... methionine and histidine side chains that coordinate the heme iron, and the cysteine side chain that forms a thioether bond between heme and protein Also shown is the methyl group of the alanine of the ... Hepes (pH 6.5); these drops were seeded with microcrystals after equilibration for $ 48 h Crystals grew, and were harvested, within week Crystals were then picked up from the mother liquor containing ... heme-binding motif, and the sulfur of Met91 The ˚ heme iron–ligand distances were restrained to A (his˚ (methionine), and the model fits well tidine) and 2.3 A with these values The vinyl a-carbon–Cys28...
Ngày tải lên: 23/03/2014, 04:21
... for the poor, is the major public program covering long-term care for the elderly and for disabled people of all ages Despite the public’s tremendous interest in, and demand for, care in the ... the availability of caregivers On the one hand, divorces may estrange families and deter caregiving On the other hand, the new configurations of families may expand the pool of caregivers in the ... of the public has ebbed and flowed during the past three decades More and more Americans and their leaders face the dilemma of how to meet the needs of elders with chronic disabilities in the...
Ngày tải lên: 28/03/2014, 17:20
Báo cáo y học: "Inhalation with Fucose and Galactose for Treatment of Pseudomonas Aeruginosa in Cystic Fibrosis Patients"
... interleukin-10) were performed before and after treatment The study protocol was approved by the local Ethics Committee of the City of Hamburg, Germany Sputum sampling After rinsing their mouth with sterile ... to the suppression of lectin synthesis via the quorum sensing system (16) Antibiotics may therefore reduce the effectiveness of fucose/galactose This remains to be further evaluated On the other ... 5’-CCT TGG TCT GGT AGG AGA CG-3’ for the downstream primer PCR amplification for β-actin was performed for 36 cycles (1 at 94ºC, at 60ºC, 40 sec at 72ºC) and for TNFα for 40 cycles (1 at 94°C, at...
Ngày tải lên: 03/11/2012, 11:48
China’s banking reform: Issues and prospects for the future
... doing? Suggestions for future steps Restricted Why all care for China’s financial reform? China’s outstanding growth performance justifies optimism And yet, such huge saving and investment ratios ... Success of ongoing bank reform key: – For China’s economic development – For the rest of the world given China’s size & interlinkages Restricted An assessment of the reform so far a Restructuring ... risk management Before foreign exchange controls lifted: – Rregulations for foreign exposure need to be enhanced – Also deposit insurance scheme Better and wider external and internal auditing...
Ngày tải lên: 26/10/2013, 16:15
Criticism and experience - philosophy and literature in the German Enlightenment
... Breitinger and many others The debates on the nature of the beautiful and the sublime, on the differences between literature and the plastic arts, on the Aristotelian concepts of fear and pity ... existence The inherent optimism of this theory is grounded on the one hand in the principle of self-determination of each monad (and therefore of each individual human being) and on the other in the ... together with other individuals if possible, enjoys such a [constant] nature What that nature is is the knowledge of the union that the mind has with the whole of nature This, then, is the...
Ngày tải lên: 01/11/2013, 09:20
Hungry Minds Cliffs Gre_ANSWERS AND EXPLANATIONS FOR THE PRACTICE TEST
... Here, the cause (the pin) is a cause because of the effect (the pinprick), and so the effect (the pinprick) is treated as the origin of the cause (the pin) They are not identical, and they both ... airplane stored with the Dino is the Rickenbacher That means the other pair — the Lear and the Airheart — must be stored in the West warehouse along with the Kressna said to be stored and at least two ... stored with the Dino is the Rickenbacher That means that the other pair — the Lear and the Airheart — must be stored in the West warehouse along with the Kressna said to be stored and at least...
Ngày tải lên: 01/11/2013, 14:20
Tips and Strategies for the AWA
... Likewise, they must understand and participate in the workings of that society They must also respect and value their fellow citizens and their environment They must, in short, be good citizens, and ... should be valued for the expertise they provide But they should not be paid equally The more their education and experience, and the more challenging their subject, the higher their salaries should ... serve on a jury or in the military, understand their duty to pay taxes, vote to elect officials, and develop projects and programs that support and improve their communities For the United States...
