the missing role of context a conceptual model

... Drug Administration (FDA) and the European Agency for the Evaluation of Medicinal Products (EMEA) have emphasized the value of PRO measures in identifying and quantifying the impact of a disease ... data used to shape the conceptual model are summarized in Tables and Table contains the comprehensive list of themes reported by the patients Each theme is grouped into a primary conceptual category ... that although group interaction can stimulate participant ideas that might not have been available on an individual basis, it may also lead to overemphasis of the opinions of the groups' participants...

Ngày tải lên: 18/06/2014, 22:20

... health governance are the World Health Organization (WHO) and the World Bank (WB) The latter plays an important role in the field of global health governance as it acknowledges the importance of ... proportions of salt, saturated fat and sugars [51,53] Another example is the worldwide spread of tobacco consumption as transnational tobacco companies take advantage of the potential for growth ... environmental and institutional factors These factors operate at different hierarchical levels of causality, because they have different positions in the causal chain The chain of events leading to a...

Ngày tải lên: 11/08/2014, 18:20

... permit the unmasking of radical intermediates that rearrange at a rate faster than that of the recombination step [16,93] Despite the apparent predominance of the hydrogen transfer mechanism as the ... [68], the enzyme variant still mediated N-oxygenation of the tertiary arylamine at a rate less than half that of the wild-type-catalyzed reaction [142], so that reasonable interpretation of the data ... higher rates than usual radical rearrangements [98,312] On the other hand, the timing of radical rearrangement (radical clocks) may depend critically on the tightness of the radical cage and the...

Ngày tải lên: 19/02/2014, 16:20

... structural disorder characterized by damage to the lung parenchyma The destruction of the alveolar walls will lead to enlargement of the alveolar airspaces The alveolar airspace enlargement was determined ... whereby a role for the tachykinin NK1 receptor in macrophage and DCs accumulation was demonstrated The impaired accumulation of these cell types seems, at least partially, mediated by the attenuated ... CS in a mouse model of COPD As inflammation of the airways is an important characteristic of COPD, these findings may have implications in the future treatment of this devastating disease Lower...

Ngày tải lên: 12/08/2014, 14:20

... Qualitative data as an attractive nuisance: the problem of analysis Administrative Science Quarterly 24: 590–601 Nonaka I 1994 A dynamic theory of organizational knowledge creation Organization ... in the way that we have The role of motivation is probably as important in a chain of hotels or supermarkets, a software vendor or a consulting company, regardless of the nature of knowledge The ... instead In the above case, the corporate involvement in terms of stimulating local management was primarily through the award routine The regular financial reporting between general managers and their...

Ngày tải lên: 24/01/2014, 00:20

... Both the Public Company Accounting Oversight Board (PCAOB) and the International Auditing and Assurance Standards Board (IAASB) have launched initiatives to reexamine the auditor’s report, and as ... audits of the financial statements and internal control over financial reporting Participants agreed that the audit does have value in providing reasonable assurance whether the financial statements ... explore areas where change may be appropriate, the CAQ formed a task force on the role of the auditor and moved to convene investors and other financial reporting stakeholders to examine the role of...

Ngày tải lên: 15/03/2014, 20:20

Ngày tải lên: 18/03/2014, 11:22

... Several data are available on the respiration of Mediterranean ecosystems Most of them were measured in the Mediterranean Basin [4, 5, 10, 15, 26, 32, 37, 38] Some other data dealing with Australian ... moisture at the same time, assumed that the effects are multiplicative whereas some of them let vary the effect of temperature with soil moisture [9, 37] The seasonality of Mediterranean climates characterised ... Australian ecosystems under Mediterranean climate are also available [12, 29] They all highlight the effect of the summer drought on soil respiration and some of them also show the negative effect of...

Ngày tải lên: 08/08/2014, 01:21

... demonstrating a solitary cm hypervascuArterial (A) segment venous phase Arterial (A) and portal venous phase (B) of IV Gadlinium enhanced axial MRI images demonstrating a solitary cm hypervascular ... scan1 CT scan (A) Axial IV contrast enhanced CT Arterial phase image showing a × 2.7 cm hypervascular, subcapsular nodule in segment VII of the liver (B) Portal venous phase image Page of (page ... investigation of this lesion, and better assessment of the extent of the disease Diagnostic laparoscopy demonstrated a cm exofitic dark brown splenunculus attached to the diaphragm and indenting the...

Ngày tải lên: 09/08/2014, 04:20

... surfactant preparations via the trachea has no impact on the amount of the intracellular surfactant pool [39], recent data suggest that alterations of the intracellular surfactant can occur already ... ultrastructural stereological analysis of the AE2 cells of the contra-lateral human donor lung (while the ipsilateral lung was transplanted) demonstrated that the alterations of intracellular surfactant ... present Otherwise a U-test was carried out In order to characterize the relationship between the luminal surface area of AE2 cells and the total surface area of the limiting membrane of AE2 cells a...

Ngày tải lên: 12/08/2014, 13:22

... endotracheal intubation, mechanical ventilation, therapeutic hypothermia, and various intravenous pharmacological infusions [10,11] Therefore, with the rapid use of AEDs by random bystanders, the ... the usual scenario of aggressive ICU care, invasive assessments and a myriad of consultations was pre-empted for a large percentage of those patients who, traditionally, would have required them ... was the fact that many of the persons who had operated the AEDs for these survivors had never been trained how to use them [9] In essence, technology has now made the average person readily capable...

