the bug the drug and the mug

... waters of the River Jamuna, heavy and swollen at that time of the year from the melting snows of the Himalayas and the monsoon rains, flowed past the massive sandstone walls of the Red Fort, the Quilla-e-Mualla ... a bow and a quiver full of arrows slung on his back, the other two carried lances After signing out for their mounts and the saddlery, they tightened the girths and then rode out through the busy ... by the noise and alarmed by the presence of the tiger in their close vicinity, the hogs had broken cover and dashed through the clearing, zig-zagging between the hunters on the ground on the...

Ngày tải lên: 08/12/2015, 12:33

... of these drugs is often necessary because the response to them are rapid, but there are risks involved in their use Because of the often severe side effects, Benzodiazepines are often used in their ... manic and depressive episodes Group therapy for patients with bipolar disorders responds to the need for support and reinforcement of medication management, and the need for education and support ... lessens the duration, frequency, and severity of the episodes of both mania and depression Unfortunately, as many as 40% of bipolar patients are either unresponsive to lithium or can not tolerate the...

Ngày tải lên: 02/04/2014, 17:48

... coating and limit the occurrence of water penetration into the drug- loaded core on various time scales, and therefore control the drug release from the microspheres, and finally, iii) the doublewalled ... consists of the coaxial nozzle and the collector, and is used to calculate the electric field Domain B consists of the region near the nozzle tip and is used to simulate the CEHDA process The coaxial ... of the shell layer could modulate the erosion of the outer coating and limit the occurrence of water penetration into the inner drug- loaded core on various time scales, and therefore control the...

Ngày tải lên: 10/09/2015, 09:05

... amine and quaternary ammonium It can be hydrolyzed and is used as the shell-forming segment Cholesterol is the pendant group and used as the core-forming segment The positive charges of the micelles ... DI water On the other hand, there were tertiary amines existing in the main chain, which could be protonized in an acidic environment Therefore, to improve their DNA binding ability, the micelles ... particle size The buffer concentration (ionic strength) and pH were the two main factors to influence the size of the micelles At lower pH and ionic strength, the particle size was smaller The micelles...

Ngày tải lên: 16/09/2015, 15:54

... the micelles may tend to dissociate after adsorption of proteins in the blood since the interactions between the shell and the proteins may damage the balance between the core and the shell The ... could interact with the positive charges on the surface of the micelles Therefore, the higher was the concentration of the salts, the larger the particle size The shielding of the positive charges ... Be-chol with the tertiary amine on the PMDS and PMDA main chains It is possibly because the conjugation of PEG onto PMDS and PMDA changed the polarity of the polymer and the compatibility of the polymer...

Ngày tải lên: 16/09/2015, 15:54

... in the range from to 20 ppm and the r2 value was at least 0.999 The encapsulation efficiency was calculated as the ratio of the actual drug mass encapsulated to the initial drug mass added The ... excitation and emission bandwidths were set at 4.5 nm The ratios of the peak intensities at 338 nm and 333 nm (I338/I333) from the excitation spectra and I3 (the third peak at 385nm)/I1 (the first ... minutes The naked DNA diluted with the same buffer without adding the micelles and the micelles without adding 53 DNA were used as the controls The tracks of the DNA and complexes were observed under...

Ngày tải lên: 16/09/2015, 15:54

... et al., 1987] On the other hand, the chemical conjugation of a drug to another compound may change its pharmacokinetics and pharmacodynamics Therefore, the incorporation of a drug by a physical ... Ndimethylformamide) in which they are both soluble The mixture is then dialyzed against water by using a membrane As the solvent is replaced by water, the hydrophobic segments of the polymer and the drug molecules ... interact and associate to form the core of micelles while the hydrophilic segments arrange towards the aqueous phase to form the shell In the case of the oil-in-water emulsion method, a drug and a...

Ngày tải lên: 16/09/2015, 15:54

... complexes In these formulations, the drug and gene were administered by separate injections However, in order to achieve synergistic effect of drug and gene therapies, both the drug and gene have ... in the blood onto the complexes, rendering the disruption of DNA/cationic polymer complexes Furthermore, the complexes themselves may not be stable enough in the blood Studies have shown that they ... have to be delivered to the same cell type Therefore, there is a great need to develop a delivery system that can carry both the drug and gene simultaneously Therefore, the main objectives of...

Ngày tải lên: 16/09/2015, 15:54

... MEN 55 % WOMEN DRUG DRIVING ACCIDENTS 25% of teens surveyed admit to driving under the influence of alcohol, prescription drugs or marijuana DRUG DRIVING ACCIDENTS alcohol and drug abuse among ... drinking MOST COMMONLY USED DRUGS AMONG 16-17 YEARS OLD 13% MARIJUANA 4% PRESCRIPTION DRUGS 2% HALLUCINOGENS 25% of college students report academic consequences of their drinking MISSING CLASS ... DRUG & ALCOHOL USE BY 8th GRADE 30% have TRIED ALCOHOL 18-24 590,000 are unintentionally injured under theinfluence of alcohol 696,000 are assaulted by another student who has...

Ngày tải lên: 01/02/2016, 15:30

... juices and juice products On the basis of all the testimony presented at the December 16 and 17, 1996 meeting, the NACMCF agreed that there is a need to understand the differences among juices and ... (1) The name of the processor or importer and the location of the processor or importer, if the processor or importer has more than one location; (2) The date and time of the activity that the ... either: (1) Obtain the juice from a country that has an active memorandum of understanding (MOU) or similar agreement with the Food and Drug Administration, that covers the food and documents the...

