors on the chondrogenic potential of human bone marrow stromal cells." Osteoarthritis Cartilage Suppl A: S36-40 Mauck, R L., B A Byers, et al (2007) "Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading." Biomech Model Mechanobiol 6(1-2): 113-25 Mauney, J R., V Volloch, et al (2005) "Matrix-mediated retention of adipogenic differentiation potential by human adult bone marrow-derived mesenchymal stem cells during ex vivo expansion." Biomaterials 26(31): 6167-75 McGiffert C, Contos JJA, et al (2002) “Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p1 in neurogenesis and s1p1-3 in angiogenesis.” FEBS Lett., 531:103-108 Megidish, T., White, T., et al (1995) “The signal modulator protein 14-3-3 is a target of sphingosine- or N,N-dimethylsphingosine-dependent kinase in 3T3(A31) cells.” Biochem Biophys Res Commun., 216: 739-747 Melendez, A., R A Floto, et al (1998) "FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking." J Biol Chem 273(16): 9393-402 Melendez, A J., E Carlos-Dias, et al (2000) "Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution." Gene 251(1): 19-26 171 Chapter References Melendez, A J and F B Ibrahim (2004) "Antisense knockdown of sphingosine kinase in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis." J Immunol 173(3): 1596-603 Melendez, A J and A K Khaw (2002) "Dichotomy of Ca2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells." J Biol Chem 277(19): 17255-62 Melendez, A.J (2008) “Sphingosine kinase signalling in immune cells: potential as novel therapeutic targets.” Biochim Biophys Acta 1784(1):66-75 Messina, E., L De Angelis, et al (2004) "Isolation and expansion of adult cardiac stem cells from human and murine heart." Circ Res 95(9): 911-21 Mets, T and G Verdonk (1981) "In vitro aging of human bone marrow derived stromal cells." Mech Ageing Dev 16(1): 81-9 Minamide, A., M Yoshida, et al (2007) "The effects of bone morphogenetic protein and basic fibroblast growth factor on cultured mesenchymal stem cells for spine fusion." Spine 32(10): 1067-71 Miranville, A., C Heeschen, et al (2004) "Improvement of postnatal neovascularization by human adipose tissue-derived stem cells." Circulation 110(3): 349-55 Miyamoto, M., H Ito, et al (2003) "Simultaneous stimulation of EP2 and EP4 is essential to the effect of prostaglandin E2 in chondrocyte differentiation." Osteoarthritis Cartilage 11(9): 644-52 Mizuno, H., P A Zuk, et al (2002) "Myogenic differentiation by human processed lipoaspirate cells." Plast Reconstr Surg 109(1): 199-209; discussion 210-1 Monick, Martha M, Kelli Cameron, et al (2004) “Sphingosine kinase mediates activation of ERK and Akt by Respiratory Syncytial Virus.” Am J Respir Cell Mol., 30: 844-52 Mori, A., Miyakawa, Y., Ohashi, E., Haga, T., et al (2006) "Pd/C-Catalyzed chemoselective hydrogenation in the presence of diphenylsulfide." Org Lett., 8: 32793281 Morita, Y., G I Perez, et al (2000) "Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy." Nat Med 6(10): 1109-14 Mueller, S M and J Glowacki (2001) "Age-related decline in the osteogenic potential of human bone marrow cells cultured in three-dimensional collagen sponges." J Cell Biochem 82(4): 583-90 172 Chapter References Nair, R P., T Henseler, et al (1997) "Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan." Hum Mol Genet 6(8): 1349-56 Nirmalanandhan, V S., M Rao, et al (2007) "Effect of length of the engineered tendon construct on its structure-function relationships in culture." J Biomech 40(11): 2523-9 Nofer, J R., M van der Giet, et al (2004) "HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3." J Clin Invest 113(4): 569-81 Nunes, V A., N Cavacana, et al (2007) "Stem cells from umbilical cord blood differentiate into myotubes and express dystrophin in vitro only after exposure to in vivo muscle environment." Biol Cell 99(4): 185-96 Nussbaum, J, Minami E, et