the expression of proteoglycans pgs

... they were isolated had an inhibitory effect [7]. The number of mature liver schizonts increased in the presence of mAbs anti-CSP of P. yoelii and the authors suggested that enhancement of ... important role in the control of malaria infection. However, they can modulate parasite development enhancing infection. The effect of anti-Plasmodium antibodies on the expression of circumsporozoite ... This study sets to understand the role of anti-Plasmodium antibodies on the erythrocytic development of Plasmodium falciparum and their effect on the expression of csp gene. 2. Materials and...

Ngày tải lên: 02/11/2012, 10:14

... inhibition of proliferation of VSMC, which is mechanistically linked to a KLF4-induced enhance- ment of the expression of the tumour suppressor gene p53 [5]. Because of the important roles of KLF4 on the ... found that the promoter of SR-BI contained multiple putative KLF4 binding sites. However, the direct effect of KLF4 on the expression of SR-BI remains unknown. Here, the expression of KLF4 in ... important role in the activation of endothelial cells and macrophages, as well as the differentiation and proliferation of VSMCs. Overexpression of KLF4 induced expression of multiple anti-inflammatory...

Ngày tải lên: 18/02/2014, 04:20

... degrada- tion in the population of hemoglobin-positive cells. To the best of our knowledge, there has been no report on the promoter function of the human HO-2 Fig. 7. Characterization of the human ... Taken together, these results indicate that hypoxia reduces the expression levels of HO-2 mRNA and protein in five out of six cell lines, with the exception of KG1 myeloid cells. Hypoxia decreases the expression ... address the question of whether hypoxia influences the promoter activity of the human HO-1 or HO-2 gene, we performed transient expression assays. Prior to the functional analysis of the HO-2 gene promoter, we...

Ngày tải lên: 19/02/2014, 06:20

... way [19]. When comparing the MLC region of the 2D gels between TA from PV– ⁄ – and PV+ ⁄ + mice, the pattern is virtually identical with the exception of the lack of the PV spot in PV– ⁄ – mice ... regions of the PV and MLC3F gene has been previously observed. A segment of 32 bp was identical in both genes and, based on these findings, the authors pro- posed that the expression of PV and ... levels of MLC3 and PV are much higher in TA than in SOL, the ratio of the two proteins in each of the two muscles seemed to be constant (Fig. 2C). A high degree of homology between short segments of...

Ngày tải lên: 19/02/2014, 07:20

... the question arises concerning the mechanisms underlying the orchestrated expression of these enzymes by the oxygen tension. The findings that the effect of hypoxia on the gene expression of the ... twofold increase of PDI mRNA, a more moderate increase of the mRNAs for prolyl hydroxylases, and did not increase the mRNA abundance of the other enzymes. Discussion Our data show that the expression ... hydroxylases. With the exception of PDI, which is known to be induced by the UPR [41], however, none of the other enzymes was relevantly induced by the UPR, supporting the assumption that they are more...

Ngày tải lên: 20/02/2014, 02:21

... and alters the expression of the two nuclear genome coded isoforms of CytOX V [10,32]. The regulation of genes CytOX5a and CytOX5b, coding for the two isofoms Va and Vb, parallels that of genes ... study therefore, we investigated how O 2 modulates the expression of mRNAs for CytOX subunits and also the catalytic activity of the enzyme complex. Our results show that the levels of some of the ... 2003 Results As a measure of the hypoxic effect on CytOX gene expression, we measured the steady state CytOX mRNA levels. The Northern blot in Fig. 1 shows the effect of hypoxia on the levels of mitochondrial...

Ngày tải lên: 20/02/2014, 23:20

... [34–36], might regulate the expression of Ppp2r5c mRNA prior to the appearance of Nrl in the retina. Like the increase in Nrl expression during development, Ppp2r5c mRNA expression was precisely ... To further examine whether the increased expression of Ppp2r5c transcripts was specifically modulated by Nrl, we used Nrl small interfering RNA (siRNA) transfectants in which the expression of Nrl ... & DePaoli-Roach AA (1996) High complexity in the expression of the B¢ subunit of protein phospha- tase 2A0. Evidence for the existence of at least seven novel isoforms. J Biol Chem 271, 2578–2588. 9...

