the design of everyday things revised and expanded edition

Ngày tải lên: 26/05/2014, 07:46

... incentives the hard glare of a passer-by and the offender’s feelings of guilt—are at least as powerful as finan- cial and legal incentives. If social forces get us most of the way there, how ... that the outcome of that election came down to a handful of voters; but their names were Kennedy, O’Connor, Rehnquist, Scalia and Thomas. And it was only the votes they cast while wearing their ... out the effect of the money. As with the police/crime rate puzzle, he had to trick the data. Because he himself had typed in the data, he had noticed some- thing: often, the same two candidates...

Ngày tải lên: 17/10/2013, 18:20

... and conditions of license. Color Atla s of Pharmac ology 3rd edition, revised and expanded Heinz Lüllmann, M.D. Former Professor and Chairman Department of Pharmacology University of Kiel Germany Klaus ... analgesic ibuprofen. The excess of analogue preparations and the unnecessary diversity of trade names for oneandthesamedrugmakethepharma- ceutical markets of some countries (e. g., Germany) rather perplexing. ... knowledge of the preventive and therapeutic value of drugs is a sine qua non for the successful treatment of patients entrusting themselves to a physician or pharmacist. Because of the plethora of proprietary...

Ngày tải lên: 17/02/2014, 05:20

... DPP-IV). Another potential bond can be proposed between the OH atom of Tyr380 and the car- bonyl group of the ligand. Finally, the valine side chain of the ligand, pointing towards the active ... be the reference); 2, docked into the active site of the human DPP-IV; 3, docked into the active site of the crystalline structure of PepX from L. lactis ;and4 , docked into the active site of the ... 2). The interactions of the bound ligand with the resi- dues of the specificity site (Fig. 4A) reveal good stack- ing between the pyrrolidine ring of the drug and the side chain of Tyr380 (Pos1 subsite),...

Ngày tải lên: 23/03/2014, 13:20

... the changes introduced in the redox cofactor environment upon complex formation. They are therefore related to the specificity and the strength of the protein–protein interaction. Therefore, the ... determination of a K d value of 25 ± 3 l M for the [FNR ox :Adx ox ] complex and of 17 ± 2 l M for the [FNR ox :Adx(4–108) ox ] complex (Table 1). Study of the kinetics of reduction of WT Adx by ... physiological significance and support the hypothesis of the existence of a ternary ET [Adx:Adx:AdR] complex in the physiological AdR/P450 system [16,36,37]. Therefore, our experimental data for the reduction of Adx...

Ngày tải lên: 31/03/2014, 07:20

... to a person (The Wizard) at another terminal who answered the subject's requests by consulting paper copies of the database tables. The experimenter then gave the details of the two tasks. ... consult the 3.1.1 Operators and the explicit specification of set properties The task of database access involves the construction and manipulation of answer sets with various prop- erties. The ... order. These would involve two operations, the first would be the generation of a set, and the sec- ond the sorting of that set in terms of some attribute such as age or date. The unknown...

Ngày tải lên: 01/04/2014, 00:20

Ngày tải lên: 02/04/2014, 14:41

Ngày tải lên: 02/04/2014, 15:05

Ngày tải lên: 02/04/2014, 16:27

Ngày tải lên: 10/04/2014, 18:53

Ngày tải lên: 11/08/2014, 05:21

Ngày tải lên: 11/08/2014, 16:20

... food stocks, and the mood of the garrison. The tactics of the Daily Mail captured the attention of the nation; the newspaper dramatized the situation of the town by emphasizing the danger that ... notions of Boer inhumanity toward Africans, the pro-war argument of the ‘‘negrophilists.’’ The other cat- egory into which mentions of Africans fall is praise of the loyalty of the Cape Boys and the ... hierarchies of race, sex, and class and of the ways in which, hand in hand, the New Imperialism and the New Journalism brought Britain into the twentieth century.  The war at home which included the...

Ngày tải lên: 21/09/2012, 10:54

... (92.34(78.8)69.8) 79 6 avg qpsf ++ ∆== Therefore, the average pressure increase in the clay layer is, The pressure p o at the center of the clay layer is, p o = γ sand h sand + γ’ sand h’ sand + γ’ clay h’ clay = (100)(4) ... being designed for a small office building with a total live load of 250 kips and dead load of 500 kips. Find: (a) the depth D f for a fully compensated foundation, (b) the depth D f if a soft ... in the x and y values, which these values are found by using the x-y coordinate system off the mat foundation. Determine the average soil reaction. (92.34(78.8)69.8) 79 6 avg qpsf ++ ∆== Therefore,...

Ngày tải lên: 16/10/2012, 10:43

... men and 0.1–0.6% in women [2]. The prevalence rises to 4.4% of men and 1.8% of women over the age of 65 [4]. A two-fold increase in incidence of gout has been reported in the USA and New Zealand ... publication was obtained from the patient. The authors wish to thank Dr. William Hsu and Dr. Tania Pringle for their contribution to the interpretation of the radiographs and providing key information ... that these were most likely due to old trauma. Mild osteoar- thritic changes were noted at the carpal-metacarpal joint at the base of the thumb. The report stated that the radio- graphs were otherwise...

Ngày tải lên: 25/10/2012, 10:06

... role in the pathogenesis of both types of diabetes mellitus. High levels of free radicals and the decline of antioxidant defense mechanisms lead to damage of cellular or- ganelles and enzymes, ... (maximum of 3 milliAm- peres) of one polarity for 11.5 minutes, which then switched to the opposite polarity for another 11.5 minutes. The device was designed to switch the di- rection of current ... Popliteal and pedal pulses were absent bilaterally with poor capillary re- fill. The left foot was red and inflamed up to and in- cluding the medial malleolus. The lateral aspect of the great toe and...

Ngày tải lên: 26/10/2012, 09:39

... molecular mechanisms of action of this polymorphism. Because these results were based on the low frequency of A/A , they might be inconsistent due to the random errors. Studies of a larger size ... diagnosis of cancer. In summary, the Gab1 A/A was associated with the low risk of H. pylori infection while the G/A and A/A genotypes together may increase the risk for gastric atrophy. The biological ... chance of natural eradication of the bacteria. However, the OR of the A/A genotype for H. pylori seropositivity was 0.25 (95% CI 0.09-0.71). So, the Gab1 polymorphism was associated with the...

Ngày tải lên: 31/10/2012, 15:37

... mainly focuses on the semantics of questions that function as a request for information. The semantics refers to the close and intense relationship between the form and the meaning of a sentence ... confirmation, we can reverse the position of the tag to the beginning of the question (Thiêm, 2004). The tags can be put at the beginning or function as a new sentence to indicate the speaker’s emphasis. ... we can see from the above examples, questions of this type contain two opposite clauses, in which the positive one normally stand at the front and the negative one is often in the back (Thiêm,...

Ngày tải lên: 22/01/2013, 09:28

... in the chivalric world of war marked either the uncon- trollable lust of the British soldier in wartime or the self-controlled lust of the British soldier in wartime. In one of the last of the ... to the camps – they were an important part of his defense of the sexual honor of the British soldier. First Doyle gave his version of the origin of the camps: ‘‘Considerable districts of the ... of the Boer soldier as defender of his country from invasion Stead weds the language of the Slaughter of the Innocents (a ‘‘decree went forth’’). In attacking Stead and the other critics of the...

Ngày tải lên: 01/11/2013, 08:20

Ngày tải lên: 15/11/2013, 20:27