al (2007) “Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response.” FASEB J 21: 1345-1357 Ohnishi, S and N Nagaya (2007) "Prepare cells to repair the heart: mesenchymal stem cells for the treatment of heart failure." Am J Nephrol 27(3): 301-7 Ohta, H, Yatomi Y, et al (1994) “A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-alpha in human neutrophils.” FEBS Lett, 355(3):26770 Okazaki H, Ishizaka N, et al (1993) “Molecular cloning of a novel putative G proteincoupled receptor expressed in the cardiovascular system.” Biochem Biophys Res Commun.190 (3):1104–1109 Olivera, A., T Kohama, et al (1999) "Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival." J Cell Biol 147(3): 545-58 Olivera, A and S Spiegel (1993) "Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens." Nature 365(6446): 557-60 Olivera, Ana, Nicole Urtz (2006) “IgE-dependent Activation of Sphingosine Kinases and and Secretion of Sphingosine 1-Phosphate Requires Fyn Kinase and Contributes to Mast Cell Responses.” J Biol Chem., 281(5): 2515-2525 Ong, S Y., H Dai, et al (2006) "Hepatic differentiation potential of commercially available human mesenchymal stem cells." Tissue Eng 12(12): 3477-85 Orgretment, B., and Hannun, Y A (2004) “Biological active sphingolipids in cancer pathogenesis and treatment.” Nat Rev Cancer 4, 604-616 173 Chapter References Orn, P (1999) "Stem cells in the brain have been identified Trials with human tissue will confirm results from animal studies." Lakartidningen 96(10): 1212-4 Oskeritzian, Carole A., Sheldon Milstien, et al., (2007) “Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis.” Parmacol Ther 115(3):390-99 Owen, M and A J Friedenstein (1988) "Stromal stem cells: marrow-derived osteogenic precursors." Ciba Found Symp 136: 42-60 Ozaki, H., T Hla, et al (2003) "Sphingosine-1-phosphate signaling in endothelial activation." J Atheroscler Thromb 10(3): 125-31 Paik, J H., A Skoura, et al (2004) "Sphingosine 1-phosphate receptor regulation of Ncadherin mediates vascular stabilization." Genes Dev 18(19): 2392-403 Payne, S G., S Milstien, et al (2002) "Sphingosine-1-phosphate: dual messenger functions." FEBS Lett 531(1): 54-7 Paugh SW, Payne SG, et al (2003) "The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2" FEBS Lett 554 (1–2): 189–93 Pébay, A., R C Wong, et al (2005) "Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells." Stem Cells 23(10): 1541-8 Peng, H and J Huard (2003) "Stem cells in the treatment of muscle and connective tissue diseases." Curr Opin Pharmacol 3(3): 329-33 Perez, G I., C M Knudson, et al (1997) "Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction." Nat Med 3(11): 1228-32 Pyne, S., J Chapman, et al., (1996) “Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle.” Eur J Biochem 237: 819–26 Pettus, B J., J Bielawski, et al (2003) "The sphingosine kinase 1/sphingosine-1phosphate pathway mediates COX-2 induction and PGE2 production in response to TNFalpha." Faseb J 17(11): 1411-21 Phinney, D G and I Isakova (2005) "Plasticity and therapeutic potential of mesenchymal stem cells in the nervous system." Curr Pharm Des 11(10): 1255-65 Pisati, F., M Belicchi, et al (2007) "Effect of human skin-derived stem cells on vessel architecture, tumor growth, and tumor invasion in brain tumor animal models." Cancer Res 67(7): 3054-63 174 Chapter References Pisati, F., P Bossolasco, et al (2007) "Induction of neurotrophin expression via human adult mesenchymal stem cells: implication for cell therapy in neurodegenerative diseases." Cell Transplant 16(1): 41-55 Pitson, S M., J D'Andrea R, et al (2000) "Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes." Biochem J 350 Pt 2: 429-41 Pittenger, M F., A M Mackay, et al (1999) "Multilineage potential of adult human mesenchymal stem cells." Science 284(5411): 143-7 Planat-Benard, V., C Menard, et al (2004) "Spontaneous