the adf proof of concept

... counts (DAS28), evaluation of the pharmacokinetics of ACZ885 and examination of the potential immunogenicity of ACZ885 The initial dose escalation phase of the study consisted of four cohorts (Figure ... drawn, because of the small sample size (n = 6) of the cohorts treated with 0.3, 1, and mg/kg ACZ885 The onset of action in those who responded was found to be rapid The majority of these responders ... of the human immunoglobulin repertoire to In the 10 mg/kg cohort there were six out of 19 (32%) ACR20 responders at day 43, as assessed by the blinded observer, versus one out of 15 (7%) in the...

Ngày tải lên: 09/08/2014, 10:23

... T-lymphocytes These events then contributed to the relatively long period of undetectable viral load after ART interruption The present proof- of- concept study was conducted to explore this hypothesis ... persistence of the infection during otherwise effective ART Other cellular pools and tissue reservoirs, such as the central nervous system, may also be obstacles to the eradication of HIV-1 [3] The present ... included in the study Written informed consent was obtained and the study was approved by the Research Ethics Committee at the University of Gothenburg and the Medical Products Agency of Sweden...

Ngày tải lên: 10/08/2014, 05:21

... found to be predictive of the total amount of fluid given to the patient on day two in the ICU The coefficients of the variables in the fitted model, their standard errors and the corresponding p ... obliterate, the impact of noise The choice of the threshold Bayes factor (the likelihood of the model with links between the parent nodes and their children as compared with a model where the variables ... the outcome was 77.8% Figure We suspect the reason why the accuracy of the Bayesian network generated from the data is not better may relate to the limitations of our methodology The subset of...

Ngày tải lên: 13/08/2014, 11:23

... duration The longer the duration of the credit and the higher the discount rate (applied to the deferred action), the higher the current value of the tCER Source: EnviroMarket Ltd Page 33 of 140 ... detailed consideration of the expected financial behaviour of particular assets, as opposed to the expected financial behaviour of the originator of the chosen assets The structure of the financial instrument ... seeking to offset the impact of their carbon emissions ITTO 2005b Page 16 of 140 FINAL 06 August 2007 Forest-Backed Bonds Proof of Concept Study Forum for the Future & EnviroMarket The Forestry...

Ngày tải lên: 06/03/2014, 08:20

... functional therapeutic outcomes for the arm and hand post-stroke These concepts have led to the development of the Virtual Piano Trainer This paper will provide a proof of concept of whether such ... with the checker stacking item of the JTHF This problem accounted for all of the regression demonstrated in her score Another subject was able to viding the sensation of the finger contacting the ... Following the proof of concept study, we investigated the difference in the effects of two different assistance algorithms, A & B, on improving the ability to flex fingers independently while using the...

Ngày tải lên: 19/06/2014, 08:20

... interval, lack of familiarity or trust of the new system, or that the effort required was acceptable to nurses with the shorter interval One limitation of any model-based approach is the model and ... Thus, the comparison of these two works, as well as to SPRINT, clearly shows the flexibility of the overall STAR framework to deliver very different glycemic control approaches within the same ... et al Annals of Intensive Care 2011, 1:38 http://www.annalsofintensivecare.com/content/1/1/38 Page of 12 Number of patients with cTIB cutoff >= 0.80 Num patients 2 Days on STAR % of patients with...

Ngày tải lên: 20/06/2014, 23:20

... during the workshop Other collaborators from the US are the two key invited presenters at the two-day workshop Together, they will bring extensive expertise on the theoretical underpinnings of implementing ... practices regarding the implementation of SDM in clinical practice using a theory-based dyadic perspective will be In line with four of the eleven priority research themes of the Institute of Health Services ... shared with the team members; 5) sharing their experience and expertise in the development of a dyadic approach to the implementation of SDM in clinical practice and the data management of large...

Ngày tải lên: 11/08/2014, 05:22

... during the workshop Other collaborators from the US are the two key invited presenters at the two-day workshop Together, they will bring extensive expertise on the theoretical underpinnings of implementing ... practices regarding the implementation of SDM in clinical practice using a theory-based dyadic perspective will be In line with four of the eleven priority research themes of the Institute of Health Services ... shared with the team members; 5) sharing their experience and expertise in the development of a dyadic approach to the implementation of SDM in clinical practice and the data management of large...

Ngày tải lên: 11/08/2014, 16:20

... a sense of rise and fall in the variable of interest Furthermore, it is not measured in the original units of the variable from which it is derived These reasons may underlie the lack of association ... using the minimum effective dose of corticosteroids The demonstration of a cardioprotective association of antimalarials highlights the staple role of this class of drugs in the management of patients ... this proof- of- concept study, our chosen lipid marker of CAD risk was TC In general, low-density lipoprotein cholesterol (LDL-C) is deemed the primary target of lipidlowering therapy [11] In the...

Ngày tải lên: 12/08/2014, 18:20

... greater than the dose applied in sheep If any of the alveolar H2S were exhaled, the ratio of the uptake via the membrane artificial lung in the present study and the uptake via the natural lungs ... during the last minutes of each period of exposure Depending on the distribution of the data as determined using the Shapiro-Wilk test for normal distribution, either Student’s t-test or the Wilcoxon ... pulmonary toxicity of inhaled H2S, we used an ECML to directly diffuse high concentrations of H2S gas into the blood The absence of H2S (lower limit of detection ppm) in the gas outlet of the artificial...