Ngày tải lên: 12/08/2014, 23:21

... effects of the next crash, rather than think that they can avoid its impact altogether The financial crash and its aftermath have already been covered extensively in the literature Academics, practitioners, ... Globalization, the instant electronic transmission of money, the Internet— these are all features of the crash of the past decade The instantaneous nature of the financial market, worldwide, is a ... of the firm’s shares, as did many of the employees, at the time of the firm’s collapse Much of the bonus payment at the company was paid in shares in the company MACROPRUDENTIAL FINANCIAL REGULATION...

Ngày tải lên: 30/10/2014, 16:18

... functional in mammalian autophagy and their mammalian counterparts have been identified and characterised such as the mammalian counterpart of Atg16, Atg16L (Mizushima et al., 2003; Mizushima et al., ... Schematic illustration of the autophagy pathway and its core machinery in mammalian cells 17 Figure Regulation of mammalian autophagy 22 Figure Autophagy in tumourigenesis and anti-cancer therapy 28 Figure ... the most abundant in autophagosomal membranes and therefore used as a marker to monitor autophagic activity (Hemelaar et al., 2003; Kabeya et al., 2000; Kabeya et al., 2004; Tanida et al., 2006)...

Ngày tải lên: 12/10/2015, 17:35

... 10 is activated and later they activate other caspases in a cascade This cascade eventually leads to the activation of the effector caspases, such as caspase and caspase These caspases are responsible ... Because the antibody against scramblase is not available at the moment, only two antibodies against scramblase and have been used for detecting the scramblases The antibody against human antigen ... important role in activating scramblases, thereby leading to the exposure of PS to outer leaflet of the cell membrane The activation of Ca2+-activated K+ channel (Gardos channel) by an increase of...

Ngày tải lên: 15/11/2015, 12:54

... management, land uses of ASS and acidic pollution have led to a 70% reduction in income of the farmers living in the ASS area of Ca Mau peninsula, a coastal area of the Mekong Delta of Vietnam On ASS, ... canals facing the West Sea will increase the flow of canal water from the East Sea toward the West Sea and hence will affect salinity and acidity propagation in the canal network The locations and ... integrated into the VRSAP model in the next time step (Fig 2) The integrative VRSAP-ACIDITY model is capable of simulating the temporal and spatial variations of water pH (as an indicator of acidity),...

Ngày tải lên: 23/02/2016, 21:26

... TESTICULAR CANCER Western Africa Eastern Asia Middle Africa Northern Africa Melanesia Eastern Africa South-Central Asia Less developed regions Caribbean South-Eastern Asia Southern Africa Western Asia ... Central America Polynesia Central and Eastern Europe South America Micronesia Western Asia Southern Africa South-Eastern Asia Caribbean Less developed regions South-Central Asia Eastern Africa Melanesia ... over the past 50-60 years in European and several other countries across the world, at least among Caucasian men (Richiardi et al 200 4a; Purdue et al 2005; Bray et al 200 6a, b) Because of the rapidity...

Ngày tải lên: 13/02/2014, 10:20

... usually lack a TATA-box and employ multiple transcriptional start sites [10,14] Mutation of either a CDE or a CHR in a promoter leads to the activation of tran- scription in quiescent cells A narrowly ... yielded a further decrease in regulation The CDE alone was not tested [41] The CDE mutation that was assayed would also alter a putative CDE site with the standard distance of four nucleotides to the ... through the cell cycle (Fig 1) Cyclins B1 and B2 appear in S phase and accumulate in G2 and mitosis before disappearing at the transition from metaphase to anaphase Synthesis is controlled at the...

Ngày tải lên: 16/02/2014, 09:20

... India Singapore Egypt Bahrain Iraq Kuwait Qatar Indonesia Indian Singapore Bahrain Atlantic Ocean Indonesia Kuwait Indian Ocean Australia South Africa Atlantic Ocean Ocean Australia South Africa ... Russia Russia Kazakhstan South Korea South Korea Japan Japan Pacific Ocean Taiwan Pacific Hong Kong Ocean Israel Libya Kazakhstan Oman India Egypt Taiwan Algeria Libya Iraq Qatar Hong Kong Oman ... SubAfrica Saharan Africa Eastern Asia South Eastern Asia Oceania Oceania Source: JMP, Progress in drinking water and sanitation, 2008 Shared: sanitation facilities of an otherwise acceptable type shared...

Ngày tải lên: 17/02/2014, 10:20

... idea of trusts and estates The stockholder was the beneficiary, profit was the income of the estate, and the capital was the corpus of the estate According to the IASB DP (2005): Financial statements ... splitting the change in value of single assets according to a piecemeal approach Following the IASBs approach, then, the combination is disregarded as a unit of accounting, and assets are always (expected ... Iss 1, Art Historical cost: Assets are recorded at the fair value of the consideration given to acquire them at the time of their acquisition Liabilities are recorded at the fair value of the consideration...

Ngày tải lên: 18/02/2014, 01:20

... on the hACMSD crystals using the same beamline, clearly indicated the presence of a Zn metal ion bound to the enzyme Analysis of the diffraction data set allowed us to assign the crystal to the ... hACMSD appears to be an important enzyme controlling the cellular levels of QA, PA and NAD As a consequence, modulation of hACMSD activity could be of considerable relevance in certain therapeutic ... tryptophan catabolism along the kynurenine pathway, and is a medically relevant enzyme in light of the important roles played by QA and PA in physiological and pathological conditions Indeed, QA is...

Ngày tải lên: 18/02/2014, 06:20