stress and the innate immune response to hsv
Báo cáo y học: "Bench-to-bedside review: Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis" ppsx
Ngày tải lên :
12/08/2014, 19:21
... related to the innate immune response, and its activation and regulation is dependent on local and systemic immune responses The simultaneous activation of clotting and the innate immune response is ... internal ligand that is tethered to the amino-terminus of its extracellular domain Thrombin cleaves the amino-terminus of the PAR, allowing the internal ligand to autoactivate the receptor There are ... replete in the human coagulation system and in the innate immune response to invasive microbial pathogens These evolutionary adaptations gave rise to the highly integrated clotting and inflammatory...
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báo cáo hóa học: " Wallerian degeneration: the innate-immune response to traumatic nerve injury" potx
Ngày tải lên :
19/06/2014, 22:20
... central to Wallerian degeneration since innate- immune cells, functions and molecules that are produced by immune and non -immune cells are involved The innate- immune response helps to turn the peripheral ... is given to the orchestration of these events with respect to their timing and magnitude, and to the identity of the cells that produce them Timing differs between species (see below) Therefore, ... inhibitor molecule, and furthermore, by the reduced production of TNFa and IL1-b Therefore, the first phase is mostly inflammatory and the second is predominantly anti-inflammatory Further, it...
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Báo cáo y học: " Characterization of the innate immune response to chronic aspiration in a novel rodent model" ppsx
Ngày tải lên :
12/08/2014, 15:21
... possible that, in the setting of a pulmonary allograft, the development of these inflammatory mediators could recruit and/ or exacerbate immune responses that predispose recipients to acute and/ or chronic ... accordance with the Guide for the Care and Use of Laboratory Animals prepared by the National Academy of Sciences and published by the National Institutes of Health Protocols were approved by the Duke ... period, the fluid from several animals was pooled together, and the mixture was then filtered through a 70-micron strainer before being stored at -80°C until immediately prior to use The pH of...
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Báo cáo y học: "Bench-to-bedside review: Biotrauma and modulation of the innate immune response" pps
Ngày tải lên :
12/08/2014, 20:21
... neutrophil function and innate immune response to lipopolysaccharide and sepsis The general strategy of innate immune detection is one in which a limited number of receptors are dedicated to the recognition ... IL-6 level in these patients reflects a reduction in the proinflammatory response secondary to decreased biotrauma to the lung Ranieri and coworkers further expanded on this hypothesis by demonstrating ... applied to injured lungs, causes the release of inflammatory mediators, which may then pass on to the circulation [9,21,24,27] The main theory in support for increasing levels of inflammatory mediators...
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Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt
Ngày tải lên :
06/03/2014, 09:22
... [7,13] C106 then binds to the ectodomain of the transmembrane receptor Toll and thereby initiates a cytoplasmic signaling pathway, resulting in the release of a rel family transcription factor Dorsal ... activation of serine proteinases to produce an active Toll ligand called Spatzle [4,6] The ¨ Spatzle ligand and Toll receptor also establish the dor¨ sal–ventral axis in the Drosophila embryo, although ... perform immune functions This mechanism leads to activation of phenoloxidase, which oxidizes catechols, leading to the formation of toxic quinones and melanin [1,2], and to the activation of cytokines...
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báo cáo hóa học: " Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice" doc
Ngày tải lên :
19/06/2014, 22:20
... infiltrate the injured CNS and have the potential to be neurotoxic which makes it difficult to determine if the increased cell death observed in the injured brains of MT-I/II-/mice is due to the absence ... absence of the neuroprotective effects of MT-I/II in the CNS or the absence of the modulatory effects that MT-I/II has on the immune system The infiltration of neutrophils into CNS injuries is the most ... directly to the skull for seconds The stereotaxic coordinates for the injury site were mm anterior of lambda and mm right of the midline The skin was sutured and the animal was allowed to recover...
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INVESTIGATING THE HOST IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS THE ROLES OF ANNEXIN a1 PROTEIN AND CLEC9A+ DENDRITIC CELLS
Ngày tải lên :
09/09/2015, 08:20
... Hutchinson and Guo Hui of the IP Flow Lab for their kind assistance regarding use of the flow cytometers, and Benson from the Kemeny Lab for accommodating my requests for animals To the members of the ... hours in the BSL 3; we had a nice view, but most comforting has been the buddy behind the mask i To my kindred spirits Weixin and Zarina, Team Omnom and the Gluttons, thank you for the unforgettable ... resistance to the two main first-line antibiotics, isoniazid and rifampicin XDR-TB is defined as resistance to isoniazid and rifampicin, and additionally, to any fluoroquinolone and any of the three...
