... flowers. Salem could hear the sound of water and birdsong.Then he heard other sounds. They came from the other old men .The men wore black, and they cried in their rooms. The first old man took ... Faisal went into the house, the barber waited outside in the street.Suddenly, he saw the judge, the girl's father. The judge came down the street and went into the house.Inside, the judge found ... Salem, and he followed the old man through the door. The inside ofthe house was very beautiful. The rooms were large, with floors of different colours. In the middle of the house was a lovely...
... flowers. Salem could hear the sound of water and birdsong.Then he heard other sounds. They came from the other old men .The men wore black, and they cried in their rooms. The first old man took ... end there. Other people weren't very happy - the forty thieves.Chapter 8 The End ofthe Forty ThievesWhen the thieves came back to the cave, they were very surprised. Where were the ... Salem, and he followed the old man through the door. The inside ofthe house was very beautiful. The rooms were large, with floors of different colours. In the middle ofthe house was a lovely...
... estimate the value of a person by his clothes. He added that he was in that shape from the curse of his sire, and that during the night he had the body of a man. Of his being the son of Indra there ... and the love of fiction. The Indians, the Persians, and the Arabians, were all famous for their fables. Amongst the ancient Greeks we hear ofthe Ionian and Milesian tales, but they have now ... ofthe most brilliant; and in the steadily increasing torpidity of his spirit, he traced the germs of that quietude which forms the highest happiness of man in this storm of matter called the...
... respectively. Although the over-all number of these modifications is low, the density of modifications is much the same as in the rest ofthe lin-ker histones. It is the shortness ofthe N-terminal tailsTable ... equalupregulation ofthe remaining variants, with only par-ticular variants being able to compensate. Third, thereare differences in the localization ofthe H1 variantswithin the nucleus, and there are ... tails ofthe H1variants does occur, but why do some researchers detectthem but others do not? Before addressing this question,there is also the issue as to what variety of PTMs occurin the...
... between the levels of expres-sion in the different experiments (Table 2). The resultsshow a clear relationship between the thermal stability of each variant and the level of protein secreted to the supernatant ... contain only the full-lengthvariants of lysozyme [15,17]. More recently, the occur-rence of another natural variantof lysozyme with the T70N mutation has been reported [18,19]. The T70Nmutation ... investigating the secreted levels of a larger number of lysozyme vari-ants, a highly significant correlation has been identifiedbetween the level of secreted protein and the thermo-stability ofthe native...
... her.’As these princesses grew up, their perfections grew with them. All the public talk was ofthe beauty ofthe elder and the rare good sense ofthe younger. It is true also that their defects ... Marquis of Carabas,’ answered they all to-gether, for the Cat’s threat had made them afraid.‘You have a good property there,’ said the King to the Marquis of Carabas.‘You see, sire,’ said the ... reached home the lord ofthe manor sent them ten crowns, which he had long owed them, and which they never hoped to see. is gave them new life, for the poor people were dy-ing of hunger. e...
... caseincontent [29,30], the M variant, like the goat as1-CasA and Bvariants, must be considered a ‘strong’ variant, given the intensity ofthe isoelectrofocusing bands and the surface of the relevant ... with the A variant. Therefore, band b represents the only componentspecific to t he M variant. The intensities ofthe bands in the MF pattern indicate that variant M is a ‘strong’ variant likevariants ... recombination at the as1-casein locus (Eur. J. Biochem. 269) 1303 skipping of three successive exons during the course of the processing ofthe primary transcripts [9]. At the peptidelevel, the CfiT...
... into the open country, past the huge flat-topped mountains of Ombokoro, the fastness ofthe Berg Damaras, thence following the dry river-bed ofthe Om- Mafako north-east to the confines ofthe ... beyond the dreams of these poor Bushmen there was a general exodus from the camp in search ofthe "bright stones." From their excited exclamations when I showed them the diamond, I gathered ... - THE SAND-STORM IV - THE PANS AND THE POISON FLOWERS V - I LOSE INYATI VI - THE CRATER THE PLEASANT BERRIES SLEEP AND THE AWAKENING VII - THE COUNTRY OF CRATERS, THE PATH OF SKULLS, AND THE...
