the real story of the fountain of youth
Báo cáo khoa học: Mapping of the 45M1 epitope to the C-terminal cysteine-rich part of the human MUC5AC mucin potx
Ngày tải lên :
07/03/2014, 05:20
... epitopes located
in the MUC5AC C-terminal cysteine-rich part.
Further localization of the epitopes of 45M1,
2-12 M1 and 166M1
In order to further locate the epitopes of the hitherto
unmapped 45M1, ... detailed
map of the epitopes for the mAbs, where 45M1 recog-
nizes an epitope located in the N-terminal region of
the C-terminal cysteine-rich part of MUC5AC, pre-
sumably in the last CysD domain of the ... mucous cells of the epithelia lining
the stomach and the trachea, where it constitutes a major component of
the gastric and respiratory mucus. A number of mAbs have been raised
against the gastric...
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Economic Impact of the Abolition of the Milk Quota Regime – Regional Analysis of the Milk Production in the EU – doc
Ngày tải lên :
18/03/2014, 00:20
... Impact of the Abolition of the Milk Quota Regime – Regional
Analysis of the Milk Production in the EU" (AGRI-2007-0444). The project aimed at a
thorough policy impact analysis of the EU ... through either the
transfer of an entire farm, the leasing or purchase of quota, or the allocation of quota from a
national reserve. The transfer of milk quota may take place via a variety of administrative ... average, with +35.5% in the EU-10 and
+13.8 in the EU-15. This excess supply makes the net trade position of the EU-27 stronger
towards the Rest of the World. Within the EU there is a quite heterogeneous...
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Báo cáo khoa học: H NMR study of the molecular structure and magnetic properties of the active site for the cyanomet complex of O2-avid hemoglobin from the trematode Paramphistomum epiclitum pdf
Ngày tải lên :
23/03/2014, 17:22
... between the projection of the tilt of the z axis on the xÂ,y plane (dened direction of tilt of z and the x axis), and j % a + c denes the
location of the rhombic (x, y) axes. The orientation of the ... at position E7 as
the source of the H-bond to ligand on the basis of a
partial sequence, which had indicated a Tyr on the distal
E-helix. The similarity in the
1
HNMRspectraofthe
three globin ... ligand.
Comparison of the strengths of dipolar interactions in
solution with the alternate crystal structures of methemo-
globin establish that the solution structure of wild-type Hb
more closely resembles the...
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Báo cáo khoa học: Role of the N- and C-terminal regions of the PufX protein in the structural organization of the photosynthetic core complex of Rhodobacter sphaeroides pptx
Ngày tải lên :
31/03/2014, 09:20
... demonstrated the
role of PufX in the orientation of the RC inside the LH1
Fig. 4. Isolation of the PMCs on a sucrose gradient. The final detergent
extracts from the ICM were loaded on the top of a 10–40% ... PufXD
2)7
neither affects the photo-
synthetic capability of the bacteria nor the efficiency of
exchange of the ubiq uinol molecules between th e RC and
the bc
1
, a s judged from the reduction kinetics of ... residues of the LH1 a
polypeptide in the organization of the LH1–RC complex
[12]. In the present work, we have investigated the
possible involvement of the N-terminus and of the
C-terminus of PufX...
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Báo cáo khoa học: An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist docx
Ngày tải lên :
07/03/2014, 21:20
... mutation of Arg46 had the dual
effect of (a) decreasing agonist affinity and (b) promoting
the agonist-induced active conformation due to the loss of a
stabilizing constraint on the ground state of the ... with the corresponding sequence of
the V
1a
R [10]. The role of the N-terminus has been
addressed recently by alanine-scanning mutagenesis of the
N-terminus of the V
1a
R; this revealed that a ... transmembrane domains traversing the lipid bilayer. The
enlarged circle shows the amino acid sequence of the distal N-terminus
of the V
1a
R and indicates the position of Arg46 that was subjected...
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Báo cáo khoa học: Role of the hinge peptide and the intersubunit interface in the swapping of N-termini in dimeric bovine seminal RNase pptx
Ngày tải lên :
16/03/2014, 23:20
... those of the parent protein, and
investigated the exchange kinetics of the corresponding
dimers. The P19A mutation slightly increases the thermal
stability of the monomer, but it does not alter the ... evaluation of the effect of single
point mutations on the solution structure of monomeric
derivatives, we analysed the 2D NMR spectra of the
different variants of mBS. Figure 3 shows the expanded
regions ... swapping
tendency of the dimer. In contrast, the L28Q mutation sig-
nificantly affects both the dimerization and swapping pro-
cesses but not the thermal stability of the monomer. Overall,
these results...
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Báo cáo khoa học: Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization pptx
Ngày tải lên :
23/03/2014, 07:20
... copies of the N protein, respectively. (C) The RNA binding efficiency of
N protein is represented as a percentage of bound RNA (i.e. the percentage of bound RNA = 100%)percentage of free probe). The ... phosphorylation.
