... (glycero-)sphingolipids. In addition the fatty acid chains ofthe phospholipids composingthese rigid domains are generally more saturated thanthose inthe lipids ofthe surrounding membrane. In fact, this ... cluster in response to extracellular stimuli andthe size of the domains containing those clusters has been estimated. In summary, multiple lines of evidence have helped toargue in favour ofthe ... carefully.Isolation of lipid rafts ⁄ caveolae is very often the firststep inthe biochemical analysis oftheroleof thesedomains in cellular signalling. After disruption of cells,lipid rafts...
... 484–487.23. Brines, R.D. & Brock, J.H. (1983) The effect of trypsin and chy-motrypsin on thein vitro antimicrobial and iron-binding proper-ties of lactoferrin in human milk and bovine colostrum. ... Berkel* and Jan H. NuijensPharming, Archimedesweg, Leiden, the NetherlandsLactoferrin (LF) is an iron-binding glycoprotein of the innate host defence system. To elucidate theroleof N-linkedglycosylation ... 2004 Tryptic susceptibility of lactoferrin variants (Eur. J. Biochem. 271) 683 Theroleof N-linked glycosylation inthe protection of human and bovine lactoferrin against tryptic proteolysisHarrie...
... for the central roleof ADAM10 and confirming thatTACE has a minor roleinthe a-secretase cleavage of APP in human cells.During the course ofthe present study it was reportedusing an RNA interference ... critically involved in blood pressure regulation due to its action in generatingangiotensin II andin inactivating bradykinin [1]. The enzyme also has a roleinthe development of vascularpathology and ... acid-basedmetalloprotease inhibitors [14] inthe presence or absence of APMA. Inthe majority of cases there was little differencebetween the effect of inhibitors on the constitutive shedding of ACE andthe APMA-induced...
... however. Ins-tead the plants formed more stem units. The role of photoperiod and temperature in the induction and the release of dormancy in Pinus sylvestris L. seedlingsI. ... (1985) Wintertime chan-ges in the fine structure and the ribosomecontent of the buds of Scots pine. In: PlantProduction in the North. (Kaurin A., Junttila O. &Nilsen ... Dormancy breaking treatments of 8 and 4 wk had a dramatic influence,hastening the tilushing rate, especially in the plants with lowest degree of dormancy. In Fig. 3 the same...
... at the level ofthe individualfund. Mutual funds are operated by management companies, andthe resources, policies, and culture of these companies play an important roleinthe determination of ... be included inthe SIF’slisting of SRI funds are rather weak. For example, a fund could b e on the list just byimposing a screen on companies with interests inthe tobacco business. If the ... provide evidence that investors pay an explicit price, inthe form of higher fees,for investing in SRI mutual funds. Investing in SRI funds, however, does not come at the cost of reduced before-...
... improving the quality of human resources; continue promoting innovation process, first of all innovation inthe field of economy towards industrialization and modernization and active in deeper integration ... higher level. According to the author, for our country talent training is one ofthe foci ofthe educational strategy inthe period of industrialization and modernization and that human resource ... agriculture and rural areas and outlines the rules of movement of human resources inthe industrialization and modernization in agriculture and rural areas. At the same time, the author analyzes the...
... providedfurther insight into the molecular mechanism driving the formation ofthe covalent C115–fosfomycin adduct. Aconservative exchange of K22 to arginine maintains fosfo-mycin binding, while ... in fosfomycinbinding, andin view ofthe multitude of interactions, it wasassumed that deletion of a single interaction would not leadto a complete loss of fosfomycin binding. Therefore it ... form ofthe protein. The results obtained with the K22V/R120K doublemutant protein point toward a central roleof arginine 120 in the conformational process occurring during catalysis.Therefore,...
... domain is one of the few ACPs in which valine replaces isoleucine (I) orleucine (L) inthe conserved sequence. To determinewhether DptF is the putative partner of DptE, weexpressed dptF using ... dptF using the pQTev vector in E. coli and purified the resulting ACP as an N-terminal His7 fusionprotein (Fig. 3) with a yield of 9.5 mgặL)1 of culture. The identity ofthe protein was proven ... [37].Interestingly, inthe case ofthe lipopeptide surfactin,neither an acyl CoASH ligase-like domain nor an ACPcould be identified within the biosynthetic gene clusterusing bioinformatic tools...
... accumulating school savings may have effects apart from financing school. Conley (2001) finds that a doubling of net worth results in an 8.3% increase inthe probability of attending college. Further, ... for their youth. Youth savings. Youth were asked in 2002 whether they had a savings or bank account in their name. If they had an account, they were also asked whether they were saving some of ... None ofthe existing research examines the effect of youth savings on college attendance, and only one study examines the relationship between parent school savings and college attendance. Theoretical...
... documents and find that the fea-ture vectors corresponding to some of these docu-ments (particularly the short ones) have all zeroes in them. In other words, none ofthe bigrams from the training ... one in which the author himself likes the movie, andinthe other, the author’s cousin likes the movie. The over-generalization resulting from these “stemmed” re-lations renders dependency information ... opinions and identifying the polarity of opinion sentences. In Proc. of EMNLP, pages 129–136.618 experiments. First, we train a polarity classifier us-ing all unigrams from thetraining set....
... suggested by the lack of coincidence of the changes in relative fluorescence intensity and in k and by the hysteresis ofthe reversibility process(Fig. 4). At the end ofthe transition, the intrinsic ... that of the wild-type; however, the integrity ofthe calcium bind-ing site formed by Asp287 and Glu53 is essential forinteraction with the cation in 7.9 m GdmCl.An interesting finding ofthe ... observed for the wild-type,indicating the involvement of Glu53 and Asp287 in the interaction with the cation (Fig. 1E,F). The regain of aromatic chirality at 295 nm andinthe 260–270 nmregion for...