Tài liệu hạn chế xem trước, để xem đầy đủ mời bạn chọn Tải xuống
1
/ 655 trang
THÔNG TIN TÀI LIỆU
Thông tin cơ bản
Định dạng
Số trang
655
Dung lượng
42,61 MB
Nội dung
MEDICAL
INFORMATICS
Knowledge Management
and DataMiningin
Biomedicine
INTEGRATED SERIES IN INFORMATION SYSTEMS
Series Editors
Professor Ramesh Sharda Prof. Dr. Stefan Vo13
Oklahoma State University Universitat Hamburg
Other published titles in the series:
E-BUSINESS MANAGEMENT:
Integration of Web Technologies with Business
Models1
Michael
J.
Shaw
VIRTUAL CORPORATE UNIVERSITIES:
A Matrix of Knowledgeand Learning
for the New Digital
DawdWalter R.J. Baets
&
Gert Van der Linden
SCALABLE ENTERPRISE SYSTEMS:
An Introduction to Recent Advances1
edited by Vittal Prabhu, Soundar Kumara, Manjunath Kamath
LEGAL PROGRAMMING:
Legal Compliance for RFID and Software Agent
Ecosystems in Retail Processes and Beyond1
Brian Subirana and Malcolm Bain
LOGICAL DATA MODELING:
What It Is and How To Do It1
Alan Chmura and
J. Mark Heumann
DESIGNING
AND
EVALUATING E-MANAGEMENT DECISION TOOLS:
The
Integration of Decision and Negotiation Models into Internet-Multimedia
Technologies1
Giampiero E.G. Beroggi
INFORMATION ANDMANAGEMENT SYSTEMS FOR PRODUCT
CUSTOMIZATIONI Blecker, Friedrich, Kaluza, Abdelkafi
&
Kreutler
MEDICAL
INFORMATICS
Knowledge Management
and DataMiningin
Biomedicine
edited
by
Hsinchun Chen
Sherrilynne S
.
Fuller
Carol Friedman
William Hersh
Springer
-
Hsinchun Chen Sherrilynne S. Fuller
The University of Arizona, USA University of Washington, USA
Carol Friedman William Hersh
Columbia University, USA Oregon Health
&
Science Univ., USA
Library of Congress Cataloging-in-Publication Data
A
C.I.P. Catalogue record for this book is available
from the Library of Congress.
ISBN-10: 0-387-2438 1-X (HB)
ISBN- 10: 0-387-25739-X (e-book)
ISBN- 13: 978-0387-2438 1-8 (HB) ISBN- 13: 978-0387-25739-6 (e-book)
O
2005 by Springer Science+Business Media, Inc.
All rights reserved. This work may not be translated or copied in whole or in
part without the written permission of the publisher (Springer Science
+
Business Media, Inc., 233 Spring Street, New York, NY 10013, USA), except
for brief excerpts in connection with reviews or scholarly analysis. Use in
connection with any form of information storage and retrieval, electronic
adaptation, computer software, or by similar or dissimilar methodology now
know or hereafter developed is forbidden.
The use in this publication of trade names, trademarks, service marks and
similar terms, even if the are not identified as such, is not to be taken as an
expression of opinion as to whether or not they are subject to proprietary rights.
Printed in the United States of America.
98765432
1
SPIN
1
1055556
TABLE OF CONTENTS
Editors' Biographies
xix
Authors' Biographies
xxiii
Preface
xxxix
UNIT I: Foundational Topics inMedicalIn formatics
Chapter
1:
Knowledge Management. Data Mining. and
Text MininginMedicalInformatics
3
Introduction
5
Knowledge Management, Data Mining, and Text Mining: An
Overview
6
2.1 Machine Learning andData Analysis Paradigms
7
2.2 Evaluation Methodologies
11
Knowledge Management, Data Mining, and Text Mining
Applications inBiomedicine
12
3.1 Ontologies
13
3.2 KnowledgeManagement
14
3.3 DataMiningand Text Mining
18
3.4 Ethical and Legal Issues for DataMining
22
Summary
22
References
23
Suggested Readings
31
Online Resources
31
Questions for Discussion
33
Chapter
2:
Mapping MedicalInformatics Research
35
1
.
Introduction
37
2
.
Knowledge Mapping: Literature Review 37
3
.
Research Design
39
3.1 Basic Analysis
39
3.2 Content Map Analysis
40
3.3 Citation Analysis
41
4
.
Data Description
42
5
.
Results
44
5.1 Basic Analysis
44
5.2 Content Map Analysis
47
5.3 Citation Network Analysis
55
6
.
Conclusion and Discussion 57
7
.
Acknowledgement 58
References
58
Suggested Readings 60
Online Resources 61
Questions for Discussion 61
Chapter 3: Bioinformatics Challenges and Opportunities
63
1
.
