the diversity of complex cells

... underneath shows the rim of the mirror, which raises the mirror’s center of mass The lower mass increases resonance frequency The mass of the circular mirror is about twice the mass of the perforated ... slight turns Sliders positioned on the torso of the robot actuate legs External forces applied to the sliders pull on the microhinged tethers These forces represent the minimum force requirement for ... modeling is to reduce the order p of the following frequency response function of the microsystem ( H p ( jω ) = f pT − ω M p + jωD p + K p ) −1 100 fp where the size of the mass Mp, damping Dp...

Ngày tải lên: 25/01/2014, 13:20

... biosynthesis of PC in HepG2 cells at the level of CT activity It interferes with the translocation process of CT from the cytosol to the membrane and finally leads to an inhibition of the biosynthesis ... interference of HePC on this regulatory process Thence, HePC could act on CT activity either by promoting the release of the enzyme from the membrane to the cytosol or by hindering the insertion of the ... the PC synthesis in HepG2 cells increasing the CT activity Thence, in another set of experiments we assayed the combined effect of HePC and oleate As it can be observed in Table 1, exposure of...

Ngày tải lên: 17/03/2014, 11:20

... the equivalent residues of the mannose complex (subunit B in the asymmetric unit) The water molecules clearly mimic the oxygen atoms of bound mannose (black, thick lines) (B) Stereo view of the ... a-configuration in the binding site of subunit A, but adopts an a ⁄ b mixture in the binding site of subunit B Accommodation of the b-configuration in the binding site of PAL requires a change in the rotamer ... complemented by thermodynamic parameters of binding determined by means of isothermal titration calorimetry for the above-mentioned complexes as well as other complexes for which the crystal structures...

Ngày tải lên: 23/03/2014, 11:20

... polypeptides all showed the expected electrophoretic mobility, those of the mutants being decreased compared with the wild-type chimera At the end of the 24 h chase period, most of the ATFSAPREDLK polypeptides ... tissue culture medium) of the recombinant polypeptides (ATF–SAP chimeras from the 72 h conditioned medium of protected oocytes, see below) At the end of the exposure period, the cells were washed ... immunostaining using the antibodies indicated The scale bar represents 20 lm of intoxication Neither the human leukemic cell line HSB-2 nor the Burkitt lymphoma Ramo cells showed any potentiation of cytotoxicity...

Ngày tải lên: 23/03/2014, 15:21

... ểéểẹểệễ ẹ ễ ề ì éé ỉ ềỉ ệ ể ỉ ặ ểé ì Critical point C L p The center of the projection is at finite distance f(p) The center of the projection is at infinite distance Critical point p f(p)...

Ngày tải lên: 31/03/2014, 16:27

... study were in the form of pairs step one and step-two designed on the basis of the conserved nature of nucleotide sequences in regions of the pre-S1 through S genes, irrespective of theHBV genotypes ... one PCR The first PCR was carried out in a tube containing 50 µl of a reaction buffer made up of the following components: 50 ng each of the outer primer, a 200 µM concentration of each of the four ... various regions of the world, that could provide more information on the relationship of HBV genotypes to the severity of liver disease and thereby clinical outcome Methods Selection of subjects...

Ngày tải lên: 18/06/2014, 18:20

... 2004 at the Cancer Center of Sun Yat-Sen University All the patients underwent radical surgery, and none of them had undergone either chemotherapy or radiotherapy before the collection of the samples ... MCCstroma, the count of tryptase-positive mast cells in the cancer stroma of the primary colon tumor; MCCadjacent, the count of tryptase-positive mast cells in the normal mucosa adjacent to the colon ... MCCstroma, the count of tryptase-positive mast cells in the cancer stroma of the primary colon tumor; MCCadjacent, the count of tryptase-positive mast cells in the normal mucosa adjacent to the colon...

Ngày tải lên: 18/06/2014, 19:20

... signal transducing subunits of the NgR1 complex remain to be identified Binding of the NgR1 inhibitory complex by MAIFs leads to activation of intracellular RhoA, thereby resulting in axonal ... provide further evidence of successful maturation (Figure 1B) Having verified the in vitro generation of myeloid DCs, we went on to examine the regulation of NgR expression in these cells NgR1 ... 75% of medium was removed The same volume of fresh medium was added back, containing 40 ng/ml GM-CSF On day 4, the culture is made up of firmly attached stromal cells covered in clusters of loosely...

Ngày tải lên: 19/06/2014, 22:20

... study were in the form of pairs step one and step-two designed on the basis of the conserved nature of nucleotide sequences in regions of the pre-S1 through S genes, irrespective of theHBV genotypes ... one PCR The first PCR was carried out in a tube containing 50 µl of a reaction buffer made up of the following components: 50 ng each of the outer primer, a 200 µM concentration of each of the four ... various regions of the world, that could provide more information on the relationship of HBV genotypes to the severity of liver disease and thereby clinical outcome Methods Selection of subjects...

Ngày tải lên: 20/06/2014, 01:20

... 2004 at the Cancer Center of Sun Yat-Sen University All the patients underwent radical surgery, and none of them had undergone either chemotherapy or radiotherapy before the collection of the samples ... MCCstroma, the count of tryptase-positive mast cells in the cancer stroma of the primary colon tumor; MCCadjacent, the count of tryptase-positive mast cells in the normal mucosa adjacent to the colon ... MCCstroma, the count of tryptase-positive mast cells in the cancer stroma of the primary colon tumor; MCCadjacent, the count of tryptase-positive mast cells in the normal mucosa adjacent to the colon...