cardiomyocyte differentiation from adipose tissue stroma cells." Circ Res 94(2): 223-9 Prieschl, E E and T Baumruker (2000) "Beyond a structural component: sphingolipids in immunology." Arch Immunol Ther Exp (Warsz) 48(3): 163-71 Prindull, G., B Prindull, et al (1978) "Haematopoietic stem cells (CFUc) in human cord blood." Acta Paediatr Scand 67(4): 413-6 Prockop, D J (1997) "Marrow stromal cells as stem cells for nonhematopoietic tissues." Science 276(5309): 71-4 Radu, E., O Simionescu, et al (2002) "Stem cells (p63(+)) in keratinocyte cultures from human adult skin." J Cell Mol Med 6(4): 593-8 Ramos, K S., M Hadi Falahatpisheh, et al (2006) "Modulation of biological regulatory networks during nephrogenesis." Drug Metab Rev 38(4): 677-83 Rangappa, S., C Fen, et al (2003) "Transformation of adult mesenchymal stem cells isolated from the fatty tissue into cardiomyocytes." Ann Thorac Surg 75(3): 775-9 Reyes, M., T Lund, et al (2001) "Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells." Blood 98(9): 2615-25 Rodriguez, A M., C Elabd, et al (2005) "The human adipose tissue is a source of multipotent stem cells." Biochimie 87(1): 125-8 Roh, C., Q Tao, et al (2004) "Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin." Physiol Genomics 19(2): 207-17 Ronnstrand, L and C H Heldin (2001) "Mechanisms of platelet-derived growth factorinduced chemotaxis." Int J Cancer 91(6): 757-62 Roviezzo, F., F Del Galdo, et al (2004) "Human eosinophil chemotaxis and selective in vivo recruitment by sphingosine 1-phosphate." Proc Natl Acad Sci U S A 101(30): 11170-5 175 Chapter References Ruck, P., J C Xiao, et al (1996) "Hepatic stem cells in the human liver." Histopathology 29(6): 590-2 Safford, K M and H E Rice (2005) "Stem cell therapy for neurologic disorders: therapeutic potential of adipose-derived stem cells." Curr Drug Targets 6(1): 57-62 Safford, K M., S D Safford, et al (2004) "Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells." Exp Neurol 187(2): 319-28 Sakakura, C, Sweeney EA, et al (1996) “Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol esterinduced terminal differentiation.” FEBS Lett 379(2):177-80 Sammons, J., N Ahmed, et al (2004) "The role of BMP-6, IL-6, and BMP-4 in mesenchymal stem cell-dependent bone development: effects on osteoblastic differentiation induced by parathyroid hormone and vitamin D(3)." Stem Cells Dev 13(3): 273-80 Santa Maria, L., C V Rojas, et al (2004) "Signals from damaged but not undamaged skeletal muscle induce myogenic differentiation of rat bone-marrow-derived mesenchymal stem cells." Exp Cell Res 300(2): 418-26 Sato, Y., H Araki, et al (2005) "Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion." Blood 106(2): 756-63 Scavo, L M., M Karas, et al (2004) "Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytes." J Clin Endocrinol Metab 89(7): 3543-53 Schaphorst, K L., E Chiang, et al (2003) "Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products." Am J Physiol Lung Cell Mol Physiol 285(1): L258-67 Schutze, N., U Noth, et al (2005) "Differential expression of CCN-family members in primary human bone marrow-derived mesenchymal stem cells during osteogenic, chondrogenic and adipogenic differentiation." Cell Commun Signal 3(1): Sekiya, I., B L Larson, et al (2002) "Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality." Stem Cells 20(6): 530-41 Shea, C M., C M Edgar, et al (2003) "BMP treatment of C3H10T1/2 mesenchymal stem cells induces both chondrogenesis and osteogenesis." J Cell Biochem 90(6): 111227 176 Chapter References Shin, S., Y Sun, et al (2007) "Whole genome analysis of human neural stem cells derived from embryonic stem cells and stem and progenitor cells isolated from fetal tissue." Stem Cells 25(5): 1298-306 Shmelkov, S V., S Meeus, et al (2005) "Cytokine preconditioning promotes codifferentiation of human fetal