the elusive gold standard in functional genomics
METFORMIN – MORE THAN ‘GOLD STANDARD’ IN THE TREATMENT OF TYPE 2 DIABETES MELLITUS
Ngày tải lên :
12/07/2015, 15:49
... Adding metformin in patients suboptimally controlled on insulin therapy compared with intensification of the insulin dose by 20% resulted in lower body weight, lower body mass index, insulin ... THAN GOLD STANDARD IN THE TREATMENT OF TYPE DIABETES MELLITUS METFORMIN AND BODY WEIGHT METFORMIN AND LIPID PROFILE While insulin secretagogues, thiazolidinediones and insulin itself promote increased ... bedtime insulin and metformin was more effective in controlling glycemia, with a significantly less weight gain compared with bedtime insulin plus glibenclamide, bedtime insulin plus metformin plus...
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báo cáo hóa học:" Is tension band wiring technique the "gold standard" for the treatment of olecranon fractures? A long term functional outcome study" docx
Ngày tải lên :
20/06/2014, 01:20
... Hardware removal recorded in 51 patients (82.3%) due to pin prominence, localized pain or direct complaint defined as the patient being "bothered" by the metalware (VAS 1–4) The above event was not ... = 2; = 1, max = 10) Wound infection developed in patients (6.5%) In cases intravenous antibiotics proved adequate for the eradication of the infection while in the other elbows wound irrigation ... satisfaction score (b) the intramedullary pin The above hypothesis wasn't confirmed by Paremain et al [22] as the results of their biomechanical study indicated no significant differences in yield loads...
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A functional genomics approach for elucidation of novel mechanisms involved in GnRH regulation of the gonadotropins
Ngày tải lên :
11/09/2015, 21:47
... carried out The conserved Egr-1 binding site on the mammalian promoter is lacking in those of the teleosts Instead, a near consensus palindromic ERE is found together with the other functional ... 2005) However, in that study, the CaMK inhibitor KN62 did not recapitulate these findings, which suggested that other CaM-dependent signaling mediators also are involved in mediating the GnRH effects ... glycoprotein structurally unrelated to the activins and inhibins Due to its high binding affinity to activin, FS binds to and neutralizes the bioactivity of activin on the FSHβ subunit (Burger et al.,...
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Báo cáo y học: "Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes"
Ngày tải lên :
31/10/2012, 15:28
... ethanol-induced mucosal injury in the upper gastrointestinal tract leading to increase in the permeability of the gut mucosa to endotoxins [43, 44] These factors are involved in ethanol-induced ... expression of the ankyrin-repeat oncoprotein (gankyrin) in human hepatocellular carcinoma Gankyrin binds to the cell-cycle regulator CDK4 and the S6b ATPase subunit of the regulatory component of the ... NM_014393 ▲ 1.52 regulation of transcription protein binding double-stranded RNA binding DNA binding ▼ 5.02 protein binding NM_001149 NM_004242 ▲- increased ▼- decreased Validation of microarray...
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difficulties in teaching reading comprehension with the new english textbook “tieng anh 10” (the set of standard textbooks) to the 10th form students at ke sat high school
Ngày tải lên :
29/01/2014, 14:43
... input This can help them to be acquainted with the theme and the language relating to the theme From then, the students can speak, listen and write about the things relating to the theme in the ... they see the first instance of the key words Students should read around the key words If they cannot find the answer in the first instance, then they should keep on reading until they can find ... of teaching in reading lessons The teachers play the key role in the classroom, being the main speakers working through the text The teachers explain new words, new structures, even give the answers...
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Tài liệu Báo cáo khoa học: Functional effects of deleting the coiled-coil motif in Escherichia coli elongation factor Ts pptx
Ngày tải lên :
21/02/2014, 00:20
... known to be involved in either protein–protein interactions [61,62] or protein–RNA interactions [63] The proposed intramolecular interaction may be an integrated step in the guanine nucleotide-exchange ... reaction in EF-Tu was investigated by studying the functional effects of deleting the motif in EF-Ts, both in vivo and in vitro The motif was deleted in endogenous EF-Ts in E coli strain UY211 ... EF-Tu–GTP and preventing the release of EF-Tu–GDP from the ribosome [24] These antibiotics bind at the interface between domain (guanine nucleotide-binding domain, G-domain) and domain of EF-Tu, and...
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International Accounting Standard 21 The Effects of Changes in Foreign Exchange Rates potx
Ngày tải lên :
06/03/2014, 15:21
... differences are recognised in other comprehensive income in the financial statements that include the foreign operation and the reporting entity (ie financial statements in which the foreign operation ... functional currency of a foreign operation, and whether its functional currency is the same as that of the reporting entity (the reporting entity, in this context, being the entity that has the ... adopting as its functional currency a currency other than the functional currency determined in accordance with this Standard (such as the functional currency of its parent) Net investment in a...