Ngày tải lên: 06/03/2014, 02:20

... effects on the expression of 12 genes and opposite effects on the regulation of eight genes. These results suggest that rapamycin inhibition of TORC1 modifies the expression of a set of genes that only ... from the intestinal digestion of proteins [4,5]. Another example of the detection of the lack of an amino acid is metabolic adaptation to cope with epi- sodes of protein malnutrition. In these ... in bold). The enrichment for a given GO category was computed as the ratio of the distribution of the amino acid-regulated genes* versus the distribution of the genes spotted onto the microarray**....

Ngày tải lên: 07/03/2014, 03:20

... steroid synthesis or the reduction in arachidonic acid release may regulate the expression of ACS4. The human gene encoding ACS4 is located in the chromosome Xq 22–23 region close to the a5 chain of the type ... mitochondria). The reason why the action of the two opposite enzymes, namely the arachidonoyl-CoA synthetase and the arachidonoyl-CoA thioesterase, is needed may be the need to sequester AA from the free ... inhibitors of the acyl-CoA synthetase and the acyl-CoA thioesterase, we have previously postulated the existence of a new pathway for AA release that operates in the regulation of steroid synthesis...

Ngày tải lên: 16/03/2014, 18:20

... that the inhibition of CDK activity increases the expression of Rb and Sp1. Fig. 1. Effects of UCN-01 on the levels of Rb and Sp1 protein. (A), (B) Dose–response of the effect of UCN-01 on the levels ... However, there are also some differences, namely (a) in the case of Rb, there is an increase in both the levels of mRNA and the stability of the protein, while the degradation rate of Sp1 does ... annealing of primers to nontarget DNA. The lower solution contained the cDNA, the MgCl 2 , the dNTPs, the [ 32 P]dATP[aP] and one half of the buffer, and the upper solution contained the four...

Ngày tải lên: 16/03/2014, 23:20

... occurs in the nuclei and the tail during the maturation process in the epididymis. The greater the extent of oxidation in nuclei, the more potent are the spermatozoa. In addition, hyper- activation of ... it to the reduced form (GSH) using an NADPH as the electron source. The function of GR in the male genital tract of the rat was examined by meas- uring its enzymatic activity and examining the ... W.R. & York, J.L. (1996) Differential expression of glutathione S-transferase iso- forms in compartments of the testis and segments of the epididy- mis of the rat. Drug Metab. Dispos. 24, 725–733. 46....

Ngày tải lên: 17/03/2014, 17:20

... On the other hand, in HeLa cells, it was reported that the expression of the full length TRAF1 potentiated the activation of NF-jB induced by TNFa or IL-1, but that of the C-terminal part of ... (Affymetrix) and the levels of the expression of each cDNA and of the reliability (Present/Absent call) were calculated with software ( AFFYMETRIX MICROARRAY SUITE ver.4.0). For comparisons of the expression ... responses. We also examined the expression of TRAF1 and TRAF2 because they interact and regulate the function of the 4-1BB proteins to induce NF-jB [18]. In the absence of T3, neither HeLa nor HeLaTR...

Ngày tải lên: 23/03/2014, 18:20

... imply the involvement of the O-glycosylation of Sp1 in the induction of SREBP-1a transcription by glutamine. The gene expression of SREBP-1c, which represented less than 20% of the SREBP-1a gene expression ... after the addition of glutamine, the gene expression of the SREBP targets, such as HMG CoA synthase and the LDL receptor, was slightly increased, but then the mRNA levels of both SREBPs and their ... increase in the gene expression of SREBPs, and second, the enhancement of SREBP processing by glutamine. We therefore investigated the effect of glutamine on the gene expression of SREBP family members,...

Ngày tải lên: 28/03/2014, 22:21

... as the overexpression of Q2-derived DM isoforms could be attributed to the overexpression of TAp73, which is known to activate the P2 promoter [13]. In this case, downregulation of DMp73 expression ... processes. Therefore, all of these issues should be addressed in the future. Taken together, our findings make it clear that there is a link between the expression of Sp1 and p73 isoforms in lung cancer. ... cells As the outcome of the action of TAp73 is dependent on the presence of the dominant negative DMp73 [13], an important issue to be considered is whether Sp1 also affects DMp73 levels in the context...

Ngày tải lên: 29/03/2014, 09:20

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Ngày tải lên: 18/06/2014, 16:20

Ngày tải lên: 19/06/2014, 22:20

Ngày tải lên: 19/06/2014, 22:20