t1 and t2 squamous cell carcinomas of the oropharynx

... thrombembolism of tumor cells The presence of the endothelium is needed for the success of this analysis Another reason is, that the conventional assessment cannot distinguish between lymphatic and blood ... concerning the status of nodal Sensitivity and specifity of the different methods for evaluation of lymphatic vessel invasion concerning the status of nodal metastasizing With the background of unknown ... World Journal of Surgical Oncology 2009, 7:25 Background Squamous cell carcinomas (SCC) are the most common malignant tumors of the larynx and hypopharynx The tumor morphology does...

Ngày tải lên: 09/08/2014, 04:21

... involving the parotid gland Head Neck 2001, 23:744-748 Joseph MG, Zulueta WP, Kennedy PJ: Squamous Cell Carcinoma of the skin of the trunk and limbs: The incidence of metastases and their outcome ... development of lymph node metastasis, the presence of scar or ulcers previously in the area of the tumor This was observed also in other studies [10,18] The association of UV damage and a burn ... number of lymph node metastasis was the presence of previous lesions on the skin of 22 patients with lymph node metastasis over the time pre- The 24 cases of amputations (42.1%) also reflected the...

Ngày tải lên: 09/08/2014, 07:21

... in the head and neck area, hypopharynx and oropharynx, were available for the risk of predisposing CHK2 mutations In the present study, we did not find the CHK2 1100delC variant in any of these ... SCCHN: squamous cell carcinomas of the head and neck Acknowledgements We are grateful to the patients who participated in this study All direct and indirect costs of this study were funded by the ... the presence of the 1100delC variant Discussion None of the investigated 91 patients with SCCHN carried the CHK2 1100delC variant The incidence of 1100delC in the population of the state NorthrhineWestphalia...

Ngày tải lên: 11/08/2014, 07:21

... http://www.head-face-med.com/content/4/1/7 midhand and in the bones of the foot [5] As to our knowledge, no case has been reported up to date on the manifestation of distant metastases of a SCC in the soft tissue of the extremities ... dysphagia The inspection of the oral cavity revealed an extensive lesion of the tongue (Fig 1) with areas of exophytic growth of the tumor as well as a large ulcus located at the dorsal part of the ... the case of the patient presented here, the quality of life was limited mainly by the tumor of the tongue causing impaired ability to swallow, reduced function of speech and impairment by esthetic...

Ngày tải lên: 12/08/2014, 01:22

... understanding of the intrinsic and extrinsic mechanisms of how these tumourigenic cells resist conventional treatments, self renew and metastasize may allow for the development of novel therapies and ... chemotherapeutics.56, 57 The abberant activation of epithelial-mesenchymal transition (EMT) facilitates metastasis by breakdown of cell- cell and cell- extracellular matrix contacts and confer cells the capacity ... characterize the role of cancer stem cells in the initiation, progression, invasion and metastasis of cancer, there is also much interest in the effect of current therapies upon these cells If by analogy...

Ngày tải lên: 02/10/2015, 17:14

... primary therapy (Table and 2), we also explored the additional impact of the use of adjuvant systemic therapy in the survival analysis (as main and interaction effect with TLR4 Asp299 genotype in the ... reviewed by one of the authors (AB) The percentage of tumor cells showing a positive membranous/cytoplasmatic staining and the intensity of staining were assessed Cases with complete lack of staining ... we investigated the influence of adjuvant systemic therapy on prognostic impact of TLR4 Page of hospital Essen, Germany All patients were diagnosed and treated at the Department of Otorhinolaryngology,...

Ngày tải lên: 18/06/2014, 22:20

... primary therapy (Table and 2), we also explored the additional impact of the use of adjuvant systemic therapy in the survival analysis (as main and interaction effect with TLR4 Asp299 genotype in the ... reviewed by one of the authors (AB) The percentage of tumor cells showing a positive membranous/cytoplasmatic staining and the intensity of staining were assessed Cases with complete lack of staining ... we investigated the influence of adjuvant systemic therapy on prognostic impact of TLR4 Page of hospital Essen, Germany All patients were diagnosed and treated at the Department of Otorhinolaryngology,...

