subcommittee investigation and findings of fact

... advantage of p53 mutation analysis, and a unique feature of this database, is the availability of the residual activity of the majority of p53 missense mutants The biological activity of mutant ... classified correctly in 85% of cases and Table Effect of cut-off value on the prediction accuracy The prediction accuracy, specificity, sensitivity, number of mutants classified and MCC values on training ... domain of the protein and were used for training and evaluation of our prediction algorithm Of the eight promoters, we studied the WAF1 promoter in greatest detail with additional testing and usage...

Ngày tải lên: 18/02/2014, 11:20

... lack of awareness by patients and physicians of the treatment guidelines and efficacy of medications for osteoporosis following fragility fracture; and the adverse effects and high costs of medications ... out of the hands of the PCP [49,53], and in one the investigation was carried out but the results were sent to the PCP to act on [54] Results Selection of studies for inclusion Development of ... countries and healthcare systems Although we pooled the results of the studies (reflecting their homogeneity of patient groups and settings), there were still a range of types of interventions and...

Ngày tải lên: 10/08/2014, 10:23

... parameter' of the SVM, which controls the softness of the margin We optimized the parameters C and σ by varying them from 2-10 to 210 in multiplicative steps of two and chose the best combination of ... frequency of pS and pT (80% and 18%, respectively) compared to pY (2%) [5] Tyrosine is more hydrophobic than serine and threonine and, therefore, tends to be located in less accessible parts of the ... in the serine set and 81.06% in the threonine set were predicted correctly The accuracy of the prediction of phosphotyrosines increased Our analysis of a large and unbiased set of in vivo phosphorylation...

Ngày tải lên: 14/08/2014, 08:20

... Ph.D Dean, School of Graduate Studies ABSTRACT Hanes, Amanda L M.S., Department of Computer Science and Engineering, Wright State University, 2009 Investigation and quantification of codon usage ... molecular level than that of amino acids and proteins Further investigation of this evolutionary mechanism will provide a greater understanding of its effects on different types of organisms, enabling ... strength, and also suggests that codon usage bias in general follows the trend of being either strong and global to the genome, or weak and present in only a subset of the genome Analysis of these...

Ngày tải lên: 30/10/2014, 20:09

... view of the buckled (b) up and (c) down diaphragm (d) The 3-D picture of the diaphragm with 2.5 μm SiNx layer on top of 0.5 μm SiO2 78 Figure 4.7: (a) and (d), (b) and (e), (c) and ... 145 vi LIST OF FIGURES List of Figures Figure 1.1: Test configurations from Smith A and C is for the extraction of longitudinal piezoresistive coefficient, and B and D are used to obtain ... are reviewed and the issues involved are presented and commented Then the general concept of piezoresistive sensors and the fatigue of MEMS are briefly reviewed Finally, the state -of- the-art research...

Ngày tải lên: 09/09/2015, 10:08

... heat output of the condenser section Qc , temperature of inlet and outlet of the coolant water, the coolant mass flow rate of water, and the surface temperatures of evaporator, adiabatic and condenser ... heat input of evaporator and the accuracy of monitoring for voltage and electrical current was ± % The temperature of inlet and outlet coolant water was measured by digital thermometer and the ... copper tubes of 1000 mm length with inside diameter of 15 and 25 mm and mm thickness were employed (Figure 1) The working length of the thermosyphon consists of three parts; a lower part of 430 mm...

Ngày tải lên: 09/09/2015, 10:32

... rigidity of the organ of Corti is given by an arch of rods and pillar cells along its length It consists of one row of inner hair cells, three rows of outer hair cells and several types of supporting ... at the region of E41-43 of Cav1.3 43 Schematic diagram of construction of full-length Cav1.3 IQ channel 45 Detailed procedure of construction of splice variant IQ at the C-terminus of Cav1.3 subunit ... sciences ix LIST OF TABLES Table 1: Classification of subunits subunits and effects of co-expression with x LIST OF FIGURES Figure 1.1 Subunit composition and transmembrane topology of voltagedependent...

