... micro-editing of the final version of the manuscript References Conclusion The provision of information on the safe storage of methadone is recalled by a minority of patients, and the vast Strang ... following the provision of written information to patients in addition to verbal information at the point that they commence their methadone treatment This will be reinforced at the point where ... prescribing, provision of measuring devices on request and the provision of information on the particular risks of methadone to children The risks to children of unsafe storage of medicines is not of...
Ngày tải lên: 11/08/2014, 20:20
... of Reporting in the Business Information Warehouse What Is the Business Information Warehouse? What Is the Business Information Warehouse? A component of SAP’s New Dimension product, the Business ... Overview of Reporting in the Business Information Warehouse Business Information Warehouse Architecture: An Overview What Is the Business Information Warehouse Server? The Business Information ... The fact table contains the key figures of the InfoCube while the dimension tables contain the characteristics of the cube InfoSources (see below) supply data to InfoCubes A query in the Business...
Ngày tải lên: 11/12/2013, 14:15
Báo cáo khoa học: Protective effects of endomorphins, endogenous opioid peptides in the brain, on human low density lipoprotein oxidation pdf
... the control the inhibition period the rate of the absorbance increase became faster, which is close to the original rate of propagation, demonstrating the exhaustion of the antioxidant The kinetic ... EM2 in protecting against Cu2+-induced apoB modification in LDL As shown in Fig 8B, exposure of LDL to 20 mm AAPH in the presence of an increasing concentration of EM1 (50–200 lm) resulted in a ... endomorphins and GSH The reaction conditions and the initial concentration of the substrates are the same as described in the legends of Fig for reactions conducted in LDL Data are the means of three...
Ngày tải lên: 23/03/2014, 10:21
Báo cáo khoa học: An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain docx
... communication The results obtained in the present study also showed predominant expression of 13cIMH in the brain, further supporting its proposed role in the modulation of neuronal function The present ... at lower levels in the brain By contrast, the 13cIMH mRNA was detected at high levels in the brain and at low levels in the eye (Fig 7A) To detect endogenous 13cIMH in the brain, we performed ... enzyme The 293T cell lysate expressing 13cIMH was incubated with: (A) liposome containing atRE; (B) liposome containing atRE in the presence of mM bypiridine; and (C) liposome containing atRE, in the...
Ngày tải lên: 29/03/2014, 00:20
Báo cáo khoa học: Inactive forms of the catalytic subunit of protein kinase A are expressed in the brain of higher primates potx
... present in brain, but not in PBL (Fig 3A, lanes and 3) To examine whether the CbD4 variants were expressed in different parts of the brain as well as in fetal brain, PCR was carried out using the ... together, these results suggest that CbD4 variants are not expressed in human PBL Next, we searched for these splice variants in the brain of other species Rhesus monkey brain and mouse brain ... gene The novel Cb variants were designated CbD4 They were identified in NT2-N cells, human and Rhesus monkey brain, but not in human PBL or mouse brain, suggesting that skipping of exon in the...
Ngày tải lên: 30/03/2014, 04:20
Báo cáo khoa học: D-Amino acids in the brain: the biochemistry of brain serine racemase potx
... Residues involved in the binding to the PLP moiety are shown in blue, whereas those involved in protein–protein interaction are shown in green The first four amino acids of the barley serine racemase ... activating the enzyme [14] In the absence of AMP, the Km of E coli Thr deaminase for Thr was 70 mm and it decreased to mm in the presence of the nucleotide [15] The residues participating in the binding ... in uence of the other PDZ domains of GRIP was not investigated Therefore, other proteins that become associated with GRIP, using some of the other six PDZ domains, might modulate the activity of serine...
Ngày tải lên: 30/03/2014, 04:20
martin - the organisation of conceptual knowledge in the brain (psychology press, 2003)
... form 20 THE ORGANISATION OF CONCEPTUAL KNOWLEDGE IN THE BRAIN INTRODUCTION A central issue in the cognitive brain sciences is the organisation of conceptual knowledge in the human brain The neuropsychological ... deficits We address the issue of whether there is convincing evidence for further fractionations within the categories of living and nonliving things We also consider the status of the categories ... that the domain-specific account does not deny the possibility that one constraint on the organisation of conceptual knowledge in the brain is modality or type of information However, the domain-specific...
