structure guided discovery of new antimicrobial agents

... Overall, the prevalence of MRSA was 6.5% (33 of 506 isolates) for community-acquired strains, and 4.4% (3 of 68) for nosocomial infections (p = 0.5) Rates of resistance of methicillin-sensitive ... general, elevated rates of multidrug resistance may emerge from diverse isolates of S aureus under antimicrobial pressure or as a result of widespread person-to-person transmission of multidrug-resistant ... skin and soft tissue infections, and pneumonia [1-3] Unfortunately this pathogen has been particularly efficient at developing resistance to antimicrobial agents Since the first isolation of methicillin-resistant...

Ngày tải lên: 08/08/2014, 19:20

... Figure Structure of the dengue virus NS3 protease active site Panel A: Overall structure of the dengue virus NS3 serine protease in complex with a partially resolved structure of the NS2B cofactor ... structural reorganizations of the active site pockets caused by insertion of a b-barrel of the NS2B cofactor and an “induced fit” mechanism of catalysis in the presence of authentic protein substrates ... pockets for amino acid side chains of the substrate [28] The aim of our study was a better understanding of structural determinants of substrate specificity of the dengue virus NS3 protease To...

Ngày tải lên: 10/08/2014, 05:21

... Annals of Clinical Microbiology and Antimicrobials 2011, 10:27 http://www.ann-clinmicrob.com/content/10/1/27 Page of 10 Figure Repartition of the AWD diameter according topical antimicrobial agents ... general use of topical antimicrobial agents Owing to clinical evidence of low efficiency of local treatment upon wounds colonized with MDR1/2 clone, we undertook the in vitro testing of these strains ... strains could be analysed over a 1-hour period of bench manipulation, including dilution of commercialized agents aliquots Activity of the topical antimicrobial compounds Since the method AWD was...

Ngày tải lên: 12/08/2014, 17:20

... set of backbone atom coordinates This compatibility automatically generates scope for the success of mutation-based replacement of one entire set of residues with a completely different set of ... truncated In comparing the amino acid sequence of cB crystallin with that of the equivalent (truncated) form of bB2 crystallin consisting of only the core domain structures without the terminal extensions, ... protein that displays many of the structural stability characteristics of cB crystallin and most of the surface characteristics of bB2 crystallin In addition, this new protein, which we call...

Ngày tải lên: 23/03/2014, 04:21

... structure pi2 reveals that the /,w angles of most of the residues of the Bowman±Birk inhibitor are distributed fairly evenly over the b- and PPII-regions of the Fig A MOLSCRIPT diagram [67] of ... examples of protein aggregation However, although the presence of signi®cant amounts of PPII structure may be necessary for the formation of regular ®brils, other factors must be important as, of all ... and A53T mutants of a-synuclein that cause familial cases of Parkinson's disease Unfortunately the quality of some of these synuclein ROA spectra is generally not as good as that of the caseins...

Ngày tải lên: 21/02/2014, 15:20

... Superposition of structure models of the ADP-EcODC complex in crystal and solution The crystal structure of 2q28 is shown in ribbon and line style in deepsalmon, the solution structure model of ADP-ThDP-EcODC ... 369–564) [5] (Fig 2A) The overall structure of the monomer is highly similar to that of ˚ OfODC (rmsd 0.62 A for 488 superimposed Ca atom pairs) The locations of the cofactor ThDP and the activator ... c-carboxyl group of the side chain of residue D302, the d and x nitrogen atoms of the guanodino group of R158 interact with the hydroxyl groups of ribose, and the main chain nitrogens of K220 and...

Ngày tải lên: 06/03/2014, 11:20

... the end of a-helix H¢¢¢3 and forms part of the xenobiotic-binding site [11] Although the thioether bond of methionine is usually considered to be of low reactivity, a number of pieces of experimental ... reaction of SDTG at the binding site of one subunit changes the conformation of the other subunit, thereby completely abolishing reaction of SDTG with the second subunit Analysis of the crystal structure ... atom of the 1,3,5-sym-trichlorotriazine ring by the -SH group of GSH The 1,3,5-triazine scaffold is of special interest because of its synthetic accessibility, i.e one can take advantage of the...

Ngày tải lên: 16/03/2014, 16:20

... Solution structure of fowlicidin-1 (A) Ribbon stereo-diagram of the restrained minimized average structure of fowlicidin-1 (B) Stereo-diagrams of the backbone trace of the 20 lowest energy structures ... (Fig 3B,C) The superimposition of the two short helical segments of the 20 final structures against an averaged structure resulted in a rmsd ˚ value of backbone of < 0.5 A (Table 1) Greater flexibility ... slight bend between Gly16 and Tyr20, as a result of the presence of Gly16 (Fig 3A) A superimposition of the backbones of the 20 lowest energy structures best fitted to residues 8–16 or residues...

Ngày tải lên: 30/03/2014, 11:20

... Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 protein Journal of Inflammation 2010 7:49 Submit your ... within a window of concentrations of about 0.0035 to 0.35 ng/mL, and that in model studies in rats feG dosage of 100 μg/kg was consistently found to be effective regardless of route of administration, ... a consequence of interruption of the signaling cascade that induces superoxide generation [66] Hence feG and its analogues appear to represent a new class of anti-inflammatory agents which act...