Ngày tải lên: 20/06/2014, 04:20

... adenocarcinomas of the pancreas, colon, or stomach by intraperitoneal seeding Squamous cell carcinoma (SCC) of the cervix is the second most common gynecologic malignancy and the majority of patients ... as they are buried deep within the crypts A detailed review of the published English literature yielded only six cases of squamous cell carcinoma of the cervix with documented metastases to the ... Extrapelvic spread of squamous cell carcinoma (SCC) of the cervix to the small bowel is rare with only reported cases in the English literature since 1981(PubMed, Medline) We report the case of a 49-year-old...

Ngày tải lên: 09/08/2014, 02:21

... Saskatchewan as the consent of the patient or her next of kin for publication could not be obtained A copy of the waiver of consent from the Research Ethics Office, University of Saskatchewan, ... carcinomatosis (LC) is the diffuse infiltration and obstruction of the parenchymal lymphatic channels by a tumour [11] Cervical cancer rarely metastasizes to the lung, and the presentation of lymphangitic ... disease [5] Often, extensive involvement of the hilar, mesenteric, and para-aortic nodes, diaphragmatic, liver, and abdominal metastases can also co-exist in these patients [13] The use of radiation...

Ngày tải lên: 09/08/2014, 03:23

... hormonal therapy: intitially tamoxifen 20 mg daily for two and a half year and Figure Mammogram of the of the right breast of the patient in two directions Mammogram of the of the right breast of the ... Primary squamous cell carcinoma of the breast is very rare It is called primary pure squamous cell carcinoma when the malignant cells are all of the squamous cell type, there is no relation with the ... found in adenocarcinoma of the breast and from metastasis of squamous cell carcinoma of an origin somewhere else The etiology and pathogenesis of squamous cell carcinoma of the breast is still unclear...

Ngày tải lên: 09/08/2014, 07:22

... Reviewed charts, gathered data, and drafted the manuscript M.G.H.: Aided in the design of the study, helped draft the manuscript D.W.L.: Aided in the design of the study, helped draft the manuscript ... (3) The first 45 Gy of radiotherapy were concomitant with the first cycles of chemotherapy and used parallel opposed fields and a daily fraction of 1.80 Gy After 30.6 Gy was administered, the ... similar between groups Currently, radiotherapy delivered concurrently with FU and MMC remains the standard of care for squamous cell carcinoma of the anal canal The RTOG initiated a multi-institutional...

Ngày tải lên: 09/08/2014, 09:21

... Mott LJ: Squamous cell carcinoma of the prostate Report of cases and review of the literature J Urol 1979, 121:833-835 Mohan H, Bal A, Punia RP, Bawa AS: Squamous cell carcinoma of the prostate ... cell, squamous cell, transitional cell, signet ring cell, mucinous and mixed types carcinomas occurs in less than 2% of cases [2,3] Pure squamous cell carcinoma (PSCC) comprises only 0,5–1% of ... radiative therapy of carcinoma of the prostate A report on 15 years of experience Radiology 1973, 106:407-418 Kastendieck H, Altenahr E: The squamous cell carcinoma of the prostate as an example of...

Ngày tải lên: 09/08/2014, 10:21

... the variant of squamous cell carcinoma and large cell carcinoma [6] However, the clinical features and prognosis of basaloid squamous cell carcinoma of Table The influence factors of post-operative ... http://www.cardiothoracicsurgery.org/content/6/1/10 Page of Figure The actual survival time of basaloid squamous cell carcinoma and PDSC patients in stage I and stage II, p = 0.145 Discussion Basaloid squamous cell carcinoma of the lung as ... by Brambilla et al.: squamous cell differentiation or intercellular bridging and individual cell keratinization can be seen within the basal cell component, and the squamous cell component takes...

