symptomatic management and palliative care in neurodegenerative disease

Ngày tải lên: 28/03/2014, 23:20

... containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes Cell 72, 971–983 2356 T L Spires and A J Hannan Young AB (2003) Huntingtin in health and disease ... variability in brain ageing and associated cognitive 2355 Gene–environment interactions in neurodegenerative disease decline in all human populations, forming a template on which specific disease ... made in identifying genetic factors contributing to PD in recent years [135] Low concordance for clinical disease in monozygotic twins indicates environmental in uences on PD [136], and the finding...

Ngày tải lên: 16/03/2014, 19:20

... patients with incurable, progressive disease receiving palliative care in South Africa and Uganda in order to inform clinical care Secondary aims were to compare QOL in patients with cancer and patients ... key outcome of palliative care and should be assessed in future research evaluating interventions and models of care in Africa, in order to inform the provision of palliative care in the region ... for use in palliative care: a systematic review PALLIAT MED 2010, 24:17-37 25 Harding R, Dinat N, Sebuyira LM: Measuring and improving palliative care in South Africa: multiprofessional clinical...

Ngày tải lên: 12/08/2014, 01:22

... case in point, formation of huntingtin-containing inclusion bodies in Huntington’s disease encourages cell survival, whereas monomers and small inclusion bodies of huntingtin, a protein possessing ... aAcrystallin requires this domain [66] Attachment of R116C aA-crystallin to Hsp27 and aB-crystallin increases in comparison to wild type, while binding to cC-crystallin and bB2-crystallin decreases ... opaque with age and contain many inclusion bodies reactive with antibody to aB-crystallin, but not to b- and c-crystallin, suggesting an important role for aA-crystallin in maintaining lens transparency...

Ngày tải lên: 19/02/2014, 18:20

... Topics in Medical Informatics Chapter 1: Knowledge Management Data Mining and Text Mining in Medical Informatics Introduction Knowledge Management, Data Mining, and Text Mining: ... data mining Keywords knowledge management; data mining; text mining Knowledge Management, Data Mining and Text Mining INTRODUCTION The field of biomedical informatics has drawn increasing popularity ... Knowledge Management, Data Mining and Text Mining Most knowledge management, data mining, and text mining techniques involve learning patterns from existing data or information, and are therefore...

Ngày tải lên: 06/03/2014, 12:20

... Topics in Medical Informatics Chapter 1: Knowledge Management Data Mining and Text Mining in Medical Informatics Introduction Knowledge Management, Data Mining, and Text Mining: ... data mining Keywords knowledge management; data mining; text mining Knowledge Management, Data Mining and Text Mining INTRODUCTION The field of biomedical informatics has drawn increasing popularity ... Knowledge Management, Data Mining and Text Mining Most knowledge management, data mining, and text mining techniques involve learning patterns from existing data or information, and are therefore...

Ngày tải lên: 06/03/2014, 12:20

... planning of services A focus on prevention and tackling inequalities Integrated care – working together Promoting independence and personalisation of care Safeguarding the most vulnerable Ensuring ... Change A Growing & Ageing Population Poorer Health and Growth in Chronic Conditions Instability in the Health and Social Care System Increasing Pressure on Health and Social Care 18 Poorer Care & Treatment ... for example in arranging appointments, in explaining how to use the service and giving timely information This leads at times to disorganisation in our response to the individual and inefficiency...

Ngày tải lên: 07/03/2014, 04:20

... d-catenin The armadillo, ARM, domains, predicted 14-3-3 binding site and a PDZ binding motif are indicated (B) d-catenin complexes in adherens junction targeting and interaction with cadherin FEBS ... the insulin receptor tyrosine kinase substrate protein of 53 kDa (IRSp53) IRSp53 is an SH3 domain-containing adaptor protein originally identified as a substrate of the insulin receptor kinase ... Mochizuki N (2004) A novel actin bundling ⁄ filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein J Biol Chem 279, 14929–14936...

Ngày tải lên: 16/03/2014, 22:20

... hyperphosphorylated in the DS brain Gene dosage-related increases in DYRK1A levels in DS appear to be the major factor distinguishing the pattern and consequences of tau protein hyperphosphorylation in DS and in ... protein at the sites that are phosphorylated in AD In NFTs, tau protein is phosphorylated by several protein kinases, including GSK-3b, cyclin-dependent kinase5 (CDK5), c-Jun N-terminal kinase, ... common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson’s disease, Pick’s disease, and Alzheimer’s disease, as well as Rosenthal fibers in cerebellar...

Ngày tải lên: 22/03/2014, 16:21

... I16 those providing day-to-day care to patients and carers those who specialise in palliative care (consultants in palliative medicine and clinical nurse specialists in palliative care, for example), ... providers is involved in delivering supportive and palliative care services, including those in primary care, secondary care and the voluntary and social sectors Many work within multidisciplinary teams ... Networks in England and the three Cancer Networks in Wales in developing integrated care, improving clinical outcomes, providing cost-effective services, improving the experience of patients and carers...

