targets mechanisms of action and resistance in candida albicans
Roles of CASPA2 and HGC1 in morphological control and virulence in candida albicans
... (final concentration of uridine, arginine and histidine is 50 µg/ml) For hyphal growth in liquid medium, yeast cells were inoculated into one of the following three hypha-inducing media and incubated ... relevance of these findings to true hyphal growth remains unclear 1.3.4 Septin ring and morphological control Besides the polarization of actin cables and patches in the budding yeast, septin ring, ... ROLES OF CASPA2 AND HGC1 IN MORPHOLOGICAL CONTROL AND VIRULENCE IN CANDIDA ALBICANS ZHENG XINDE A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY INSTITUTE OF MOLECULAR AND CELL BIOLOGY...
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Characterization of CMX 13 and evaluation of efficacy and mechanisms of action in animal model of autoimmunity
... Annexin V- Fluorescein-isothiocyanate (FITC) /PI 49 VI Staining of Apoptotic Cells 2.3 CLINICAL AND HISTOLOGICAL STUDIES ON MRL-lpr/lpr MICE 2.3.1 52 Breeding Conditions and Examination for Clinical ... histological indices Hence CMX-13 appeared to be effective in attenuating the clinical and histological disease activity in the MRL-lpr/lpr mouse model of SLE In the final part of the thesis, we examined ... be the driving force for autoreactive B-cells in SLE resulting in abnormalities in cytokine production, and suppression of these autoreactive lymphocytes could result in inhibition of autoantibody...
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Tài liệu Women''''s attitudes towards mechanisms of action of family planning methods: survey in primary health centres in Pamplona, Spain doc
... in inconsistent responses We found inconsistencies in 12.2% of the sample, indicating the difficulties in communicating the information about the mechanism of action To assess the influence of ... would consider using and would stop or continue using In addition, hypothetical choices were examined in terms of a non-specific "method of family planning" and not in terms of actual methods ... beliefs independently of their actual choices and independently of their perceptions of available choices In our study, we also assessed women's understanding about the mechanisms of action of specific...
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Tài liệu BIOCHEMICAL TARGETS OF PLANT BIOACTIVE COMPOUNDS A pharmacological reference guide to sites of action and biological effects doc
... stereoisomer of cinchonidine), hydroquinidine (quinotidine), quinine and quinidine (P-quinine), these compounds all having a quinuclidinemethanol (l,4-ethylpiperidinylmethanol) substituent Quinine is ... iodothyronine deiodinase inhibitors (fisetin, kaempferol and morin); NADH and succinate dehydrogenase inhibitors (fisetin and myricetin); and protein kinase inhibitors (fisetin, galangin, isorhamnetin, ... anthocyanin cyanidin 3-O-glucoside Other anthocyanidins include apigeninidin, delphinidin, hirsutidin, luteolinidin, malvidin, pelargonidin, peonidin and petunidin, the structural variations arising...
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Báo cáo khoa học: Carbohydrate binding sites in Candida albicans exo-b-1,3-glucanase and the role of the Phe-Phe ‘clamp’ at the active site entrance ppt
... faces of sugar rings is a recurring feature of protein–carbohydrate interactions [16] and is a critical element of substrate recognition and specificity It involves a CH ⁄ p interaction in which ... diffusing too quickly away from the cell wall Surfacebased carbohydrate binding sites of weak affinity are well known (e.g in lectins and haemagglutinin) where Carbohydrate binding sites in Candida ... structure of Exg involving an oligosaccharide and provides an insight into the enzyme’s mechanism of action in the C albicans cell wall Finally, the unexpected discovery of an isolated binding site...
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Báo cáo khoa học: Mechanisms of obesity and related pathologies: Role of apolipoprotein E in the development of obesity potx
... tolerance and insulin sensitivity of the ApoE) ⁄ ) · Ay ⁄ + mice, and triggered obesity, indicating that circulating ApoE is involved in increased adiposity and obesity-related metabolic disorders Of ... phenotype and insulin and glucose levels became stronger with increasing body mass index [60,61] These findings again raise the interesting possibility that, although hyperplastic types of obesity ... lipolysis Development of : a) Diet-induced obesity b) Insulin resistance c) Glucose intolerance Fat cells Fig Model for the role of ApoE in the development of diet-induced obesity in mice Dietary lipids...
