... account [7] The aim of the present study was to 95 determine the impact of CYP3A5*1 and CYP3A5*3 genotype on the kinetics of tacrolimus in renal transplant recipients The drug dose and level, the drug ... Cadaver transplantation Age at the onset of the chronic renal deficiency (years) Age at the onset of the chronic renal deficiency for females (years) Age at the onset of the chronic renal deficiency ... pharmacokinetics are the drug transporters and the metabolizing enzymes [7,9] CYP3A, the primary subfamily of the cytochrome P450 (CYP) enzymatic system, is responsible for the metabolism of tacrolimus...
Ngày tải lên: 26/10/2012, 09:32
... of the cell in the event of a second BRCA mutation Current data suggest that ATM, CHK2 and p53 may be candidate genes for these permissive mutations as impaired functions of these genes, either ... Interestingly, when either Ku-70 or Ligase IV was also mutated, the PARP-1-/cells became resistant to the killing by DSB-inducing drugs The underlying mechanism is that the absence of Ku70 or ... cells to repair DSBs, therefore, preventing their lethality Can PARP-1 inhibitors specifically kill BRCA1 mutant breast cancer cells? These observations cast significant doubts on the effectiveness...
Ngày tải lên: 31/10/2012, 16:57
AbrahamLincoln - the long-purposed man
... persisted in the aristocratic, plantation economy of the South and the nation became eVectively divided into free Northern and Southern slave sections along the line of the Ohio River and the southern ... sympathy from the gallantry with which they have maintained their cause, and from the obvious truth that the struggle was for the separation on the one part and compulsory retention on the other.42 ... abolish it altogether, by violence if necessary They began to strengthen their militias and to mobilize for the defense (as they saw it) of their civilization, threatening to leave the Union if a...
Ngày tải lên: 01/11/2013, 10:20
Nghiên cứu quy trình sản xuất chế phẩm kháng thể lòng đỏ chống mycoplasma gallisepticum và ứng dụng thử nghiệm
... Theo Ph m Th Thu Lan v c ng s (1988) [10] theo dừi b nh CRD xớ nghi p g thnh ph Nha Trang cho th y t l g nhi m b nh l 27,84% Tr ng i h c Nụng nghi p H N i Lu n th c s khoa h c nụng nghi p Theo ... 1x109 t bo/ml Sau tiờm theo dừi ủn g 21 ngy, theo dừi bi u hi n c a ủn g, s s ng, ch t Tr ng i h c Nụng nghi p H N i Lu n th c s khoa h c nụng nghi p 37 2.3.9 Phng phỏp theo dừi th i gian b o ... KTLMG * i u ki n theo dừi: - Nhi t ủ theo dừi: - 80C - m tng ủ i: 75 - 85% - Quy cỏch m u: m u ủ ng l nh a trung tớnh cú dung tớch 20 ml, 50 ml, 100 ml * Cỏc ch tiờu ủ c ủỏnh giỏ theo phng phỏp...
Ngày tải lên: 23/11/2013, 10:06
Tài liệu Báo cáo đề tài "Màn hình tinh thể lỏng LCD" pdf
... hoạt động LCD • Các phần tử tinh thể lỏng xếp dọc theo khe rãnh • Khi tiếp cận với bề mặt có khe rãnh, phần tử tinh thể • lỏng xếp song song dọc theo khe rãnh • Ánh sáng xoay xuyên suốt, hệt tinh ... Công nghệ hình tinh thể lỏng LCD Các hệ thống hiển thị LCD • Hệ thống đoạn: Hiển thị độ dài xếp theo dạng hình số "8" để hiển thị số • Hệ thống ma trận điểm ( hiển thị ký tự ) • Hệ thống ma trận...
Ngày tải lên: 20/01/2014, 19:20
Tài liệu The long-term reproductive health consequences of female genital cutting in rural Gambia: a community-based survey doc
... In 85% of the operations, efforts were made to reduce the pain, although the question did not specify whether this was pain at the time of the operation or the period after In 83% of the operations ... whether they had been circumcised, at what age, and about their attitude to the continuation of this practice Women with circumcised daughters were asked about the details of the operation for the ... (either at the time of the operation or during delivery) could introduce bias The hypothesized mechanisms by which cutting might affect long- term reproductive morbidity are shown in Figure The...
Ngày tải lên: 13/02/2014, 16:20
Tài liệu Is the long-term interest rate a policy victim, a policy variable or a policy lodestar? docx
... held their bonds The spreads on their bonds over US Treasuries fell from 84 bp on the Friday before the announcement of nationalisation to 56 bp on the Monday after In the years that followed, there ... was that the long- run natural interest rate in the US was around 3% over the period 1965 to 2001 and that it varied between about 2½% and 3½% The low real long- term rate – well below these historical ... are meant to follow the IRB, and not the standardised approach But there was a more subtle link between the stance of monetary policy and the long- term rate on this occasion The “measured pace”...
