targeted therapy in squamous cell carcinoma of the head and neck

... The checkpointkinase (CHK2) 1100delC germ line mutation is not associated with the development of squamous cell carcinoma of the head and neck (SCCHN) Journal of Negative Results in BioMedicine ... basal cell carcinoma, and a melanoma; another one suffered from a prostate and a bladder carcinoma, and one patient experienced a colon carcinoma and a basal cell carcinoma Table The table shows the ... http://www.jnrbm.com/content/9/1/10 other than 1100delC in SCCHN as well as the definition of the role of CHK2 in the carcinogenesis of SCCHN remain to be an interesting matter for future investigations Abbreviations...

Ngày tải lên: 11/08/2014, 07:21

... glycosaminoglycan-associating proteins, increasing the capacity of these ligands to interact with their receptors, thereby lowing the threshold for signal transduction The binding of such ligands, including osteopontin ... Cancer stem cells in Head and Neck Squamous Cell Carcinoma In head and neck squamous cell carcinoma (HNSCC), Prince et al first isolated a highly tumourigenic subpopulation of cancer cells that ... a cancer on the decline in the developed world, a rising incidence suggests a continuing increase in the absolute numbers of cases to be treated in the coming decades.3 In India, incidence rates...

Ngày tải lên: 02/10/2015, 17:14

... doi:10.1186/1748-717X-5-89 Cite this article as: Jingu et al.: Carbon ion radiotherapy for basal cell adenocarcinoma of the head and neck: preliminary report of six cases and review of the literature Radiation Oncology ... L: Basal Cell Adenocarcinoma of the Salivary Glands Report of Seven Cases and Review of the Literature Cancer 1996, 78:2471-2477 Ellis GL, Wiscovitch JG: Basal cell adenocarcinoma of the major ... contrastenhanced MRI The clinical target volume (CTV) had minimum margins of 5.0 mm added around the GTV The planning target volume (PTV) included margins of 3.0-5.0 mm around the CTV, and this could...

Ngày tải lên: 09/08/2014, 09:20

... operation on the patient and was the primary editor of the manuscript RRB assisted in the care of the patient and edited the manuscript FW and YH provided the pathology images and interpretation ... search, no reports of SCC of the nipple following radiation therapy for breast carcinoma were found This result is surprising given the large number of patients undergoing radiation therapy for breast ... study, radiation therapy was associated with a 6.3 fold-increase in risk for NMSC (SCC and basal cell carcinoma) Of these cancers 90% occurred within the radiation field [10] The association between...

Ngày tải lên: 11/08/2014, 12:20

... Adjuvant and adjunctive chemotherapy in the management of squamous cell carcinoma of the head and neck region A meta-analysis of prospective and randomized trials J Clin Oncol 1996, 14:838-847 Jeremic ... AL: Influence of time delay and clinical upstaging in the prognosis of head and neck cancer Oral Oncol 2001, 37:94-98 Rapoport A, Sobrinho JA, Junior JS, Cubrero JD: Bleomycin on head and neck ... normal squamous epithelium (red arrows); carcinoma showing100×) Histology: a G3-grading (hematoxylin and eosin (HE) staining; Histology: normal squamous epithelium (red arrows); carcinoma showing...

Ngày tải lên: 12/08/2014, 01:22

... Metastases from Squamous Cell Carcinoma of the Cervix as Reported in the Literature (PubMed and Medline available since 1981) – search terms: squamous cell carcinoma AND “cervix”/ carcinoma cervix” ... nonkeratinizing squamous cells(*) similar to the cells seen in Figure 2a (*) 4b: Photomicrograph of staining with Cytokeratin shows strong cytoplasmic and membrane staining of the lesional cells ... lesional cells (*) with no staining in the adjacent duodenal mucosa (#) 2c: Photomicrograph of staining with P63 shows strong nuclear staining of the lesional cells (*) with no staining in the adjacent...

Ngày tải lên: 09/08/2014, 02:21

... strong positive membranous staining of the lesional cells (1E, black arrow); cytokerain (CK7) demonstrates the strong positive staining of the lesional cells in the subpleural lymphatics (1F, ... exempted by the Research ethics board of University of Saskatchewan as the consent of the patient or her next of kin for publication could not be obtained A copy of the waiver of consent from the Research ... metastases of carcinoma of the cervix in patients after primary surgical and radiotherapeutic management Int J Gynecol Cancer 2007, 17(5):1056-61 Shin MS, Shingleton HM, Partridge EE, et al: Squamous cell...

