the role of the private sector in the state procurement system

... satisfactory in the evaluation of nodal status in this patient group Since the highly cellular tissue in reactive lymph nodes may also show increased intensity, the role of DWI and ADC in distinguishing ... tissue in the uterine cervix and endometrium In the uterine myometrium, the ADC value may play a limited role due to the large overlap between sarcomas and benign leiomyomas The role of DWI for the ... enhancing cervical cancer (arrow) The tumor invades the cervical stroma (arrowhead) c DWI with b = 1,000 s/mm2 shows a well-defined hyperintensity mass in the cervical area The shape of the uterine...

Ngày tải lên: 13/02/2014, 06:20

... Protein targeting to the microsomes requires the cotranslational insertion of the newly synthesized protein into the microsomal membrane, where the N-terminal hydrophobic signal sequence of the ... mitochondria-targeting signal in the yeast system Mitochondrial localization of intact CYP2E1 in yeast cells Because of the existing ambiguity in the literature on the nature and extent of CYP2E1 import into ... consistent with the model suggesting a transmembrane topology of CYPs with a single N-terminal membrane anchor and most of the remaining protein exposed to the cytosolic side [15,17,30,31] The intramitochondrial...

Ngày tải lên: 18/02/2014, 16:20

... lysine reduces the probability of forming the fully closed form of the protein The results obtained with the K22V/R120K double mutant protein point toward a central role of arginine 120 in the ... enthalpies of binding and stoichiometries were determined from the binding isotherm by fitting a : binding model to the data using the software provided by the manufacturer Results Reaction of fosfomycin ... chain of K22 participates in fosfomycin binding, thus providing a rationale for the loss of fosfomycin binding to the K22V and K22E mutant proteins However, two other positively charged amino...

Ngày tải lên: 19/02/2014, 13:20

... iron-peroxo intermediate [11] The sum of these ndings points at the involvement of more than one active oxidant in the diverse types of P450-catalyzed substrate processing [1215] The goal of the present ... reect ring opening of an epoxide intermediate at either of its two C-O bonds [219,220] The sum of these ndings strongly invokes the notion of oxygen activation during redox cycling of the diverse ... alterations in the environment can cause drastic changes in the reactivity of the active species [76] Further support in favour of the idea of the involvement of a high-valent iron-oxene in P450...

Ngày tải lên: 19/02/2014, 16:20

... Regional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny ... $28,000 in average annual salary) Preserving Value Continuing education is important to preserving the market value of specialized education – particularly in professional fields Continuing education ... Shippensburg University Small Business Initiative in the Frehn Center for Management; offering information and assistance to individuals and groups planning to start a new business Best Practice Highlights...

Ngày tải lên: 21/02/2014, 01:20

... Amino–aromatic interactions in proteins FEBS Lett 203, 139–143 19 Chakrabarti, P & Samanta, U (1995) CH/, p interaction in the packing of the adenine ring in protein structures Advan Protein ... determined as part of the investigation into the shielding from solvent of the electrostatic interaction between Asp113 and His210 With increasing NaCl, the maximum activity decreased, while the ... deviation, the solvent ASA of the side-chain of His210 increased with the decrease in size of the side-chain at residue 169 (Table and Fig 3A) However, the ASAs of Asp113 and His57 remained constant...

Ngày tải lên: 21/02/2014, 03:20

... Ala219 of the catalytic site and His135 of the Mg2+ binding site The most striking result was the loss of the psychrophilic character of mutant W260K/A219N (as reflected by a threefold increase of the ... value in this temperature range is considerably lowered On the basis of the model, the behavior of the G261A variant can be interpreted in terms of constraints introduced by the Ala side chain The ... our incomplete understanding of the relation between enzyme properties and conformational flexibility limits the exploitation of the full potential of protein engineering in the redesign of psychrophilic...

Ngày tải lên: 22/02/2014, 04:20

Ngày tải lên: 24/02/2014, 04:20

... by the C domain of the initiation module of daptomycin That DptE and DptF are involved in the lipidation process of daptomycin was first shown by Miao et al [1] In their work, the daptomycin gene ... tryptophan of the nonribosomally synthesized peptide is necessary Here, we report the results of a steady -state kinetic analysis of DptE The aim of this kinetic study was to determine the specificity of ... is GLDSV, indicating that this putative ACP domain is one of the few ACPs in which valine replaces isoleucine (I) or leucine (L) in the conserved sequence To determine whether DptF is the putative...

Ngày tải lên: 07/03/2014, 04:20

... evaluate the OS-fitness of the clone, the ratio of the specific absorbance in the presence of 10 lgÆmL)1 HEL to that in the absence of HEL was taken as an index To analyze the effect of the type of each ... clarify the effect of the interface mutations on the antigenbinding affinity To investigate systematically this unsought relationship between the antigen-binding affinity of Fv and the VH ⁄ VL interaction ... antigen binding, this ‘increasing the affinity by increasing the VH ⁄ VL interaction’ might represent a mechanism of increasing Fv affinity This is also supported by the kinetic study of purified...

