... are seen in the transition from normal to intraepithelial cancer to invasive disease The understanding of the timing of instability during progression, the rate of instability and the mechanisms ... described and favor the clonal progression of cancer Yet cancer remains a rare event if one considers the total number of bronchial epithelial cells and the proliferation rate of patches of clonal ... Tumor expression profiles are also influenced by the surrounding non-malignant cells The combination of tumor and cell line profiling allows for the study of the regulatory role of both entities...
Ngày tải lên: 12/08/2014, 18:21
... Wholeness and the Implicate Order, 1980) Think of these two aspects as the domain and the realm of architecture and compare them to the two “wings of the library.” Structural equilibrium and air-conditioning ... to further the systems basis of architecture: function as the foundation of design and industrial standardization as the basis of construction The Bauhaus sought to close the gap between the progress ... that placed these presentations back to back: the last of the structural eras and the first of the environmental ones The changing of the guard officially occurred in the early 1970s and was emphatically...
Ngày tải lên: 29/04/2014, 15:42
GENOMIC DISORDERS The Genomic Basis of Disease doc
... or required further explanation of the need for their samples I often thought of the irony of the situation At these reunion parties, Dr Garcia would oversee the administration of the electrical ... with the arrowheads representing the short, direct repeats formed at the point of insertion The left half of Alu contains the A and B boxes of the RNA polymerase III promoter The two halves of the ... from the Publisher The content and opinions expressed in this book are the sole work of the authors and editors, who have warranted due diligence in the creation and issuance of their work The...
Ngày tải lên: 05/03/2014, 23:20
Báo cáo Y học: The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis doc
... immunohistochemistry (data not shown) As the activity difference was small, the difference in intensity of the bands for the protein and the mRNA were faint Effects of inhibitors of cGCS and GR on primary cultured ... investigate the contribution of de novo synthesis and the recycling of GSH to the intracellular glutathione pool, the Ó FEBS 2002 1574 T Kaneko et al (Eur J Biochem 269) Fig GR activity and the protein ... during their migration through the epididymis, the oxidation of sulfhydryls is related to the acquisition of motility [4,5] During epididymial migration, sulfhydryls in the nucleus and the tail of...
Ngày tải lên: 17/03/2014, 17:20
Báo cáo khoa học: "The Linguistic Basis of Text Generation" doc
Ngày tải lên: 18/03/2014, 02:20
The Biological Basis of Nursing: Clinical Observations ppt
... from the left side of the heart to the tissues and back to the right heart, and a pulmonary circulation from the right side of the heart to the lungs and back to the left heart (Figure 2.4) The ... part of the body to another is vital to the very existence of the individual The blood has the task of transporting: water and nutrients from the digestive system to the cells; oxygen from the ... exercise The respiratory centre of the brain stem and irregular forms of breathing The blood gas tensions in arterial and venous blood compared with the gas tensions of the lungs and tissues The oxygen...
Ngày tải lên: 22/03/2014, 22:20
Báo cáo khoa học: The structural basis of calpain behavior pptx
... and oscillations of [Ca2+], in particular those involving specific phosphorylations of calpastatin, calpains and targets The following Minireviews develop three themes on the role of calpain and ... questions are raised by these molecular studies What is the correlation between the in vitro and in vivo Ca2+ requirements for calpain activity? How the two isoforms target their specific substrates ... The structural basis of calpain behavior Y Benyamin two parts, DIIa and DIIb, come closer together, with concomitant release of constraints between the domains (large arrows)...
Ngày tải lên: 23/03/2014, 10:21
Báo cáo khoa học: "The Linguistic Basis of a Mechanical Thesaurus " doc
... from the description of a finite number of languages ) avoids the necessity of the comparative (source-target) identification of word (and other grammatical) categories The word class of the target ... equivalences The autonomy thus acquired by the lexis of the target language allows the thesaurus stage of the dictionary to be the same for one target language whatever the source language, and at the ... 'verb' and 'plural' ), these are dealt with in the grammatical part of the program and only after having reached the target language they re-enter the range of features determining word choice The...
