symptoms of advanced nonsmall cell lung cancer

... mance of the registration method in p resence of large left lung atelectasis and mediastinum shift in the direction of the left lung: while the rigidly realigned MVCT lung presented a lung volume ... anatomical changes. In the cas e of Non-Small -Cell Lung Cancer (NSCLC), lung parenchyma can significantly modifyitsvolumeandshape[3].Asadirectconse- quence, in lungs, dose discrepancies can oc ... Abstract Background: The study of lung paren chyma anatomical modification is useful to estimate dose discrepancies during the radiation treatment of Non-Small -Cell Lung Cancer (NSCLC) patients. We

Ngày tải lên: 09/08/2014, 09:20

... BMC Cancer (2020) 20:275 Background Non-small -cell lung carcinoma (NSCLC) is one of the most common cancers worldwide, contributing for 13% of all cancer types [1] NSCLC represent the 85% of lung ... process Page of 10 of necrosis, presence/absence of TAR (a large variety of organic and inorganic chemicals generated by burning tobacco that forms a brown substance between lung cells; it is ... mutations from exons 18 to 21 in human lung cancer FFPE material (according to the latest IASLC atlas of EGFR testing in lung cancer) [21] The performance of the Idylla™ platform has been previously

Ngày tải lên: 17/06/2020, 11:13

... Mokhles et al BMC Cancer (2018) 18:79 DOI 10.1186/s12885-018-3986-5 RESEARCH ARTICLE Open Access Treatment selection of early stage nonsmall cell lung cancer: the role of the patient in clinical ... routine clinical practice in lung cancer care This can be explained by the fact that there is lack of familiarity with SDM [13, 14], and also because the care of lung cancer patient can be complex ... J M Takkenberg1 Abstract Background: The objective of this study is to investigate the role and experience of early stage non-small cell lung cancer (NSCLC) patient in decision making process

Ngày tải lên: 24/07/2020, 00:19

... stated Rouanne et al BMC Cancer (2016) 16:483 Background Lung cancer, with non-small cell lung cancer (NSCLC) constituting 85 % of cases, remains the most prevalent and lethal cancer worldwide [1] ... non-genetically altered stromal cells [8] Nevertheless, the dynamic process of dissemination and growth of cancer cells in metastatic sites remains unclear [9] Members of matricellular proteins, such ... crucial roles in cancer progression that lead to dissemination of tumor cells into pre-metastatic niches of other organs [6] Whereas genetic and epigenetic alterations in malignant cells have been

Ngày tải lên: 20/09/2020, 14:15

... non-small -cell lung cancer, treatment Citation: Duong Hong Quan, 2020 Personalized medicine for effective treatment of non-small -cell lung cancer with targeted therapies Academia Journal of Biology, ... treatment of lung cancer, with current focus on significant detection of clinical oncogenic drivers responsible for tumor initiation and maintenance and development of drug resistance In lung cancer, ... cell lung cancer (SCLC) accounts for 85% and 15% of all patients with lung cancer, respectively (Travis et al., 2013) NSCLC is divided into subtypes, being adenocarcinoma (ADC) and squamous cell

Ngày tải lên: 27/09/2020, 13:34

... BMC Cancer (2020) 20:837 Background Lung cancer is the cancer with the world’s highest morbidity and mortality [1] Non-small cell lung cancer (NSCLC) accounts for 80–85% of the cases of lung cancer ... diagnosis of brain metastasis in nonsmall cell lung cancer Neuro-Oncology 2010;12:1193–9 18 Enomoto Y, Takada K, Hagiwara E, Kojima E Distinct features of distant metastasis and lymph node stage in lung ... Brain metastases (BMs) are the main form of distant metastases in lung cancer and is one of the main causes of treatment failure [2, 3] Approximately 25% of patients with NSCLC suffer from BM,

Ngày tải lên: 28/09/2020, 09:27

... 157,300 deaths from lung cancer [4]. Lung cancer has traditionally been dichotomized into two groups based on the histological features of the tumor: small cell and non-small cell lung cancer. NSCLC ... common of the two sub-types of lung cancer, constituting 85% of cases [5,6]. Further- more, studies have shown that NSCLC has less of a cau- sal association with smoking than other forms of lung cancer ... non-small cell lung cancer comprise the majority of cases annotated within the database. Other cancers contained in the database include small cell lung cancer, mesothelioma, esophageal cancer,