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Báo cáo khoa học: "A Comprehensive Gold Standard for the Enron Organizational Hierarchy" potx
Ngày tải lên :
07/03/2014, 18:20
... T ⊂ G to be the set of pairs in the gold standard such that the people involved in the pair in T communicate with each other These are precisely the dominance relations in the gold standard which ... dominance relation in the gold standard, we then predict which person dominates the other Note that we not predict if two people are in a dominance relation to begin with The task of predicting ... dominance relations of only 132 people in the Enron corpus for creating their training and test data Our gold standard has dominance relations for 1518 Enron employees The Enron Hierarchy Gold Standard...
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Báo cáo khoa học: "Creating a Gold Standard for Sentence Clustering in Multi-Document Summarization" potx
Ngày tải lên :
08/03/2014, 01:20
... judge if the paragraphs contained ’common information’ They were given the guideline that only paragraphs that described the same object in the same way or in which the same object was acting the ... The starting point was a single DUC document set which was clustered by the author and her supervisor with the task in mind to find clusters of sentences that represent the main topics in the documents ... between the United Kingdom, and I believe the European Union, with Iran, and the opening of a new chapter in our relations,” Cook said after the meeting Another judge however puts these sentences into...
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Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot
Ngày tải lên :
18/03/2014, 01:20
... gp130 are involved in ligand binding: the Ig-like domain and the CBM [9–11] In the case of LIF-induced heterodimerization of LIFR with gp130, the cytokine first binds to the Ig-like domain of the LIFR ... an intramolecular bond between the remaining cysteines C466 and C491 of gp130 This could result in a conformational change within the receptor chain enabling the activating interaction with the ... IL-12R, ligand binding leads to a receptor dimer, in which the C-terminal domains of the CBM are separated from each other The three membrane-proximal FNIII domains function in bringing the transmembrane...
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Báo cáo khoa học: Functional transitions of F0F1-ATPase mediated by the inhibitory peptide IF1 in yeast coupled submitochondrial particles pdf
Ngày tải lên :
23/03/2014, 12:20
... (compare terminal parts of curves b and c) In the experiment shown in Fig curve d, inhibition by IF1 was studied using SMP in the presence of malonate, which fully inhibited the respiratory chain (control ... give rates of hydrolysis in lmolÆmin)1Æmg protein)1 (B) Dependence of the uncoupler-induced ATPase activity (j) on the time separating dilution of SMPIF1 in succinate-containing medium and addition ... be readily interpreted It suggests that a special enzyme state, formed in the presence of D~Hþ from the IF1-inhibited l state and remaining ATPase-inactive as long as D~Hþ is l maintained, immediately...
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Báo cáo khoa học: Functional genomics by NMR spectroscopy Phenylacetate catabolism in Escherichia coli docx
Ngày tải lên :
23/03/2014, 18:20
... Detected in the experiment with the paaF-deficient mutant of E coli; (B) simulated for the AA¢MM¢XX¢ spin system using the chemical shifts and coupling constants summarized in Table Fig Proposed outline ... phosphate, pH 4, containing 8% (v/v) acetonitrile for 15 and then developed with a linear gradient of 8–40% acetonitrile in the same buffer for The flow rate was mLÆmin)1 The effluent was monitored ... major finding is that C6 dicarboxylic acids formed later in the pathway are derived from the aromatic ring carbons of phenylacetylCoA This indicates that removal of the original C2 side chain yields...
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Báo cáo khoa học: The functional genomics of guanylyl cyclase⁄natriuretic peptide receptor-A: Perspectives and paradigms potx
Ngày tải lên :
28/03/2014, 23:20
... postulated that the binding of ANP to the extracellular domain of the receptor causes a conformational change, thereby transmitting the signal to the GC catalytic domain (GCD); however, the exact mechanism ... was initially isolated from the brain; however, it is primarily synthesized in the heart, circulates in the plasma, and displays the most variability in primary structure CNP is mainly present in ... family, containing at least four distinct regions: an extracellular ligand-binding domain, a single transmembrane-spanning region, an intracellular protein kinase-like homology domain (KHD), and...
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Báo cáo khoa học: From functional genomics to systems biology Meeting report based on the presentations at the 3rd EMBL Biennial Symposium 2006 (Heidelberg, Germany) Sergii Ivakhno pot
Ngày tải lên :
30/03/2014, 09:20
... machine learning, algorithmic network theory, differential equation modelling, and simulation being introduced In the following, I will discuss some of the talks representing different areas of functional ... described the chromosome conformation capture methodology which uses formaldehyde cross-linking to covalently link interacting chromatin segments in intact cells [5] Cross-linked chromatin is then ... reported the development of a new scoring system for measuring the potency of proteins for forming associations, the ‘socioaffinity index’ The socioaffinity index represents the tendency of proteins...