Ngày tải lên: 09/08/2014, 03:23

... malignancy involving the parotid gland Head Neck 2001, 23:744-748 Joseph MG, Zulueta WP, Kennedy PJ: Squamous Cell Carcinoma of the skin of the trunk and limbs: The incidence of metastases and their ... squamous cell carcinoma of the skin: Defining a high-risk group Ann Surg Oncol 2006, 13:902-909 Johnson TM, Rowe DE, Nelson BR, Swanson NA: Squamous cell of the skin (excluding lip and oral mucosa) ... cutaneous squamous cell carcinoma of the head and neck Head Neck 2006, 28:785-791 O'Brien CJ, McNeil EB, McMahon JD, Pathak I, Lauer CS: Incidence of cervical node involvement in metastatic cutaneous...

Ngày tải lên: 09/08/2014, 07:21

... hormonal therapy: intitially tamoxifen 20 mg daily for two and a half year and Figure Mammogram of the of the right breast of the patient in two directions Mammogram of the of the right breast of the ... squamous cell carcinoma when the malignant cells are all of the squamous cell type, there is no relation with the skin and if there is no indication for a primary location somewhere else in the ... to distinguish this type from mixed tumours, where some patches of squamous cells can be found in adenocarcinoma of the breast and from metastasis of squamous cell carcinoma of an origin somewhere...

Ngày tải lên: 09/08/2014, 07:22

... radiotherapy is the standard treatment for squamous cell carcinoma arising in the anal canal (1-4) Trials of conventional radiotherapy techniques have shown significant toxicity (1), and interest ... an abdominoperineal resection Interest in improving outcomes for these patients led to the discovery that these tumors responded to chemotherapy and radiotherapy Such therapy, delivered in a neoadjuvant ... FU and MMC remains the standard of care for squamous cell carcinoma of the anal canal The RTOG initiated a multi-institutional effort to prospectively treat patients with IMRT-based chemoradiotherapy...

Ngày tải lên: 09/08/2014, 09:21

... of the prostate (a; origHematoxilin Hematoxilin and eosin-stained sections showing solid sheets of squamous cells infiltrating the right lobe of the prostate (a; original magnification 10×) and ... cell, squamous cell, transitional cell, signet ring cell, mucinous and mixed types carcinomas occurs in less than 2% of cases [2,3] Pure squamous cell carcinoma (PSCC) comprises only 0,5–1% of ... variants of adenocarcinoma and other carcinomas of prostate: pathologic criteria and clinical significance Mod Pathol 1997, 10:612-619 Mott LJ: Squamous cell carcinoma of the prostate Report of cases...

Ngày tải lên: 09/08/2014, 10:21

... the variant of squamous cell carcinoma and large cell carcinoma [6] However, the clinical features and prognosis of basaloid squamous cell carcinoma of Table The influence factors of post-operative ... basaloid squamous cell carcinoma cases and 98 from PDSC cases Clinical features of basaloid squamous cell carcinoma and PDSC cases are summarized in Table Compared to the basaloid squamous cell carcinoma ... Hence, this single-center and retrospective study examines and compares the clinical features and prognosis of basaloid squamous cell carcinoma with PDSC of the lung to determine whether the former...

Ngày tải lên: 10/08/2014, 09:23

... malignancy in a single patient including a cervical carcinoma, a basal cell carcinoma of the skin and a neuroendocrine carcinoma from an unknown primary site: A case report and review of the literature ... synaptophysin, chromogranin and neural cell adhesion molecules (CD56) [11] The association of basal cell carcinoma and neuroendocrine carcinoma of the skin, also called Merkel cell carcinoma (MCC), is ... her cervix and involving the upper half of her vagina Biopsy confirmed the diagnosis of a well differentiated squamous cell carcinoma and the absence of parametrial infiltration; neither adenopathies...