Introduction
65
2
.
Overview of the Field
69
2.1 Definition of Bioinformatics
69
2.2 Opportunities and Challenges
-
Informatics Perspective
70
2.3 Opportunities and Challenges
-
Biological Perspective
79
3
.
Case Study 83
3.1
Informatics Perspective
-
The BIOINFOMED Study
and Genomic Medicine
83
3.2 Biological Perspective
-
The BioResearch Liaison
Program at the University of Washington
85
4
.
Conclusions and Discussion
89
5
.
Acknowledgements 91
References
91
Suggested Readings
92
Online Resources
93
Questions for Discussion 93
Chapter
4:
Managing Information Security and Privacy in Health Care
Data Mining: State of the Art
95
1
.
Introduction 97
.
2 Overview of Health Information Privacy and Security 98
2.1
Privacy and Healthcare Information
99
2.2
Security and Healthcare Information
99
3
.
Review of the Literature: DataMiningand Privacy
and Security 109
vii
3.1
General Approaches to Assuring Appropriate Use
110
3.2 Specific Approaches to Achieving Data Anonymity
112
3.3 Other Issues in Emerging "Privacy Technology"
116
3.4 "Value Sensitive Design": A Synthetic
Approach to Technological Development
117
3.5 Responsibility of Medical Investigators
119
4
.
Case Study: The Terrorist Information Awareness
Program (TIA)
12 1
4.1 The Relevance of TIA to DataMininginMedical
Research
121
4.2 Understanding TIA
122
4.3 Controversy
124
4.4 Lessons Learned from TIA's Experience for Medical
Investigators Using "Datamining" Technologies
128
5
.
Conclusions and Discussion
129
6
.
Acknowledgements
131
References
131
Suggested Readings
134
Online Resources
135
Questions for Discussion
13 7
Chapter
5:
Ethical and Social Challenges of Electronic
Health Information
139
1
.
Introduction
141
2
.
Overview of the Field
142
2.1 Electronic Health Records
142
2.2 Clinical Alerts and Decision Support
146
2.3 Intemet-based Consumer Health Information
150
2.4 Evidence-based Medicine, Outcome Measures.
and Practice Guidelines
152
2.5 DataMining
153
References
156
Suggested Readings
157
Online Resources
157
Questions for Discussion
158
viii
UNIT 11: Information andKnowledgeManagement
Chapter 6: Medical Concept Representation
163
1
.
Introduction 165
1.1 Use-cases 165
2
.
Context
168
2.1 Concept Characteristics
169
2.2 Domains
170
2.3 Structure 171
3
.
Biomedical Concept Collections
172
3.1 Ontologies 172
3.2 Vocabularies and Terminologies 174
3.3 Aggregation and Classification 175
3.4 Thesauri and Mappings 176
4
.
Standards and Semantic Interoperability
177
5
.
Acknowledgements 178
References 178
Suggested Readings 180
Online Resources 181
Questions for Discussion
181
Chapter
7:
Characterizing Biomedical Concept
Relationships: Concept Relationships as a Pathway
for Knowledge Creation and Discovery
183
.
1 Introduction
185
2
.
Background and Overview: The Use of Concept
Relationships for Knowledge Creation 188
2.1 Indexing Strategies and Vocabulary Systems 190
2.2 Integrating Document Structure in Systems 192
2.3 Text Mining Approaches
194
2.4 Literature-based Discovery IR Systems 195
2.5 Summary 198
.
3 Case Examples 198
3.1 Genescene 199
3.2 Telemakus 200
3.3 How Can a Concept Relationship System Help
with the Researcher's Problem and Questions?
202
3.4 Summary
206
4
.
Conclusions and Discussion
206
5
.
Acknowledgements
207
References
207
Suggested Readings
209
Online Resources
210
Questions for Discussion
210
Chapter 8: Biomedical Ontologies 211
1
.
Introduction
213
2
.
Representation of the Biomedical Domain in General
Ontologies
215
2.1 OpenCyc
215
2.2 WordNet
215
3
.
Examples of Medical Ontologies
217
3.1 GALEN
217
3.2 Unified Medical Language System
219
3.3 The Systematized Nomenclature of Medicine
220
3.4 Foundational Model of Anatomy
222
3.5 MENELAS ontology
223
4
.
Representations of the Concept
Blood
224
4.1
Blood
in Biomedical Ontologies
225
4.2 Differing Representations
227
4.3 Additional Knowledge
229
5
.
Issues in Aligning and Creating Biomedical Ontologies
230
6
.
Conclusion
231
7
.