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Báo cáo khoa học: A functional polymorphism at the transcriptional initiation site in b2-glycoprotein I (apolipoprotein H) associated with reduced gene expression and lower plasma levels of b2-glycoprotein I docx
Ngày tải lên :
31/03/2014, 07:20
... mutations, other than the Cys306Gly and Trp316Ser We therefore hypothesized that the 5¢ flanking region of b2GPI harbors functional mutations that determine the interindividual variation in b2GPI ... measured using the Bio-Rad Protein Assay Kit (Bio-Rad Laboratories, Hercules, CA, USA) according to the manufacturer’s instructions Bovine serum albumin was used as standard to determine the protein ... plasma levels However, in multivariate analysis, the effect of Trp316Ser was no longer significant, indicating that the )1CfiA is the functional mutation Of the 27 individuals in the CA genotype group...
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báo cáo hóa học:" Of gastro and the gold standard: evaluation and policy implications of norovirus test performance for outbreak detection" ppt
Ngày tải lên :
18/06/2014, 15:20
... the absence of a gold standard underlines the face validity of each approach In summary, the absence of a traditional "gold standard" for the evaluation of test characteristics in the identification ... norovirus infections caused by both genogroup (G1) and (G2) strains These assays have utilized in a variety of geographic settings and in the context of both outbreak investigation and in the evaluation ... define positivity The RT2-PCR assay was evaluated for a year, and trialed in our laboratory for an additional year, before being integrated into the laboratory's clinical testing repertoire The...
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Báo cáo hóa học: " Application of functional genomics to the chimeric mouse model of HCV infection: optimization of microarray protocols and genomics analysis" potx
Ngày tải lên :
20/06/2014, 01:20
... to the probes there should be an increase in the number of differentially expressed genes as the mouse RNA is present in only a single dye In this way, both the number and the identity of the ... hybridization for the reasons outlined above The focus of the present study was to determine the feasibility of applying functional genomics to a chimeric tissue The SCID-beige/Alb-uPA mouse contains a chimeric ... observed in this experiment In an attempt to further reduce the amount of ML-RNA hybridization, the specificity of the reaction was increased by using more stringent hybridization conditions Increasing...
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Báo cáo hóa học: " On the stability of an AQCQ-functional equation in random normed spaces" potx
Ngày tải lên :
21/06/2014, 01:20
... conceived of the study, participated in its design and coordination, drafted the manuscript, participated in the sequence alignment, and read and approved the final manuscript Competing interests The ... of the functional equation (1.4): an even mapping case In this section, we prove the Hyers-Ulam stability of the functional equation D f (x, y) = in complete RN-spaces: an even mapping case Theorem ... 4f (−y) (1:4) in random normed spaces in the sense of Sherstnev under arbitrary continuous tnorms In the sequel, we adopt the usual terminology, notations and conventions of the theory of random...
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Báo cáo hóa học: " Research Article On the Stability of Generalized Additive Functional Inequalities in Banach Spaces" pdf
Ngày tải lên :
22/06/2014, 02:20
... Consider a mapping f : X→Y satisfying the following functional inequality: af x bf y cf z ≤ f αx βy γz 2.1 for all x, y, z ∈ X We investigate the generalized additive functional inequality in Banach ... number, then |ai | ≤ |αi | Proof a Let xk in 2.12 except for three xk ’s Then by the same reasoning as in the proof of Theorem 2.1, it is proved and so we omit the details b Letting xi x, xj y, by the ... following additive functional inequality αf x βf y γf z ≤ f αx βy γz 3.15 for all x, y, z ∈ X In the following theorem, we prove the Hyers-Ulam-Rassias stability of the above additive functional inequality...
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Báo cáo sinh học: "Deciphering the genetic code of morphogenesis using functional genomics" pdf
Ngày tải lên :
06/08/2014, 19:21
... proliferation of data, the current challenge is to develop the tools to translate the information contained in these data sets into meaningful biological insight http://jbiol.com/content/8/8/76 The study ... functions using combinatorial RNAi [14] Future directions: the shape of things to come In the past decade, genome-wide studies have provided insight into the dynamics of gene expression during development ... wholegenome tiling arrays can be used to determine in vivo protein-DNA interactions Work from the Berkeley Drosophila Transcription Network Project (BDTNP) has characterized the in vivo DNA binding sites...
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