... front ofthe other and are separated by a short barrier or a full screen. They both have a map with some objects. Some of them are in the same position and with the same name, but most of them ... condi-tion the follower or the giver can alternatively be a confederate, with the aim of getting the other participant angry. In this condition the psycho-physiological state ofthe confederate ... utterance choic-es to the accuracy ofthe route performed on the map. Bethan Davies extended the meaning of “move” to the goal evaluation, from a narrow set of indicators to a sort of data-driven...
... cost. There is no cure for AD,and the development of effective therapeutic strategiesis hampered by a paucity of information on the biolo-gical mechanisms underlying the disease. The severity of ... (COX). In these enzymes, the redox potential of the metals is harnessed to provide the enzymes withtheir electron transfer capabilities. Paradoxically, it is the same redox potential ofthe metals ... events. With the loss of biometal homeostasis placed central to all of theseAD-related neurodegenerative mechanisms, the modu-lation of metal bio-availability has strong potential in the therapeutic...
... preparation of questionnaire, pre-testing of questionnaire for the confirmation and interpretation ofthe factors and then processing ofthe completed questionnaire and reporting. The second part ofthe ... (AHP) for assessing the strength of University-Industry-GRI cooperation by measuring the magnitude of different types of factor flows and the relative importance ofthe linkages. The model for assessment ... amount of money. For them, R&D activities are less important than high profit and cash flow.1.3Objectives ofthe Study The objective ofthe study is to address the measurement problem on the...
... equality and women’s rights in terms of either the inclusion of indicators tracking the focus of development cooperation on gender equality or the participation of women’s organisations in initiatives ... gender equality and the empowerment of women. Despite the prominence of gender issues in the IADGs, effectiveness of development cooperation has not focussed enough on outcomes of gender equality ... development cooperation. The Nairobi outcome document ofthe High-level United Nations Conference on South-South Cooperation also acknowledged the need to enhance the development effectiveness of South-South...
... 1B shows the patternseen after the development ofthe blot. With increasein time of incubation, the intensity ofthe band for the monomeric protein decreased, whereas the bands for the higher ... solu-tion of ThT and the fluorescence intensity ofthe solu-tion was measured at 482 nm. Figure 4A shows the kinetics of aggregation of a-synuclein in the presence of 100 lm MPTP and the effect of 50 ... are of a-synuclein incubated alone (A), in the presence of 100 lM MPTP (B), in the presence of 200 lM MPTP (C), in the presence of 100 lM MPP+(D), in the presence of 200 lM MPP+(E), in the...
... pro-duction network. THE COMMONSINSTITUTE FOR THE FUTURE3Social Dilemmas: The Problem ofthe One and the ManyPeter Kollock, author of Social Dilemmas: The Anatomy of Cooperation, explains ... compellingviews ofthe problem of social dilemmas. In this chapter, we look at cooperation through each of these lenses, pointing to some ofthe fundamentalideas emerging from the diverse disciplines ... with their peers thanwith their employers. They share competitiveinformation and resources across organizationalboundaries, and favor the integrity of theirwork over the integrity of their...
... affect sterol biosynthesis dur-ing the formation of a mating projection. Nevertheless, the phenotypes of mutants defective in ergosterolsynthesis clearly demonstrate the importance of sterolsfor ... and 200 lg of protein from the homogenate of cells grown to logarithmic phase [69].This method relies on the measurement ofthe amount of radiolabeled steryl esters formed during the assay relative ... diethyl ether ⁄ acetic acid (25 : 25 : 1, v ⁄ v ⁄ v) was usedas mobile phase and plates were developed to half-distance. Then the plates were dried briefly and furtherdeveloped to the top of the...
... ofthe WHO country of ce in Yemen As per the recently introduced human resources reform, the WHO country of ce, in close consultation with the Ministry of Public Health and Population, the ... throughout the country. The per capita water supply is 2% ofthe world average (198 cubic metres per person) and the consumption of water for agriculture purposes is one of the highest. Only 43% of ... 19Country Cooperation Strategy for WHO and YemenHealth care nancing Funding ofthe health sector is one of the most critical issues affecting the performance ofthe national health system. The...