Ngày tải lên: 10/08/2014, 23:20

... finding: Well-differentiated squamous cell carcinoma Biopsy finding: Well-differentiated squamous cell carcinoma plications, FA patients can have serious problems in adjuvant therapy due to increased ... [2,11,13] In FA patients, radiotherapy and chemotherapy follow different therapeutic principles In FA patients the increased susceptibility to XRT and CTx can present problems to determine and to ... Singh B: High incidence of head and neck squamous cell carcinoma in patients with Fanconi anemia Arch Otolaryngol Head Neck Surg 2003, 129:106-112 Kaplan MJ, Sabio H, Wanebo HJ, Cantrell RW: Squamous...

Ngày tải lên: 11/08/2014, 23:22

... cystic carcinomas of the head and neck are a unique kind of tumour deriving from cells of the major and minor salivary glands, they account for 25% of all malignant salivary gland tumours in different ... safe and feasible modality in the treatment of complex-shaped ACCs in the head and neck By using IMRT, high doses in the GTV and PTV can be achieved together with an excellent normal tissue sparing, ... Morrison WH, Ang KK, Peters LJ: The influence of positive margins and nerve invasion in adenoid cystic carcinoma of the head and neck treated with surgery and radiation Int J Radiat Oncol Biol Phys...

Ngày tải lên: 09/08/2014, 10:21

... Esophageal squamous cell carcinoma, BSCC = Buccal squamous cell carcinoma, OSCC = Oral squamous cell carcinoma, OSMF = Oral sub-mucous fibrosis, NPC = Nasopharyngeal carcinoma, HNSCC = Head and neck squamous ... metalloproteinase inhibitors (MMPIs) in cancer therapy Inhibition of MMP activity in the ECM has been involved in invasion of malignant cells Shah et al reported functional degradation of ECM and therapeutic ... capable of degrading most components of the extra cellular matrix (ECM) [7-9] Degeneration of matrix is a key event in invasion and metastasis of malignant lesions of the head and neck Tissue inhibitors...

Ngày tải lên: 10/08/2014, 05:21

... begins in the gut of the sandfly, but the organism completes its life cycle in the host following the fly bite The sandfly inoculates the host with the organisms in the promastigote stage Once the ... Montone / HEAD AND NECK INFECTIONS samples, and shell vial assays The hallmark of CMV infection is the finding of intranuclear inclusions consistent with herpesvirus infection The cells are often ... classified nasopharyngeal carcinoma into categories: WHO-1, keratinizing squamous cell carcinoma; WHO-2, nonkeratinizing squamous cell carcinoma; and WHO-3, undifferentiated carcinoma This latter entity...

Ngày tải lên: 19/02/2014, 08:20

... experts in the field of the pathology of the head and neck As such they are the main members of the Working Group on Pathology of the Head and Neck of the European Society of Pathology, one of the ... pioneers of Head and Neck Pathology in Europe and founding members of the Working Group on Head and Neck Pathology of the European Society of Pathology Foreword Pathology of the Head and Neck is an ... carcinomas can be distinguished from SCCs by the presence of glands and mucin secretion within the tumour cells 1.3.2.7 Treatment and Prognosis Squamous cell carcinomas of the head and neck have an overall...

Ngày tải lên: 29/06/2014, 09:20

... distribution of RT for NHL of the maxillary sinus (a) Dose distribution of RT for NHL of the maxillary sinus (b) and (c) PET-CT showing second SCC infiltrating the bone malignancies of the head and neck ... the site and pathological diagnosis, the interval from the time of RT to the diagnosis of the second HNC, and the clinical course of the second cancer We calculated the expected numbers of second ... diagnosis of the second HNC in all the cases (2 cases of cancer of the gum, case of tongue cancer, and case of maxillary sinus cancer) was SCC (fig 2) The median interval after the RT to the development...

Ngày tải lên: 09/08/2014, 10:20

... AA: An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer J Clin Oncol ... Papakostas P, et al: Induction chemotherapy with docetaxel and cisplatin followed by concomitant chemoradiotherapy in patients with inoperable non-nasopharyngeal carcinoma of the head and neck Anticancer ... cause inter- and intrastrand cross-linking These DNA cross-links are recognized and removed by the nucleotide excision repair pathway which arms to guard the integrity of the genome [15,16] The...

Ngày tải lên: 18/06/2014, 19:20