the drug development pipeline clinical trials to marketing authorization

... informa­ tion has been lost in the translation from scientific research to the clinical setting The meeting gave an opportunity to identify further obstacles on the path to the promised land of Hulot ... DC, USA) the FDA recently modified numerous drug labels to recommend or require genetic testing before drug prescription At the same time, the FDA cleared for marketing molecular assays to promote ... Because of the multifactorial nature of drug- related phenotypes, the development of global risk assessment scores based on traditional clinical risk factors, environmental and lifestyle factors, biological...

Ngày tải lên: 11/08/2014, 12:20

... “despite the increasingly crucial role of genetic tests in clinical medicine, and their growing availability directly to the public, no formal evaluation or regulatory system exists to ensure the clinical ... with­ n i the public research sector as well as between the public research sector and the private sector; developing oppor­ tunities for south-south and north-south collaboration; improving the commercialization ... and the idea that it is too early to intervene in this http://genomemedicine.com/content/1/11/109 emerging market Exploring the possibilities for regulatory intervention, Hogarth stressed the...

Ngày tải lên: 11/08/2014, 12:20

... integrative approach They revealed to their physicians their use of CAM only about 28 to 47% of the time, mainly because they did not feel it was important for the doctors to know or because their physicians ... There are 12 main meridians within the body These anatomic channels and their tributaries are naked to the eye, but are well delineated on extensive anatomic charts and models used to guide therapies ... to influence or unblock this healing biofield Some methods use a practitioner to either directly touch the individual or merely pass their hands over the patient to strengthen or rejuvenate the...

Ngày tải lên: 16/02/2014, 07:20

... and to develop optimal methods for administering therapies In contrast to the past history of medicine, the recent history of some aspects of American medicine may be the history of removing the ... approved by the FDA in 2006 These drugs decrease the number and severity of relapses, slow the progression of the disease, and decrease the development of new brain lesions Because of the positive ... addressed or that claims of the effectiveness of the therapy are exaggerated On the other hand, they may attempt to obtain CAM information from their physician or other health care provider and...

Ngày tải lên: 16/02/2014, 07:20

... research, dedicated to the furtherance of science and technology and to their use for the general welfare Upon the authority of the charter granted to it by the Congress in 1863, the Academy has ... mind, that takes it into the realm of drugs and out of the realm of foods Secondly, the idea that those marketing these supplements are only marketing them for the effects they will have on structure ... manufacturers to any research as to the safety or the effectiveness of the dietary supplement The medical community and FDA lack knowledge about the safety of these products, their efficacy, and the substantiation...

Ngày tải lên: 17/02/2014, 14:20

... wonderful that at the present time the visitor may see this ancient work in the Roman Forum, and trace its course to the Tiber In the Forum, too, to the left of the Temple of Castor, is the sacred district ... called the gymnasiarch, the sub-director or gymnast, and the subordinates The directors regulated the diet of the young men, the sub-directors, besides other duties, prescribed for the sick, and the ... and "to the north the verdant plain of Cos, with the white houses and trees of the town to the right, and the wide expanse of turquoise sea dotted by the purple islands of the Ægean, and the dim...

Ngày tải lên: 17/02/2014, 22:20

... A face to- face interview method to administer the questionnaires by the researcher was used The interviews, which lasted for about 15 minutes, were conducted by the investigator in the patient’s ... were too ill to complete the interview were excluded Procedures 75.0 Because the clinic chief’s approval is enough to carry out the descriptive studies, the study was approved by the chief of ... The third section of the questionnaire asked patients 25.0 Income

Ngày tải lên: 05/03/2014, 15:20

... contrasts with the classic scientific stance, where the crucial decisions about the research are in the hands of the researchers rather than in the hands of the subjects of the study The rationale ... facilitator Rather than being the detached investigator, the researcher’s role is one of facilitator and networker in the process of helping the group formulate their interpretation of the situation ... it more helpful to start with some of the propositions and theories that they intend to utilise within the study, then move towards a specific question You may find it helpful to work back and...

Ngày tải lên: 06/03/2014, 09:20

... Plato, Aristotle, Augustine, Aquinas and Hegel Although there are distinctions to be drawn between the work of each of these contributors—according to the significance given, for example, to the ... and worker, in the locus of the factory, was the hallmark of industrial society, the clash between the professional and the populace, in the organization and in the community, is the hallmark of ... groups rather than individual practitioners, and to service to the wider public as opposed to the client alone in the sense embodied in this book The continuing association of altruism with the professions...

Ngày tải lên: 06/03/2014, 09:20

... is not the use of the therapies, but the failure of the physicians to recognize and address the patient’s emotional distress (Holland 1999) We might then speculate about the meaning of the widespread ... psychologically, whether good or bad, must so via the brain Wherever the mind is, one must first go through the brain to get to the mind From a narrow perspective, therapies that employ talk as the central ... whatever the theory that informs the therapy, because humankind has sought to understand itself for as long as there has been recorded history Successful therapy employing talk has been shown to change...

