the formation of volcanoes by hot spots

... that of Ca2+-CaM [10,11,25,26], and therefore adversely affects binding of CaM to the Ca2+-CaM-binding domain of nNOS CaM is not only essential for the operation of nNOS and the other NOS isoforms, ... of the target peptide This is shown in Fig 4B for the 20residue binding domain of the plasma membrane Ca2+ pump ⁄ Ca2+-CaM complex, where the first 12 residues of the peptide are encompassed by ... this type of structure is also adopted by Ca2+-CaM when it binds to the CaM-binding domain of endothelial nitric oxide synthase (eNOS) [33] The second example is when the C-terminal lobe of Ca2+-CaM...

Ngày tải lên: 23/03/2014, 09:21

... lacking the 6-hydroxymethyl group Noticeably, the axial 1-OH of a-galactose projects out of the active site in the model and the catalytic nucleophile Asp511 together with Trp221, from the N-terminal ... intermediate by direct attack at the anomeric centre In the next step, water is deprotonated by the general base catalyst and attacks the anomeric centre, releasing the carbohydrate moiety For GH36, the ... complexes of GH27 were performed to illustrate the donor and acceptor specicity and the regioselectivity of AglC Results and Discussion Sequence similarity of AglC The amino acid sequence of AglC,...

Ngày tải lên: 29/03/2014, 21:20

... aorta The level of HSP90 and the type of NOS isoform present in rat brain and aorta were determined by immunoblotting (Fig 1) In brain, nNOS was the most preferentially expressed isoform, together ... in these digestion processes was demonstrated by the protective effect on both HSP90 and NOS degradation of the administration to the HSD-treated NMS animals of C.I.1 (Fig 5) In the brain of ... to explore the relationship between the HSP90 to NOS ratio and the formation of calpainresistant heterocomplexes, we first studied, by immunoprecipitation analysis, the association of the two proteins...

Ngày tải lên: 30/03/2014, 04:20

... that Hotel of Lyons, that Hotel of Holland, what charming places to live in![Footnote: Instead of naming the hotels (= mansions) of the great noblemen, Julia names the hotels (= inns) of the time ... that the dissensions which exist between our two families deprive us of the possibility of seeing each other anywhere else, and that neither my brothers nor my father are likely to approve of our ... pack of hounds, and took the title of Count in all the deeds that he signed JU They know better how to live in Paris, in those large hotels you must remember with such pleasure! That Hotel of...

Ngày tải lên: 06/11/2012, 14:13

... work, the play "The Merchant of Venice" - Studying the theme "The victorious laugh of love, friendship, justice and commonsense" in the play "The Merchant of Venice" by Shakespeare V The methods of ... citizen, The party' against the which he both contrive 49 Shall seize one half his goods, the other half Comes to the privy coffer of the state , And the offender's life lies in the mercy Of the Duke ... defeated They did not believe in God God was not the creator of the world, they praised life on the earth Their happiness, their life only existed on the earth, not on the heaven They believed in their...

Ngày tải lên: 18/12/2013, 21:45

... of perceiving, of thinking, of understanding and of interacting spring out of the boundaries of ”humanity,” spring out of the boundaries of ”nationhood,” and spring out of the boundaries of the ... strength) of the wave length According to survivors of near-death experiences, the higher the level of the spirit the brighter the light shines, and the lower the level the darker the light seems ... were of Old Norse, the language of the Vikings and the precursor of modern Icelandic, and these words were actually used by the Vikings The other twelve words were all related to seafaring, and of...

Ngày tải lên: 24/12/2013, 13:15

... features of the text and the intention of the writer In this thesis, the text chosen is the short story The Law of Life” by the famous American writer, Jack London Aims of the study The study ... choosing the topic, the aims of the study, the methodology, the scope, and the design of the study Part B, the main part of the thesis, consists of three chapters Chapter 1, entitled Theoretical ... that the aim of the analysis has been achieved: some of the features of the genre and the intention of the writer have been discovered through the study of this relation between clauses in the...