Ngày tải lên: 07/03/2014, 12:20

... Cardie, Vincent Ng, David Pierce, Chris Buckley Examining the role of statistical and linguistic knowledge sources in a general-knowledge que stion answering system In Proceedings of the 6th Applied ... hypernyms in the answer semantic form Step 3: The assessment of the similarities of dependencies In the third step, two classes of similar dependencies are considered, generating unications of the ... example, in the case of question Q209: Who invented the paper clip ?, the expected answer type is P ERSON and so is the subject of the verb invented , lexicalized as the nominalization inventor...

Ngày tải lên: 08/03/2014, 05:20

... change their brand attitude, may suggest an interesting implication for the new brand advertising strategy Instead of focusing on the content of the message which only emphasizes the benefits of the ... situational conditions of gift-giving may differ according to characteristics of the gift-giving occasion, whether the presentation of the gift is public, private, or anonymous, and whether the gift is ... of mixed feelings Merton and Barber (1976) described the sociological ambivalence as follows: “ the ambivalence is located in the social definition of roles and statuses, not in the feeling-state...

Ngày tải lên: 14/03/2014, 14:20

... important for explaining wilt In the case of income, youth living in low-income households experience higher levels of wilt (45%) than youth living in either modest-income (35%) or high-income (23%) ... financing school Conley (2001) finds that a doubling of net worth results in an 8.3% increase in the probability of attending college Further, when net worth is included in the model, Black youth are ... youth Youth savings Youth were asked in 2002 whether they had a savings or bank account in their name If they had an account, they were also asked whether they were saving some of this money for...

Ngày tải lên: 15/03/2014, 10:20

... that the increase of Glc6P in the presence of S4048 was caused by the inhibition of Glc6P hydrolysis in the absence of detectable changes in glucose phosphorylation S4048 causes inactivation of ... [31], for evaluating the role of Glc6P, we determined the effect of different inhibitor concentrations on the Glc6P content and the rate of glycogen synthesis in hepatocytes incubated with 15 ... Harndahl et al ¨ levels through the interaction of glucokinase with binding proteins [5,6] The glucokinase regulatory protein (GKRP) is a specific inhibitor of glucokinase [5] and also a nuclear...

Ngày tải lên: 16/03/2014, 14:20

... is causing increased weather volatility with the effects increasing in intensity in coming years Warming may induce sudden shifts in regional weather patterns such as the monsoon rains in South ... here for the private sector are discussed above in this chapter The contributions envisaged in the table provide a useful segue into conceptualizing the role of the public sector and of international ... and other private sector financing for climate adaptation investments and catalyze ongoing sustainable investments in these sectors beyond the initial PPCR investments Financial Sustainability:...

Ngày tải lên: 16/03/2014, 14:21

... the short ones) have all zeroes in them In other words, none of the bigrams from the training set appears in these reviews This suggests that the main problem with the bigram model is likely to ... Following Pang et al (2002), we use frequency as presence In other words, the ith element of the document vector is if the corresponding unigram is present in the document and otherwise The resulting ... relation is capturing two different situations, one in which the author himself likes the movie, and in the other, the author’s cousin likes the movie The overgeneralization resulting from these “stemmed”...

Ngày tải lên: 17/03/2014, 04:20

... strong indications for the involvement of a bacterial P450 in the hydroxylation of octane in Rhodococcus rhodochrous, the role of bacterial P450s in alkane degradation in addition to the well-established ... biological functions The proteins displaying the lowest similarity to the other P450s are those involved in oxylipin biosynthesis (2–6% amino acid identity) This can be explained in part by their bifunctional ... enzymes The FUM6 protein (CYP505B1) intervenes in one of the first steps in fumonisin synthesis by hydroxylation of the polyketide-amino acid at C-14 and C-15 (Fig 3) Fum6 deletion mutants of F verticilloides...

Ngày tải lên: 22/03/2014, 16:21

... the transaction from the vantage point of firm A, the floatingrate payer The cost of synthetic floating-rate financing is determined by the cost of servicing fixed-rate debt plus the net cost of the ... to the desire on the part of firms to hedge cash flows against the effects of interest rate volatility The timing of the appearance of interest rate swaps, coming as it did during a period of volatile ... system of margin requirements, along with the guarantee of the exchange clearinghouse (which, in turn, is jointly backed by the paid -in capital of the clearinghouse member firms) This system of...

Ngày tải lên: 22/03/2014, 17:20

... unfolding of one of the I27 modules in the chain Unfolding then extends the overall length of the protein, relaxing the pulling force to a low value As the slack in the length is removed by further ... gain insight into the role of solvent hydrogen bonds in protein unfolding, we repeated these SMD simulations of force unfolding of the I27 protein in D2O The simulations were completed using the ... b-strands near the amino terminus of the protein domain causes an initial extension of the protein, before the unfolding transition state is reached.[53] The hump observed both in the force-extension...

Ngày tải lên: 22/03/2014, 18:20

Ngày tải lên: 22/03/2014, 19:20