Ngày tải lên: 20/06/2014, 03:20

... representing the position of the particle, were also taken to represent the position of the myosin head The position of the myosin head, determined by the above method, was compared between the two ... splicing of the human ATP2A2 genes, protein sizes of the SERCA2 isoforms A Representation of the 3'-end of the human ATP2A2 gene Broken lines with letters represent alternative splicings The position ... sparks, but provides the necessary amount of Ca2+ to charge up the ER and sensitize the RyR [52] Another way of internal store reloading is achieved by the various isoforms of the transient receptor...

Ngày tải lên: 28/06/2014, 15:20

... increased the expression of the anti-apoptotic protein Bcl-xL, and increased the mobilization of p65 subunit molecules into the DC nucleus Furthermore, we found that the inhibition of NF-κB by ... future study, the knockdown study of Bcl-xL using siRNA may further confirm their role of taxol-treated DCs Although the expression of Bax was increased in TaxolDCs, the expression of Bax occurred ... rationale for the use of taxol in DC immunotherapy and insights into the development of combinational DC therapies with other anticancer drugs that not harm the viability or activity of DCs Acknowledgments...

Ngày tải lên: 07/08/2014, 23:22

Ngày tải lên: 08/08/2014, 21:20

... independent of the proximity of adjacent critical structures to the target volume Simple linear regressions on the tumor volume for each of the three indices were then performed The estimates of the ... (metastases)) The calculated indices for this group were similar to the indices obtained for the base of skull lesions: mean NCI of 1.73 and a mean HI of 1.21 (Table 3) These data suggest that the CyberKnife® ... single measure of how well the treatment dose distribution of a specific radiation treatment plan conforms to the size and shape of the target volume In general, the conformity index of a given radiosurgical...

Ngày tải lên: 09/08/2014, 10:21

... relationships among the amino-acid sequences of the RT protein, the most highly conserved of the retrotransposon proteins Two retrotransposon families - the Pseudoviridae and the Metaviridae - ... thaliana to predict the strategies used to express their gag and the pol genes By analyzing the genomic structure and the nucleotide sequences surrounding the gag-pol junction, the type of recoding used ... function in the life cycle of the LARDs On the basis of sequence identity, it seems that barley LARDs may be mobilized by a retrotransposon related to the metaviruses Erika-1 of the wheat Triticum...

Ngày tải lên: 09/08/2014, 20:20

... of T cells in the liver Although their precise distribution within the lymphoid organs is still unknown, they reside within the liver sinusoids, which they appear to patrol Their expression of ... rarity of iGb3 and the dominance of the regioisomer Gb3 Furthermore, other than the enzymatic pathways of synthesis and degradation, little is known about the general biology of iGb3, its subcellular ... in the cell wall of Sphingomonas, a Gram-negative, LPS-negative member of the class of α-proteobacteria (53, 54) These glycosphingolipids are responsible for the strong stimulation of NKT cells...

Ngày tải lên: 10/08/2014, 03:20

... membrane of the cell walls of Sphingomonas and Escherichia coli The inner leaflet of the outer membrane is composed of phospholipids, whereas the outer leaflet is made of LPS for E coli In the case of ... follow the same pre-Tα path as mainstream T cells (120, 134) Therefore, the question arises whether the biased usage of Vβ8, Vβ7, and Vβ2 in mouse (and Vβ11 in human) is due to the inability of the ... by the autoreactive IL-2 response of NKT hybridomas to DP thymocytes (18) and by the proliferative and cytokine response of fresh NKT cells to synthetic iGb3 (26) The other reason is that the...

Ngày tải lên: 10/08/2014, 03:20

... complicating the task of drawing a clear picture of the involvement of NKT cells in noninfectious diseases Type I diabetes The relative deficiency of NKT cells in NOD mice (36, 37), combined with the notion ... explained by the reduced frequency of isletspecific T cells and the general Th2 bias of these mice (219) Likewise, the suppression of diabetes by αGalCer multi-injection regimens could be the mere ... neutrophils in the bronchoalveolar lavage (197) This may not be the case at other sites of infection (198) Variations have been noted as well in reports assessing the role of NKT cells versus NK cells...

Ngày tải lên: 10/08/2014, 03:20

... not thymic epithelial cells can mediate negative selection of NKT cells J Exp Med 197:907–18 137 Xu H, Chun T, Colmone A, Nguyen H, Wang CR 2003 Expression of CD1d under the control of a MHC class ... IL-12-mediated rejection of tumors Science 278:1623–26 196 Park SH, Kyin T, Bendelac A, Carnaud C 2003 The contribution of NKT cells, NK cells, and other γ-chain-dependent non-T non-B cells to IL-12-mediated ... during the development of Vα14i NKT cells Blood 107:2797–805 163 Atherly LO, Lucas JA, Felices M, Yin CC, Reiner SL, Berg LJ 2006 The Tec family tyrosine kinases Itk and Rlk regulate the development...

Ngày tải lên: 10/08/2014, 03:20

... manifestation of the reperfusion injury In order to determine the usefulness of therapies against mast cells, it is important to know the degree to which mast cells are involved in IR injury of other ... muscles (p < 0.05) There were no mast cells in the C57/DBA Wf/Wf skeletal muscles as expected However, there was twice the density of mast cells in their normal compared to their heterozygous ... muscles to IR injury irrespective of the other abnormalities in these mice The role of mast cells has not been considered when investigating the susceptibility of different muscle fibre types Figure...

Ngày tải lên: 11/08/2014, 08:21