... by DNA sequencing. The design ofthe mutants was intended to preserve the amino acid character and to modify only the relativevolume of their R groups. The expression ofthe FNR mutants as soluble ... phe-nol as the tyrosine R group. This system has been usedpreviously to analyze the geometry ofthe tyrosinestacked on the si-face ofthe flavin in FNRs [12]. The single point energies ofthe flavin–tyrosine ... in the protein stability of our mutants. There-fore, these conclusions strengthen our hypothesis that the catalytic efficiencies ofthe recombinant enzymesused in our study were related to the...
... 3B). The pK2increased as the size ofthe residue at position 169 increased. The effect ofthe size ofthe residue at position 169 may berelated to the solvent accessibility ofthe side-chain of His210 ... was supported by the independency ofthe ionic strength ofthe pH-activity curve(Fig. 5).In the X-ray crystal structure, the Trp169 side-chain islocated on the outside ofthe His210 side-chain ... nucleophilicity ofthe Ser194 hydroxyl oxygen. Accord-ingly, the Asp113–His57 diad is primarily important for the expression ofthe nucleophilicity ofthe catalytic Ser194. The side-chain of Asp113...
... (pre-)financed by the European taxpayer in the course of 2008 to 2012. These operations, together with the faltering of economic activity caused by the spread of uncertainty about the stability of the overall ... at the scale of all 27 Member States10. Risks of fragmentation ofthe internal market and of a distortion of competition will first of all be reduced and/or avoided within the scope ofthe ... number of Member States. At the beginning ofthe enhanced cooperation, the immediate benefits for the internal market would, by necessity, only accrue within the geographical reach of such cooperation, ...
... activation of human prothrombin was determinedby measuring the generation of thrombin using the chromogenic substrate Spectrozyme TH, in the presence ofthe indicated concentrations of plactin ... B and 2 nM in the other panels), PCPS (PL) (50 lM) or CaCl2(2 mM) were included. The concentration of Xa was 1 pM in (B) and 0.5 nM in the other panels. Inset shows the effect of plactin D ... markedlypromoted conversion of scu-PA to the two-chain form. The apparent molecular masses ofthe resulting poly-peptide chains were comparable with those of the A- and B-chains of tcu-PA (an A-chain...
... center ofthe enzyme. These modifications may beattributed to either the presence ofthe substrate and/or aproduct in the vicinity ofthe T2Cu active center rather thanto disruption of this ... 271) 2365from the electrode and donates them to the Nir, in the presence of nitrite. Under these conditions, the shape of the voltammogram becomes sigmoidal, with an increase of the cathodic current ... CoCl2,0.6andNa2B2O7,0.1. The optical density, the concentrations of nitrate [17]and nitrite [18], the pO2and the pH ofthe medium weremonitored, and the composition ofthe gaseous phase in the fermentor...
... about the faith of zincbound in Cd5Zn2-MT2 after the addition of NO, the amount of cadmium is reduced at this rather extreme NOFig. 1. Wavelength and time scans ofthe CD of MT2 in the presenceand ... by nitric oxide. The decay occurs in the first 10 min after the addition of NO as observed bymonitoring the CD at the maximum ofthe charge transferband at 260 nm (Fig. 1B). The lower molar ellipticity ... function in the stimulation of guanylyl cyclase requires the presence of reduced gluta-thione [39]. To elucidate the possible role of peroxynitrite in the metal release from MTs in the presence of reduced...
... represent the next logicalstep in the unfolding story ofthemodulationof the oligomeric structures of HIV-1 viral enzymes by syntheticpeptides and small molecules.ACKNOWLEDGEMENTS The authors ... according to the method described by Zhang et al. (1991) [16].Ó FEBS 2002 Modulationofthe quaternary structure of HIV-1 enzymes (Eur. J. Biochem. 269) 5105REVIEW ARTICLE Modulation ofthe oligomeric ... enzymatic func-tioning of each of these enzymes is entirely dependent ontheir oligomeric structures, suggesting that inhibition of subunit-subunit assembly or modulationof their quaternarystructures...