the adaptive immune system
Báo cáo khóa học: Collectins Players of the innate immune system docx
... infection, further points to the possibility of SP-D having a role in mucosal defense systems outside the lung [25] Structure of the collectins The basic functional unit of collectins is a trimer The number ... ligands, or that they are involved in the recognition of immune cell surface receptors In addition, the electrostatic potential pattern on the surface of the protein might be altered by the additional ... carbohydrate ligands on the microbial surface [83] on the one hand, and on the degree of oligomerization of the collectin [66], on the other Clustering of glycoproteins or glycolipids on the surface of...
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báo cáo hóa học:" Angiostatin anti-angiogenesis requires IL-12: The innate immune system as a key target" docx
... although AST seems to have no effect in the same system [15] There is rapidly expanding evidence that immune system components, in particular the innate immune system, play a key role in induction ... have independent functions The immune system is capable of sensing at least some forms of proteolytically generated peptides [34], a role for the immune system in the function of this class of ... in animals gene targeted for either the IL-12 specific receptor IL-12Rβ2 (IL-12Rβ2-/-) for the IL-12 signal system or for the IL-12 p40 subunit (IL-12p40-/-) Another angioegensis inhibitor, fenretinide...
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Báo cáo y học: " Lack of effect of glutamine administration to boost the innate immune system response in trauma patients in the intensive care unit" pdf
... may exert a positive effect on other cell types or even at the level of cross-talk between cells of the innate immune system Studies are on going to test these hypotheses In this study, we have ... some other investigators we did not observe any adverse effect, studied through the SOFA score, due to the use of these doses of glutamine (Table 1) There were detected 21 positive cultures in the ... Phagocytosis of pathogens also relies on the activation of TLRs [28] The phagocytic capability of both groups studied before the beginning of the treatment, or at the end of the treatment (Day 6) or at Day...
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Báo cáo y học: "Comparative genomic analysis of the Tribolium immune system" pps
... is conserved in the beetle Furthermore, the modulation of these pathways may also resemble each other - we have identified putative 1:1 orthologs of IAP2, Tab2 and caspar in the Tribolium genome ... of the clip-domain family of SPs and SPHs in the T castaneum genome Expansion of the clip-domain family of SPs and SPHs in the T castaneum genome The catalytic and proteinase-like domains in the ... and their phylogenetic relationships with the serpins from other insect species A major family expansion of Tribolium serpins and their phylogenetic relationships with the serpins from other...
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Development of live bacterial delivery systems for presentation of dengue EDIII to the mucosal immune system 2
... vectors for their transmission; therefore, the geographical distributions of these viruses follow the distributions of their vectors [5] With the worldwide presence of the Aedes mosquito in the tropics ... in the immune sera was confirmed by the plaque reduction neutralisation test These results therefore indicated that BPZE1 was not ideal for the presenting EDIII to the respiratory mucosal immune ... the host and it is believed that their prolonged presence would provide sustained immune stimulation, thereby augmenting the immune response without the need of multiple boosts [99] Despite the...
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Understanding the adaptive immune responses against newly emerged viruses, SARS coronavirus and avian h5n1 influenza a virus 1
... Sara Akerstrom, for their help in the H5N1 infectious studies done in BSL4 facilities in the Department of Microbiology, Tumor and Cell Biology, Karolinska Institute For the collaboration work ... Kemeny for their valuable guidance throughout the course of my PhD studies I would also like to extend my thanks to my PhD committee members, Prof Hong Wan Jin and Dr Hwang Le-Ann for their advice ... Bertoletti and his lab members from the Singapore Institute of Clinical Sciences for all the help and guidance and Dr Leong Hoe Nam and Dr Ling Khoon Lin from the Singapore General Hospital for...
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Understanding the adaptive immune responses against newly emerged viruses, SARS coronavirus and avian h5n1 influenza a virus 2
... viruses are the severe acute respiratory syndrome coronavirus (SARS-CoV) and the H5N1 influenza A virus Together with innate immunity, the host adaptive immune responses are crucial for the clearance ... particles carrying HA on the surface, mAb 9F4 was shown to effectively neutralize the homologous and other H5N1 strains belonging to clade 1, 2.1 and 2.2 but not other subtypes of the influenza A virus ... putative T cell epitopes in the accessory 3a and the nucleocapsid (NP) protein The IFNγ ELISPOT and intracellular cytokine staining assays showed that approximately 50% of them had positive memory...
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Understanding the adaptive immune responses against newly emerged viruses, SARS coronavirus and avian h5n1 influenza a virus 3
... a vector Once inside the body, the next line of defense will be the host immune system which can be divided into two arms, the innate and the adaptive immunity The innate immune response is non-specific ... HA, NA and the cell surface, thus the release of virus from the host cell It may also allow the transport of the virus through the mucin layer in the respiratory tract to the target epithelial cells ... race between the virus and the host’s immune system at the early stage of a viral infection There are several important players that constitute the innate immunity, the IFN response, the natural...
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Paradoxical roles of the immune system during cancer development docx
... apart from adaptive immune cells Acute activation of innate immunity sets the stage for activation of the more sophisticated adaptive immune system Induction of efficient primary adaptive immune ... that the adaptive immune system differentially modulates de novo cancer development in an organ-dependent and aetiology-dependent manner The paradoxical influence of the adaptive immune system ... innate immune cells form the first line of immune defence and regulate activation of adaptive immune responses By contrast, during chronic inflammation, these roles can be reversed — adaptive immune...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
... digesting the fragment with HindIII and Bgl II and the plasmid with HindIII and Bam HI The fragment was ligated into the plasmid and the integrity of the insertion was validated by digesting the plasmid ... purified (< 820 bp) The insert was then ligated into the pSPORT vector and the resulting full-length siglec-10 clone was designated 995-2 and the sequence was verified against the other siglec-10 clones ... plate and determining the binding of the polyacrylamide biotinylated glycoconjugates (Fig 5A) In the first panel, the 2,60 -PAA conjugate bound significantly greater than either the unsialylated lactose...
