... at the sn-2 position ofthe phospholipid, this proton is donated by the imidazole ring to the oxygen, which then forms the alcohol group ofthe lysophospholipid to be released together with the ... representation ofthe catalysis mechanism proposed for the PLA2s Interaction ofthe residues from the catalytic site of sPLA2s and the calcium ion with the transition state ofthe catalytic reaction ... polarized by the His48 and Asp99 residues binds to the carbonyl group ofthe substrate [18] The substitution ofthe Asp49 residue by the Lys49 significantly alters the binding site of Ca2+ in the phospholipase...
... longer applies once they are pooled So if they conflict, the results of meta -analysis, despite the fanciness ofthe word, should never be privileged over a large RCT In the case ofthe example above, ... move from the 50% mark closer to the 100% mark Depending on the strength ofthe scientific literature, the quality ofthe studies, the amount of replication, and our own interpretation of that ... probability thus: The probability of any event is the ratio between the value at which an expectation depending on the happening ofthe event ought to be computed, and the value ofthe thing expected...
... charactertstic of an equilibrium, such as the vapour pressure of a liquid, the solubility of a solid, or the equilibrium constant of a reaction Then some ofthe most useful results of thermodynamics are of ... determined by the relative speeds of these two reactions on the surface ofthe catalyst It is therefore a problem of rates and not of equilibria The theory of equilibria, based on thermodynamics, ... regarding thermodynamics as having its own secure empirical basis On the other hand, the laws of thermodynamics may themselves be interpreted in terms ofthe fine structure of matter, by the methods of...
... endorsement by the U.S Department of Justice The National Institute of Justice is a component ofthe Office of Justice Programs, which also includes the Bureau of Justice Assistance, the Bureau of Justice ... into the organic phase ofthe microemulsion Once dissolved, the agent can react with the water-soluble decontaminant at the surface ofthe organic portion ofthe microemulsion The rate of agent ... Statistics, the Office of Juvenile Justice and Delinquency Prevention, and the Office for Victims of Crime U.S Department of Justice Office of Justice Programs National Institute of Justice Guide for the...
... endorsement by the U.S Department of Justice The National Institute of Justice is a component ofthe Office of Justice Programs, which also includes the Bureau of Justice Assistance, the Bureau of Justice ... Statistics, the Office of Juvenile Justice and Delinquency Prevention, and the Office for Victims of Crime U.S Department of Justice Office of Justice Programs National Institute of Justice Guide for the ... Opinions or points of view expressed in this document represent a consensus ofthe authors and not necessarily represent the official position or policies ofthe U.S Department of Justice The products...
... died ofthe disease and three were still alive at the end ofthe follow-up (370 months) The authors concluded that 83% of GIST with PDGFRA mutations have a good prognosis [27] The same group of ... mutation of tyrosine kinase receptors is a mechanism of drug resistance occurring either at the beginning of treatment (primary resistance) or during the course of therapy (secondary resistance) The ... and 2002 The primary endpoint ofthe study was RFS and the patients were randomized to receive imatinib at the two doses with the possibility of cross over to the higher doses in case of progressive...
... died ofthe disease and three were still alive at the end ofthe follow-up (370 months) The authors concluded that 83% of GIST with PDGFRA mutations have a good prognosis [27] The same group of ... mutation of tyrosine kinase receptors is a mechanism of drug resistance occurring either at the beginning of treatment (primary resistance) or during the course of therapy (secondary resistance) The ... and 2002 The primary endpoint ofthe study was RFS and the patients were randomized to receive imatinib at the two doses with the possibility of cross over to the higher doses in case of progressive...
... because ofthe Nazi takeover Regardless of whether they had converted to other religions, they never shied away from their Jewishness They also proudly maintained their Hungarian identity Some of them ... applications of symmetry principles to atomic physics Von Neumann was the father ofthe modern computer and Teller the father ofthe hydrogen bomb The American hydrogen bomb saved the world from the Soviet ... to the otherwise growing awareness ofthe importance of athleticism and sports for the healthy development ofthe individual John Lukacs, a historian ofthe Budapest of around 1900, noted the...
... before the Blowpipe Ores of Antimony Ores of Arsenic Ores of Bismuth Ores of Chromium Ores of Cobalt Ores of Copper Ores of Iron Ores of Lead Ores of Manganese Ores of Mercury Ores of Nickel Ores of ... Blowpipe. The common blowpipe ofthe jeweller is not particularly well suited to the operations of blowpipe analysis, since the flame has often to be kept playing upon the assay for some time, and the ... moisture ofthe breath would seriously interfere with the passage ofthe air through the jet One ofthe best and least expensive forms of blowpipe is shown in Fig This consists, as is seen from the...