Effect of RS motif phosphorylation on
oligomerization of the N protein
To better understand the effect of RS motif phosphor-
ylation on the biological function of the N protein, we
Fig. 3. The translation ... that of the
full-length N protein (data not shown). Taken together,
these data suggest that the RS-rich region of the SARS-
CoV N protein is possibly phosphorylated by SRPK1.
Phosphorylation of...
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Báo cáo khoa học: Structure of the exceptionally large nonrepetitive carbohydrate backbone of the lipopolysaccharide of Pectinatus frisingensis strain VTT E-82164 doc
Ngày tải lên :
23/03/2014, 18:20
... and showed, in particular, the
configuration of ManNAc to be
D
.
From the combined the data on the structures of the
isolated oligosaccharides, the overall structure of the
P. frisingensis LPS carbohydrate ... with 7a (Table 1) because of the b-
effect of the acetylation. Acetylation of 7b was confirmed by
ESI MS data, which gave the expected mass of 3221.4 Da.
The spectra of oligosaccharide 6 were ... 3-O-methyl-
6-deoxytalose, as setting the
L
-isomer instead of the
D
-isomer resulted in the disappearance of the contact
between protons U6 and P4.
To determine the absolute configurations of the mono-
saccharides,...
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Báo cáo khoa học: Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1 doc
Ngày tải lên :
23/03/2014, 21:20
... FAD/NADPH domain
(% 16-fold) (29). However, the domain mixture still recon-
stituted only % 2% of the activity of the full length CPR. In
thecaseofNR1,thek
cat
for the full length enzyme is low
(1.3 s
)1
) ... enzymes, the potentials for the FAD/NADPH
domains are rather more negative than those for the FMN
domain, reflecting the direction of electron transfer from
NADPH through FAD, then FMN and on to the ... BM3 [28]. Aggregation of the NR1
FAD/NADPH domain was much less extensive in the
absence of cofactor reduction.
Stopped-flow kinetic studies
Reduction of the FAD/NADPH domain of NR1 was
investigated...
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Báo cáo khoa học: Structure of the O-polysaccharide fromProteus myxofaciens Classification of the bacterium into a newProteusO-serogroup pptx
Ngày tải lên :
23/03/2014, 21:20
... LPS)
[5,6]. The serological specificity of the bacteria is defined
by the structure of the O-specific polysaccharide chain
(O-antigen) of the lipopolysaccharide. On the basis of the
O-antigens, the strains ... the
D
configuration (the b effect on C3 of
L
-GlcA
wouldbeclosetozero[27]).
On the basis of the data obtained, it was concluded that
the repeating unit of the O-polysaccharide of P. myxofac-
iens has the following ... 2.01–2.10.
These data together suggest that the tetrasaccharide
repeating unit of the polysaccharide consists of two residues
of GlcNAc and one residue each of GalNAc, GlcA and
AlaLys.
The
1
Hand
13
C...
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AUDIT OF THE CONTROL SYSTEM GOVERNING THE PRODUCTION, PROCESSING, DISTRIBUTION AND IMPORTS OF ORGANIC PRODUCTS potx
Ngày tải lên :
28/03/2014, 19:20
... reports and transmit them
to the Commission, within six months of the end of the year to
which the reports relate.’
REPLY OF THE
COMMISSION
60
Special Report No 9/2012 – Audit of the control system ... is the responsibility of the competent authority of the
Member State to verify the competence of the control
body to issue a certificate of inspection, and in particu-
lar the evidence that the ... send these
supervision reports.
There were no reports from Austria, for example.
At the end of the audit (November 2004), of
the 48 reports due over the period 2000–03 in
respect of the 12...
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Báo cáo khoa học: Expression and characterization of soluble forms of the extracellular domains of the b, c and e subunits of the human muscle acetylcholine receptor pot
Ngày tải lên :
30/03/2014, 10:20
... amounts of the ECDs of the non-a sub-
units of human muscle AChR for use as starting material for the determin-
ation of the 3D structure of the receptor ECDs and for the characterization
of the ... data
from electron images of the AChR found in large
amounts in the electric organ of the marine ray,
Torpedo californica [3]. The acquisition of the crystallo-
graphic structure of the mollusc acetylcholine-binding
protein ... domain [3]. The
N-terminal ECD of each of the two a subunits con-
tains the major part of the binding site for the cho-
linergic ligands. The two sites are nonequivalent, one
being formed at the interface...
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LORD NEUBERGER OF ABBOTSBURY, MASTER OF THE ROLLS JUSTICE IN A TIME OF ECONOMIC CRISIS AND IN THE AGE OF THE INTERNET ppt
Ngày tải lên :
31/03/2014, 03:20
... And, apart from the defence of the realm, there is no duty as important as
maintaining the rule of law; and just as every fundamental aspect of the defence of the
realm must be real and practical, ... buildings owe their design to the necessities of parties,
witnesses and their lawyers attending court for hearings, and, behind the scenes, the
needs of the judges and of the back offices, which ... Sir Anthony May, the recently retired President of the
Queen’s Bench Division put it recently, the fabric of justice . . . is part of the fabric of
society.
7
’ The fabric of justice demands...
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