Ngày tải lên: 02/11/2013, 17:20
Tips and Strategies for the Verbal Section
... irregular verbs with the same past and past participle forms irregular verbs with three distinct forms irregular verbs with the same present and past participle forms The following table lists the most ... performs the action For example, lie is intransitive; the subject of the sentence performs the action on itself: I will lie down The transitive verb laid, on the other hand, is an action that the ... rules for forming the present participle, past tense, and past participle: ■ ■ ■ ■ The present participle is formed by adding -ing The past and past participle are formed by adding -ed If the verb...
Ngày tải lên: 02/11/2013, 17:20
Esp at hanoi water resources university – recommendations and suggestions for the current course
... meets their needs much and only informants are satisfied with the course It can be proved that the course as well as the materials and the syllabus were not quite appropriate and interesting for the ... determine the content of the syllabus, the materials and methods of teaching / learning for these purposes With specific purposes in mind, the learners know clearly what they need to learn, and they ... in the form of question and answer All these constraints have negative effect on the quality of the English teaching and learning at the HWRU Until 2004, the textbooks used for stage one and...
Ngày tải lên: 29/01/2014, 14:43
Tài liệu TREES OF THE NORTHERN UNITED STATES THEIR STUDY, DESCRIPTION AND DETERMINATION FOR THE USE OF SCHOOLS AND PRIVATE STUDENTS doc
... The last of the four kinds of parts is found in the center of the flower, and is called the pistil It is this part which forms the fruit and incloses the seed The stamens and the pistil are the ... the pencil till it is in line with the ground at the base of the tree; move the arm and pencil upward till the thumb is in line with the paper, and note where the end of the pencil comes on the ... acquainted with all the useful and ornamental woods used in a region; the differences in the color of the heart-wood, the character of the annual layers, and the size and the distribution of the medullary...
Ngày tải lên: 13/02/2014, 12:20
Tài liệu Bevacizumab and cetuximab for the treatment of metastatic colorectal cancer docx
... respectively, with IFL as the comparator • 8.6% vs 0% in the smaller study with 5-FU/LV as the comparator • 16% vs 3% in the larger study with 5-FU/LV as the comparator For other grade and toxicities there ... guide for healthcare professionals Information for people with metastatic colorectal cancer and their carers (‘Understanding NICE guidance’) Details of all the evidence that was looked at and other ... 4.2.3 With discounting of 6% for costs and 1.5% for benefits, the cost per qualityadjusted life year (QALY) gained was £88,364 for bevacizumab combined with IFL compared with IFL alone With the...
Ngày tải lên: 14/02/2014, 22:20
Tài liệu Đề tài " Global well-posedness and scattering for the energy-critical nonlinear Schr¨odinger equation in R3 " docx
... from the rest of the solution One then removes this bubble, the remainder of the solution evolves, and then one uses perturbation theory, augmented with the additional information about the isolation ... paper, to Monica Visan and the anonymous referee for their thorough reading of the manuscript and for many important corrections, and to Changxing Miao and Guixiang Xu for further corrections We ... ≥N3 ≥N4 Performing the N1 sum, then the N2 , then the N3 , then the N4 , we obtain the desired bound of O(ε9/10 ), if δ is sufficiently small 3.4 Local well-posedness and perturbation theory It...
Ngày tải lên: 16/02/2014, 06:20
Tài liệu Báo cáo khoa học: Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc docx
... seen for the metabolism of D3, and not for the metabolism of 20-hydroxyvitamin D3 or 23-hydroxyvitamin D3, consistent with it being 17a-hydroxyvitamin D3 Reaction chemes with structures for the formation ... derivatives with potential physiological and therapeutic implications The present study aimed to determine the pathways for the metabolism of vitamin D3 by P450scc and to identify both major and minor ... prerequisite for cleavage of the bond between C20 and C22 [1,14] Another difference between the metabolism of vitamin D3 and cholesterol by P450scc is that the dissociation of intermediates occurs for the...