Ngày tải lên: 25/10/2013, 21:20

... judgment and decisions of another federal government agency, the U.S Food and Drug Administration (FDA) FDA, exercising authority under the Federal Food, Drug, and Cosmetic Act and the Public ... Rome.” In the same way, all critical functions in the development and acquisition of drugs and biologics in the United States lead to and through FDA The agency regulates drug development in the premarket ... whether the therapeutic or prophylactic benefits of a drug or vaccine exceed the risk of use In the case of drugs and vaccines for CBW defense, the appropriate risk-benefit analysis against the...

Ngày tải lên: 17/02/2014, 11:20

... disease, the primary pathology is in the kidney [1], the major site of Gb3 synthesis in man [11], and in the heart, possibly due to the association of Gb3 synthesis with the microvasculature GSL synthesis ... and glycogen breakdown [23] Unlike all other GSLs, GlcCer is made on the outer leaflet of the Golgi bilayer [24] and must be ‘flipped’ into the lumen to access the glycosyltransferases for further ... synthesis in the Fabry mouse model Our studies have further delineated the abnormal Gb3 synthesis in this model and have shown that the inhibition of MDR1 is a viable potential approach to the...

Ngày tải lên: 19/02/2014, 07:20

... dedicated to the furtherance of science and technology and to their use for the general welfare Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that ... represent the formal positions of the planning committee, the Forum, the IOM, INSA, or ICMR; however, they have provided valuable input to the Forum and to the IOM and the workshop contributors as they ... by the Global Drug Facility, WHO, and the RNTCP have brought Indian drug manufacturers together to educate them and encourage them to adhere to established standards An important component of the...

Ngày tải lên: 05/03/2014, 11:20

... in the Health Products and Foods Branch to replace the Therapeutic Products Programme: the Therapeutic Products Directorate (TPD); the Biologics and Genetic Therapies Directorate (BGTD); and the ... – the industry, on the one hand, and the consumer’s health movement, on the other, with government showing favour to both camps, depending on the political climate of the day Women in both the ... consultation with the women’s health community and include the principle of the right to be warned and informed expands regional reporting centres and adequately funds these as the front lines of the reporting...

Ngày tải lên: 22/03/2014, 11:20

... Food and Drug Administration, with assistance from the Center for Biologics Evaluation and Research, the Center for Drug Evaluation and Research, the Center for Devices and Radiological Health, and ... Alexander technique, Feldenkrais method, and a host of others Manipulative and body-based practices focus primarily on the structures and systems of the body, including the bones and joints, the ... Dietary supplement; o Drug, as well as "new drug" and "new animal drug; " o Food; and o Food additive These statutory definitions cover some CAM products a Second, neither the Act nor the P H s Act exempts...

Ngày tải lên: 23/03/2014, 10:20

... leaflet of the membrane to the aqueous medium rather than to the extracellular leaflet [12,13] The question remains as to whether the release of drugs from the cytoplasmic leaflet of the plasma ... membrane into the cytoplasm is fast, resulting in a practical equilibrium between the drug concentrations in the cytoplasmic leaflet and the cytoplasm, or whether the release is slow, and drugs taken ... multidrug-type drugs and modulators suggest that, upon association of the TMRM with the plasma membrane, it is located between the phosphate of the lipid headgroups and the upper segments of the...

Ngày tải lên: 29/03/2014, 08:20

... collagen, the initial step in the GPVI signaling cascade [13,14] These results strongly suggest that triplatin-1 and -2 are antagonists for GPVI To the best of our knowledge, triplatin-1 and -2 are the ... focusing on Drug Innovation (KH23306) and Young Scientists Fellowship B (16790249) to HI from the Naito Foundation, the Japan Health Sciences Foundation and JSPS, respectively, and a grant from the Research ... pallidipin are 63 and 49%, respectively We named this salivary gland protein and its isoprotein ‘triplatin-2’ and ‘triplatin-1’, respectively To investigate the function of these triplatins,...

Ngày tải lên: 30/03/2014, 10:20

... but this domain in the TK1 family is more similar to other ATP-binding structures in the RecA family [14] Furthermore, instead of the helical part forming the substrate site and the LID region being ... of the phosphate donor in the dNK family, there is a domain in hTK1 and Uu-TK that contains a structural zinc atom and lasso-like loop In the feedback inhibitor complexes of Uu-TK and hTK1, the ... enzyme in a similar way to the dT moiety of the feedback inhibitor dTTP (Figs 1B and 2) and has the same interactions with the main chain of the lasso-like loop This loop has the same conformation...

Ngày tải lên: 30/03/2014, 11:20

... contributed to the conception of the studies and the critical review of the manuscript DCQ contributed to the design of the experiments and analysis of the data KAK contributed to the acquisition and interpretation ... contributed to the conception of the studies and the critical review of the manuscript PCT contributed to the design of experiments, the acquisition and analysis of data and the critical review of the manuscript ... was selected and a standard plaque reduction assay was used to evaluate the susceptibility of the dUTPase mutant and the parent virus The mutant remained fully sensitive to all of the drugs tested...

Ngày tải lên: 20/06/2014, 01:20

... negatively on both physical and mental HRQoL [10,31] However, the nature of the symptoms and whether they were attributed to the disease process or to HAART was not clear In the developing world, Jelsma ... manuscript Acknowledgements The authors are grateful to Dr Catherine Orrell and Dr Richard Kaplan for the use of their drug toxicity data, and to Sis' Lulu Mtwisha and her team of Sizophila adherence ... Between weeks 16 and 32, peripheral neuropathies were the main reason for drug changes Elevated transaminases and hyperlactatemia were the main causes of drug toxicities between weeks 32 and 48 of HAART...

Ngày tải lên: 20/06/2014, 08:20