Ngày tải lên: 06/03/2014, 09:20

... cross-cutting themes of importance About the book This book is then based around the findings of the international study introduced above The book is split into three parts The purpose of Part is to provide ... relation to the UK arm of the study, we pay particular attention to describing the history and character of the eight support groups in which fieldwork took place As will become evident, although they ... anything other than a superficial level (they may be happy to refer patients to therapists for, say, massage or relaxation even if they not practise CAM therapies themselves), does little to quell...

Ngày tải lên: 06/03/2014, 09:20

... in the consumption of cigarettes, no professional removed the handle of the pump: rather, to continue the analogy, people were exhorted to stop drinking the water Their health was seen to be their ... and content The aim of the book, then, is to bring together sociologically informed pieces about key issues in the ongoing mainstreaming of CAM We have drawn together contributors from the UK, Australia, ... recommendation was the reason they first tried CAM Now they encourage others to use these techniques One woman said that ‘for the most part’ patients tell their family members and ‘bring them into consciousness...

Ngày tải lên: 06/03/2014, 09:20

... persons will turn to CAM to seek treatments for some of these conditions, and the more accurate information about this topic available to them and their caregivers, the better off they will be This ... advise patients on what to add (or not to add) to their regimen Despite the fact that the therapeutic mechanism underlying homeopathy is controversial and not well understood by the biomedical community, ... inspire doctors, nurses, gerontologists, and social workers to learn more about integrated medicine, helping them include some of these approaches into their practices or giving them the necessary...

Ngày tải lên: 15/03/2014, 09:20

... attempt to practice diagnosis Craniosacral Therapy This therapy is credited to both chiropractors and osteopaths, and is aimed at the base of the skull and the lower back and buttocks area The theory ... evidence to confirm efficacy but rather to extend their work on quackery and fraud To add even more interest to the story, the nine-year-old who conducted the study was Emily Rosa, the daughter ... lab indicators over the body of a dying patient One may as well: the fact is, no method has all the answers and the sooner the modalities work together, rather than questioning one another’s integrity,...

Ngày tải lên: 15/03/2014, 09:20

... either to train in the therapy themselves or be in a position to discuss the potential use of the therapy with patients and carers They will also be able to indicate if the therapy is safe to ... including the care of the dying The aim of the book is not to turn nurses into CAM experts nor to suggest that they use the therapies or techniques without training, but to highlight the contribution ... addition to routine examinations common to both systems, observation of the tongue is part of the diagnostic process, the tongue being seen to represent the internal organs; the appearance of the tongue,...

Ngày tải lên: 15/03/2014, 09:20

... role is to facilitate the trance state and, allegedly, to use suggestion to help the user attain their goal, such as to stop smoking or to be more confident Here the practitioner often sees the user ... with the ideas, products and potentials of complementary therapy and self-help People often want to be their own therapist, to use oils at home, to learn how to massage and to use therapies to ... important to their sense of themselves in comparison with what they believe, what activities they enjoy and who they want to be New technologies such as the internet give people the opportunity to change...

Ngày tải lên: 15/03/2014, 09:20

... digitorum profundus tendons in the hand and the flexor digitorum longus in the foot The oblique fibers of the vastus medialis arise from the tendon of the adductor magnus The oblique fibers of the ... laterally, relative to the axis of the tendon The occupation and sports activity of the individual may alter the alignment of the fibers of the tendon The majority of the fibers run in the direction ... of the fibers of the tendon of flexor digitorum superficialis as they flatten, fork, and fold around the flexor digitorum profundus to allow it to reach its insertion into the distal phalanx of the...

Ngày tải lên: 15/03/2014, 09:20

... wonderful that at the present time the visitor may see this ancient work in the Roman Forum, and trace its course to the Tiber In the Forum, too, to the left of the Temple of Castor, is the sacred district ... returns." It was the custom for patients to sleep under the portico of the Temple of Æsculapius, hoping that the god of the healing art might inspire them in dreams as to the system of cure they should ... should adopt for their illnesses Sick slaves were left there by their masters, but the number increased to such an extent that the Emperor Claudius put a stop to the cruel practice The Church of...

Ngày tải lên: 15/03/2014, 15:20

... working back to the submandibular nodes then further back to the jugulodigastric node (Fig 1) Then continue by palpation of the parotid region downwards to the retromandibular area and down the cervical ... so that the patient knows what to expect Then repeat this over the symptomatic area, asking the patient to say whether they can feel anything Record the area of altered sensation in the notes ... in the tongue (owing to damage to the function of the hypoglossal nerve) and the soft palate (owing to lesions affecting the vagus nerve) With hypoglossal nerve lesions, there is deviation of the...

Ngày tải lên: 15/03/2014, 17:20