Ngày tải lên: 18/02/2014, 17:20
Tài liệu China’s Economic Rise: History, Trends, Challenges, and Implications for the United States pdf
... History, Trends, Challenges, and Implications for the U.S and reportedly forced the government to shut down some factories and reduce the level of official cars on the road.71 The Chinese government ... Challenges, and Implications for the U.S are in the United States (and China) Thus, one dollar exchanged for local Japanese currency would buy fewer goods and services there than it would in the United ... overtook Germany to become both the world’s largest merchandise exporter and the second-largest merchandise importer (after the United States) In 2012, China overtook the United States as the world’s...
Ngày tải lên: 20/02/2014, 20:20
Tài liệu department of defense policies and procedures for the acquisition potx
Ngày tải lên: 23/02/2014, 02:20
Cloning for reproductive purposes and cloning for the purposes of biomedical research potx
... reasons for limiting the freedom to reproduce are damage to the clones themselves, on the one hand, and, on the other, risks to the fabric of society, the d 43 potential for abuse, or the erosion ... further blurring of the boundary between human organisms on the one hand and, on the other, objects and instruments produced, used and consumed for purposes not inherent in those objects and ... intervention and normative regulation In the case of artificial fertilization, there is the additional factor that the transfer of the embryo to the uterus calls for the action of another person; the...
Ngày tải lên: 05/03/2014, 16:20
Culturally and Linguistically Appropriate Health Education Materials: Access, Networks, and Initiatives for the Future pdf
... who not speak the language of the patient they are looking for the materials for I think there should be one-to-one translation If you not speak the language or are not familiar with the culture ... credibility with providers and the public Formats: Participants listed several formats and formatting issues that may aid in producing materials and systems more likely to resonate with and be used ... together in a reasonable way They have created a center for people with communication issues, they know the latest technology, and they focus on ESL and vocational needs They have worked with...
Ngày tải lên: 05/03/2014, 21:20
Ethical Journalism A Handbook of Values and Practices for the News and Editorial Departments pdf
... set for bidding on the project 85 Within a reasonable period, taking into account the time frame for the project, The Times will inform the staff member in writing whether it wants to compete for ... individual to whom the guidelines apply The Times reserves the right to modify and expand the guidelines from time to time, as appropriate (See the letter of understanding with the Newspaper Guild ... ignoring their letters and e-mails that warrant reply 17 The Times gathers information for the benefit of its readers Staff members may not use their Times position to make inquiries for any other...
Ngày tải lên: 06/03/2014, 11:20
Unfolding the Future of the Long War - Motivations, Prospects, and Implications for the U.S. Army docx
... explores the concept of the long war and identifies potential ways in which it might unfold as well as the implications for the Army and the U.S military more generally Framework for Understanding the ... combined with our understanding of the components of the long war, provided the basis for a set of seven strategy options for the United States in the long war xvi Unfolding the Future of the Long ... the force based on the long war should weigh the effects they will have on longer-term planning horizons, and the enduring missions of the force In these terms, maintaining flexibility in the force...
Ngày tải lên: 06/03/2014, 20:20
Báo cáo khoa học: The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts doc
... significantly absorbed in the intestinal tract, and reach the colon mainly intact [27] They are therefore bioavailable to the epithelial cells in the intestinal wall, where procyanidins and other phenolics ... effective and safe agents for the prevention and treatment of cancer remains inefficient and costly, and falls short of the requirements for primary prevention among the high-risk population and for ... the cell cycle of the intestinal nontumoral cell lines IEC-18 and IEC-6, and even induced 10% necrosis in the IEC-6 cell line (Figs 2C and 3C) The results obtained provide information about the...
Ngày tải lên: 07/03/2014, 05:20