the insulin like growth factor igf system

Báo cáo Y học: Characteristics of binding of insulin-like growth factor (IGF)-I and IGF-II analogues to the type 1 IGF receptor determined by BIAcore analysis pptx

Ngày tải lên : 08/03/2014, 22:20

... Miller, R.E & Cascieri, M.A (1990) The roles of tyrosines 24, 31, and 60 in the high anity binding of insulin- like growth factor- I to the type insulin- like growth factor receptor J Biol Chem 265, ... analysis of IGF- I and IGF- I analogue binding to highanity recombinant IGF1 R Binding of IGF- I (A), des-(1±3) -IGF- I (B), Arg3 -IGF- I (C), Gly3 -IGF- I (D), Long IGF- I (E), Ala31 -IGF- I (F), Leu24 -IGF- I ... insulinlike growth factor type receptor Growth Horm IGF Res 9, 389 18 Hale, K., Murray, A.W., Cosgrove, L.J., Bach, L.A & Hart®eld, P.J (2000) Prevention of apoptosis by insulin- like growth factor...

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Báo cáo sinh học: " Liver-spleen axis, insulin-like growth factor-(IGF)-I axis and fat mass in overweight/obese females" pot

Ngày tải lên : 18/06/2014, 22:20

... diameter; IGF- I, Insulin- like growth factor- I; IGF- I zSDS, SDS of IGF- I levels according to age; IGFBP-1, IGF- binding protein-1; IGFBP-3, IGF- binding protein-3; IGF- I/ IGFBP-3, IGF- I/IGFBP-3 ratio ... diameter; IGF- I, Insulin- like growth factor- I; IGF- I zSDS, SDS of IGF- I levels according to age; IGFBP-1, IGF- binding protein-1; IGFBP-3, IGFbinding protein-3; IGF- I/IGFBP-3, IGF- I/IGFBP-3 ratio ... obesity Abbreviations FM: (fat mass); IR: (insulin resistance); HS: (hepatic steatosis); GH: (growth hormone); IGF- I: (insulin- like growth factor- 1); IGFBP: (IGF binding protein); BMI: (body mass...

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báo cáo hóa học:" Liver-spleen axis, insulin-like growth factor-(IGF)-I axis and fat mass in overweight/obese females" docx

Ngày tải lên : 20/06/2014, 04:20

... diameter; IGF- I, Insulin- like growth factor- I; IGF- I zSDS, SDS of IGF- I levels according to age; IGFBP-1, IGF- binding protein-1; IGFBP-3, IGF- binding protein-3; IGF- I/ IGFBP-3, IGF- I/IGFBP-3 ratio ... diameter; IGF- I, Insulin- like growth factor- I; IGF- I zSDS, SDS of IGF- I levels according to age; IGFBP-1, IGF- binding protein-1; IGFBP-3, IGFbinding protein-3; IGF- I/IGFBP-3, IGF- I/IGFBP-3 ratio ... obesity Abbreviations FM: (fat mass); IR: (insulin resistance); HS: (hepatic steatosis); GH: (growth hormone); IGF- I: (insulin- like growth factor- 1); IGFBP: (IGF binding protein); BMI: (body mass...

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Tài liệu Báo cáo khoa học: An ecdysteroid-inducible insulin-like growth factor-like peptide regulates adult development of the silkmoth Bombyx mori docx

Ngày tải lên : 18/02/2014, 13:20

... Silkmoth IGF -like peptide N Okamoto et al Members of the insulin- like peptide (ILP) family are present in a wide variety of metazoans In vertebrates, insulin and insulin- like growth factors (IGFs) ... A (1993) Role of insulin- like growth factors in embryonic and postnatal growth Cell 75, 73–82 26 Holt RIG (2002) Fetal programming of the growth hormone insulin- like growth factor axis Trends ... is the role of circulating IGF- I? Trends Endocrinol Metab 12, 48–52 22 Yakar S, Liu J-L & LeRoith D (2000) The growth hormone ⁄ insulin- like growth factor- I system: implications for organ growth...

