the role of genetic polymorphisms

... group The SLIC study examined a group of steroid-naive asthmatics with baseline FEV1 # 80% of predicted, demonstrating the ability of LABA to reduce the dose of ICS without an increase in the exacerbation ... investigated the genetic contribution to the variation in response to ICS therapy in asthma by assessing the association of change in lung function from candidate genes crucial to the biologic actions of ... obvious that the consistency of the SNP effect is far from universal These inconsistencies may be a result of the fact that not one SNP but multiple genetic loci may play a simultaneous role in response...

Ngày tải lên: 08/08/2014, 21:20

... and in kidneys of lupus mice with nephritis [20,21], suggesting that STAT1 may play a role in the pathogenesis of SLE A possible role of SNPs in the STAT1-STAT4 region other than the haplotype ... study and the recently reported study in a Japanese population [12] These studies were reviewed and approved by the research ethics committees of the University of Tsukuba, the University of Tokyo, ... (Table 5) Because the frequency and OR of the risk genotype of rs7574865 were greater in the Japanese population than those of North Americans of European descent [8], PAR% in the Japanese population...

Ngày tải lên: 09/08/2014, 13:22

... Position(red) ofgenotyped polymorphisms (SNPs) in the ADAM33 gene in respect to the 22 exons (blue) and untranslated Figure of regions the the gene Position of the genotyped polymorphisms (SNPs) in the ... remodeling of the lungs, the impact of genetic variations in ADAM33 could be variable in different forms of asthma In other words, ADAM33 genetics may have more impact on those forms of asthma ... because of different techniques of BHR assessment in the case-control study and in the cohort study analysis in the cohort study because of low number of cases while FEV1 was increased in carriers of...

Ngày tải lên: 12/08/2014, 16:20

... neurulation, the borders of the neural plate converge at the dorsal midline to form the neural tube Subsequently, neural crest cells from the roof plate of the neural tube undergo an epithelial to ... creation of a new artificial gap, by scratching a confluent cell monolayer Shortly after the generation of the “scratch” gap, the rows of cells on the edge of the gap will reorient and polarized themselves ... form the structural core of the complex, with the remaining subunits surrounding them ARPC2 and ARPC4 contact the mother filament, whereas ARP2 and ARP3 associated with the pointed end of the...

Ngày tải lên: 10/09/2015, 15:48

... who are truthful and demonstrate regard for their own  outcomes and those of others • Moderately Politicized Area – greater acceptance of behind­ the scenes tactics so long as the goals of the group are  achieved ... Outline  Role of Power  Rules for Using Power Role of Power  Power defined:  • Ability or official capacity to exercise control;  authority • Ability to influence or control others  Sources of Power ... Find the Soft Spot  Encourage others to open up • Gain disclosure of something private or  personal about your counterpart • Expression of trust  Identify true motivations and sources  of objections...

Ngày tải lên: 22/08/2012, 22:07

... DC: The World Bank) Chernow, Ron, 1997, The Death of the Banker The Decline and the Fall of the Great Financial Dynasties The Triumph of the Small Investor (New York: Vintage Books, a Division of ... to further improve the bank’ risk position s and counterparties, on their side, might consider for them unnecessary to further assess the riskiness of the bank Finally, the inadequacy of the static ... factoring the long-term market potential of borrowing firms in their risk analysis The higher their reputational capital, the stronger their incentive to lengthen the time horizon of their approach...

Ngày tải lên: 24/10/2012, 09:33

... such professional colleagues on the world The Association has the role of coordinating the activities of the members in order to protect the interests of the members and improve the position of Vietnam ... to the realization of the objectives and duties of the Association, may be invited to join the Association as Honorary members In general, this stipulation on the membership in the Statue of the ... expanding With their experiences, they have learned the value of offering quality services In the way of growing, they have also open branches to establish a worldwide presence These companies...

Ngày tải lên: 27/10/2012, 16:42

... where the consequences of infection can be very severe, while the risk of living with one’s beloved cat is practically nill References Angulo FJ, Glaser CA, Juranek DD et al Caring for pets of immunocompromised ... with the human immunodeficiency virus Clin Infect Dis.1994;18:14-24 Han K, Shin DW, Lee TY, et al Seroprevalence of Toxoplasma gondii infection and risk factors associated with seropositivity of ... 94: 963-965 Grant S and Olsen CW Preventing zoonotic diseases in immunocompromised persons: the role of physicians and veterinarians Emerg Infect Dis 1999; 5: 159-163 http://www.medsci.org ...

Ngày tải lên: 03/11/2012, 11:06

... and English at the expense of the other languages that exist in the country, the adult language program in Botswana maintains the hegemony and the gap between the poor and the rich, the major and ... improve the quality of life of the poor and rural people adult education programs should include as one of its components the observation and imitation of the artisans and other skilled persons in the ... for the betterment of their conditions It could mobilize the so called minorities to oppose their status and challenge the hegemony of the majority communities in Botswana 31 In most parts of the...

