th1 th2 type immune responses and the regulating role of the th3 type

Báo cáo hóa học: " First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity" pptx

Ngày tải lên : 18/06/2014, 16:20

... characteristic and a benefit of chemo-immunotherapy protocols To investigate the role of the immune response behind the above clinical results, we analyzed both the absolute numbers of PBMC subsets and ... Correlation between the monocyte gain of function at D170 and tumor regression (Panel B) The monocyte gain of function calculated as the mean of the percentage increases of each of the eight activation ... the study and performed the statistical analysis MG and FT conceived the study, and participated in its design and coordination and helped draft the manuscript All authors read and approved the...

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Báo cáo khoa học: " Characterisation of immune responses and protective efficacy in mice after immunisation with Rift Valley Fever virus cDNA constructs" pot

Ngày tải lên : 12/08/2014, 04:21

... designing the experiments and in the writing of the manuscript GB conceived of the study, designed and coordinated the research and drafted the manuscript All authors read and approved the final ... towards the N protein and truncated variants thereof Western blot reactivity towards the N protein and truncated variants thereof (A) Schematic presentation of the full length and deleted variants of ... encoding the N protein, the glycopolyprotein GN/GC, and the separate GC and GN proteins were analysed The N and the GN/GC constructs displayed the most promising results regarding the elicited immune...

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Báo cáo y học: "Neonatal immune responses to TLR2 stimulation: Influence of maternal atopy on Foxp3 and IL-10 expression" pot

Ngày tải lên : 12/08/2014, 16:20

... history of atopy, and 19 mothers had maternal atopy Of these 19, mothers had a doctor's diagnosis of asthma, of them had also asthma and hay fever; mothers had only hay fever, had only eczema, and ... cells; the role of Foxp3 in the development of the neonatal immune system remains to be determined It is intriguing that both IL-10 and Foxp3 levels are decreased in cord blood of neonates of mothers ... detection of the PCR product was monitored by measuring the increase in fluorescence caused by the binding of SYBR Green to dsDNA Using µl of cDNA, µl of primer, and 10 µl of SYBR Page of (page...

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Báo cáo khoa học: Mechanisms of obesity and related pathologies: Role of apolipoprotein E in the development of obesity potx

Ngày tải lên : 29/03/2014, 22:21

... Despite the pivotal role of obesity and dyslipidemia in the development of the metabolic syndrome and heart disease, the functional interactions between adipose tissue and the lipid and lipoprotein ... reducing the expression of ApoE in the fed state Certainly, additional studies are required to determine the role of adipocyte-synthesized ApoE, and to distinguish between the functions of peripherally ... lower potential to promote these conditions One study [55] investigated the contribution of the natural human ApoE3 and ApoE4 phenotypes in the development of obesity and other metabolic abnormalities...

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Báo cáo khoa học: Cytoskeleton-modulating effectors of enteropathogenic and enterohemorrhagicEscherichia coli: role of EspL2 in adherence and an alternative pathway for modulating cytoskeleton through Annexin A2 function pot

Ngày tải lên : 29/03/2014, 09:20

... which is bound to the cytosolic plasma membrane, and enhances the activity of bundling actin ﬁlament and linking of the membrane to the cytoskeleton Role of the membrane microdomain, the lipid raft, ... A2: strengthening the linkage between polymerized actins and reorganization of the cytoskeleton–membrane interaction may result in the aggregation of actin pedestals and the induction of membrane ... II) may be the target of EspL2 in host cells Coprecipitation of Annexin A2 with EspL2 from a puriﬁed mixture of the two in vivo supported the interaction of both proteins and, furthermore, indicated...

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báo cáo hóa học: " The impact of shift work induced chronic circadian disruption on IL-6 and TNF-a immune responses" pot

Ngày tải lên : 20/06/2014, 00:20

... proinflammatory immune responses As possible markers of these changes in the immune system we investigated the proinflammatory cytokines IL-6 and TNF-a and measured the lymphocyte cell count Materials and ... conceived of the study and its design, led the coordination, data collection, data analysis and interpretation of results and drafted the manuscript SWW participated in the design of the study, ... interpretation and took part in preparation of the manuscript MSpallek participated in the design of the study, study Page of coordination and data collection RK participated in the design of the study,...