Ngày tải lên: 23/03/2014, 13:20
Báo cáo khoa học: The molecular basis of heme oxygenase deficiency in the pcd1 mutant of pea pot
... characterized the contribution of these assay components by omitting them individually In the absence of ferredoxin the reaction rate decreased to 46.5% of the complete reaction while the absence of ascorbate ... indicate the direction of the major changes in absorption over the course of the measurements (C) Michaelis– Menten plot of the PsHO1 reaction for heme concentrations of 1, 2, 5, 10 and 20 lM ... conservation between HO1s and HO2s would also account for the failure of the PsHO1 probe to detect any HO2-like sequences in Southern blot experiments Whatever the basis of the recovery of phytochrome responses...
Ngày tải lên: 30/03/2014, 11:20
eccles - evolution of the brain - creation of the self (routledge, 1986)
... to the most important of all the big problems the evolution of the human brain, and of the human mind The book is a synthesis of comparative anatomy—especially brain anatomy of the evidence of ... comparison of mind -brain theories 194 8.8 A new hypothesis of mind -brain interaction based on quantum physics the microsite hypothesis 195 8.9 Reconsideration of the mind -brain problem 200 The self and ... large-brained Homo habilis In EVOLUTION OF THE BRAIN: CREATION OF THE SELF 21 Figure 2.5 A schema of hominid phylogeny Figures in the left-hand margin refer to the numbers of millions of years...
Ngày tải lên: 03/04/2014, 12:06
a means to an end the biological basis of aging and death apr 1999
... Reznick, and Joan Valentine, among others The length of human life, according to the Greeks, was in the hands of the Fates, or Moerae These three sisters, daughters of the Goddess of the Night, ... food and oxygen T h e death of a relatively small number of brain cells through lack of oxygen, and the consequent inability of the brain to coordinate physiological activities in the rest of the ... hormones produced in the pituitary gland of the brain, and the pattern of synthesis and release of these hormones changes in an age-dependent manner In virtually every species, the degenerative changes...
Ngày tải lên: 11/06/2014, 05:26
báo cáo hóa học: " Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease" pdf
... sensitivity to the pro-inflammatory effects of DE Subchronic DE Exposure Modifies the Pro-inflammatory Profile of the Midbrain In an effort to further address the degree of sensitivity of the midbrain ... hypothesized point of entry of PM in the brain) ; the frontal lobe (damaged in AD and Frontaltemporal lobe dementia); the temporal lobe (damaged in AD and Frontaltemporal lobe dementia); the midbrain ... homogenized the brain samples, calculated protein concentrations, ran ELISAs, and completed most of the experiments for these studies MJS ran the gels and did the densitometry for the midbrain α...
Ngày tải lên: 19/06/2014, 22:20
THE MOLECULAR BASIS OF PLANT GENETIC DIVERSITY pdf
... etc Another impact of the Pleistocene glacials pertained to the connection between the Borneo and Thai-Malay Peninsula (the continent of Asia) The land bridge of the Sundaland accelerated the migration ... by counting the number of alleles per locus and taking the average of these counts These values then can be compared with the effective number of alleles (ne), which is the number of alleles needed ... disjunction and the changing climate affect the distribution of plants and animals in East Asia The species of postglacial East and South Asia have gone through the process of speciation In the Northern...
Ngày tải lên: 28/06/2014, 11:20
Báo cáo sinh học: "X-chromosome inactivation: the molecular basis of silencing" ppt
... Tsix The role of DNA methylation Figure Transcription of Xist and Tsix on the X chromosome The coding sequences of Xist and Tsix overlap on opposite strands of the X-chromosome DNA effect: the ... initiated A second cause of non-random X-chromosome inactivation is the selective death of cells that inactivate the incorrect number of X chromosomes: because the fates of the X chromosomes are ... selected as the XA and the other as the XI in each cell In addition to having opposing roles in random choice, Xist and Tsix also negatively regulate each other in ES cells Xist and Tsix are...