Ngày tải lên: 05/11/2012, 16:27

... sells the transaction to the acquire and is reimbursed the amount of the sales ticket by the acquirer (4) - The acquirer then summits the ticket to the issuer for payment, via the ICO interchange ... system 9 (5) - The issuer bills the cardholder (6) - Finally, the cardholder repays the issuer for the goods or services originally purchased from the merchant ICO are at the centre of the transaction ... maintaining the flow of funds and information between issuing and acquiring members The exchange of financial information is called clearing The exchange of the actual funds for the transaction and the...

Ngày tải lên: 03/04/2013, 12:13

... “bộ” “trọn gói” theo nguyên tắc giá gói nhỏ tổng số tiền mua hàng theo phương thức riêng rẽ  Định giá theo nguyên tắc địa lý: cách thức mà doanhnghiệp định giá bán sản phẩm theo nguyên tắc địa ... sản phẩm Bề rộng chủng loại sản phẩm phân giải số lượng mặt hàng thành phần theo tiêu thức định ví dụ theo kích cỡ, theo công suất… Bề rộng chủng loại sản phẩm mục tiêu công ty định phần Những ... trường theo giác độ khác Theo quan điểm Marketing thị trường bao gồm tất khách hàng tiềm ẩn có nhu cầu mong muốn cụ thể sẵn sàng có khả tham gia vào trao đổi để thoả mãn nhu cầu Như vậy, theo khái...

Ngày tải lên: 08/04/2013, 17:01

... values, others say advertising merely reflects the values of society rather than shaping them They argue that consumers' values are defined by the society in which they live and are the results of ... in the other countries, partly due to the limitation of means of communication and citizens’ perception The most popular type of advertising is on TV Following is the advertising price chart of ... promotion, which is one of the most vital tools in Marketing The appearance and the role of advertising is increasingly higher in the market economy Advertising shows the rapid growth in technology...

Ngày tải lên: 16/04/2013, 11:05

... will further explore the recent theories of leadership, and evaluate if these make a further contribution to the recognition of the skills and attributes of women in management or leadership roles ... to the role each theory may have played in raising the profile of women in management or leadership roles Early leadership theories In the 18th and 19th centuries, philosophers suggested a theory ... Hence, the behavioural theories can be viewed as limited in raising the profile of women in management However, during this period of research, there was an emerging recognition of the importance of...

Ngày tải lên: 08/10/2013, 15:56

... negotiated price The trade of inter-bank bond market relies on the securities booking system of the CGSDTC and the bond trading system of the inter-bank lending centre The trading system of the national ... bonds In the case of the latter, commercial banks trade with investors at the prices they offer through their outlets, and provide depositing and clearing services to the investors B Roles of the ... reflect the true quality of loans In recent years, the application of the fivecategory classification method has been advanced thanks to the strong push of the central bank and the efforts of commercial...

Ngày tải lên: 18/10/2013, 07:15

Ngày tải lên: 25/10/2013, 05:20

... throughout the world bears little resemblance to teosinte, the original ancestor of corn The newer techniques involving genetic engineering, on the other hand, allow for the transfer of a few genes ... signiÞcant changes in the genetic makeup of plants and animals due to the random recombination and sorting of thousands of genes As a result of intervention by people, the hybrid seed corn currently ... than its conventional counterpart; therefore, the Þnal assessment of safety is always comparative The scientiÞc basis of the evaluation process is the concept of “substantial equivalence.” Regulatory...

Ngày tải lên: 25/10/2013, 21:20

... how the profile of the university corresponds with the profile of the economic structure of the region The hypothesis is that such a correspondence open up for transfer of knowledge from the ... the spirals from which they emerged and the larger society The capitalization of knowledge transforms both the way that academic scientist view the results of their research and the role of the ... define the system of innovation a priori Our point of departure is the universities in the selected regions The issue is to explore the role of the universities in the economic transformation of the...

Ngày tải lên: 16/01/2014, 16:33

... workers), one of the two less successful did improve on par with the average of the other four, but the other unsuccessful plant actually experienced a reduction of productivity of 20% (The six plants ... chain of hotels or supermarkets, a software vendor or a consulting company, regardless of the nature of knowledge The method of analysis is generalization to theory, and given the level of abstraction ... will be emphasised even further The proposition that theory subconsciously makes these assumptions is also reflected by the fact that most of them see the objective of knowledge transfer to be...

Ngày tải lên: 24/01/2014, 00:20

... ensuring the effective use of ICTs in the health sector Programme designs should consider the role of the intermediary at the same time as, if not before, the role of the technology The time ... as much of the detail of these targets as possible, This could include the range of roles at each level within the target institutions, the capacity of the stakeholders, compared to the necessary ... overview of the knowledge map of the subject a number of recommendations are put forward The scope of the exercise is limited in terms of time and resources, as outlined in the Terms of Reference...

Ngày tải lên: 14/02/2014, 09:20

... They induce the permeabilization of the mitochondrial membrane with the release of cytochrome c and the formation of the apoptosome [38] The major pro-apoptotic protein Bax exists mainly in the ... particular emphasis on the induction of DNA fragmentation, which is one of the most typical characteristics of apoptosis Regulators of DNA fragmentation One of the terminal processes of apoptosis is ... dephosphorylation of these sites Ser70 is the major physiological phosphorylation site for the survival function of Bcl-2 [82] The pro-apoptotic Bcl-2 proteins relocate to the surface of mitochondria...

Ngày tải lên: 14/02/2014, 22:20