Ngày tải lên: 17/02/2014, 03:20
Tài liệu MARRIAGE LAW AND PRACTICE IN THE LONG EIGHTEENTH CENTURY ppt
... designed to serve the interests of the ruling classes whose aim was to increase their control over the marriages of their children rather than to benefit the majority of the population.7 Others have ... related to the theory of the general canon law of Europe prior to the Council of Trent in the sixteenth century,6 which he assumed to be the law of Scotland, where the events at the heart of the case ... contract and completion In the conveyancing process, the contract signed by the parties binds them to the sale If either party attempts to renege on the contract, the other may seek specific performance,...
Ngày tải lên: 18/02/2014, 13:20
Tài liệu The long-term economic impact of higher capital levels docx
... focused on the steady-state impact at a point after the banks and the wider economy are assumed to have adjusted to the revised requirements (eg BCBS (2010)); others on the impact during the transition ... in the probability of crises, or about 55% of GDP Including other UK banks in the model is unlikely to affect the precision of our estimates materially, because the banks in our sample cover the ... capital requirements are independent of the capital ratio, whereas the incremental benefits decrease the higher the capital ratio We therefore present estimates of the costs and benefits for various...
Ngày tải lên: 20/02/2014, 19:20
Tài liệu BÁO CÁO " Xác định liều điều trị của chế phẩm KT04 -bột kháng thể lòng đỏ trứng đối với bệnh tiêu chảy do E.coli ở lợn con sau cai sữa " pptx
... lô, xác định hiệu độ ổn định theo liều xác định -Phương pháp điều trị theo dõi lợn điều trị: Khi phát ca bệnh, lợn đánh dấu, ghi số tai, cân trọng lượng, dùng liều theo phác đồ dẫn Thí dụ phác ... lặp lại lần để đánh giá ổn định liệu trình Kết theo dõi lợn lành bệnh theo lô trình bày bảng TT Liều (gam/kgP) 0,5 1,0 Bảng Tỷ lệ lành bệnh KT04 theo liều lô thử nghiệm Lô (n=10) Lô (n=10) Lô ... & Dewey, C E.(2003) Field trial assessment of the efficacy of specific egg-yolk antibody product for control of postweaning E coli diarrhea Vet Ther 4, 279-284 Erhard, M H., Bergmann, J., Renner,...
Ngày tải lên: 26/02/2014, 02:20
Unfolding the Future of the Long War - Motivations, Prospects, and Implications for the U.S. Army docx
... understanding of the components of the long war, provided the basis for a set of seven strategy options for the United States in the long war xvi Unfolding the Future of the Long War Divide and ... change the force based on the long war should weigh the effects they will have on longer-term planning horizons, and the enduring missions of the force In these terms, maintaining flexibility in the ... uses of the term long war” and describe our synthesis definition of the long war to aid in further analysis In Chapter Three, we describe the participants in the long war to date and examine the...
Ngày tải lên: 06/03/2014, 20:20
Báo cáo khoa học: "Cutting the Long Tail: Hybrid Language Models for Translation Style Adaptation" doc
... very much in the world and so on , you know of the world around the world Thank you the United States all the time to it and so forth don ’t know to that in the future the same time ... frequency, are quite similar in the two corpora However, there are important exceptions: the pronouns I and you are among the top 20 frequent forms in the TED, while in the NEWS they are ranked only 40th ... instance, the word sequence “and so on [/s] ” is ranked 4th in the TED and 157th in the NEWS while “, you know [/s] ” is 5th in the TED and only 1652th in the NEWS These figures confirm that the talks...
Ngày tải lên: 08/03/2014, 21:20
The Long-Term Labor Market Consequences of Graduating doc
... and the other comparing these …ndings to an analysis of the 1990’ recession using the March CPS Section discusses the results in s relation to the theories outlined in section and concludes Theory ... for the national rate using the unemployment rate in the year an individual turned 22 and the state rate using the age 22 unemployment rate in the state if residence at age 14 (hereafter the ... attainment in the population (see for s example DeLong, Goldin, and Katz (2003)) Roughly speaking, the high group graduated at the beginning of the sample and the low group graduated at the end Thus...
Ngày tải lên: 17/03/2014, 03:20
RUNNIN’ WITH THE BIG DOGS The Long, Twisted History of the Texas-OU Rivalry docx
... in the nation Texas was number two So they checked into the Adolphus hotel in downtown Dallas the Plaza of the plains, the Waldorf-Astoria of the white-trash nation My father would join them there, ... his way from the fifty-yard line all the way down to the thirty-five, while the people screamed They didn’t generate the noise of the 1948 Oklahoma crowd, though, when they beat the Longhorns, ... good, 17 RUNNIN’ WITH THE BIG DOGS and then the spirit of the people of the land took over Before long, and for decades then to come, anybody staying downtown the night before the Texas-OU game would...