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NATIONAL ACTION PLAN for CHILD INJURY PREVENTION: An Agenda to Prevent Injuries and Promote the Safety of Children and Adolescents in the United States pptx
... existing training and education needs in schools and in professional organizations When developing a strategic framework for improving education and training for child injury prevention, each of ... identifying risk and protective factors, and, on the basis of this information, developing, implementing, and evaluating interventions, and promoting widespread adoption of evidence-based practices and ... training, and the need for in- service programs are among the challenges to integrating child injury prevention education and training into existing educational systems In addition, child injury...
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reaction mechanisms of inorganic and organometallic systems (topics in inorganic chemistry)
... Differentiation of Inner-Sphere and Outer-Sphere Mechanisms, 273 Bridging Ligand Effects in Inner-Sphere Reactions, 274 Intervalence Electron Transfer, 281 Electron Transfer in Metalloproteins, 285 Inorganic ... ball and stick models This type of modeling is capable of providing an indication of the effects of steric interactions on reactivity, but gives no measure of the actual energetics of the reaction ... straight line and the dashed curve shows the extent of the deviation from linearity The density and viscosity of liquids normally increase with increasing pressure and decrease with increasing temperature...
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báo cáo hóa học: " Type D personality in the general population: a systematic review of health status, mechanisms of disease, and work-related problems" docx
... an independent predictor of negative health outcomes such as poor health status, (recurrent) myocardial infarction, and increased risk of mortality [4-7] Given the clinical relevance of findings ... 2), Canada, Ireland, Poland, and Ukraine The results of the studies included in this review are first described below according to the impact of Type D personality on mental and physical health ... and experimental evidence regarding the role of Type D personality in potential mechanisms of disease as well as work-related Type D personality and mechanisms of disease Type D personality and...
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Báo cáo sinh học: "High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area" pdf
... 1.5 and were thus defined as having a high expression of ERCC1 As can be seen in Table a summary of result of the ERCC1 immunostaining of the cancer cells and its correlation with the clinicopathologic ... interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway Cancer Cell 2005, 7:575-589 40 Rabik CA, Dolan ME: Molecular mechanisms of resistance and toxicity associated with platinating ... antibody against the ligand-binding domain of EGFR Cetuximab binds Chiu et al Journal of Translational Medicine 2011, 9:31 http://www.translational-medicine.com/content/9/1/31 Page of Table Risk...
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báo cáo hóa học:" High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area" pdf
... 1.5 and were thus defined as having a high expression of ERCC1 As can be seen in Table a summary of result of the ERCC1 immunostaining of the cancer cells and its correlation with the clinicopathologic ... interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway Cancer Cell 2005, 7:575-589 40 Rabik CA, Dolan ME: Molecular mechanisms of resistance and toxicity associated with platinating ... antibody against the ligand-binding domain of EGFR Cetuximab binds Chiu et al Journal of Translational Medicine 2011, 9:31 http://www.translational-medicine.com/content/9/1/31 Page of Table Risk...
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Báo cáo y học: "Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action" pps
... amounts of leukotriene C4, 6-keto-prostaglandin F1alpha, prostaglandin F2alpha and interleukin-1beta in synovial fluid of patients with internal derangement in disorders of the temporomandibular joint ... synthesis, since HA inhibited their synthesis in a MW-dependent manner [16] Further, HA has been shown to induce analgesia in a bradykinin-induced model of joint pain in rats [17] This analgesic action ... proinflammatory cytokines IL-1 and TNF-α [29–31,36] NO may be involved in cartilage catabolism by inhibiting the synthesis of collagen and PG, enhancing MMP activity, reducing the synthesis of...
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Báo cáo khoa học: "Deletions of neuraminidase and resistance to oseltamivir may be a consequence of restricted receptor specificity in recent H3N2 influenza viruses" doc
... propagation in the presence of NA inhibitors include mutations in the drug binding site of NA, as in the resistance of recent H1N1 human isolates that carry the H274Y mutation, but in the 2003–2008 ... were intrinsic differences in HA binding in those viruses that are susceptible to loss of NA when grown in MDCK cells We previously showed that there were only quantitative differences in binding ... Hemagglutination and neuraminidase assays Hemagglutinin titrations were done in 96 well plates using 50 μl of serial dilutions of virus harvested from MDCK cells, and adding 50 μl of 0.8% human...
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Báo cáo y học: "Mechanisms of quadriceps muscle weakness in knee joint osteoarthritis: the effects of prolonged vibration on torque and muscle activation in osteoarthritic and healthy control subjects" pps
... interpretation of the data and the drafting and revision of the manuscript PM was involved in the conception and design of the study, analysis and interpretation of the data and in the revision of the ... transmission in Ia afferent fibres by increasing presynaptic inhibition, raising the activation threshold of Ia fibres and/ or causing neurotransmitter depletion at the Ia afferent terminal ending [29] In ... knee joint within weeks of testing Weight-bearing, fixed flexion radiographs of the knee were taken in the posteroanterior and lateral views [37] and scored by a single radiologist according to...
