the in vivo evaluation of qaf805

... the stem of the prosthesis is custom made for each individual patient, during the operation [27] After reaming of the femoral cavity, a 3D imprint of the cavity is made in the form of a silicone ... frequencies The graph change in shape and position is more important at the beginning of the insertion when the stem displacement is important as well At the end of the insertion, when the resistance ... *The circle indicates the place of the measuring hardware (presented in the left picture) behind the transparent wall A member of the surgical team holds the shaker during the insertion procedure...

Ngày tải lên: 20/06/2014, 01:20

... previous work, we studied the stability and toxicity of PANs, and further investigated the sustained release behavior in vivo of drug loading in PANs PA was firstly synthesized and characterized ... dose of 200 mg/kg In vivo pharmacokinetics The plasma levels of EPI were determined following a single i.v injection of EPI or PA/EPI (10 mg/kg EPI equiv.) in female Wistar rats The plasma levels ... for the clearance of NPs, thus the reducing rate of MPS uptake could be considered as the best strategy for prolonging the circulation of NPs (Li & Huang, 2008) Therefore, PA/EPI prepared in this...

Ngày tải lên: 23/04/2013, 21:38

... powders were injected with Argon as the carrier gas to produce coating with thickness ranging from 40-70 microns (nominal 50 microns) The coating had a minimum total crystallinity of 65% The minimum ... cleaned of soft tissue, and fixed in 70% ethanol The femur bone was trimmed above and below the ends of the implant, cleaned of soft-tissue, and fixed in 70% alcohol The specimen was further dehydrated ... rabbit and included in the SEM analysis The details of this in vivo rabbit model have been described previously (Figure 2) [22,28] The appropriate experimental implant was press-fit into the intramedullary...

Ngày tải lên: 20/06/2014, 04:20

... Presence of GNPs in Organs The acute symptoms and eventual death of mice receiving GNPs indicated that the injected GNPs might damage major organs In the tissues samples stained with haematoxylin and ... Starting from day 14, mice injected with 8–37 nm GNPs showed a significantly camel-like back and crooked spine The majority of mice in these groups died before the end of the fourth week The median ... performed to measure the cytotoxicity of GNPs in cultured Hela cells The viability of cells exceeded 80% at the highest concentration of GNP (0.4 mM), indicating that regardless of their size, all...

Ngày tải lên: 22/06/2014, 00:20

... possible for their spores to germinate without being inhibited by the presence of bile salts in the small intestine It could also be concluded that among the six strains the tolerance of spores ... through the stomach of a pig The fact that the viable counts of most of the six Bacillus strains did not decrease after h of incubation suggests that a reasonable percentage of these Bacillus strains, ... originally obtained from the fresh faeces of healthy piglets The size of the inhibitory zone for the six selected isolates against the four indicator pathogens is shown in Table An example of a plate...

Ngày tải lên: 07/07/2014, 19:20

... model of autoimmunity Transient autoimmunity can be induced in mice by the administration of a single high dose of LPS This induces a pulse of nucleosomes and chromatin in the plasma within the ... administered during the most active stage of disease [29] The discrepancy between the two studies could be due to a number of factors, including the longevity of the injected protein and the level of free ... of the DNase I present in the supernatants purified as in (b) The activity was determined in the presence of the normal DNA-MG assay buffer, described in Materials and methods, or following the...

Ngày tải lên: 09/08/2014, 07:20

... phenytoin solution administered through the medial lumen and the TPN administered through the distal lumen In the final phase, the phenytoin was administered through the proximal lumen and the TPN ... catheters in the pediatric population, and especially in the pediatric intensive care setting, are commonly used for the administration of intravenous fluids, drugs, chemotherapeutic agents, inotropic ... the intravascular space, the proximal lumen may be close to the site of entry of the vein or even outside the vein This increases the possibility of extravasation if the catheter is accidentally...

Ngày tải lên: 12/08/2014, 18:20

... during the inspiratory phase in the in vitro and in vivo studies The Performer, the Hygroster, or the Hygrobac was placed between the Y piece of the ventilator circuit and the test lung or the ... proportional to the dryness of the gas, and so the difference in temperature between the dry and wet probe is related to the dryness of the gas [19] At the start of the measurements, we inserted the two ... variations We used this offset (in the order of 0.1–0.2°C) to correct the measurements obtained during the study In each condition, the average of three or four readings from the wet and dry probe...

Ngày tải lên: 12/08/2014, 20:20

... http://www.retrovirology.com/content/1/1/33 tion The data in the right side of panel A indicate that Cterminal deletions of GagPol extending into the connection domain result in an 85% or greater decrease in the initiation of reverse ... role of the RT thumb domain in GagPol in tRNALys3 viral packaging tRNALys3 incorpora- tion into HIV-1 is not affected by deletion of the IN domain in GagPol, nor by further deletion of the RNaseH ... similarly in vivo is not known Alternatively, the RT connection domain may undergo interactions with Gag that may result in placing the tRNALys3 bound to the thumb domain in RT closer to either NC in...

Ngày tải lên: 13/08/2014, 13:20

... PREFACE The thesis is submitted for the degree of Master of Engineering in the Department of Mechanical Engineering at the National University of Singapore under the supervision of Professor ... fall off and interact with the surrounding medium The falling of TCP then created voids within the polymer, thus exposing their surfaces to hydrolytic attack and weakening the overall structure of ... concentric rings (lamellae) of matrix Between the rings of matrix, the osteocytes are located in the lacunae The osteonic canals contain blood vessels that are parallel to the long axis of the bone These...