liver CD133+ stem cells into angiomyogenic tissue." Circulation 111(9): 1175-83 Shu, S N., L Wei, et al (2004) "Hepatic differentiation capability of rat bone marrowderived mesenchymal stem cells and hematopoietic stem cells." World J Gastroenterol 10(19): 2818-22 Shu, X., W Wu, et al (2002) "Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases." Mol Cell Biol 22(22): 7758-68 Simmons, P J., B Masinovsky, et al (1992) "Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells." Blood 80(2): 388-95 Smythe, G M and M D Grounds (2000) "Exposure to tissue culture conditions can adversely affect myoblast behavior in vivo in whole muscle grafts: implications for myoblast transfer therapy." Cell Transplant 9(3): 379-93 Solchaga, L A., K Penick, et al (2005) "FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells." J Cell Physiol 203(2): 398-409 Song, H Y., E S Jeon, et al (2007) "Oncostatin M promotes osteogenesis and suppresses adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells." J Cell Biochem 101(5): 1238-51 Sotiropoulou, P A., S A Perez, et al (2006) "Cell culture medium composition and translational adult bone marrow-derived stem cell research." Stem Cells 24(5): 1409-10 Spiegel, S., O Cuvillier, et al (1998) "Sphingosine-1-phosphate in cell growth and cell death." Ann N Y Acad Sci 845: 11-8 Spiegel, S and S Milstien (1996) "Sphingoid bases and phospholipase D activation." Chem Phys Lipids 80(1-2): 27-36 Spiegel, S and S Milstien (2000) "Functions of a new family of sphingosine-1phosphate receptors." Biochim Biophys Acta 1484(2-3): 107-16 Spiegel, S and S Milstien (2002) "Sphingosine 1-phosphate, a key cell signaling molecule." J Biol Chem 277(29): 25851-4 177 Chapter References Spiegel, S and S Milstien (2003) "Sphingosine-1-phosphate: an enigmatic signalling lipid." Nat Rev Mol Cell Biol 4(5): 397-407 Siess, W., M Essler, et al (2000) “Lysophosphatidic acid and sphingosine 1-phosphate: two lipid villains provoking cardiovascular diseases?” IUBMB Life 49:167–171 Stenderup, K., J Justesen, et al (2003) "Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells." Bone 33(6): 919-26 Suzuki, Erika, Kazuko Handa, et al (2004) “Sphingosine-dependent apoptosis: A unified concept based on multiple mechanisms operating in concert.” Proc Natl Acad Sci 101(41): 14788–14793 Sweeneyc, Elizabeth A., Uhei Sakakurat, et al (1996) “Sphingosine and its methylated derivative in a variety of human cancer cell lines.” Int J Cancer: 66,358-366 Taha, T A., Y A Hannun, et al (2006) "Sphingosine kinase: biochemical and cellular regulation and role in disease." J Biochem Mol Biol 39(2): 113-31 Takagi, M., Y Umetsu, et al (2007) "High inoculation cell density could accelerate the differentiation of human bone marrow mesenchymal stem cells to chondrocyte cells." J Biosci Bioeng 103(1): 98-100 Tao, H., R Rao, et al (2005) "Cytokine-induced stable neuronal differentiation of human bone marrow mesenchymal stem cells in a serum/feeder cell-free condition." Dev Growth Differ 47(6): 423-33 Thomson, J A., J Itskovitz-Eldor, et al (1998) "Embryonic stem cell lines derived from human blastocysts." Science 282(5391): 1145-7 Trivedi, P and P Hematti (2007) "Simultaneous generation of CD34+ primitive hematopoietic cells and CD73+ mesenchymal stem cells from human embryonic stem cells cocultured with murine OP9 stromal cells." Exp Hematol 35(1): 146-54 Tropel, P., N Platet, et al (2006) "Functional neuronal differentiation of bone marrowderived mesenchymal stem cells." Stem Cells 24(12): 2868-76 Tseng, S C and D Q Li (1996) "Comparison of protein kinase C subtype expression between normal and aniridic human ocular surfaces: implications for limbal stem cell dysfunction in aniridia." Cornea 15(2): 168-78 Tsonis, P A (1991) "1,25-Dihydroxyvitamin D3 stimulates chondrogenesis of the chick limb bud mesenchymal cells." Dev