... ethylene per mole of ethane fed (the yield ofthe process is 80%) What is the cash flow ofthe process? What must be the cost of producing ethylene if we want a profit of 10% of sales? 1.9 What ... typical chemical processes the capital and operating costs ofthe reactor may be only 10 to 25% ofthe total, with separation units dominating the size and cost ofthe process Yet the performance of ... principles of operation ofchemical equipment rather than just memorize pictures of them Only in the Process Design course does there remain much discussion ofthe processes by which chemicals...
... ethylene per mole of ethane fed (the yield ofthe process is 80%) What is the cash flow ofthe process? What must be the cost of producing ethylene if we want a profit of 10% of sales? 1.9 What ... typical chemical processes the capital and operating costs ofthe reactor may be only 10 to 25% ofthe total, with separation units dominating the size and cost ofthe process Yet the performance of ... principles of operation ofchemical equipment rather than just memorize pictures of them Only in the Process Design course does there remain much discussion ofthe processes by which chemicals...
... plot ofthe log ofthe power of earthquakes (i.e the Richter scale) against the log ofthe frequency of their occurrence reveals a straight line with negative slope of -1 Thus, the probability of ... periodicity Note that the square ofthe contribution of each frequency is the power of that frequency to the total spectrum, and the total power of spectral analysis (area under the curve ofthe power spectrum) ... to the square root of variance; and variance is equal to the sum ofthe squares of difference from the mean, divided by the number of degrees of freedom Evaluating HRV, the standard deviation of...
... on theanalysis results that contains analytical proof ofthe presence of chemicals reported and provides high certainty ofthe absence of other chemicals relevant for the implementation ofthe ... from the Organic Synthesis Group for providing the analytes used in the study and all users ofthe GC MSD for sharing the use ofthe instrument Even though people come and go, the memories ofthe ... can be used in place of LLE in the ROPs for sample treatment of aqueous samples for theanalysisof CWC-related chemicals [62] 1.8 Motivation ofthe Project The objective ofthe project is to improve...
... called the neckline, drawn across the bottoms ofthe declines on both sides ofthe head The break out is confirmed when the stock price closes k percent below the neckline The break out ofthe head-andshoulders ... to the other traders (non-chartists) The Group of Thirty [26] surveyed the views of market participants on the functioning ofthe foreign exchange market in 1985 The respondents were composed of ... countries The survey results indicated that 97% of bank respondents and 87% ofthe securities houses believed that the use of Technical Analysis had a significant impact on the market The Group of Thirty...
... shadow price of λi is assigned to the entity of constraint i, then the value ofthe ith bound is λi bi and the total value of bound b exhausts the value ofthe objective function Since the shadow ... By (1.38) the shadow prices ofthe materials are simply equal to the world prices And by (1.37) the prices are equal to the sum ofthe material costs ofthe inputs, the capital costs, the labor ... with the same number of rows as of columns; we say it is n×n-dimensional, where the first n refers to the number of rows (i.e the length ofthe columns) and the second n refers to the number of...
... some of these phenomena may be interconnected within the catalytic mechanism ofthe enzyme Structural insights into the mechanochemical nature of a-CT catalysis A more detailed analysisofthe ... cutoff distance (rc ẳ 6.0 A) The dynamics ofthe resulting network are then dened by the Ni ã Nj Kirchhoff connectivity matrix of interresidue contacts (G) where the off diagonal elements of ... excluded from the experiments to simplify theanalysisofthe results because preliminary experiments revealed that the binding of calcium to the protein surface was perturbed by thechemical glycosylation...
... 10% ofthe patients had witnessed arrest It is not surprising that the initial rhythm in more than 50% ofthe study patients was asystole Nineteen percent ofthe arrest group had a return of spontaneous ... to the metabolic acidosis in equal amounts to that of lactate The presence of unmeasured ions alters the clinical interpretation and treatment ofthe patient This study has identified another ... area that needs further investigation to determine the significance ofthe presence of unmeasured ions in the postarrest patient Competing interests The author(s) declare that they have no competing...
... both extremes ofthe emotional spectrum were shown At the end ofthe videos, the brachial artery constricted for five minutes and was then released In fourteen ofthe twenty volunteers the artery ... expression (27) Therefore, the crux of individualism is the ethnic diversity of various individuals It is not the particular view ofthe individual that makes them an individualist, but it is the differing ... conditions, and then to specify the name of that condition If the participant failed to indicate the name ofthe condition regardless of a “yes”, the survey was discarded assuming the participant...
... large inventory of normalized mathematical indexes of abnormality It is the pattern of these mathematical indexes of abnormality, obtained from analysisof multiple cardiac cycles ofthe resting ... centers included in the meta -analysis The boundaries ofthe box are Tukey’s hinges The median is identified by the line inside the box The length ofthe box is the interquartile range (IQR) computed ... patients had prior revascularization The boundaries ofthe box are Tukey’s hinges The median is identified by the line inside the box The length ofthe box is the interquartile range (IQR) computed...