Ngày tải lên: 28/03/2014, 23:20

... 13.2 Rating assignment 13.2.1 Internal ratings and agency ratings: how they differ? 13.2.2 The assignment of agency ratings 13.2.3 Rating assessment in bank internal rating systems 13.3 Rating quantification ... Risk Management and Shareholders’ Value in Banking For other titles in the Wiley Finance Series please see www.wiley.com/finance Risk Management and Shareholders’ Value in Banking From Risk ... directors and senior management; policies and procedures for managing interest rate risk; systems for measuring and monitoring risk, and for internal controls; and information to be provided to supervisory...

Ngày tải lên: 30/03/2014, 15:20

... undertaken in palliative care sites, in South Africa and in Uganda, based in rural, periurban and urban areas, including homecare, day care and inpatient facilities Two of the sites provide care from ... multi-centre, international approach with early and ongoing input of pan-African clinicians and researchers, and the full validation in diverse inpatient and home care settings, in both HIV and cancer ... outcome tools Progress in Palliative Care 2007, 15:55-59 12 Collins K, Harding R: Improving HIV management in sub-Saharan Africa: How much palliative care is needed? AIDS Care 2007, 19(10):1304-1306...

Ngày tải lên: 18/06/2014, 19:20

... 13.2 Rating assignment 13.2.1 Internal ratings and agency ratings: how they differ? 13.2.2 The assignment of agency ratings 13.2.3 Rating assessment in bank internal rating systems 13.3 Rating quantification ... Risk Management and Shareholders’ Value in Banking For other titles in the Wiley Finance Series please see www.wiley.com/finance Risk Management and Shareholders’ Value in Banking From Risk ... directors and senior management; policies and procedures for managing interest rate risk; systems for measuring and monitoring risk, and for internal controls; and information to be provided to supervisory...

Ngày tải lên: 28/06/2014, 17:20

... http://www.implementationscience.com/content/3/1/35 Interpreting CPGs Variability in client needs In interpreting clinical practice guidelines and translating these into a skill and competency input required for individual management, ... the prevention and management of chronic diseases in the primary care setting This includes allied health disciplines, community nursing and medical, covering both current and emerging occupational ... best practice care Because of the large involvement of governments in the funding and delivery of health care, and the joint control over training and accreditation by governments and professional...

Ngày tải lên: 11/08/2014, 05:21

... often provides primary and inpatient care services to a surrounding urban and nearby rural catchment area and, in principle, also provides referral care and inpatient services in support of a network ... made in improving paediatric care, or in implementing available WHO and national treatment recommendations in the four years between the baseline surveys reported and similar surveys in 2002 involving ... diagnosis, and treatment, key aspects of inpatient care and outcome Aim: 400 randomly selected case records per site from the six months prior to the survey Caretaker interview (used after gaining informed...

Ngày tải lên: 11/08/2014, 05:21

... hospitals, during the 18 months intervention period H1 Length of Initial Training (days) Total staff at initial training Doctors at initial training Clinical Officers at initial training Nurses at initial ... Baseline training Baseline training Baseline training Baseline training Supervision and feedback Supervision and feedback Survey two Supervision and feedback Survey two Survey two Supervision and ... Within the full intervention package (four hospitals) we aimed to deliver training, guidelines, external supervision, and feedback on progress made in improving care in line with the standards and...

Ngày tải lên: 11/08/2014, 05:21

... often provides primary and inpatient care services to a surrounding urban and nearby rural catchment area and, in principle, also provides referral care and inpatient services in support of a network ... made in improving paediatric care, or in implementing available WHO and national treatment recommendations in the four years between the baseline surveys reported and similar surveys in 2002 involving ... diagnosis, and treatment, key aspects of inpatient care and outcome Aim: 400 randomly selected case records per site from the six months prior to the survey Caretaker interview (used after gaining informed...

Ngày tải lên: 11/08/2014, 16:20

... http://www.implementationscience.com/content/3/1/35 Interpreting CPGs Variability in client needs In interpreting clinical practice guidelines and translating these into a skill and competency input required for individual management, ... the prevention and management of chronic diseases in the primary care setting This includes allied health disciplines, community nursing and medical, covering both current and emerging occupational ... best practice care Because of the large involvement of governments in the funding and delivery of health care, and the joint control over training and accreditation by governments and professional...

Ngày tải lên: 11/08/2014, 16:21

... the prodomain maintaining the catalytic site inactive and the metalloproteinase domain containing the Zinc binding site ADAM activation mechanisms are mostly similar to MMP's activation and generally ... metalloproteinase domain with its catalytic consensus site is active in only about half of ADAM proteinases The following domains are characteristic of ADAMs and include a disintegrin domain mediating ... cell-matrix interactions via the interaction with integrins; a cystein-rich domain implicated in cell adhesion; an epidermal growth factor (EGF)-like domain and a cytoplasmic tail involved in various intracellular...

Ngày tải lên: 12/08/2014, 14:20