Biol 143(1): 130-4 178 Chapter References Tsuchiya, H., H Kitoh, et al (2003) "Chondrogenesis enhanced by overexpression of sox9 gene in mouse bone marrow-derived mesenchymal stem cells." Biochem Biophys Res Commun 301(2): 338-43 Tsutsumi, S., A Shimazu, et al (2001) "Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF." Biochem Biophys Res Commun 288(2): 413-9 Uccelli, A., E Zappia, et al (2006) "Stem cells in inflammatory demyelinating disorders: a dual role for immunosuppression and neuroprotection." Expert Opin Biol Ther 6(1): 1722 Van Brocklyn, J R., M H Graler, et al (2000) "Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6." Blood 95(8): 2624-9 Van den Bos, C., J D Mosca, et al (1997) "Human mesenchymal stem cells respond to fibroblast growth factors." Hum Cell 10(1): 45-50 Van Veldhoven, P P., R J Foglesong, et al (1989) "A facile enzymatic synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate." J Lipid Res 30(4): 611-6 Vilquin, J T and P Rosset (2006) "Mesenchymal stem cells in bone and cartilage repair: current status." Regen Med 1(4): 589-604 Visentin, B., J A Vekich, et al (2006) "Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages." Cancer Cell 9(3): 225-38 Vogel, G (2005) “Cell Biology Ready or not? Human ES cells head toward the clinic.” Science, 308: 1534-1538 Wakitani, S, Takaoka K, et al (2003) “Embryonic stem cells injected into the mouse knee joint form teratomas and subsequently destroy the join.” Rheumatology (Oxford) 42:162-165 Wall, M E., S H Bernacki, et al (2007) "Effects of serial passaging on the adipogenic and osteogenic differentiation potential of adipose-derived human mesenchymal stem cells." Tissue Eng 13(6): 1291-8 Wang, F., N E Buckley, et al (1996) "Involvement of sphingolipids metabolites in cellular proliferation modulated by ganglioside GM1." Glycoconj J 13(6): 937-45 Wang, F., J R Van Brocklyn, et al (1999) "Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor Potential involvement in angiogenesis." J Biol Chem 274(50): 35343-50 179 Chapter References Wang, Wengang, Markus H Graeler, et al (2005) “Type sphingosine 1-phosphate G protein-coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration” The FASEB 19:1731-1733 Wang, Z., J Goh, et al (2006) "Efficacy of bone marrow-derived stem cells in strengthening osteoporotic bone in a rabbit model." Tissue Eng 12(7): 1753-61 Watternberg, Brinks W., Stuart M Pitson, et al (2006) “The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function” J Lipid Research, 47:1128-1139 Wiehe, J M., O Zimmermann, et al (2005) "Labeling of adult stem cells for in vivoapplication in the human heart." Histol Histopathol 20(3): 901-6 Wilmut, I., M D West, et al (2005) "Human embryonic stem cells." Science 310(5756): 1903 Wu, W., R D Mosteller, et al (2004) "Sphingosine kinase protects lipopolysaccharideactivated macrophages from apoptosis." Mol Cell Biol 24(17): 7359-69 Wu, J., S Spiegel et al., (1995) “Sphingosine 1-phosphate rapidly activates the mitogenactivated protein kinase pathway by a G protein-dependent mechanism” J Biol Chem 270:11484–8 Xia, P., J R Gamble, et al (1998) "Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway." Proc Natl Acad Sci U S A 95(24): 14196-201 Xia, P., J R Gamble, et al (2000) "An oncogenic role of sphingosine kinase." Curr Biol 10(23): 1527-30 Xia, P., L Wang, et al (1999) "Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells." J Biol Chem 274(48): 34499505 Xu, C B., J Hansen-Schwartz, et al (2004) "Sphingosine signaling and atherogenesis." Acta Pharmacol Sin 25(7): 849-54 Xu, C B., Y Zhang, et al (2002) "D-erythro-N,N-dimethylsphingosine inhibits bFGFinduced proliferation of cerebral, aortic and coronary smooth muscle cells." Atherosclerosis 164(2): 237-43 Yagi, H., R Kamba, et al (2000) "Immunosuppressant FTY720 inhibits thymocyte emigration." Eur J