Ngày tải lên: 10/08/2014, 09:22

... the sensitivity of non-small cell lung cancer (NSCLC) cells to cisplatin (DDP) remains unclear The aim of this study is to evaluate the roles of miR-451 in the sensitivity of NSCLC cells to DDP ... strategy for the treatment of human NSCLC Background NSCLC accounts for the majority of lung cancer cases and chemotherapy has been the mainstay of treatments of lung cancers [1] Up to date, DDP ... percentage of apoptotic cells was calculated as the number of apoptotic cells per number of total cells × 100% The mock or stably transfected A549 cells were seeded into 96-well plates (6.0 × 103 cells/well)

Ngày tải lên: 10/08/2014, 10:21

... patients who experienced curative-intent surgical resection of stage I non-small -cell lung cancer (NSCLC) Methods: We investigated a series of 1387 patients with stage I NSCLC who underwent surgical ... influencing overall survival, recurrence and postrecurrence survival in resected stage I nonsmall- cell lung cancer Chengdi Wang , Yuxuan Wu , Jun Shao , Dan Liu* and Weimin Li* Abstract Background: ... Wang et al BMC Cancer (2020) 20:150 https://doi.org/10.1186/s12885-020-6621-1 RESEARCH ARTICLE Open Access Clinicopathological

Ngày tải lên: 17/06/2020, 03:11

... stated in a credit line to the data Xu et al BMC Cancer (2020) 20:262 Background Non-small cell lung cancer (NSCLC) is the most common type of lung cancer Chemotherapy and radiotherapy, have reached ... Representative results of the cell cycle analyses by FACS CHD4 arrested the cell cycle in G1/S phase in A459 and H1299 cells (left) Quantification of the results of the cell cycle analysis was ... CHD4-mediated promotion of Xu et al BMC Cancer (2020) 20:262 Page of 11 Fig The effects of CHD4 up-regulation on NSCLC cell proliferation and migration a Detection of over-expression of the CHD4 gene

Ngày tải lên: 17/06/2020, 11:36

... Prognosis Background Non-small cell lung cancer (NSCLC) is a malignant tumor of the lung accounting for 85–90% of all lung cancers [1] It affects mainly adults > 65 years of age, men, and tobacco smokers ... is a member of the SET domain protein family [5–7] SETD5 is related to the aggressiveness of prostate and mammary cancers [22–24], but the mechanism of its role in nonsmall cell lung cancer remains ... is related to the aggressiveness of prostate and mammary cancers, but its association with non-small cell lung cancer (NSCLC) is unknown Therefore, the purpose of this research was to determine

Ngày tải lên: 17/06/2020, 16:59

... progression in a mouse model of lung cancer Genes Dev 2010;24(8):837–52 Rosell R, Lord RV, Taron M, Reguart N DNA repair and cisplatin resistance in non-small -cell lung cancer Lung Cancer 2002;38(3):217–27 ... non-small cell lung cancer cells by downregulating SAMD9 Oncol Lett 2016;11(2):945–52 19 Li W, Wang W, Ding M, Zheng X, Ma S, Wang X MiR-1244 sensitizes the resistance of non-small cell lung cancer ... knockdown of CCNJ increased cell sensitivity to DDP by inducing cell cycle arrest and cell apoptosis Notably, we found downregulation of CCNJ could enhance the gains of the Shi et al BMC Cancer

Ngày tải lên: 20/09/2020, 01:30

... Survivin, Non-small cell lung cancer, Pathological characteristics, Meta-Analysis Background Non-small cell lung cancer (NSCLC) remains one of the most fatal health problems in terms of morbidity and ... prognostic biomarker predicting the clinical outcome of nonsmall cell lung cancer (NSCLC) The study was conducted to explore the potential correlation of survivin protein expression with NSCLC and its ... survivin protein) and (non-small cell lung cancer or NSCLC or non-small -cell lung carcinoma) (update to January 2016) We also checked out the reference lists of all retrieved studies and relevant