Ngày tải lên: 29/01/2014, 14:44

... photographs) by Mr D.W Williamson, Melbourne Place, and the lines of incision for the various operations were added by the author The rough woodcuts scattered through the work were drawn on wood by the ... ***START OF THE PROJECT GUTENBERG EBOOK A MANUAL OF THE OPERATIONS OF SURGERY*** E-text prepared by Michael Ciesielski, Pilar Somoza Fernández, and the Project Gutenberg Online Distributed Proofreading ... TO THE UNIVERSITY LONDON: SIMPKIN, MARSHALL, & CO 1883 TO THE MEMORY OF JAMES SYME, ESQ., F.R.C.S AND F.R.S.E SURGEON TO THE QUEEN IN SCOTLAND PROFESSOR OF CLINICAL SURGERY IN THE UNIVERSITY OF...

Ngày tải lên: 17/02/2014, 07:20

... which these putative sub-complexes bind to each other during the assembly of the bc1 complex is also unknown Furthermore, as in the case of the biogenesis of other multi-subunit complexes of the ... that the association of the Qcr9p subunit with the bc1 complex precedes the binding of ISP In fact, the direct absence of ISP (DISP), or the block of its insertion into the bc1 complex due to the ... incorporated into the bc1 complex On the other hand, the absence of Qcr9p in the DQCR9 ⁄ DQCR10 strain prevented the binding of ISP (Fig 4B) Interestingly, in the absence of Qcr9p, the catalytic...

Ngày tải lên: 18/02/2014, 08:20

... show that the data fit well with the individual determination of flux control coefficients by PFK, PK and LDH The role of the las operon is discussed on the basis of the distribution of flux control ... analysis of the las operon Comparison of control by the las enzymes Based on the data presented here and on earlier data for LDH [10], it is possible to compare the flux controls of the individual ... encoded by the las operon in L lactis MG1363 were modulated both individually and simultaneous by changing the expression of the respective genes We found that neither the individual enzymes nor the...

Ngày tải lên: 19/02/2014, 17:20

... entrusted by the Saviour with the guardianship of the Vine" But the Vine in the universal language of the Fathers betokened the whole Church of God And the Council refers the confirmation of its ... persons in the eyes of the world without amounts to this, that by denying the Primacy they disprove the existence of the Church Their negation goes to the profit of total unbelief Asserters of the Church's ... empire of another sort The raid of Genseric in the year 455 is the first of three hundred years of warfare carried on from the time of the Vandal through the time of the Lombard, under the neglect...

Ngày tải lên: 21/02/2014, 11:20

... over-expressing the Arg252-variant, these dimers may contribute to the formation of active oligomers in the presence of the endogenously expressed Gly252containing subunits The exact composition of the heterocomplexes ... chimeras were constructed by use of the EcoRV and SacI sites in the cDNA and were then used to transform 293-cells The region responsible for the different degree of association of the human and murine ... been ascribed to the insert between Asp and His of the catalytic domain of TPP II We can now report that the region surrounding Arg252 is of importance for the formation of the oligomeric enzyme...

Ngày tải lên: 21/02/2014, 15:20

... again by the old-fashioned loveliness of the place The way the arches of the porte cochere conjured images of the elegant necks of horses, the skirts of ladies alighting from carriages The way the ... TV room as they grew older, the place they spent much of their time, the more formal first floor being the domain of their mother Eloise still felt like that part of the house didn’t quite belong ... and the bay windows above it resembled the top tiers of a wedding cake As they grew close they noted the wrought-iron grille on the front door, the leaded-glass windows, and then inside they...