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Báo cáo khoa học: Identiﬁcation of the amniotic ﬂuid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms docx

Ngày tải lên : 07/03/2014, 00:20

... elevation of insulin- like growth factor (IGF) binding protein-1 decreases plasma free IGF- I and muscle protein synthesis Endocrinology 144, 3922–3933 Westwood M (1999) Role of insulin- like growth factor ... Cellular actions of the insulin growth factor binding proteins Endocr Rev 23, 824–854 Baxter RC (2000) Insulin- like growth factor (IGF- ) binding proteins: interactions with IGFs and intrinsic ... suggest that not only the degree, but also the position of the phosphate groups inﬂuence the process As for the other IGFBPs, the proteolytic cleavage of IGFBP-1 occurs within the central domain...

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Nồng độ Hóc Môn "Insulin - Like Growth Factor - I / IGF - I" huyết thanh ở trẻ em Việt Nam - lứa tuổi tiền học đường pot

Ngày tải lên : 25/03/2014, 03:22

... Serum insulin- like growth factor I /IGF- I concentrations in Vietnamese pre-school children The study was carried out in 642 pre-school children in order to determine the reference values of serum IGF- I, ... Thissen JP, Collette et al 1996 Zinc supplementation increases growth and circulating insulin- like growth factor I (IGF- I) in Vietnamese growth- retarded children Am J Clin Nutr 63: 514-519 Ninh NX, ... tuyến tính với nồng độ IGF- I Nồng độ IGF- I tình trạng dinh dỡng Bảng 3: Nồng độ IGF- I (ng/mL) theo số dinh dỡng Thể suy dinh dỡng Tình trạng dinh dỡng Cân/tuổi Cao/tuổi Cân/cao IGF- I/trẻ không SDD...

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báo cáo hóa học:" Assessing the clinical utility of measuring Insulin-like Growth Factor Binding Proteins in tissues and sera of melanoma patients" potx

Ngày tải lên : 18/06/2014, 15:20

... Insulin- like Growth Factor; (IGF1 R): Insulin- like Growth Factor- 1 receptor; (IGFBP-3): Insulin- like Growth Factor Binding Protein-3; (IGFBP-4): Insulin- like Growth Factor Binding; Protein-4; (MAPK): ... [1-3] Components of this system include the ligands IGF1 and IGF2 , their cell surface tyrosine kinase receptors IGF1 R and IGF2 R, and seven IGF binding proteins (IGFBP) IGF1 R has been shown to ... secreting IGFBPs in melanoma However, data not support the clinical utility of measuring levels of IGFBP-3 and -4 in sera of melanoma patients Abbreviations (IGF) : Insulin- like Growth Factor; (IGF1 R):...

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Báo cáo hóa học: " The emerging role of insulin-like growth factor 1 receptor (IGF1r) in gastrointestinal stromal tumors (GISTs)" pdf

Ngày tải lên : 18/06/2014, 16:20

... Glycemic derangements related to insulin- like growth factors such as the pro -IGF- IIE and insulin- like growth factor- binding proteins have been described in GISTs, and they may become more important ... growth factor receptor- and insulin- like growth factor- 1 receptor signaling: implications for cancer therapy Curr Cancer Drug Targets 2009, 9:748-60 Zha J, Lackner MR: Targeting the Insulin- like ... Hankinson SE: Insulin- like growth factors and neoplasia Nat Rev Cancer 2004, 4:505-18 20 21 Tao Y, Pinzi V, Bourhis J, Deutsch E: Mechanisms of diseases: signalling of the insulin- like Growth Factor...

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Báo cáo sinh học: " Liver mitochondrial dysfunction is reverted by insulin-like growth factor II (IGF-II) in aging rats" doc

Ngày tải lên : 18/06/2014, 22:20

... I: Role of serum insulinlike growth factor I in mammalian brain aging Growth Horm IGF Res 2004, 14(Suppl A):S39-43 30 Tong M, Dong M, de la Monte SM: Brain insulin- like growth factor and neurotrophin ... roles of insulin- like growth factor- I in the adult brain Growth Horm IGF Res 2007, 17(2):89-95 34 Llorens-Martín M, Torres-Alemán I, Trejo JL: Mechanisms mediating brain plasticity: IGF1 and ... specific properties of IGFs In this context, since mitochondria are one of the most important cellular targets of IGF- I, the present study analyzed the effects of IGF- II therapy on hepatic mitochondria...