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Báo cáo y học: "CD14 mediates the innate immune responses to arthritopathogenic peptidoglycan–polysaccharide complexes of Gram-positive bacterial cell walls" docx
Ngày tải lên :
09/08/2014, 01:23
... persistence of PG-PS in the host [2] The primary events and the identity of cellular receptors that mediate the innate immune response to and the arthritogenic properties of peptidoglycan and PG-PS are ... similar to those in wild-type animals [20] R274 In order to elucidate the role played by CD14 in the innate immune response to PG-PS in vitro and in vivo, we assessed the inflammatory responses to ... proinflammatory cytokines, including IL-1, IL-6, and tumor necrosis factor (TNF)-α [8,10] It is less clear which primary events and cellular receptors mediate the innate immune responses to and the...
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Báo cáo y học: "Human metapneumovirus induces more severe disease and stronger innate immune response in BALB/c mice as compared with respiratory syncytial virus" pps
Ngày tải lên :
12/08/2014, 15:20
... of and immune response to this pneumovirus [17] Although RSV can directly affect the integrity of the respiratory epithelium, the immune response is the most crucial factor in pathogenesis, and ... days and 14 post infection [18] In contrast to RSV, the immune response to HMPV was characterized by a low inflammatory response, minimal innate immunity and limited T cell trafficking to the ... neutrophils and NK cells to the BAL when compared to RSV (Fig 3B and 4D) These findings support the concept that HMPV may elicit a more pronounced innate immune response that, on the one hand, is beneficial...
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Báo cáo khoa học: Functional studies of crustacean hyperglycemic hormones (CHHs) of the blue crab, Callinectes sapidus – the expression and release of CHH in eyestalk and pericardial organ in response to environmental stress pot
Ngày tải lên :
16/03/2014, 06:20
... into the specific sites in which the nerve fibers of the PO innervate the anterior ramifications On the other hand, as a neurohormone, PO-CHH may be released from the surface of the PO and into ... cDNA of PO-CHH and identified the presence of the neuropeptide forms in the ES and PO For the first time in crustaceans, the expression profiles of these two CHHs in response to oxygen and temperature ... 0.001) (C) The profiles of CHH, AK and eIF4A expression in the ES and PO in response to hypothermia and hyperthermia Closed bar: controls Hatched bar: hypothermia Crossed bar: hyperthermia Bars...
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Báo cáo y học: "Celastrus aculeatus Merr. suppresses the induction and progression of autoimmune arthritis by modulating immune response to heat-shock protein 65" pptx
Ngày tải lên :
09/08/2014, 10:20
... facilitated the secretion of the anti-inflammatory cytokine IL-10 over the pro-inflammatory cytokine IFN-γ, resulting in the overall skewing (immune deviation) of the cytokine response to an anti-inflammatory ... anti-inflammatory type [26] This relative deviation of the cytokine response, caused either by decreased Th1-type cytokines and/ or by enhanced Th2-type cytokines leading to the regression of an autoimmune ... Research & Therapy Vol No Tong and Moudgil Figure Celastrus feeding to LEW rats induces preferential secretion of anti-inflammatory cytokines over proinflammatory cytokines in response to Bhsp65 To test...
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Báo cáo y học: " Lack of effect of glutamine administration to boost the innate immune system response in trauma patients in the intensive care unit" pdf
Ngày tải lên :
14/08/2014, 07:21
... analysis and interpretation of data, and writing the article CC and VR assisted with flow cytometry PM and JMR assisted with design, analysis, and writing the article JI gave final approval to the ... We and others [12-15] have shown that trauma patients present a dysregulation of the innate immune system, namely reduced expression of TLRs and blunted response to specific agonists markedly to ... of TLRs leads to the induction of inflammatory responses, phagocytosis but also to the development of antigen specific adaptive immunity [10] Among this family of receptors, TLR2 and TLR4 have...
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Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"
Ngày tải lên :
26/10/2012, 09:32
... of the dependent variables and fixed effects exist, the effects of between- and within-subjects factors as well as the interaction between factors and covariates and its effects are analyzed The ... taken into account [7] The aim of the present study was to 95 determine the impact of CYP3A5*1 and CYP3A5*3 genotype on the kinetics of tacrolimus in renal transplant recipients The drug dose and ... CYP3A4 and CYP3A5 enzyme isotype CYP3A5 polymorphisms seem to affect tacrolimus kinetics at a greater degree compared to CYP3A4 ones and thereby, these polymorphisms are thought to be the best candidates...