Ngày tải lên: 21/09/2020, 09:52

... synthesis a Cell cycle of A549 cells and A549/DDP cells was analyzed with FACS The bar graphs showed the relative quantity of G1/S and G2/S ratio b Cell cycle analysis of A549/DDP cells transfected ... the world, and about 80 % cases are nonsmall cell lung cancer (NSCLC) In NSCLC, about 70–80 % cases are diagnosed at advanced stage and lost the opportunity of surgery, and chemotherapy is the ... tumorigenesis of many cancer types, such as lung cancer, medulloblastoma, leukaemia, hepatocellular carcinoma and so on [10–12] Cisplatin is a very common chemotherapeutic drug for anticancer chemotherapy

Ngày tải lên: 22/09/2020, 23:46

... cell lung cancer Clin Cancer Res 2005, 11:6459–6465 Chang YS, Kim HJ, Chang J, Ahn CM, Kim SK, Kim SK: Elevated circulating level of osteopontin is associated with advanced disease state of nonsmall ... significance of bone markers in patients with lung cancer metastatic to the skeleton: a review of published data Clin Lung Cancer 2011, [Epub ahead of print] Wai PY, Kuo PC: The role of Osteopontin ... chemotherapy and surgery for lung cancer However, the role of this hypoxia-related protein in radiotherapy of lung cancer is unclear We previously demonstrated the prognostic effect of baseline OPN plasma

Ngày tải lên: 30/09/2020, 15:07

... treatment in advanced non-small -cell lung cancer: a multicentre, randomised, placebo-controlled phase study Lancet Oncol 2010;11(6):521–9 Wang D, Lippard SJ Cellular processing of platinum anticancer ... al p53 sensitizes chemoresistant non-small cell lung cancer via elevation of reactive oxygen species and suppression of EGFR/PI3K/AKT signaling Cancer Cell Int 2019;19:188 Becker DJ, Lowe JB Fucose: ... controlling the levels and functions of proteins required for chemoresistance of cancer cells [27, 28] Inhibition of PI3K/Akt signaling can effectively augment tumor cell chemosensitivity to cisplatin

Ngày tải lên: 05/11/2020, 01:38

... microRNA-7 inhibited the growth of human non-small cell lung cancer A549 cells through targeting BCL-2 [29] Moreover, miRNA-145 was found to inhibit nonsmall cell lung cancer cell proliferation by targeting ... apoptotic rate of A549/antimiR-100 cells showed no significance changes compared with that of A549/anti-miR-NC cells (P > 0.05) Next, the effect of miR-100 expression on cell cycle of A549 cells was ... squamous cell carcinoma; AD: adenocarcinoma Effects of miR-100 expression on growth, apoptosis and cell cycle of NSCLC cells Next, the effects of miR-100 expression on malignant phenotypes of NSCLC cells

Ngày tải lên: 05/11/2020, 07:45

... surgery of the patients with recurrence of lung cancer was 1116 days Fig Lung cancer in midst of fibrotic shadow and/or interface of fibrotic shadow and normal lung These are examples of computed ... location of the cancers (p < 0.001) In group A, 84% of the cancers were in the lower lobe; in group B, 90% of the cancers were in the upper lobe; and in group C, the cancers Fig Lung cancer in ... normal lung (apart from reticular shadows or emphysema) a The example of computed tomography findings in the lung of a patient with lung cancer b This is an image showing rest of the lung of patient

Ngày tải lên: 06/05/2021, 15:36

... expansion of cancer stem cells in severely hypoxic regions in tumors (Keith & Simon, 2007) In our model of SCC, antiangiogenic treatments induce the expression of stem cell markers independently of ... of cancer- related death worldwide (Siegel et al, 2013) with about 1.4 million deaths annually across the world (Jemal et al, 2011) Non-small cell lung cancer (NSCLC) is the most common type of ... most common type of lung cancer accounting for approximately 85% of lung cancers NSCLC can be subdivided into two main histological subtypes: adenocarcinoma (ADC) and squamous cell carcinoma (SCC)

Ngày tải lên: 02/11/2022, 08:49

... Non-small cell lung cancer Background Lung cancer is the leading cause of cancer- related deaths globally, with an estimated 1,589,900 deaths in 2012 [1] In the USA, over 220,000 patients with lung cancers ... usually poor [5–7] In recent years, the molecular targets of lung cancer, especially for the main histological type non-small cell lung cancer (NSCLC), have been investigated, including epidermal ... feasible in every lung cancer clinic CT is a routinely used and relatively cost-effective modality in the diagnosis of lung cancer that presents various imaging features, some of which have been

Ngày tải lên: 24/11/2022, 17:45