Ngày tải lên: 14/08/2014, 07:21

... down-regulated the expression of essentially all of the selected genes in the seven pathways while lindane up-regulated the expression of most of these genes Similarly, TCDD downregulated the expression of ... value of 10.33 and they could not correctly discriminate all of the five groups, particularly the two concentration groups of E2 treatment (Figure 4B) All other gene sets (3 or more genes) of the ... indicate the positions of vtg1, and red arrows indicate the positions of cyp1a1; White boxes indicate the positions of genes that did not pass the model test and could not be used to discriminate the...

Ngày tải lên: 23/09/2015, 14:47

... hypotheses of latent vectors for the definition of bank#n#1 Learning Latent Semantics of Definitions 2.1 Intuition Given only a few observed words in a definition, there are many hypotheses of latent ... highly related to the observed words Therefore, missing words can be used to prune the hypotheses that are also highly related to the missing words Consider the hypotheses of latent vectors in ... those of the authors and should not be construed as representing the of cial views or policies of IARPA, the ODNI or the U.S Government References Eneko Agirre and Aitor Soroa 2009 Proceedings of...

Ngày tải lên: 19/02/2014, 19:20

... bullet -proof fashion that will stand the test of time The second, and for the working mathematician the most important, aspect of proof is that the proof of a new theorem explains why the result ... really not know how the formal concept of proof evolved The Republic of Plato contains a clear articulation of the proof concept The Physics of Aristotle not only discusses proofs, but treats minute ... had a paper rejected there for lack of a proof 0.5 THE PURPOSE OF PROOF 25 A TIMELINE OF MATHEMATICAL PROOF Event Date Babylonian tablet with first proof Thales uses proofs √ Pythagoras proves...

Ngày tải lên: 21/02/2014, 09:20

... formula In the second paper [II], we established a key reduction in the proof of one of the global theorems In this paper, we shall complete the proof of the theorems We shall combine the global ... argument, the reader can consult the proof of Lemma 5.2 of [A2] and the discussion at the end of Section 10 of [AC].) The terms in the expansion therefore vanish The remaining distribution has ... endoscopic groups Various reductions of the proof have been carried out in other papers, by methods that are generally independent of the trace formula The rest of the proof will have to be established...

Ngày tải lên: 05/03/2014, 23:20

... 2004 In the summer 2005 an alternative proof of Theorem 2.6 appeared in the preprint [19], and a proof of Conjecture 2.5 was announced by C Schultz Proof of Theorem 1.3 (Lov´sz conjecture) .The case ... and all n 2.3 Completion of the sketch of the proof of the Lov´sz conjecture Cona sider one of the two maps ι : K2 → C2r+1 mapping the edge to the Z2 -invariant edge of C2r+1 Clearly, ι is Z2 ... differentials leads to the proof of the Lov´sz conjecture for the case of even k as well a The results of this paper were announced in [1], where no complete proofs were given The reader is referred...

Ngày tải lên: 06/03/2014, 08:21

... description of the objects while the A-Box contains the set of the assertions on the objects The former corresponds to the ability of describing by the use of NPs, and the latter to that of constructing ... configurations of objects and so on new example The conlplex phenomena of to the notion of a set of reasoning the manipulation of to of of of In terms of SI-Nots this process can be represented as ... use the notion of predicate to interpret this complex process as well as the other possible interpretation of the adjective: the one c o r r e s p o n d i n g to tile notion of "type of" aQ in the...

Ngày tải lên: 18/03/2014, 02:20

... structure of the proof Statement of theorems Basic concepts in the proof Logical skeleton of the proof Proofs of the central claims Construction of the Q-system 2.1 Description of the Q-system ... proof of the main theorem of the chapter A PROOF OF THE KEPLER CONJECTURE 1089 Proof of Theorem 2.9 The rules defining the Q-system specify a uniquely determined set of simplices The proof that they ... paper Here, we describe the top-level outline of the proof and give references to the sources of the details of the proof An expository account of the proof is contained in [Hal00] A general reference...

Ngày tải lên: 22/03/2014, 20:20

... on the concepts of the background knowledge A discourse state is defined by the actual state of all the five layers of the text representation, which renders the actual state of the view and the ... distinguishing the mechanisms involved in terms of the textual function of linguistic means with respect to the different layers of the text representation In our model the units of the layer of thematic ... "dietionary" Therefore "dictionary" must at this state of the discourse no longer access the concept of "dictionary" of the background knowledge as freely as at the beginning of the text, when there...

Ngày tải lên: 01/04/2014, 00:20

... interpret these and other aspects of the behaviour of their patients as posing difficulties for both the domain-specific and the standard form of S/ FT They go on to argue that the heterogeneous set of ... properties of the objects themselves Nevertheless, both theories are property, rather than category, based The alternative to these property-based theories is the domain-specific theory (Caramazza ... authors themselves A major emphasis has been on whether the results support one or another theory of the organisation of conceptual knowledge in the brain In this effort, we have presented the three...

Ngày tải lên: 03/04/2014, 12:07

... speak out their own ideas in the family, they began take more of advisory role in the choice of their child’s mate - Parents are beginning to listen to their children and talk to them when they make ... with their parents until marriage, then the couple moved to the husband's father's household The extended family arranged marriage, but individuals were usually consulted on the choice of their ... often decided by the couple, individuals were usually consulted on the choice of their mate Their parents not prevent of against their choice, they even get marriage and tell to their parent later...

Ngày tải lên: 28/05/2014, 17:31