Ngày tải lên: 11/08/2014, 03:20

... the presence of a new human retrovirus in the peripheral blood cells of a Central African native This virus is closely related to STLV-3 In the context of multiple interspecies Page of (page number ... the rain forest area of the Southern part of Cameroon The 240 plasma were tested at a 1/40 dilution for the presence of HTLV-1/2 antibodies with a highly sensitive immunofluorescence test (IF), ... negative Sequencing of this fragment indicated the presence of an HTLV pol sequence that is highly related to STLV-3 strains (86.6% to 99.2% nucleotide identity) Based on an alignment of different STLV-3...

Ngày tải lên: 13/08/2014, 09:21

... the structure of inner-document, while Web structure mining tries to discover the link structure of the hyperlinks at the inter-document level Based on the topology of the hyperlinks, Web structure ... sites Web structure mining can also have another direction – discovering the structure of Web document itself This type of structure mining can be used to reveal the structure (schema) of Web pages, ... tries to infer the structure of the Web site of to transform a Web site to become a database S Chakrabarti [19] provides a in-depth survey of the research on the application of the techniques...

Ngày tải lên: 31/08/2012, 16:46

... 80% of patients with AF convert to SR within 24 hours The use of β-blockers before the start of AF and the absence of diabetes and left ventricular hypertrophy were independent predictors of conversion ... Goodman SN, Powe NR, Bass EB: Efficacy of agents for pharmacologic conversion of atrial fibrillation and subsequent maintenance of sinus rhythm: a meta-analysis of clinical trials J Fam Pract 2000, ... a retrospective study of surgical patients with new- onset supraventricular tachycardia (93% with AF), 75% had SR within 48 hours after the start of continuous infusion of amiodarone [77] In a...

Ngày tải lên: 25/10/2012, 10:35

... Dictionary The aim of the Oxford Dictionary of New Words is to provide an informative and readable guide to about two thousand high-profile words and phrases which have been in the news during the ... mean excluding most of the words which ordinary speakers of English think of as new; instead, the deciding factor has been whether or not the general public was made aware of the word or sense ... When a new word or sense is used in more than one part of speech, the parts of speech are listed in the headword section of the entry and a separate definition section is given for each part of speech...

Ngày tải lên: 17/08/2013, 08:52

... Dictionary The aim of the Oxford Dictionary of New Words is to provide an informative and readable guide to about two thousand high-profile words and phrases which have been in the news during the ... mean excluding most of the words which ordinary speakers of English think of as new; instead, the deciding factor has been whether or not the general public was made aware of the word or sense ... When a new word or sense is used in more than one part of speech, the parts of speech are listed in the headword section of the entry and a separate definition section is given for each part of speech...

Ngày tải lên: 19/08/2013, 13:40

... Dictionary The aim of the Oxford Dictionary of New Words is to provide an informative and readable guide to about two thousand high-profile words and phrases which have been in the news during the ... mean excluding most of the words which ordinary speakers of English think of as new; instead, the deciding factor has been whether or not the general public was made aware of the word or sense ... When a new word or sense is used in more than one part of speech, the parts of speech are listed in the headword section of the entry and a separate definition section is given for each part of speech...

Ngày tải lên: 19/08/2013, 13:40

... 2009) 663 Linh Dam new town - Solution for the High-density development of New settlements in the South-West of Hanoi 3.2 Linh Dam New Town - more than 10 years for a model of New Towns Due to ... still deserve one of the new urban models of Hanoi and Vietnam, dealing with the high-density development in the south-west of Hanoi 3.4 Discussions With every new projects of New Town, the planning ... the development of the southern gateway of Hanoi capital Since 22 - 01 - 2009, the Minister of Construction has officially signed a decision that recognized Linh Dam is one of two new urban models...

Ngày tải lên: 29/08/2013, 08:15

Ngày tải lên: 29/08/2013, 08:15

... political of ce he often sought, proved himself a master of information abuse As Grand Wizard of the Knights of the Ku Klux Klan, he was able to compile a mailing list of thousands of rank-and-file ... currency of the Internet As a medium, the Internet is brilliantly efficient at shifting information from the hands of those who have it into the hands of those who not Often, as in the case of term ... Real-Estate Agents The practitioners of such acts, especially in the realm of high finance, inevitably offer this defense: “Everybody else was doing it.” Which may be largely true One characteristic of...

Ngày tải lên: 17/10/2013, 18:20

... add new access methods A complete extended type system should allow: 1) the definition of user-defined data types 2) the definition of new operators for these data types 3) the implementation of new ... Boxes Table We turn now to a review of the prototype presented in [STON83] which supports some of the above function 2.2 DEFINITION OF NEW TYPES To define a new type, a user must follow a registration ... methods that allow efficient retrieval utilizing subsets of the collection of keys are beyond the scope of this paper 3.1 Registration of a New Access Method The basic idea which we exploit is that...

Ngày tải lên: 22/10/2013, 10:15

... students to find their own structure or understanding of the organization of an area of study Multimedia provides an opportunity to offer a variety of different ways of structuring knowledge A ... important element of text is that the writer controls the structure Novelists and text-book authors give a great deal of thought to the sequence and structure of their work The reader can of course ignore ... wide variety of ways to stimulate various forms of learning The most significant feature of the multiple forms of media is that they allow for the presentation of knowledge in a variety of ways Thus...

Ngày tải lên: 04/11/2013, 20:15