Ngày tải lên: 03/04/2014, 12:07
báo cáo hóa học: " Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: a clinical and experimental study in head-injured patients and in a murine model of closed head injury." pot
... effects of pro-inflammatory mediators, depending on the kinetic of their expression and posttraumatic regulation in the injured brain [3,12,13] However, the TNF-dependent regulation of IL18 in the injured ... corresponds to the time-point of maximal extent of intracerebral inflammation in the model of CHI used in this study [17] For assessment of intracerebral IL-18 levels, the murine brains were immediately ... wavelength of 405 nm The experimental part of the study was set-up on two different protocols with the aim to assess the TNF-dependent regulation of IL-18 in the murine brain: (1) The first part of the...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " Joint optimization of MIMO radar waveform and biased estimator with prior information in the presence of clutter" pot
... ST (17) The problem of main interest in this study is the joint optimization of the WCM and bias estimator to improve the performance of parameter estimation by minimizing the constrained biased ... on the following three cases: the CRB of two angles with exactly known initial parameters, the effect of the optimal biased estimator or prior information on the CRB, and the effect of the initial ... error of the clutter estimate is defined as the ratio of the estimation error of the initial total clutter power to the exact one Figure shows the CRB versus the estimation error of the initial...
Ngày tải lên: 21/06/2014, 02:20
Báo cáo y học: " The contrasting roles of PPARδ and PPARg in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue" ppt
... changes The Δ 6-desaturase is integral to both pathways; the enzyme introduces the initial double bond into linoleate forming g-linolenate in the ω-6 pathway and introduces the double bond into linolenate ... isoforms [28] Furthermore, the upregulation of the transcription of genes involved in calcium signaling as a consequence of PPARg activation may play a role in defining the constituents of the ... discussed the upregulation of fatty acid oxidation in brown adipose tissue following the over expression of PPARδ in terms of the expression of a range of enzymes involved in uncoupling (uncoupling...
Ngày tải lên: 09/08/2014, 23:20
Báo cáo y học: "Regional characterization of energy metabolism in the brain of normal and MPTP-intoxicated mice using new markers of glucose and phosphate transport" doc
... understanding of the metabolism in the brain, as well as in others organs such as the heart, the liver or kidneys In addition, these new ligands could help a better understanding of the role of their ... PiT1-binding immunoadhesin generated by fusing the aminoterminal residues of the GALV (SEATO strain) Env, comprising the signal peptide, the RBD and the proline-rich region, to the rFc tag, herein, ... studies at the cellular level including kinetic studies to further determine the regulation of the inorganic phosphate transporters in the brain In conclusion, our data suggest that these new...
Ngày tải lên: 10/08/2014, 05:21
Báo cáo y học: " Evolution of changes in the computed tomography scans of the brain of a patient with left middle cerebral artery infarction: a case report" pps
... analysis of CT scanning of the brain Normal brain and fundamentals of CT interpretation The brain normal grey/white matter differentiation should be examined, remembering that the fatty content of the ... definition of the grey/white interface in the lateral margins of the insula, leading to loss of insular ribbon [1], attenuation of the lentiform nucleus [2], hemispherical sulcus effacement and the ... CT brain scan was performed after the weekend on the third day after admission (Figure 2) Discussion CT scanning of the brain is invariably performed in the evaluation of patients presenting...
Ngày tải lên: 11/08/2014, 23:21
Báo cáo y học: "Clinical and Molecular Allergy: a new open access journal that addresses rapidly evolving information in the field of allergy and immunology" pptx
... solicited In the age of information technology, online journals provide novel ways of disseminating medical information We are grateful to our publisher BioMed Central for providing us with the opportunity ... submitting your manuscripts to the Journal Information is available at the following URL: http:// www.clinicalmolecularallergy.com/manuscript/ With your assistance, it will grow to become a distinguished ... Clinical and Molecular Allergy The submission, peer review, and publication of manuscripts will be done by an efficient, online process This method will shorten the time for publication of the...