Acknowledgments
232
References
232
Suggested Readings
234
Online Resources
234
Questions for Discussion
235
Appendix: Table showing characteristics of selected ontologies 235
Chapter
9:
Information Retrieval and Digital Libraries
237
Overview of Fields
239
Information Retrieval
241
2.1 Content
242
2.2 Indexing
247
2.3 Retrieval
254
2.4 Evaluation
257
2.5 Research Directions
261
Digital Libraries
262
3.1 Access 262
3.2 Interoperability 263
3.3 Preservation 263
Case Studies 264
4.1 PubMed
264
4.2 User-oriented Evaluation 265
4.3
Changes in Publishing
267
Acknowledgements
269
References
269
Suggested Readings
273
Online Resources
274
Questions for Discussion
275
Chapter
10:
Modeling Text Retrieval inBiomedicine
277
1
.
Introduction
279
2
.
Literature Review
280
3
.
An Ideal Model
282
4
.
General Text Retrieval
284
4.1 Vector Models
284
4.2 Language Models
286
5
.
Example Text Retrieval Systems Specialized to a
Biological Domain
288
5.1 Telemakus
289
5.2 XplorMed
290
5.3 AI3View:HivResist
291
5.4 The Future
292
[...]... major US corporations and been awarded numerous industry awards including: AT&T Foundation Award in Science and Engineering, SAP Award in ResearchlApplications, and Andersen Consulting Professor of the Year Award Dr Chen has been heavily involved in fostering digital library, medical informatics, knowledge management, and intelligence informatics research and education in the US and internationally Dr... l@health.state.ny.us) Zan Huang is a PhD candidate inManagement Information Systems at the University of Arizona and is a research associate in the Artificial Intelligence Lab He earned his B.Eng inManagement Information Systems from Tsinghua University His research interests include data miningin biomedical and business applications, recommender systems, and mapping knowledge domains (Eniail: zhuang@eller.arizona.edu... research interests are in text -mining andknowledge representation (Email: dingjing@iastate.edu) Pan Du received the BS and MS degrees in Electrical Engineering from National University of Defense Technology, Changsha, China, in 1995 and 1998, respectively He is currently a co-major PhD student in Electrical Engineering major and Bioinformatics and Computational Biology major at Department of Electrical and. .. tagging, information extraction and text datamining (Email: tanabe@ncbi.nlm.nih.gov) Peter Tarczy-Hornoch, MD, is an Associate Professor in the Department of Pediatrics andin the Department of Medical Education and Biomedical Informaticsand an Adjunct Associate Professor in the Department of Computer Science and Engineering at the University of Washington Within the Department of Medical Education and. .. Telemakus: Miningand Mapping Research Findings to Promote Knowledge Discovery in Aging funded by the Ellison Medical Foundation; Co-Investigator of Biomedical Applications of the Next Generation Internet (NGI): Patientcentric Tools for Regional Collaborative Cancer Care Using the NGI funded by the National Library of Medicine; Co-Investigator of an International Health and Biomedical Research and Training... University Purdue University Indianapolis He received his Ph D in computer science from Concordia University, Montreal in 1987 His primary research interests are in pattern analysis and machine intelligence He is working on problems related to information management using information filtering and text mining approaches and structural health monitoring and smart diagnostics based on intelligent computational... Sciences and MS inManagement Information Systems from the University of Arizona Her research interests lie in biomedical data mining, knowledge integration, and their applications in genomics (Email: hsu@eller arizona.edu; URL: http:Nai.eller.arizona.edu/people/hsu/) Lorraine Tanabe, PhD, holds a B.S in Molecular Biology from San Jose State University, and a PhD in Computational Sciences and Informatics. .. Division of General Internal Medicine of the Department of Medicine andin the Department of Public Health and Preventive Medicine Dr Hersh obtained his B.S in Biology from the University of Illinois at Champaign-Urbana in 1980 and his M.D from the University of Illinois at Chicago in 1984 After finishing his residency in Internal Medicine at University of Illinois Hospital in Chicago in 1987, he completed... Readings 590 Online Resources 590 Questionsfor Discussion 591 Chapter 21: Joint Learning Using Multiple Types of Dataand Knowledge 593 1 2 3 4 Introduction 595 Overview of the Field 597 2.1 Large-scale Biological Data and Knowledge Resources .597 2.2 Joint Learning Using Multiple Types of Data 599 2.3 Joint Learning Using Data and. .. Professor in the Department of Computer and Information Science and Associate Director (Bioinformatics) in the School of Informatics at Indiana University Purdue University Indianapolis Dr Mukhopadhyay is a holder of degrees from Jadavpur University, India and the Indian Institute of Science, India as well as a Master of Science and Doctorate in Electrical Engineering from Yale University His research interests . Management, Data Mining, and Text Mining
Applications in Biomedicine
12
3.1 Ontologies
13
3.2 Knowledge Management
14
3.3 Data Mining and Text Mining. Topics in Medical In formatics
Chapter
1:
Knowledge Management. Data Mining. and
Text Mining in Medical Informatics
3
Introduction
5
Knowledge Management,