Ngày tải lên: 06/08/2014, 18:21
Báo cáo toán học: "The cluster basis of Z[x1,1, . . . , x3,3]" potx
... On the other hand, for each index , and for i ∈ I and j ∈ J , we have that row i and column j of the matrix φ(z ) both sum to The definition of the map φ thus implies that row and column sums of ... , and by Theorem 3.17 they are in bijective correspondence with the elements of the natural basis of AM,N Expanding each cluster monomial in terms of the natural basis of AM,N as in Theorem 4.2, ... canonical basis Using a well-known description of the natural basis in terms of Mat3 (N), we will show in Theorem 4.3 that the set M of cluster monomials is a basis as well (The fact that M is a basis...
Ngày tải lên: 07/08/2014, 15:23
Báo cáo y học: "Introducing Arthritis Research & Therapy’s 10th anniversary issue, ‘The Scientific Basis of Rheumatology: A Decade of Progress’" pdf
... molecular-based therapy Szekanecz and Koch [4] review the crucial involvement of the vasculature in inflammatory rheumatic diseases, including the role of the vasculature in atherosclerosis and increased ... the cellular and molecular levels Specific rheumatic diseases Developments in the scientific understanding of systemic lupus erythematosus are the focus of the contribution of Ardoin and Pisetsky ... Lundberg and Grundtman [9] describe available evidence for the immunological and nonimmunological basis of disease and the implications for future treatment options The Scientific Basis of Rheumatology:...
Ngày tải lên: 09/08/2014, 13:22
Báo cáo khoa hoc:" Statistical methods and the subjective basis of scientific knowledge" pps
... because the history of scientific theories is the history of the abandonment of old hypotheses and of the keeping of the newly formulated ones For example, when a law f (x, B) derived from theoretical ... manner of contrasting the hypotheses r and the conclusion about the value of r is subjective the rules =- r ; - OPTIMUM ESTIMATION We shall now examine another aspect of the question of the rule of ... posing the rule of the most probable value: choose the hypothesis i B having the largest posterior probability, with the risk of error given by the sum of the probabilities of the hypotheses...
Ngày tải lên: 09/08/2014, 18:21
báo cáo khoa học: " Genetic mapping of wild introgressions into cultivated peanut: a way toward enlarging the genetic basis of a recent allotetraploid" docx
... allowed the synteny analysis of the A and B genomes, the comparison with diploid and tetraploid maps and the analysis of the introgression segments from the wild synthetic into the background of a ... genome, and the number and size of the linkage groups For the A genome, 181 loci were mapped in 10 LGs with a number of markers per LGs varying between 12 and 30 (average of 18.1), and the length of ... given LG and the best possible return to the background of the cultivated variety The percentage of wild genome in the BC1F1 and BC2F1 generations and its relative diminution between the two generations,...
Ngày tải lên: 12/08/2014, 03:21
Báo cáo y học: "Application of the comprehensive set of heterozygous yeast deletion mutants to elucidate the molecular basis of cellular chromium toxicity" potx
... global effects of Cr treatment on the heterozygous mutants Analysis of the global effects of Cr treatment on the heterozygous mutants The plot shows the distribution of the sizes of the growth effects ... resistance of the cell to the toxic action of the metal Over-representation of specific Gene Ontology terms in the annotations of genes found in the haploinsufficiency and haploproficiency datasets ... contributions SVA and SGO conceived the study DD and EL performed the genome-wide screen SH and TS performed all other experiments IC, KG, SH, DCH, and TR analyzed the data from the screens SVA, SH and SGO...
Ngày tải lên: 14/08/2014, 08:20
THE SCIENTIFIC BASIS OF MATURATION CULTURE AND TECHNOLOGY OF WHISKER CATFISH REPRODUCTION (micronema bleekeri)
... characteristics and technology of artificial reproduction The contribution of building the process of whishker catfish reproduction which is: The scientific basis of maturation culture and technology of ... by 1/3 the content of female 3.3.2.5 Recording of results: The results of artificial breeding of whishker catfish were evaluated through some indexes: the rate of spawning, the times of effective ... plasma of fish proportional increased with the development stages of gonad of fish Vg content increased the highest when the gonad of fish changed from III to IV stages The number of erythrocytes and...
Ngày tải lên: 10/08/2015, 12:59
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