... in the uniqueN-terminus, (b) binding ofthe N-terminus by ancillaryfactors, (c) the lack of a negatively functioning modulethat is present in the N-terminus of SAF-1 [26], or (d)all ofthe ... addition, methylation of the cytosines of CpG islands in the promoter or the firstexon has been shown to affect the rate of transcription[33], and ever since the clear demonstration of a causalrelationship ... matches the translationinitiation site consensus sequence as determined byKozak [25] (Fig. 2B). The second exon of SAF-3 (exon1C) starts at around the middle ofthe first exon of SAF-1/SAF-2. The...
... con-served in the primary structure ofthe GTPase domain of hGBP5, so the formation of GMP must be impairedin an as yet unknown manner. Sequence alignments of the large GTP-binding domains of hGBP1, ... for the lack of GMP formation(see Fig. S2). The similar hydrolytic activities of the a ⁄ b and C-terminally truncated forms of hGBP5 are incontrast to that ofthe analogous deletion mutant of hGBP1 ... account). The size ofthe protein complex is onlyslightly increased when nucleotide-free or in the presence of GTP. As with hGBP5ta, the complex isincreased to the size of a tetramer after binding of GppNHp,...
... indica-ted by the numbers on the right side. The migration ofthe proteinmarkers is indicated by pencil marks on the membrane. The arrowindicates the position ofthe wild-type and N130D variants of human ... corrected by subtracting the spectrum ofthe buffer solution (5 mm Tris ⁄ HCl, pH 7.5) in the absence of protein. The stability to thermal inactivation was examined byincubation ofthe enzymes at 80 ... further corro-borate the existence of active site differences between the isoenzymic forms of human arginase. In fact,whereas partial arginase activity is retained by the N130D variantof arginase...
... Glu103 residues of one subunit andArg104 residues ofthe other [8]. In this dimer, the rel-ative positions ofthe two subunits would prepare the molecule for the swapping ofthe N-terminal domainwhile, ... Analysis ofthe open interface ofthe dimeric form of PM8(DPM8). Ribbon representation ofthe domain-swapped crystallo-graphic structure ofthe human pancreatic ribonuclease variant, PM8, showing the ... have the same structure as the original monomer, with the exception ofthe ‘hinge loop’ that connects the tail with the rest ofthe structure (often referred to as the ‘body’). The interface between...
... temperature dependence of the ellipticity at 220 nm in the range of 25–85 °C; the tempera-ture was continuously changed at a rate of 0.5 Cặmin)1.Tm(temperature at the midpoint ofthe thermal transition)and ... aspergillosis; a-fragment, the oligonucleotide released from the 3Â end ofthe 28S rRNA in the largeribosomal subunit by the action of ribotoxins; D(7–22) mutant, protein variantof either a-sarcin or ... increased thermal stabilities. Thesechanges in stability can be explained by the sequencevariations between Aspf1 and a-sarcin, and also by the loss of a region ofthe protein in the deletion...
... the intracellular segment ofthe b1subunit isrequired for the interaction with the a subunit, probably acrucial step for the regulation of channel properties. The tissue distribution ofthe ... splicing variant ofthe b1subunit, rat b1A[7], have been cloned andcharacterized. The rat b1Asubunit is a splicing variantofthe b1subunit via intron retention. The N-terminal half of the b1Asubunit ... from that ofthe rat b1Asubunit.Therefore, a RACE-PCR technique was applied to clonea novel, splicing variantofthe human b1subunit. Toperform RACE-PCR of a novel C terminus ofthe humanb1subunit,...
... that impairment of signaling through the cAMPcascade occurs in these cells even in the absence of mutations in the coding region ofthe gene. Finally, ourstudy ofthe natural MC1R variants highlights ... shift ofthe displacement curve and by the lower amount of radioactivity bound in the absence of competitor (in spite ofthe lack of statistically significantdifferences in the number of binding ... the basis of their different meta-static potential.Fig. 1. Structure of MC1R. The topology ofthe TM fragments isdepicted according to the model proposed in [31], and the length of the signal...