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báo cáo hóa học:" Liver mitochondrial dysfunction is reverted by insulin-like growth factor II (IGF-II) in aging rats" pot

Ngày tải lên : 20/06/2014, 04:20

... I: Role of serum insulinlike growth factor I in mammalian brain aging Growth Horm IGF Res 2004, 14(Suppl A):S39-43 30 Tong M, Dong M, de la Monte SM: Brain insulin- like growth factor and neurotrophin ... roles of insulin- like growth factor- I in the adult brain Growth Horm IGF Res 2007, 17(2):89-95 34 Llorens-Martín M, Torres-Alemán I, Trejo JL: Mechanisms mediating brain plasticity: IGF1 and ... specific properties of IGFs In this context, since mitochondria are one of the most important cellular targets of IGF- I, the present study analyzed the effects of IGF- II therapy on hepatic mitochondria...

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Báo cáo sinh học: "Stage debut for the elusive Drosophila insulin-like growth factor binding proteins" potx

Ngày tải lên : 06/08/2014, 18:21

... establish the similarities and differences between the mammalian IGF- IGFBP system and the Drosophila Dilp-Imp-L2 system Characterization of the Dilps at the protein level, and of whether and how they ... binding proteins (IGFBPs) [8] The effects of IGFBPs on IIS are complex IGFBPs act as regulators of the activity of IGFs, by prolonging their half-life, altering their local and systemic availability ... Imp-L2: the Drosophila IGFBP IIS is an important regulator of growth, and overexpression of the Drosophila insulin receptor in the eye during development results in hyperplasia (overgrowth) of the...

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Báo cáo y học: "Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes" ppt

Ngày tải lên : 09/08/2014, 01:23

... cultured factor (IGF) -1 to IGF- binding proteins (IGFBPs), in insulin- like of NBI-31772, a small-molecule inhibitor of the binding of priActivitygrowth rabbit chondrocytes lin -like growth factor (IGF) -1 ... insulin- like growth factor I (IGFI) and IGF- binding protein-3 (IGFBP-3) and -5, but not IGF- II or IGFBP-4 J Clin Endocrinol Metab 1996, 81:1096-1103 Middleton J, Manthey A, Tyler J: Insulin- like ... binding R insulin- like analog of IGF- 1 with to IGF- binding proteins for IGFBPs) primary cultured humanNBI-31772, a small-moleculeincubatedof the IGF- 1 orof IGF- 1 (an growth factor (IGF) -1 a greatly...

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Báo cáo y học: "Parenteral versus enteral nutrition: effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis" pps

Ngày tải lên : 13/08/2014, 08:20

... in the activity of the immune system In this regard, the effect of sepsis and the influence of nutrition on tissue protein metabolism and on the functioning of the growth hormone (GH) insulin- like ... Circulating levels of IGF- I and of the insulin- like growth factor binding protein-I (IGFBP-I) are exquisitely sensitive to provision of nutrients, the former being increased and the latter being suppressed ... Bars represent the mean expression of mRNA of insulin- like growth factor- 1 (IGF- I) and growth hormone receptor (GHR), normalized to 18S rRNA (mean normalized expression), measured in the liver from...

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Tài liệu Báo cáo khoa học:Insulin-like growth factor 1 signaling regulates cytosolic sialidase Neu2 expression during myoblast differentiation and hypertrophy doc

Ngày tải lên : 19/02/2014, 06:20

... (1996) Growth hormone and the insulin- like growth factor system in myogenesis Endocrine Rev 17, 481–517 DeVol DL, Rotwein P, Sadow JL, Novakofski J & Bechtel PJ (1990) Activation of insulin- like growth ... Journal compilation ª 2006 FEBS 3713 Insulin- like growth factor signaling A Fanzani et al A B Fig Neu2 expression is strictly dependent on insulin- like growth factor (IGF- 1) signaling (A) C2BP5 cells ... Maturation of the myogenic program is induced by postmitotic expression of insulin- like growth factor I Mol Cell Biol 19, 3115– 3124 James PL, Stewart CE & Rotwein P (1996) Insulin- like growth factor...

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Tài liệu Báo cáo khoa học: Identiﬁcation of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25) doc

Ngày tải lên : 19/02/2014, 07:20

... binding of IGFs to IGFBPs limits the interaction of the growth factors with the cell surface receptors Therefore, IGFBPs generally inhibit IGF- stimulated cell growth in vitro [25] In contrast, IGFBP-rP1 ... ﬂuids, IGFBPs bind IGFs with high afﬁnity, protecting the growth factors from proteolytic degradation The proteolytic cleavage of IGFBPs is thought to contribute to the release of IGFs from IGF ⁄ IGFBP ... and regulation Growth Horm IGF Res 9, 85–95 Collett-Solberg PF & Cohen P (1996) The role of the insulin- like growth factor binding proteins and the IGFBP proteases in modulating IGF action Endocrinol...