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scientific american - 1993 09 - special issue - life, death, and the immune system
... and to destroy them The second is the adaptive immune system, in which antibodies play a leading role The receptors used in the adaptive immune response are formed by piecing together gene segments, ... control 126 The Immune System as a Therapeutic Agent Hans Wigzell Knowledge of the immune system has given clinicians a potent instrument: the system itself Researchers are seeking to guide immune ... chemicals that boost the activity of other cells in the immune system the junctions between the V and D or D and J segments when they interlink, which further increases the number of possible...
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Báo cáo sinh học: " Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response" pptx
... HCV protein either in the interferon-gamma ELISPOT assay or in the proliferation assay in five of the seven patients (figures and 2) None of the patients who remained negative in the anti-HCV ... individuals from the young offender institution as a "negative" control group but applied identical methods as for the other projects run in the laboratory T cell responses were investigated in the laboratory ... antibodies and HCVRNA in the year 2002 (n = 1176) The study was approved by the Ethics Committee of the Hannover Medical School including additional blood sampling to study cellular immune responses...
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Báo cáo sinh học: " Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system" docx
... not dependent on virus infectivity Later and systemically, the virus protects the host from any fatal consequences of the suppression of the immune system by compensatory enhanced activities of ... has the capacity to impair the initiation of an acquired immune response [16,21] If the viruses fail to secrete such immunomodulating proteins, as when the respective genes are deleted or the ... Competing interests The author(s) declare that they have no competing interests Authors' contributions Abu-El-Saad participated in the design of the study, carried out the work with the mice, assisted...
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Báo cáo hóa học: " Feasibility of the adaptive and automatic presentation of tasks (ADAPT) system for rehabilitation of upper extremity function poststroke" pptx
... However, the design of ADAPT departs from that of most other current robotic systems In these systems, the task goal is generally prespecified, and the robot modulates the assistance provided to the ... between the current tool and the next tool in the rack The functional task model generates a desired trajectory to simulate the dynamics of the selected task with the difficulty specified by the ... changing the parameters of the local linear models empirically At each trial, the high-level adaptive task scheduler adaptively changes the task difficulty by controlling the Diff in equation (1) The...
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Báo cáo hóa học: " Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response" potx
... HCV protein either in the interferon-gamma ELISPOT assay or in the proliferation assay in five of the seven patients (figures and 2) None of the patients who remained negative in the anti-HCV ... individuals from the young offender institution as a "negative" control group but applied identical methods as for the other projects run in the laboratory T cell responses were investigated in the laboratory ... antibodies and HCVRNA in the year 2002 (n = 1176) The study was approved by the Ethics Committee of the Hannover Medical School including additional blood sampling to study cellular immune responses...
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báo cáo hóa học:" Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system" doc
... not dependent on virus infectivity Later and systemically, the virus protects the host from any fatal consequences of the suppression of the immune system by compensatory enhanced activities of ... has the capacity to impair the initiation of an acquired immune response [16,21] If the viruses fail to secrete such immunomodulating proteins, as when the respective genes are deleted or the ... Competing interests The author(s) declare that they have no competing interests Authors' contributions Abu-El-Saad participated in the design of the study, carried out the work with the mice, assisted...
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Báo cáo sinh học: "Parasite immunomodulation and polymorphisms of the immune system" ppsx
... consistent with the broader immunosuppression seen in laboratory models By targeting innate immune responses, the parasite is also reducing cytokine-based stimulation of the adaptive immune system Moreover, ... between pathogen species These graduated effects may, in turn, have driven quantitative polymorphisms in the contemporary immune system that control the strength of the immune response, exemplified ... patterns, the fine-tuning effect of multiple allelic variants allows the immune system to be variably calibrated across the population In the absence of infection, and where genotypes tend to the higher...
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Báo cáo sinh học: "Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system" docx
... components of the immune system Unraveling the complex functions of AhR in the immune system, which may also give clues http://jbiol.com/content/8/7/61 towards crosstalk between the immune system, the ... just the beginning We still know little about the physiological impact of AhR expression on other cells of the immune system and the consequences of exposure to AhR ligands for these Given the ... subsets, distinguished by the different cytokines they produce (indicated under each CD4 T cell type): the cytokines act on other immune cells, activating them in turn The four known subsets of...
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Báo cáo khoa học: "The use of crossreactive monoclonal antibodies to characterize the immune system of the water buffalo (Bubalus bubalis)" pdf
... evaluate the immune responses of water buffalo to infectious agents and potential vaccines, it is necessary to characterize the immune system of the water buffalo and elucidate the changes in the immune ... populations in water buffalo is similar to the composition in cattle One of the unique features to emerge from the study of the immune system of cattle is the presence of two complex subpopulations ... in other related species With the mAbs identified here, it will now be possible to characterize the immune system of the water buffalo and begin to analyze the immune response to infectious agents...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
... paradigm The fate of the TR cells induced at the site is not known — whether these cells exist only transiently then die, whether they persist in the body as TR cells, or whether they return to their ... impossible to prove whether the TR cells isolated from peripheral blood originate in the thymus, and are expanded in the periphery, or whether they have been generated in the periphery The possibility ... treat autoimmune disease A better understanding of how these forces work together will allow us to understand immunologic settings where either the immune response is inadequate, such as the response...
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