Ngày tải lên: 14/09/2015, 18:17

... various pH and irradiation sources (sunlight, darkness, indoor incandescent lighting and artificial UV lighting) Hydrolysis was found to be very much 143 pH-dependent irrespective of the type of water ... applied to analyze the residues of N-methylcarbamate and related compounds (propoxur and its metabolisms as model compounds) in biological materials (goldfish, tortoises and sea lettuce) Orthogonal ... half-lives and degradation rates were obtained in various matrix and irradiation sources Based on kinetic studies, propoxur was found to degrade more rapidly at higher light exposure and pH Furthermore,...

Ngày tải lên: 16/09/2015, 17:13

... regard to the optimization of extraction from sea lettuce Factor A, factor B, and factor D are statistically significant at p < 0.1, whereas the effects of factor C and interaction (B х C) are ... assignment of the main variables (A, B, C and D), two-variable interaction, and the level setting values of the main variables applied to aquatic animals (goldfish and tortoises) and sea lettuce ... of 0.02 s and a mass span of mass unit Quantitation was based on the area under the peak from the mass chromatogram of the above molecular ions at m/z 60, 151, and 210 For the LC separation of...

Ngày tải lên: 16/09/2015, 17:13

... significant factor A is independent of factors B and C, a further experimental design was established to obtain optimum conditions of factor A The factor A varies among four levels while factors B and ... matrix, moisture, aging of spiked soil on recovery of tested pollutants The effects of matrix, moisture and aged spiked soil on recovery of analytes were investigated and the results are shown ... corresponds to the number of factors, and row number to the number of experimental trials The intersections between the columns and rows indicate the level settings that apply to those factors for the...

Ngày tải lên: 16/09/2015, 17:13

... application of LC-APCI-MS for the determination of carbamates: carbofuran and 3hydroxy-carbofuran, and the analysis of triazine herbicides in water [8] LC-ESI-MS ... sets of standards of propoxur dissolved individually in methanol and ultrapure water were prepared with the concentrations of 0.025, 0.05, 0.10, 0.25, 0.50 and 1.0 ng/µl, respectively A set of ... RESULTS AND DISCUSSION 3.3.1 Identification of TPs of Propoxur and Comparison of ESI and APCI The results showed that under alkaline condition (0.5M NaOH), propoxur was hydrolyzed to two TPs (1, and...

Ngày tải lên: 16/09/2015, 17:13

... fortification standards for recovery and analytical precision, a portion of each fish sample was added an appropriate volume of standard solution, thereby obtaining the required levels of target analytes ... air-dried, pulverized and sieved through a 60mesh sieve In order to remove possible traces of PAHs, PCBs, triazines, carbamates and other organic contaminants, 100 g of each of the soil sample was ... of caffeine, L-methionyl-arginyl-phenylananyl-alanine acetate·H2O and a mixture of perfluoroalkoxycyclotriphosphazenes in both positive and negative ionization modes as suggested by the manufacturer...

Ngày tải lên: 16/09/2015, 17:13

... conveniently done by applying tandem MS There are many reasons for the predominant use of ESI: ease of operation, sensitivity, reliability, robustness, and expanded areas of application ESI is a highly ... [50-54] Currently, LC-APCI-MS is often used in various stages of drug analysis, environmental analysis of pesticides and herbicides (in water, air, and soil), and metabolite studies 1.3 SAMPLE ... separation and determination of pesticide 13 residues in environmental and biological samples In order to obtain qualitative and quantitative information on the presence of trace levels of pesticides...

Ngày tải lên: 16/09/2015, 17:13

... Testing of Prototypes 46 3.4.1 Results of Design 48 3.4.2 Results of Design 50 Discussions 53 Chapter 4: Investigation and Design of Novel Spatial Power Combiner 56 4.1 Investigation 56 4.2 Design of ... both of my supervisors, Professor Leong Mook Seng and Associate Professor Ooi Ban Leong from the Department of Electrical and Computer Engineering, for their invaluable guidance, suggestions and ... able to enhance both the bandwidth and the out -of- band stability performance of the designs At the end, the proposed techniques and ideas will be verified through testing of the prototypes Chapter...