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Báo cáo khoa học: Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1⁄TSC2 in C2C12 myotubes pptx

Ngày tải lên : 15/03/2014, 11:20

... to either activate or inhibit protein synthesis and cell growth [2] The most well deﬁned signaling mechanism regulating mTOR activity in skeletal muscle is the insulin like growth factor- 1 (IGF- 1) ... U0126 treatment on IGF1 -induced phosphorylation of either Akt or S6K1 (Fig S1C) These results support the hypothesis that IGF- 1-induced activation of mTOR signaling is mediated by the PI3K ⁄ Akt-dependent ... S2) These observations suggest that the stability of the complex between TSC1 and TSC2 is not a critical factor in determining the function of the TSC1 ⁄ TSC2 protein complex in response to IGF- 1...

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BÁO CÁO " ĐA DẠNG DI TRUYỀN GEN INSULIN - LIKE GROWTH FACTOR BINDING PROTEIN 2 TRÊN GÀ " potx

Ngày tải lên : 24/03/2014, 23:21

... trình chạy điện di thể bảng 37 Đa dạng di truyền gen Insulin- like growth factor binding protein gà đa dạng di truyền gen Insulin- like growth factor binding protein gà Bảng Các cặp primer sử dụng ... cuối AA quần thể nghiên cứu 39 Đa dạng di truyền gen Insulin- like growth factor binding protein gà đa dạng di truyền gen Insulin- like growth factor binding protein gà Bảng Tần số kiểu gen alen ... of a single nucleotide polymorphism of the insulin- like growth factor binding protein gene and its association with growth and body composition traits in the chicken J Anim Sci 84: 2902-2906 Nie,...

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báo cáo hóa học: " Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide" ppt

Ngày tải lên : 19/06/2014, 22:20

... show whether all the effects are mediated by the IGF- 1R With this in mind we determined whether the naturalistic product of IGF- I cleavage within the brain that acts independent of the IGF- 1R ... outside the nervous system Thus GPE may represent a centrally active IGF- derivative, separating it from the global role of IGF- I Importantly, purification of IGF- I from brain yields IGF- I lacking the ... FST The behavioral changes did not occur with naïve mice but these neurotrophins attenuated the behavioral changes induced by i.p LPS These data extend the anti-depressant activity of the IGF system...

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Nghiên cứu tạo dòng, biểu hiện và thu nhận hIGF 1 (human insulin like growth factor 1) từ escherichia coli

Ngày tải lên : 25/07/2014, 08:29

... Chromatography GH Growth Hormone HRP HorseRadish Peroxidase IPTG IsoPropyl-β-D-Thio-Galactoside hIGF-1 human Insulin- like Growth Factor IGF1 R IGF- 1 Receptor IGFBP Insulin- Like Growth Factor Binding ... hIGF-1 chủ yếu tồn dạng liên kết với loại protein chuyên biệt IGFBPs (insulin- like growth factor binding protein) (IGFBP1-6), IGFBP-3 chiếm tỉ lệ cao Có đến 90% hIGF1 tạo thành phức hợp với IGFBP-3 ... trọng nhóm hormone tăng trưởng insulin- like growth factors (IGFs) IGFs họ protein hormone có trình tự amino acid tương đồng với proinsulin khoảng 50% bao gồm IGF- 1 IGF- 2 (hay gọi somatomedin C...

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Báo cáo y học: "Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1" doc

Ngày tải lên : 09/08/2014, 01:21

... increased Both of these results — the effects on the IL-6/ sIL-6R pathway and on IGF- 1 in the endocrine system — may be involved in the mechanisms mediating the beneficial effects of HRT There is a ... WA: Insulin- like growth factor- 1 (IGF- 1) and growth hormone (GH) in immunity and inflammation Cytokine Growth Factor Rev 1999, 10:5-14 29 Jansson JO, Eden S, Isaksson O: Sexual dimorphism in the ... the endocrine system, increasing the production of insulin- like growth factor (IGF- 1), which has anabolic effects on bone [3,4] dose of 500 mg calcium and 400 IU vitamin D3 Women in the HRT group...

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