Immunol 30(5): 1435-44 180 Chapter References Yamaguchi, F., Tokuda, M., et al (1996) “Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9.” Biochem Biophys Res Commun 227, 608-614 Yamazaki, Y., J Kon, et al (2000) "Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway." Biochem Biophys Res Commun 268(2): 583-9 Yang, J., Q Y Xie, et al (2007) "[Differentiation of QY1 bone marrow pluripotential mesenchymal stem cell line cells into cardiomyocytes and vascular endothelial cells in vitro]." Zhong Nan Da Xue Xue Bao Yi Xue Ban 32(1): 93-8 Yang, Libo, Yutaka Yatomi, et al (1999) “Sphingosine 1-Phosphate Formation and Intracellular Ca2+ Mobilization in Human Platelets: Evaluation with Sphingosine Kinase Inhibitors1.” J Biochem 126, 84-89 Yatomi, Y., Y Igarashi, et al (1997) "Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum." J Biochem (Tokyo) 121(5): 969-73 Yen, Men-luh, Chih-Cheng Chien, et al (2007) “Multilineage differentiation and characterization of the human fetal osteoblastic 1.19 cell line: a possible in vitro model of human mesenchymal progenitors.” Stem Cells 25: 125 -131 Yim, E K., S W Pang, et al (2007) "Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage." Exp Cell Res 313(9): 1820-9 Young, H E., T A Steele, et al (2001) "Human reserve pluripotent mesenchymal stem cells are present in the connective tissues of skeletal muscle and dermis derived from fetal, adult, and geriatric donors." Anat Rec 264(1): 51-62 Zahradka, Peter, Jeffrey P Werner, et al (2002) “NF-κB Activation is Essential for angiotensin II-dependent Proliferation and Migration of Vascular Smooth Muscle Cells” J Mol Ce Card 34(12):1609-21 Zaragosi, L E., G Ailhaud, et al (2006) "Autocrine fibroblast growth factor signaling is critical for self-renewal of human multipotent adipose-derived stem cells." Stem Cells 24(11): 2412-9 Zhang, H., N N Desai, et al (1991) "Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation." J Cell Biol 114(1): 155-67 Zhang, G., Contos, J J., et al (1999) “Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate.” Gene (Amst.) 227:89-99 181 Chapter References Zhang, S., J Ge, et al (2006) "Comparison of various kinds of bone marrow stem cells for the repair of infarcted myocardium: single clonally purified non-hematopoietic mesenchymal stem cells serve as a superior source." J Cell Biochem 99(4): 1132-47 Zhi, L., B P Leung, et al (2006) "Sphingosine kinase regulates pro-inflammatory responses triggered by TNFalpha in primary human monocytes." J Cell Physiol 208(1): 109-15 Zieske, J D., G Bukusoglu, et al (1992) "Characterization of a potential marker of corneal epithelial stem cells." Invest Ophthalmol Vis Sci 33(1): 143-52 Zohar, R., J Sodek, et al (1997) "Characterization of stromal progenitor cells enriched by flow cytometry." Blood 90(9): 3471-81 Zuk, P A., M Zhu, et al (2002) "Human adipose tissue is a source of multipotent stem cells." Mol Biol Cell 13(12): 4279-95 Zuk, P A., M Zhu, et al (2001) "Multilineage cells from human adipose tissue: implications for cell-based therapies." Tissue Eng 7(2): 211-28 Efficacy and safety of fingolimod in patients with relapsing-remitting multiple sclerosis Clinical Trials.gov (2007-08-20) Retrieved on 2007-11-06 182 ... messenger in cell proliferation induced by PDGF and FCS mitogens." Nature 365 (64 46) : 557 -60 Olivera, Ana, Nicole Urtz (20 06) “IgE-dependent Activation of Sphingosine Kinases and and Secretion of Sphingosine. .. N, N-dimethyl-derythro -sphingosine- induced apoptosis and signaling in U937 cells: independence of sphingosine kinase inhibition.” Prostaglandins & Other Lipid Mediators 86( 1-4):18-25 Kimura, T.,... (1999) "Sphingosine kinase expression increases intracellular sphingosine- 1-phosphate and promotes cell growth and survival." J Cell Biol 147(3): 545-58 Olivera, A and S Spiegel (1993) "Sphingosine- 1-phosphate