Ngày tải lên: 08/11/2015, 17:00

... (0–2 risk factors), and high risk (3–5 risk factors) EQ-5D The EQ-5D was used as a measure of respondents' HRQoL and utility values The EQ-5D provides a simple descriptive profile and a single ... individuals with a diagnosis of diabetes and those with risk factors associated with a diagnosis of diabetes In 2004, the screening survey was mailed to a stratified random sample of 200,000 U.S households ... development and/ or diagnosis of diabetes [11,12] Respondents with 0–2 risk factors were classified as low risk and those with 3–5 risk factors were grouped as high risk for a diagnosis of diabetes...

Ngày tải lên: 18/06/2014, 22:20

... capacity of the Cau Duong factory and its parent company (Bai Bang Paper Company) only meets the social demand of 35% Private sector and other State-owned firms satisfied the rest demand of the ... together with an increase in standard of culture of Vietnamese result to a strong demand of plywood and note-paper However, marketing work with the purpose of making most of business chances, strictly ... market, it concludes information about demand, supply, structure of demand – supply, relation ship between demand – supply and each kind of goods, price and its influent, etc Becoming a decisive...

Ngày tải lên: 07/08/2013, 11:04

... domains of Spir-2 and PTPN13 were generated by RT-PCR and inserted into pEGFP-C1 and pGEX-4T-2 The N- and C-terminal regions of the v-KIND KIND2 and the MAP2 CD were generated by PCR and cloned ... series of GST-fused deletions of the CD2-1 region (Fig 3E) and examined the interactions between bacterially expressed proteins of these subregions (Fig S1C) and 1654 Fig Of all members of the ... KIND2-binding specificity of residues 702–744 of MAP2, we performed a pulldown assay of combinations of EGFP-fused KIND1 or KIND2 of v-KIND with GST-fused CD2-1-6-1 or CD2-1-6-2 of MAP2 We successfully...

Ngày tải lên: 14/02/2014, 19:20

... tissue of mouse and spleen and thymus of human and mouse [11,37] Foxp3 is also highly expressed in lymphoid organs, such as the thymus and spleen [49], and its expression within a variety of other ... t-bet, stat6 and foxp3 were also determined and found to be very similar to their human homologues Both the human and zebrafish T-bet and Foxp3 genes contained the same number of exons and introns ... the expression of these genes within humans and mice, of T-bet within Ginbuna crucian carp [27] and STAT6 in mandarin fish [28] have shown similar widespread expression In the case of STAT6, highest...

Ngày tải lên: 16/02/2014, 09:20

... activation of a family of cytosolic cysteine proteases, caspases, which are required for many of the morphological changes that occur during apoptosis The mitochondrial release of cytochrome c and second ... between EGF-induced reduction in Bid and tBid levels and the ubiquitin ligase activity of Itch In this study, we first examined the ability of Itch to interact with Bid and tBid We found that Itch specifically ... cells were cotransfected with constant amounts of rLuc–Itch and various amounts of either Bid–GFP of tBid–GFP The graph is a representative example of the saturation studies performed to provide...

Ngày tải lên: 16/02/2014, 09:20

... Thiolate is a soft ligand and therefore shows a preference for soft metals Moreover the structures of metallothioneins are not rigid and hence there is little selectivity concerning the size of the ion ... Cu(I)4,Cu(I)4MT3 and Cu(I)6,Cu(I)6MT3] The determination of a 3D structure seems crucial for understanding the differences between Cu–MT3 and Cu–MT1 ⁄ (structure also not known) and the presence and role of ... structure and the flexibility of Zn(II) and Cd(II) by NMR spectroscopy Another interesting (and to my knowledge not yet reported) experiment would be assessment of the growth-inhibitory activity of the...

Ngày tải lên: 16/02/2014, 15:20