Ngày tải lên: 05/03/2014, 18:20

... reported, such as the average a4v in each hot- spot, the area of the aggregation profile above the HST, the total area (the HST being the zero axis) and the area above the HST of each profile peak ... which the location of aggregation hot- spots was known from experiment) This average is called a4v [22] A plot of a4v over the entire sequence defines the aggregation profile of the polypeptide The hot- spot ... hydrogen bond formation observed for this type of residue; then, the obtained values are averaged inside the window and the average is assigned to the central residue of the window The smoothed expected...

Ngày tải lên: 06/03/2014, 00:20

... speak of the WHOLE of its Subject, but only of a PART of it The other two kinds are said to be 'UNIVERSAL', because they speak of the WHOLE of their Subjects the one denying niceness, and the other ... 'EXHAUSTIVE' division of the class "new Cakes": i.e between them, they EXHAUST the whole class, so that all the new Cakes, that exist, must be found in one or the other of them And now suppose ... Thus, in the first case, the class of "m-Things" is the Middle Term; and, in the second case, the two classes of "m-Things" and "m'-Things" are the Middle Terms The Attribute, which occurs in the...

Ngày tải lên: 06/03/2014, 13:20

... whose consequent is the thesis of the theorem It is often said that the hypothesis is the sucient condition of the thesis, and the thesis the necessary condition of the hypothesis; that is to ... term 0.25 The Formulas of De Morgan In any development of 1, the sum of a certain number of constituents is the negative of the sum of all the others For, by hypothesis, the sum of these two ... In the rst case we have the product of the consequents, in the second, the sum of the antecedents The formulas of the principle of composition can be transformed into equalities by means of the...

Ngày tải lên: 06/03/2014, 16:20

... THE CAR OF DESTINY BY C N AND A M WILLIAMSON Illustrations by Armand Both iv The Car of Destiny NEW YORK THE McCLURE COMPANY MCMVII OTHER BOOKS BY THE SAME AUTHORS Lady Betty Across the Water, ... the cause of the car's sudden loss of power But even as he spoke, the mystery was solved There was a leak in the petrol-tank, near the bottom; the last drop of essence had run away, and, as they ... to them,” I said Waring looked shocked “Just enough of a something to stop the car, and tempt the ladies to take off their motor-veils I may never have another chance to see the future Queen of...

Ngày tải lên: 07/03/2014, 11:20

... prior formation of 17a-OH-preg and DHEA The lack of androstadienol synthesis in the presence of lM of ketoconazole (C), an inhibitor of cytochrome Fig Thin layer chromatography showing the transformation ... compared the formation of Ó FEBS 2003 Biosynthesis of 5,16-androstadien-3b-ol by human P450c17 (Eur J Biochem 270) 1353 Fig Role of cyt b5 in the formation of androstadienol from pregnenolone by human ... Identification of metabolites by HPLC analysis and corecrystallization To verify the nature of the metabolites obtained from the transformation of preg by human and porcine P450c17, we identified by HPLC...

Ngày tải lên: 08/03/2014, 08:20

... whose consequent is the thesis of the theorem It is often said that the hypothesis is the sucient condition of the thesis, and the thesis the necessary condition of the hypothesis; that is to ... term 0.25 The Formulas of De Morgan In any development of 1, the sum of a certain number of constituents is the negative of the sum of all the others For, by hypothesis, the sum of these two ... In the rst case we have the product of the consequents, in the second, the sum of the antecedents The formulas of the principle of composition can be transformed into equalities by means of the...

Ngày tải lên: 15/03/2014, 15:20

... Mg2+ is ligated by residues in the hinge motif in the P domain and by residues in the N domain, whereas in the E2 state the latter are replaced by residues in the TGES motif of the A domain [37] ... in the hinge motif plays a role in the transition between the states E1 and E2 Together with the recent determination of the crystal structure of the sarcoplasmic Ca-ATPase [4], analysis of these ... activity of the wild-type and mutated enzymes The ATPase activity (percentage of the activity of the wild-type) present in membranes shown The ATPase activity present in the absence of zinc has...

Ngày tải lên: 17/03/2014, 17:20