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Báo cáo y học: "A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses" pps

Ngày tải lên : 09/08/2014, 01:23

... through the inhibition of APCs or pathogenic T cells, by maintenance of the TR cell population and/ or by enhancement of their function (reviewed in [54]) Elucidation of the mechanism of TR cell ... cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin in the prevention of autoimmune thyroiditis in rats by peripheral CD4+CD45RC– cells and ... The overt immunological similarities seen with genetic defects of Foxp3 and the experimental depletion of CD25+CD4+ TR cells led several groups to investigate the potential role of Foxp3 in the...

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Báo cáo y học: "The role of leptin in innate and adaptive immune responses" doc

Ngày tải lên : 09/08/2014, 08:22

... a major role in the regulation of the inflammatory process in experimental models of hepatitis and colitis in mice, emphasizing the critical role of adipose tissue-derived leptin in immune modulation ... proinflammatory state Effects of leptin on phagocytes The role of leptin in the regulation of important macrophage functions is further emphasized by alterations in the phenotype of those cells during ... is a part of the cytokine cascade, which orchestrates the innate immune response and host defense mechanisms [28,29] Like other members of the IL-6 family, leptin was shown to activate the Janus...

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Mechanisms and functions of lymphangiogenesis in regulating the immune response and inflammation resolution 2

Ngày tải lên : 09/09/2015, 18:48

... through the LN could influence the spatial-temporal distribution of VEGF-A during the course of inflammation and, as a consequence, modulate the remodeling of cortical and medullary sinuses As other ... of the LN The heparin-binding carboxyl-domain of the predominant VEGF-A isoform, VEGF164 may bound the molecule to the extracellular matrix and limit its access deeper into the LN via the reticular ... indispensable for the occurrence of lymphangiogenesis in µMT LNs, it is unlikely that they were the only cells driving the process Depletion of monocytes and macrophages by the use of AFS98 MAb inhibited...

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Mechanisms and functions of lymphangiogenesis in regulating the immune response and inflammation resolution 1

Ngày tải lên : 09/09/2015, 18:48

... reabsorbed at the venous side of the capillary bed, where the colloid osmotic pressure of the blood exceeds the blood pressure The main function of the lymphatic vasculature is to return the remaining ... observed only in the absence of pathogen-derived signals (Podgrabinska et al., 2009) Together, these data imply that LECs can play a direct role in the modulation and curtailing of immune responses ... and so forth The mouse isoforms are one amino acid residue shorter than the corresponding human isoform and they are denoted as VEGFA120 and so forth Human VEGF-A121, VEGFA165, VEGFA189 and their...

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The role of CD8 t cells in the differentiation of TNF iNOS producing dendritic cells and TH1 responses

Ngày tải lên : 09/09/2015, 18:58

... described These main subsets are known as Th1, Th2, Th17 and Treg cells (Harrington et al., 2005; Langrish et al., 2005; Mosmann and Coffman, 1989; Sakaguchi, 2004) 1.4.1 Th1 and Th2 cells Before the ... such as Fas Ligand (FasL) and secrete the pore forming molecule perforin and granule enzymes granzyme A and B (Berke, 1995) They then induce cytolysis of infected cells either by the granule exocytosis ... chains, α and β, linked together by disulphide bonds They can also recognize antigen on MHC class II molecules and provide help to other immune cells by secreting cytokines On the other hand, B...

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Understanding the adaptive immune responses against newly emerged viruses, SARS coronavirus and avian h5n1 influenza a virus 1

Ngày tải lên : 11/09/2015, 09:58

... Bertoletti and his lab members from the Singapore Institute of Clinical Sciences for all the help and guidance and Dr Leong Hoe Nam and Dr Ling Khoon Lin from the Singapore General Hospital for ... performing the HLA typing of the SARS individuals To all fellow laboratory members, past and present, in the Collaborative Anti-Viral Research group from the Institute of Molecular and Cell Biology, ... Yee Joo and co-supervisor Prof Michael Kemeny for their valuable guidance throughout the course of my PhD studies I would also like to extend my thanks to my PhD committee members, Prof Hong...

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Understanding the adaptive immune responses against newly emerged viruses, SARS coronavirus and avian h5n1 influenza a virus 2

Ngày tải lên : 11/09/2015, 09:58

... humoral and T cell responses in the mouse model This was followed by the production of mAb 9F4 using the rHA MAb 9F4 binds both the denatured and native forms of HA and recognizes the HA proteins of ... (SARS-CoV) and the H5N1 influenza A virus Together with innate immunity, the host adaptive immune responses are crucial for the clearance of the virus during an infection In the first part of this ... multiple CD8+ T cell responses 77 Representative data of the cytokine profile of CD4+ T cell response stained with Th1/ Th2 cytokines 80 Representative data of the cytokine profile of CD4+ T cell response...