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Strengthening the Education Sector Response to School Health, Nutrition and HIV/AIDS in the Caribbean Region: A Rapid Survey of 13 Countries pdf
Ngày tải lên :
14/03/2014, 20:20
... behaviours To this end, governments have made efforts to strengthen the education sector response to HIV throughout the Caribbean region 1.5 The Education Sector Response to HIV in the Caribbean The ... similar to patterns of response globally, the Caribbean response to the HIV/AIDS epidemic was largely focused within the health sector Initial activities by the education sector to respond to HIV ... Prevention d Orphans and Vulnerable Children Through these documents, CARICOM made clear the intent to strengthen the multi-sectoral response to HIV in the Caribbean region At the centre of the CARICOM...
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Audit and Accountability in Central Government: The Government’s response to Lord Sharman’s report “Holding to Account” pdf
Ngày tải lên :
29/03/2014, 22:20
... work together to identify how best the current obstacles to the ability of the C&AG to be appointed as an auditor under the Companies Act can be removed The aim should be for the C&AG to be the ... the Government Resources and Accounts Act 2000 In doing this, the C&AG, the bodies involved, their regulators, and other auditors should produce protocols for the exercise of these new statutory ... the Northern Ireland Audit Office (NIAO), the Audit Commission for Local Authorities and the National Health Service in England and Wales, and the Accounts Commission for Scotland It brings together...
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Báo cáo khoa học: BRCA1 accumulates in the nucleus in response to hypoxia and TRAIL and enhances TRAIL-induced apoptosis in breast cancer cells pdf
Ngày tải lên :
30/03/2014, 03:20
... TRAIL-mediated apoptosis in HCT116 human colon carcinoma cells by inhibiting the translocation of Bax from the cytosol to the mitochondria, thereby preventing the release of cytochrome c and progression ... signaling, leading to the activation of two distinct pathways One pathway might lead to increased nuclear localization of BRCA1 and the other to apoptosis Hypoxia could block the apoptotic arm (Fig ... of chemotherapeutic drugs and tumor necrosis factor-related apoptosisinducing ligand ⁄ Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo Cancer Res 63, 5390–5400 Tomlinson...
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báo cáo hóa học: " Neuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo" doc
Ngày tải lên :
19/06/2014, 22:20
... cascades, and effectors The initial signaling cascade starts with ligand activating one of the plasma membrane TLRs All of these receptors require the adaptor protein MyD88 for immediate response to ... combination of these initial and secondary signaling cascades produces a robust innate immune response This same response can occur in response to endogenous ligands that also activate the CD14/TLR-4 ... challenge to the significance of oxidative damage in neurodegeneration There are differences, of course, between the acute stress of ICV LPS stress and the presumably chronic stress of AD; nevertheless,...
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báo cáo hóa học: " The acute inflammatory response to intranigral a-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation" pptx
Ngày tải lên :
19/06/2014, 22:20
... SNCA into the SNpc, the mRNA of the major proinflammatory cytokines, IL-1b, IL-6 and TNFa, were significantly up-regulated compared to the BSA controls (Figure 3) Both eSNCA and BSA failed to alter ... phagocytic and inflammatory microglia is generated [35] Following the central injection of LPS the inflammatory cytokine response dwarfed the observed elevation in TGFb and COX, and reveals the potential ... diseases, we were interested to discover whether the activation of the innate immune system by LPS would affect the host response to eSNCA Groups of animals were challenged with either systemic LPS or...
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Báo cáo hóa học: "Clinically important improvement in the WOMAC and predictor factors for response to non-specific non-steroidal anti-inflammatory drugs in osteoarthritic patients: a prospective study" docx
Ngày tải lên :
21/06/2014, 19:20
... for the measurement of knee height (16) To measure knee height, the knee was bent to a 90° angle, and the distance from the undersurface of the heel (the heel rested on the caliper blade, and sandbags ... bent to a 90° angle, and the distance from the undersurface of the heel (the heel rested on the caliper blade, and sandbags placed under the foot ensured that the foot remained level with the ... were included to the model and stayed in the model To examine whether disease severity is a predictor for response the WOMAC global baseline score was included in the analysis with the dependent...
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Báo cáo khoa học: "Efficiency of Matricaria chamomilla CH12 and number of doses of rabies vaccine on the humoral immune response in cattle" potx
Ngày tải lên :
07/08/2014, 23:22
... between the first and the second weighing divided by the number of animals that fed at the feeder was considered the average salt consumption per calf in 24 h From these calculations, the amount ... among the groups on days 30 and 60 [3] To compare the serum titers between days 30 and 60 within each group (groups FEV1, FEV2, V1 and V2), the Student t-test for paired samples was used For all the ... approved by the Brazilian Ministry of Agriculture, Livestock and Supply (MAPA) All the animals (groups FEV1, FEV2, V1 and V2) were vaccinated on day 0; the cattle from groups FEV2 and V2 received...
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