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Báo cáo khoa học: " Science review: Mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids" pdf
... are continuous with the sinuses of the medulla, which drain into the central vein of the medulla The right adrenal vein drains into the inferior vena cava and the left into the renal vein Hence, ... receptor binding domain of GRinteracting protein Thus, TNF-α may induce glucocorticoid resistance acting upstream and independently of nuclear factor-κB (NF-κB) [72] Molecular action of glucocorticoids ... corticosteroidbinding globulin and the free cortisol index during septic shock and multitrauma Intensive Care Med 2001, 27:1584-1591 46 Garrel DR: Corticosteroid-binding globulin during inflammation and burn injury:...
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Báo cáo y học: "Determinants and impact of multidrug antibiotic resistance in pathogens causing ventilator-associated-pneumonia" doc
... aetiology of VAP is an independent predictor of mortality using a multivariate competing risk analysis according to the methodology of Fine and Gray [21] Materials and methods Study design, patients and ... give consent Routine microbiological work-up of airway samples consisted of rapid Gram-staining and semi-quantitative culturing of tracheal aspirate On clinical request (in cases of discrepancy ... underpowering as few patients received inappropriate therapy: appropriate antibiotics were administered within 24 hours and within 48 hours in 85% and 93% of episodes, respectively, and in the subgroup...
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Báo cáo y học: "Quantifying the major mechanisms of recent gene duplications in the human and mouse genomes: a novel strategy to estimate gene duplication rates" docx
... cumulative number of duplicated genes in TAGs as a function of Ks were plotted in R [46] in both two-copy gene families and in the entire genome The interval of the data points in terms of Ks of the curves ... genes Of these, 8,312 in human and 8,105 in mouse are single-copy genes, and the remaining are clustered by Ensembl into 3,538 families in human and 3,600 families in mouse reviews Data compiling ... the results of this study will further our understanding of the mechanisms of gene duplication in mammals Pan and Zhang R158.3 comment of the human genome [32], and usually not contain genes [33]...
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Tasks in action in Vietnamese EFL high school classrooms- The role of rehearsal and performance in teaching and learning through oral tasks
... time and trust I sincerely thank the Department of Education and Training, the Head of the school and teaching staff of the school back home in Vietnam for their support and encouragement during ... teacher thinking underlying the way they design and implement tasks, and student engagement in tasks and learning outcomes, an important relationship given the tandem nature of teaching and learning ... from both teaching and learning Furthermore, existing research into general EFL instruction in Vietnam, mainly in university settings, has shown a lack of meaningful communication in the classroom...
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Mechanism of action and binding mode revealed by the crystal structures of key enzymes in plants sugar metalbolic pathway
... The ribokinase superfamily of proteins consists of fructokinases, E coli’s minor 6-phosphofructokinase, 1-phosphofructokinase, 6-phosphotagatokinases, E coli inosineguanosine kinase Following the ... Superimposition of F6P-SPS and S6P-SPS complexes Ten docked models of UDP interacting with the binding residues of H orenii SPS Ten docked models of ADP interacting with the binding residues of H orenii ... alignment of HoFRK 90 3.7 Stereo diagram of the conserved, binding residues of RK (magenta; PDB code 1RKD) interacting with both of its ligands ADP (white) and Ribose (white), with the corresponding and...
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Characterization of candida albicans cyclase associated protein CAP1 and its roles in morphogenesis g actin associates with the adenylyl cyclase cyr1 through cap1 and regulates cAMP synthesis in candida albicans hyphal morphogenesis
... shown to bind Abp1, an F-actin binding protein (Olazabal and Machesky, 2001), through the SH3binding domain (P2) This interaction leads to indirect interactions between Cap1 and F-actin Thus, ... of Cap1 and actin in regulating the adenylyl cyclase activity of Cyr1 both in vitro and in vivo First, I demonstrated that a protein complex containning Cyr1, Cap1 and actin can be purified and ... killing, release of chemokines and cytokines • neutrophil: phagocytosis, killing, release of chemokines and cytokines, costimulation • endothelial cell: killing, release of chemokines and cytokines...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn xác định thời lượng học về mặt lí thuyết và thực tế điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25