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Understanding the adaptive immune responses against newly emerged viruses, SARS coronavirus and avian h5n1 influenza a virus 3

Ngày tải lên : 11/09/2015, 09:58

... M and N, and the set of accessory proteins (namely ORF 3a, 3b, 6, 7a, 7b, 8a, 8b and 9b) The surface S protein is involved in the attachment and entry of the host cell The N together with M and ... properties and functions of the hemagglutinin of the H5N1 virus will be discussed in details in section 1.3.2.2 The characteristics, functions and/ or putative roles of the other structural and non-structural ... HA, NA and the cell surface, thus the release of virus from the host cell It may also allow the transport of the virus through the mucin layer in the respiratory tract to the target epithelial...

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Báo cáo y học: "The association of meat intake and the risk of type 2 diabetes may be modified by body weight"

Ngày tải lên : 31/10/2012, 16:49

... the amount consumed in lians (50g/lian) per unit of time A lian is the unit of weight in China equivalent to 50 g The reproducibility and validity of the FFQ was assessed in a random sample of ... a reduction in the risk of type DM for normal weight and overweight participants, but was unrelated to the risk of type DM in obese participants and the interaction factor was of marginal significance ... decrease in risk of type DM in the NHS II [6] No association between poultry consumption and risk of type DM was found in the Health Professionals Follow-Up Study [7], the WHS [3], or the NHS I [5]...

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Tài liệu THE GLOBAL ECONOMIC AND FINANCIAL CRISIS: Regional Impacts, Responses and Solutions doc

Ngày tải lên : 17/02/2014, 21:20

... impacting the member states of the five Regional Commissions of the United Nations, and examines the type and adequacy of responses at the national and regional levels It suggests ways in which the ... 978-92-1-120585-5 The designations employed and the presentation of the material in this publication not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations ... at the beginning, to the social consequences, and the disproportionate burden of the crisis on the poor and women Putting in place social protection systems is a centrepiece of the policy responses...

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Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf

Ngày tải lên : 18/02/2014, 04:20

... an important role in the formation of the MT1-MMP–furin complex; therefore, 3168 disruption of the interaction between GRASP55 and furin should perturb the activation of pro-MT1-MMP and reduce ... the important role of the LLY573 motif in the interaction between the protease and GRASP55 Interestingly, mutation of the LLY573 motif led to the detection of pro-MT1-MMP in the immunoprecipitate, ... on the other hand between GRASP55 and furin led us to hypothesize that GRASP55 could potentially play a role in the formation of a complex between MT1-MMP and furin To test this hypothesis, bbHT1080...

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Tài liệu Regulating Deviance: The Redirection of Criminalisation and the Futures of Criminal Law pptx

Ngày tải lên : 18/02/2014, 12:20

... moral standing in the matter of redressing wrongs Under the older welfare-liberal model of the state, a clear line was drawn between the role of the state and the role of the public, and in particular ... of the accused; the widening boundaries of the criminal law to include offences of preparation and planning; the scope and justification of offences against the person such as rape, assault and ... interpreters engaged in the rationalisation and modernisation of the criminal law On the other hand, they bear responsibility to interrogate the problems of the law, and to seek to understand its inherent...

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Tài liệu Regulating Football Commodification, Consumption and the Law pot

Ngày tải lên : 22/02/2014, 00:20

... terms of public order and ground safety The key theme running through this is the role played by the law in altering the shape and nature of the game and in particular the control of ‘fandom’ ... the creation of the Football Task Force The membership of the FTF raised eyebrows, especially the selection of David Mellor as the Chair, although the rest of the body attempted to draw together ... between 1924 and 1985.’ One of the crucial factors that greatly affected the shape of the game Regulating Football throughout the 1970s and 1980s was the condition of the grounds themselves A...

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Control of Innate and Adaptive Immune Responses during Infectious Diseases ppt

Ngày tải lên : 05/03/2014, 23:20

... is then secreted by the infected cell variety of stimuli, including PGE2 (Levy et al 2001) The interplay between these mediators, the induction of 5-lipoxygenase and the control of immune responses ... evasion and manipulation of immune responses as well as pathogen persistence The further investigation on the roles played by all of these mediators, their cellular sources, biochemical and cellular ... causing disease On the other hand, the absence of a proper timely host response may lead to uncontrolled pathogen replication and spread, often leading to the death of the host Nevertheless, this...

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