the genome exposure defect in cancer
The NR4A orphan nuclear receptors are target genes of the novel drug c1 in cancer cells and potential mediators of drug induced apoptosis
... than 97% homology in their DNA binding domains They also display 37 – 53% homology in the N terminal transactivation domains and 53 - 77% in the C terminal ligand binding domains (Fu et al., 2007) ... associated proteins, myosin, gelsolin, filamin, spectrins, microtubular proteins including tubulins, microtubule associated proteins, and intermediate filament proteins including vimentin keratin and ... 116 kDa intact form into 85 kDa and 25 kDa fragments This process separates the aminoterminal DNA-binding domain of the enzyme from the carboxy-terminal catalytic domain resulting in the loss...
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The role of the small GTPase rab31 in cancer
... is highly expressed in the epithelial cells of the gastrointestinal tract, lungs and kidney, has in the past few years been implicated in cancers from multiple organs These include breast [59, ... [68] The micro-RNA (miR)-50 inhibits autophagy and tumour growth in colon cancer cells by suppressing, among other genes, the expression of Rab1B [69], the latter being an important factor in the ... [77–79] In the next section, we outline how Rab31 has been implicated in human cancers, and in the section after postulate the underlying mechanisms based on recent findings Rab31 and findings implicating...
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Báo cáo y học: " the Value of Serum Biomarkers (Bc1, Bc2, Bc3) in the Diagnosis of Early Breast Cancer"
... CHAPS) at the ratio of 5:1 Sera were then diluted again with binding solution at the ratio of 10:1 and were applied in 100 µL amounts in the wells on the chip Protein chips on which the samples ... surrounding cytoplasmic membrane in at least 10% of invasive carcinoma cells or presence of membranous staining in less than 30% provided that the staining is intense (++) Score 3: Presence of intense ... Izmir Ataturk Training and Research Hospital were obtained Serum samples were obtained from the patients who were included in the study Blood sampling was performed after surgery in the patients...
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Tài liệu Psychotherapy and Survival in Cancer: The Conflict Between Hope and Evidence pptx
... express interest in improving adherence, many of the distinctive elements of the interventions in these two trials would not have been included, and indeed, much of the content of these interventions ... the groups, suggesting that outcomes were more inconsistent in one group than in the other In this case, the intervention group had a variance 12 times that of the controls, suggesting that the ... involves integrating the results of trials that differ in their quality, primary outcomes, recruitment criteria, and sample sizes and in the interventions being evaluated Integrating these disparate...
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The Use of Mushroom Glucans and Proteoglycans in Cancer Treatment potx
... Japan in 1996 to foster the development of AHCC as an anticancer therapy In their circulating abstracts14 they report on other preliminary studies with AHCC against cancer They state that of 300 cancer ... Trials in Stomach Cancer PSK and Stomach Cancer Stomach cancer continues to inflict major mortality in Japan and has been the object of more clinical trials with PSK than any other cancer Beginning ... when chemotherapy was also utilized In contrast to the incredible response rates claimed in the Chinese study, in the Japanese study less than 50 percent of the leukemias and cancers of the prostate,...
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Báo cáo khoa học: The dipeptidyl peptidase IV family in cancer and cell biology pot
... DP9 The observed decreases in DP9-overexpressing cells of the ECM-interacting molecules discoidin domain receptor 1, a kinase activated by collagen binding, and the MMP inhibitor, tissue inhibitor ... and Toll-interacting protein to disengage from caveolin-1, resulting in the phosphorylation of IRAK-1 and the upregulation of CD86 expression Interaction with caveolin-1 also results in the recruitment ... in cell biology A number of DPIV-binding proteins have been identified, including adenosine deaminase [78,79], CD45 (protein tyrosine phosphatase) [80], caveolin-1 [81], CARMA1 [82], fibronectin...