Ngày tải lên: 13/08/2014, 13:22
Báo cáo y học: "Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic/neurotrophic factors and neuroplasticity systems in the brain" pptx
... muscarinic receptor stimulation [2,3,31] Together, the present findings raise the possibility that CTSinduced reversal of impaired neurosignaling system in the brain of the SAMP8 groups is one of the ... decreased in the brains of older SAMP8, indicating aging-induced dysfunction of the VEGF-VEGFR2 signaling system Therefore, the impaired VEGF-VEGFR2 signaling systems likely induce a decrease in angiogenesis ... signaling in the brain and are implicated in aging-induced cognitive deficits in SAMP8 Considering a role of the VEGFVEGFR2 signaling systems in cognitive function, we, in this study, raise the...
Ngày tải lên: 13/08/2014, 14:20
Báo cáo y học: "Mouse maps of gene expression in the brain" pot
... consistent, indicating that the pattern is due to the promoter elements of the gene of interest rather than the genomic insertion point The anatomical annotators of the GENSAT data have embraced the ... recombinant strain of mouse that eliminates a gene’s expression only in the cells that express the Cre These lines will be a valuable resource for investigators looking to understand the role of individual ... distributed through the Mutant Mouse Research Resource Centers [8,9] In addition, for some of the most interesting expression patterns, the project is developing lines where the BAC containing the gene...
Ngày tải lên: 14/08/2014, 07:21
Distribution and role of calcium independent phospholipase a2 in the brain
... sources (Ginsburg et al 1993; Hope et al 1993) Quinacrine appears in monkey brain 24 h after intrauterine administration (Dubin et al 1982), indicating that this inhibitor can cross the blood brain ... damage to the mitochondria and release of calcium resulting in exocytosis The results highlight the importance of normal “housekeeping” phospholipase A2 in maintaining the normal function of neurons ... dramatic loss of dopaminergic neurons in the substantia nigra (SN), resulting in bradykinesia, tremor and rigidity There are two forms of inherited PD Mutations in the gene coding for α-synuclein and...
Ngày tải lên: 11/09/2015, 09:58
Distribution of betaine gaba transporter BGT 1 in excitotoxic brain injury and its role in osmoregulation in the brain
... function in the brain BGT-1 is capable of transporting both betaine and GABA, as examined in Xenopus oocytes and various cell lines But the physiological substrate of BGT-1 in the brain remains to ... hyponatremia causes brain edema as a consequence of influx of water into brain Due to increased intracranial pressure, brain edema leads to life-threatening cessation of the brain s blood supply ... swelling following head injury or stroke In summary, the present study has revealed the distribution of betaine/GABA transporter BGT-1 in normal brain and in excitotoxic brain injury, as well as the...
Ngày tải lên: 16/09/2015, 15:55
The relative importance of earnings and other information in the valuation of rd intensive firms
... Other Information As the importance o f other information in firm valuation increases, the probability of errors in firm valuation increases This is because other information is incorporated into ... forecasts of future earnings If there were an increase in the importance o f other information to firm valuation then the coefficients in a regression of either stock prices or returns on accounting ... earnings The other information is the increase to future earnings related to the new product If the new product is a computer that is expected to generate revenue for four years then the other information...
Ngày tải lên: 30/09/2015, 16:44
Evaluation of advanced paclitaxel drug delivery implants for controlled release post surgical treatment against glioblastoma multiforme in the brain
... completely into the incision created The scarp of the rat was then closed by suturing and the animal allowed to recover while the weights of the animals were monitored daily At the respective time points, ... that these two options or the combination of both would provide the surgeon with room for decision making based on the specific circumstances in the operating theatre The in vitro release profile ... on the basis of two times the Area Under the Curve (AUC) levels An AUC level is the area under the curve of a plot of axis between Concentration of the drug vs the duration of exposure to the...
Ngày tải lên: 05/10/2015, 21:33
On the front lines the role of information in enhancing customer service
... On the front lines The role of information in enhancing customer service Preface On the front lines: The role of information in enhancing customer service is an Economist Intelligence ... collaborative.” In effect, the CEO of Netflix is heavily involved in customer service as he is in every other part of the business The challenge of execution The survey shows the vast majority of companies ... difference Increasingly, these expectations are shaped by interactions via web portals, online forums, social media and other new information channels Gathering information from these sources and integrating...
Ngày tải lên: 04/12/2015, 00:15