Ngày tải lên: 09/10/2015, 11:18

... agents include the naturally occurring vinca alkaloids (e.g vincristine and vinblastine) and their semi-synthetic analogues (e.g vinorelbine) and the taxanes (e.g paclitaxel and docetaxol) They ... on the microtubules, an essential part of the cytoskeleton of eukaryotic cells The vinca alkaloids prevent the protein from polymerizing into microtubules by binding specifically to β-tubulin In ... protein binding after IV administration (Extra et al., 1993) Docetaxel is mainly bound to alpha acid glycoprotein, lipoproteins, and albumin Among them, alpha acid glycoprotein is the main determinant...

Ngày tải lên: 09/10/2015, 11:18

... Services Department of the Weizmann Institute by a single injection of 150 lg of the purified protein, followed by two booster shots of the same amount of protein at 2-week intervals Serum was ... between the amounts of UP12 and the total amount of protein in the extracts, a series of samples containing determined amounts of the purified UP12 were separated by SDS/PAGE along with the cell ... has been identified by other means as an in vivo substrate of GroEL [27] Interestingly, GatY is also included in a list of proteins that aggregate at 42 °C in E coli containing a dnaK deletion mutation...

Ngày tải lên: 22/02/2014, 07:20

... that controls the protein expression in the wild-type is the shuttling of Gal80p Increasing the amount of Gal80p in the cytoplasm by increasing the distribution coefficient (K) causes the switch ... model provide insights into the importance of their roles in the overall performance of the network A similar experimental evaluation of the roles of individual elementary mechanisms in vivo is very ... between the various components However, these in vitro experiments may not yield the in vivo mechanism of the regulatory system An experimental determination of the in vivo mechanism in a genetic...

Ngày tải lên: 07/03/2014, 16:20

... In vivo tracking of 75 Se-labelled Der p intrinsic biological properties of the allergens may all contribute to their allergenicity [1–4] The intrinsic properties required for evoking an ... application of a newly developed technique for specific labelling of recombinant proteins by means of incorporating a radioactive selenocysteine residue in a C-terminal Sel-tag [18] Der p carrying the ... mimicking inhalation of the natural allergen The fact that i.t instillation of [75Se]Der p led to deposition of radioactivity in alveoli and bronchioli with no detectable allergen remaining in the...

Ngày tải lên: 07/03/2014, 21:20

... of their crystal structure of Pisum sativum PSI, in which the loop of PSI-G is suggested to face the stroma The amount of PSI-G in the transformed knock-out line does not reach the level of the ... conformation of the loop His-tags were employed in a topological study of the major light harvesting chlorophyll a ⁄ b binding apoprotein, Lhcb1 [18] Interestingly, fusion of a His-tag to the C-terminus, ... light harvesting complex (LHCI), consisting of four members (Lhca1–4) of the chlorophyll a ⁄ b binding protein family LHCI is bound along one side of PSI only, in the vicinity of the PSI-F and...

Ngày tải lên: 07/03/2014, 21:20

... previously to induce an increase in the level of [Ca2+]i and a correlated calpain activation [28] This increase in [Ca2+]i is more intense in aorta than in brain Under these conditions, in brain, no ... reproduced in in vitro conditions if nNOS digestion by calpain is carried out in the presence of HSP90 [27] This finding can also explain the large extent of digestion of eNOS in aorta, in which, in association ... milli-calpain isoforms were reduced to a limited extent in brain, whereas, in aorta (Fig 2B), the decrease in the two protease isoforms was more pronounced Moreover, in brain, the natural inhibitor of...

Ngày tải lên: 30/03/2014, 04:20

... the survival of H-RS cells [2] Cytokines and chemokines operating in a complex interaction have been suggested to be involved in the pathogenesis of HL [3] A number of studies indicate that the ... respectively Furthermore, the UV spectra of the materials in peaks II and IV were in agreement with the UV spectra for eoxins (Fig 4, inset) [11] To further analyze the identity of the materials in peak ... the orientation of the enzyme in the membrane of L1236 cells and the exogenous addition of arachidonic acid reaching the active site of the cytosolic enzyme to a greater extent than that of the...

Ngày tải lên: 30/03/2014, 04:20

... http://www.translational-medicine.com/content/7/1/41 QK performing ex vivo experiments of vascular reactivity in WKY common carotid rings [12], and then we evaluated in vivo the role of this small peptide studying the ... not bind to VEGFRs, indicating that the helical structure is necessary for the biological activity The N-terminus of these peptides is capped with an acetyl group, while the Cterminus ends in an ... hematoxylin and eosin [4] Quantitative analysis was done by counting the total number of endothelial cells, identified by lectin staining (see immunohistology), in the Matrigel plug in each of 20 randomly...

Ngày tải lên: 18/06/2014, 15:20

... murine receptor resulted in a faint stain of the cytoplasm and rarely in staining of the membrane of the tumor cells (Figure 3B) In the more advanced 30 weeks tumors the staining patterns changed ... demonstrating the inverse correlation of the expression of the two tumor relevant molecules and implying their functional link Discussion The understanding of the mechanism responsible for the in vivo ... to the logarithm of the initial amount of the target DNA in the sample The relative concentration of one target with respect to another is reflected in the difference of the cycle number, the...

Ngày tải lên: 18/06/2014, 16:20

... in- vivo The objective of the current study was to measure the change in apparent length of the ATFL and CFL, in- vivo, in uninjured healthy ankles during a dorsiflexion-plantarflexion and supination-pronation ... the understanding of function of these ligaments and injury mechanisms However, the in- vivo behavior of the lateral ankle ligaments during the range of motion has not been well studied Data in ... applying inversion/eversion and internal/external rotational forces during the flexion-extension arc of motion They demonstrated increased strain in the ATFL with increasing plantarflexion, inversion...

Ngày tải lên: 20/06/2014, 01:20