Ngày tải lên: 17/03/2014, 21:21
Measuring the long-term perception of monetary policy and the term structure docx
... of the model The second stage is to include these endpoints in the autoregressive model for forecasting The use of these endpoints serves to anchor the long term forecast of each variable of the ... the VAR model of Kozicki and Tinsley the shifting endpoint for in‡ ation is based on the stochastic process of the observed in‡ ation, so they use the hypothesis that the in‡ ation is under the ... series due to the central place of the German policy in the European Monetary System before the launch of the ECB and because the German bond rates remain the benchmark for the long- term interest...
Ngày tải lên: 22/03/2014, 23:20
Báo cáo " Hoàn nguyên than hoạt tính bằng phương pháp oxy hóa xúc tác dị thể lỏng - rắn " doc
... material possesses the adsorption capacity as high as that of virgin AC Moreover, the spent Me/AC was easily regenerated by H2O2 under very mild condition (40oC, atmospheric pressure), the adsorption ... catalyst for the total oxidation of phenol in aqueous solutions, Applied Catal.B: Environmental 34 (2001) 267 Regeneration of spent activated carbon by heterogeneously oxidative catalysis in the liquid-solid ... Alvarez et al., Comparison between thermal and ozone regeneration of spent activated carbon exhausted with phenol, Water Res 38 (2004) 2155 [4] Moreno-Castilla et al., Thermal regeneration of an activated...
Ngày tải lên: 28/03/2014, 10:20
Are Bonds Going to Outperform Stocks Over the Long Run? Not Likely. pptx
... the last 40 years were virtually in line with the long- term historical average On the other hand, bond returns were not only much higher than their historical averages, but also higher than their ... Ibbotson Despite the substantial decline in yields over the last 40 years, Chart shows the bulk of the bond returns come from the income return portion, or yield On average, the bond income return ... As of the end of the first quarter of 2009, the Long- Term Government Bond yield was 3.55% and the Intermediate-Term Government Bond yield was only 1.68% For bonds to continue to enjoy the same...
Ngày tải lên: 29/03/2014, 03:20
''''Mách nước'''' bạn chọn màn hình tinh thể lỏng pptx
... nhìn theo chiều ngang chiều dọc Bạn không cần quan tâm nhiều tới góc nhìn ngoại trừ bạn liên tục phải dùng LCD để trình chiếu Trong trường hợp này, góc nhìn đảm bảo 120 độ theo chiều ngang 100 theo ... giành chiến thắng! Chính lý này, đa phần game thủ nhà sản xuất game tránh xa LCD Theo họ, chất lượng LCD không theo kịp CRT- đặc biệt LCD thường xuất hiệu ứng “ma” (vết hình ảnh kéo dài cảnh quay ... hỏng hóc lại lớn nhiều.Chính vậy, không khôn ngoan bạn chọn giải pháp kết hợp “2 1” Lựa chọn LCD theo mục tiêu sử dụng Trên bạn tư vấn cách chọn LCD từ tiêu chí kích cỡ, độ phân giải, giá v.v…...
Ngày tải lên: 29/03/2014, 11:20
Fiscal Dominance and the Long-Term Interest Rate: FINANCIAL MARKETS GROUP SPECIAL PAPER SERIES doc
... lending long It also affects the incentives of banks to lengthen the duration of their liabilities The level of long- term rates influences asset prices by providing the discount rate to value the ... developed the theoretical models of how central bank operations in long- term debt markets work He stressed the importance of the policies of government debt finance – not the central bank – on the long- term ... also drive down long- term yields, reinforcing the impact of the Federal Reserve’s QE But the impact on the exchange rate would have the opposite sign – at least to the extent that the alternative...
Ngày tải lên: 29/03/2014, 13:20
Báo cáo sinh học: "Methylation levels of the “long interspersed nucleotide element-1” repetitive sequences predict survival of melanoma patients" doc
... from the date of stage IIIC diagnosis until the date of death According with the specific goals of the analysis, we did not classify the deaths considering their cause Patients were censored at the ... Substantial decreases in the 5-methylcytosine content in the genome mainly reflect the hypomethylation of repetitive genomic sequences Among these, methylation levels of the Long Interspersed Nucleotide ... studies have investigated the influence of the overall level of genomic DNA methylation on CM prognosis Accordingly, we investigated whether the extent of methylation of the LINE-1 repetitive elements...
Ngày tải lên: 18/06/2014, 19:20