Ngày tải lên: 10/08/2014, 09:23

... carried out the operation on the patient and was the primary editor of the manuscript RRB assisted in the care of the patient and edited the manuscript FW and YH provided the pathology images and interpretation ... 5), and calponin and negative for estrogen and progesterone receptors as well as Her-2/ neu, supporting a diagnosis of SCC The resection margins were free of tumor and there was no evidence of ... immunostaining of SCC Page of vivor study, radiation therapy was associated with a 6.3 fold-increase in risk for NMSC (SCC and basal cell carcinoma) Of these cancers 90% occurred within the radiation...

Ngày tải lên: 11/08/2014, 12:20

... Preoperative hard and soft palate lesion Preoperative hard and soft palate lesion At the age of seven the patient was recovered for an orthopaedic trauma He had been diagnosed with FA at the age of seven ... screening of the oral cavity and oropharynx that should start between the ages of 15 and 20 However, in patients with FA with histrory of leucoplakia or recurrent oral lesions, head and neck examinations ... localization of hard and soft squamous cell carcinoma in a FA patient The atypical clinical manifestation rendered the diagnosis more difficult We recommend a quarterly follow up of the oral-rhino-phar-...

Ngày tải lên: 11/08/2014, 23:22

... approximately 26% of all OSCC of the head and neck worldwide [7] but the most accurate and consistent study for OSMF and OSCC, in which viral integration and the expression of viral oncogenes (E6 and E7) ... Integration often disrupts the integrity and expression of the E1 and E2 open reading frames, which may affect the transcription of E6 and E7 genes [10-13] In HPV-16 and HPV-18, the E2 proteins ... 34.23% females) On the basis of demographic distribution of the patients with 208 cases of the OSMF, of which 105 (50.48%) and 103 (49.52%) cases were below and above the age of 45 years respectively...

Ngày tải lên: 12/08/2014, 01:22

... from the date of start of chemotherapy to the date of death or most recent follow-up Progression free The median age of the patients was 53 years (range 3672 years), and fifty-five (96.5%) out of ... cisplatin is the backbone of the chemotherapy regimen as a component of IC and CCRT in the treatment of locally advanced HNSCC Its main cytotoxic activity is based on the formation of DNA adducts, ... an H score of more than 1.5 and were thus defined as having a high expression of ERCC1 As can be seen in Table a summary of result of the ERCC1 immunostaining of the cancer cells and its correlation...

Ngày tải lên: 18/06/2014, 19:20

... that of the three cell lines tested, MCF7 cells had high levels of Her3, BxPC3 cells had intermediate Her3, and A549 cells had low Her3 (Figure 1) We analyzed the expression pattern of Her2 and ... compartments of the cell - the cell membrane, using the same scoring system as applied for Her2, and the cytoplasm For the cytoplasmic staining, we scored both the intensity (0 (negative) to (strong)) and ... for the presence of tumor cells Western blot analysis of Her3 antibody For three cell lines, A549, MCF7 and BxPC3, a total × 107 cells were rinsed twice with ice-cold PBS and added 0.5 ml of the...

Ngày tải lên: 18/06/2014, 22:20

... approved by the Institutional Animal Care and Use Committee at the University of Kentucky and are in strict accordance with the National Institutes of Health Guidelines for the Care and Use of Laboratory ... detection of the level of dopaminergic neuronal terminals, and for normalization of the loading protein The signal was visualized by enhanced chemiluminescence according to the instructions of the ... counting The optical fractionator method of cell counting combines the optical dissector with fractional sampling, and is unaffected by the volume of reference (i.e., SNpc) or the size of the counted...

Ngày tải lên: 19/06/2014, 22:20

... from the date of start of chemotherapy to the date of death or most recent follow-up Progression free The median age of the patients was 53 years (range 3672 years), and fifty-five (96.5%) out of ... cisplatin is the backbone of the chemotherapy regimen as a component of IC and CCRT in the treatment of locally advanced HNSCC Its main cytotoxic activity is based on the formation of DNA adducts, ... an H score of more than 1.5 and were thus defined as having a high expression of ERCC1 As can be seen in Table a summary of result of the ERCC1 immunostaining of the cancer cells and its correlation...

Ngày tải lên: 20/06/2014, 03:20