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Báo cáo khoa học: Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model doc
... of the Hupki mouse A common polymorphism occurs at codon 72 in TP53, resulting in either a proline (Pro72) or an arginine (Arg72) This occurs in the region of the gene encoding the polyproline ... sites may increase the potential for planar carcinogen compounds to intercalate prior to covalent binding, although the precise mechanism still remains to be determined Furthermore, the majority ... and other urinary organs Morphology inclusion criteria: carcinoma not otherwise specified, carcinoma in situ not otherwise specified, dysplasia not otherwise specified, papillary carcinoma not otherwise...
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Báo cáo khoa học: A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells potx
... prosemin in ovarian cancer cell lines Ovarian cancers express some kinds of chromosome 16 serine proteases, including testisin and prostasin We investigated the expression of prosemin in ovarian cancers ... undergo processing by serine proteases in extracellular regions [30] Prosemin might be involved in the processing of some proteins In contrast to the specific expression of prosemin in normal tissues, ... Black bars indicate the enzymatic activity of enterokinase on the substrate The closed circles and line indicate prosemin enzyme activity after activation of the protein by enterokinase; the enzymatic...
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Thuốc chống viêm ức chế lipooxygenase và cyclooxygenase dùng dự phòng và điều trị ung th- (LOX an COX - inhibitors as adjunctive therapies in the prevention and treatment of cancer) ppt
... ung th in vitro, thấy quercetin làm thoái giáng đột biến p53 - protein, làm ngừng chu kỳ tế bào giai đoạn G1 , ức chế tyrosin - kinase, ngăn chặn hoạt tính protein - ras In vitro, quercetin ức ... Curcumin có nhiều ảnh hởng đến sinh lý bệnh học tế bào ung th: in vitro, curcumin làm ngừng chu kỳ tế bào u, thúc đẩy chết theo chơng trình (apoptosis) Tuy nghiên cứu hạn chế, nhng thấy curcumin ... bào khác nhau, thấy quercetin làm tăng hiệu lực điều trị cisplatin, adriamycin, busulfan, cyclophosphamid làm tế bào ung th giảm đề kháng với gemcitabin topotecan Bromelain Là hỗn hợp protease chứa...
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Báo cáo khoa học: S1 – The genome in the 3rd millennium docx
... to binding, as apparent in binding constants and/or the functional readout of the interaction In addition, fuzziness may also underline the observed sequence-independence of binding, when interaction ... during each S phase is crucial for maintaining the integrity of the genome This is achieved by a two-step mechanism The first step, known as licensing, involves the loading of the Mcm2– proteins ... development, including in the somatic cells of the adult brain In this talk I will discuss recent developments in linking somatic genome mosaicism with phenotypic effects in the human brain Using a...
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Cancer Research UK’s strategy 2009–2014: Cancer Research UK’s aim is to reduce the number of deaths from cancer. Our future plans are ambitious, but they are in line with the challenge and the responsibility we face. docx
... effectiveness in clinical trials Since then temozolomide plus radiotherapy has become the international standard of care for the brain cancer glioblastoma, leading to a pronounced increase in survival Informing ... in training most of the medical oncologists practising in the UK We will build on this to address the current deficit in clinician scientists working at the translational interface and in cancer ... and outcomes from the NCIN Tackling cancer inequalities A number of different groups in society experience unacceptable inequalities in cancer The nature of these inequalities in cancer is complex,...
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Báo cáo khoa học: Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73c in lung cancer doc
... lines, whereas it was significantly increased in the lung epithelial anaplastic carcinoma cell line (CALU6), in the squamous lung cancer cell lines (HTB59, HTB58, and SKMES1), in the adenocarcinoma ... TAp73 expression in vivo by treating the standard TAp73expressing cell line A549 with either Sp1 small interfering RNA (siRNA) or an Sp1 protein inhibitor The resulting changes in TAp73 expression ... IMR90), and substantially increased in the lung epithelial anaplastic carcinoma cell line (CALU6), the small cell carcinoma cell line (DMS53), the squamous lung cancer cell lines (CRL5802, HTB182,...
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Báo cáo khoa học: The tumor suppressor HIC1 (hypermethylated in cancer 1) is O-GlcNAc glycosylated doc
... activity, but their involvement in protein stability or in protein–protein interaction had to be investigated By contrast, BTB/POZ-truncated proteins generated either during the synthesis in rabbit ... protein, this modification occurs in the extreme C-terminal tail (residues 670–711) and not in the DNA-binding domain (Fig 6) These results provide another convincing example highlighting the Ó ... preferentially in the zinc finger domain involved in specific DNA-binding, does not significantly affect this functional property in the context of the full-length protein O-GlcNAc glycosylation within the...
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aging of the genome the dual role of dna in life and death mar 2007
... chance of being inherited together, whereas the farther away they are from each other, the more chance of their INTRODUCTION being separated by the process of crossing over The Morgan is now the unit ... out by bringing the mRNA and the set of tRNAs charged with the appropriate amino acids to the ribosomes, discovered earlier as the protein-making apparatus in the cytoplasm The guiding role of ... sequence the human and other genomes was initiated in 1998 by the Celera Genomics Corporation28 In the course of completing the sequence, two separate interim working drafts of the human genome...
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Báo cáo hóa học: "The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer" docx
... grading The study was conducted in accordance with the Helsinki Declaration and approved by the Ethics Committee of our institution Patients were informed of the investigational nature of the ... conceived the study, participated in the design, and coordinated and helped draft the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they ... infiltration along the tumor front correlated with improved survival in colon cancer compared to rectal cancer In the current study, the Cox model indicated that the CD68TFHotspot was independently...
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báo cáo hóa học: " Quality of life data as prognostic indicators of survival in cancer patients: an overview of the literature from 1982 to 2008" pot
... each other, in many instances when one includes both physical functioning and performance status in the regression models, the likelihood of finding inconsistent results can be expected In other ... that pain and appetite loss are independent determinants of overall survival One found that a 40-point increase in the pain subscale of the EORTC QLQ-C30 was associated with a 27% increase in the ... between patients receiving intermittent and continuous treatment strategies The findings indicated that changes in the quality of life index, measured by a series of Linear Analog Self Assessment...
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báo cáo hóa học:" Enhancing the efficacy of cisplatin in ovarian cancer treatment – could arsenic have a role" potx
... front-line therapy documented at second-look surgery will recur [15] Chemotherapy The most active chemotherapy agents in ovarian cancer are the platinum analogues, cisplatin and carboplatin The ... action binding to tubulin polymers (microtubules) and stabilizing the microtubule against depolymerization [29-32] During this time analogues of cisplatin were investigated in an effort to maintain ... twenty years there has been interest in the delivery of intraperitoneal therapy for ovarian cancer in order to maximize the efficacy and reduce the toxicity Dedrick proposed that the intraperitoneal...
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báo cáo hóa học:" Pain in cancer. An outcome research project to evaluate the epidemiology, the quality and the effects of pain treatment in cancer patients" pptx
... drug (750) during the longitudinal evaluation period Overall, considering the inception and the longitudinal evaluation, the entire duration of the study is estimated around months At the moment, ... enrolled in the study and eligible will be included in the statistical descriptive analyses To avoid and minimize the impact of missing data, a bias that may be present in the case of using patient-reported ... Background Pain afflicts most cancer patients, mainly in the advanced and metastatic phase of the disease [1] Recent reviews of published literature suggest that the prevalence of pain in advanced cancer...
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Exposure Science in the 21st Century: A Vision and A Strategy potx
... Engineering in providing services to the government, the public, and the scientific and engineering communities The Council is administered jointly by both Academies and the Institute of Medicine ... secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public The Institute acts under the responsibility given to the ... rapid interpretation of the concentrations in the samples However, inferring the sources and routes of these internal exposures remains a research challenge Biosignatures of exposure reflect the...
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