... reproduction in any medium, provided the original work is properly cited Intensity-Modulated Radiotherapy for Squamous Cell Carcinoma of the Anal Canal: Efficacy of a Low Daily Dose to Clinically ... to the article as it appeared upon acceptance Fully formatted PDF and full text (HTML) versions will be made available soon Intensity-Modulated Radiotherapy for Squamous Cell Carcinoma of the ... about other BioMed Central publications go to http://www.biomedcentral.com/ © 2011 Call et al ; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative
Ngày tải lên: 09/08/2014, 09:21
... range of functions CD44+ expression has been identified as a marker for a population of cells with cancer stem cell characteristics in head and neck squamous cell carcinoma (HNSCC) The aim of this ... HNSCC is the variability of the parameters investigated The main variables are: firstly, the CD44 isoform being investigated; secondly, the method of determining CD44 expression; thirdly, the tumour ... as a cell surface marker for cancer stem cells, flow cytometry analysis is often used to quantify the proportion of tumour epithelial cells expressing the molecule FACS is quantitative for the
Ngày tải lên: 02/10/2015, 17:14
A phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell carcinoma of the esophagus or head and neck and HER2-overexpres
... Boston, MA 02114, USA Full list of author information is available at the end of the article © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution ... to dosing schedule The model was of the form Study objectives where d represents the total Cycle dose, d* represents the reference dose of 40 mg/kg, πd is the probability of a DLT at dose d, ... indication (FAS) Footnote: ESCC esophageal squamous cell carcinoma, PD progressive disease, Q2W once every two weeks, QW once weekly, SCCHN squamous cell carcinoma of the head and neck, SD stable disease,
Ngày tải lên: 06/08/2020, 04:06
Narrow band imaging versus lugol chromoendoscopy to diagnose squamous cell carcinoma of the esophagus: A systematic review and meta-analysis
... 90% of cases are squamous cell carcinoma; squamous cell carcinoma is also the principal histological type worldwide [2] The importance of individual risk factors in the development of squamous cell ... convenience without the risks inherent to the use of vital dye The purpose of this systematic review and meta-analysis was to evaluate the ability of NBI to diagnose squamous cell carcinoma of the esophagus ... bear no risk of pulmonary aspiration of the dye or allergic reaction, and they provide a safe assessment of the upper third of the esophagus Disadvantages include the high cost of the device,
Ngày tải lên: 20/09/2020, 01:04
Systemic inflammation is an independent predictive marker of clinical outcomes in mucosal squamous cell carcinoma of the head and neck in oropharyngeal and nonoropharyngeal patients
... of Sydney, Sydney, NSW 2006, Australia Full list of author information is available at the end of the article © 2016 Charles et al Open Access This article is distributed under the terms of the ... Survival outcomes were determined from the start of radiotherapy until the date of the event or death from any cause (date of death obtained from hospital records) The exploratory variables analysed ... metastasis At the end of the study, there were 35 deaths and a median 1-year OS of 91 % Median follow-up time of patients was 29 months (range, 42 days to years) Page of 13 Comparison of demographics
Ngày tải lên: 21/09/2020, 11:23
Wilms’ tumor gene 1 regulates p63 and promotes cell proliferation in squamous cell carcinoma of the head and neck
... cancer cell growth Keywords: WT1, p63, p53, Cell proliferation, Squamous cell carcinoma of the head and neck (SCCHN) Background Squamous cell carcinoma of the head and neck (SCCHN) is the sixth ... cDNA synthesis The mean of triplicates of the WT1 gene copy numbers was divided by the mean of duplicates of copy numbers of the β-actin Primers and probes for the WT1 and βactin gene and the amplification ... suppressor or activator of tumourigenesis in different types of human malignancies The role of WT1 in squamous cell carcinoma of the head and neck (SCCHN) is not clear Overexpression of WT1 has been
Ngày tải lên: 29/09/2020, 16:23
Phase II Trial of Post-operative Concurrent Radiation and Cetuximab for Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck
... futility The trial may go on to accrue a total of 110 patients The sample size of 110 (40 form the University of Cincinnati and 70 for the patients begins with the hypothesis that the use of concurrent ... blepharitis, cellulitis, cyst) Two cases of S aureus sepsis were reported The onset of acneiform rash was generally within the first two weeks of therapy Although in a majority of the patients the event ... Page 29 of 35 3/25/2016 The assessments will be completed prior to the start of cetuximab (baseline) and at 3, 12, and 24 months from the end of RT 9.5.1 The Functional Assessment of Cancer Therapy-Head
Ngày tải lên: 18/10/2022, 13:06
Comprehensive analysis of spread through air spaces in lung adenocarcinoma and squamous cell carcinoma using the 8th edition AJCC/UICC staging system
... score was obtained by multiplying the grades of intensity by the percentage of positively stained cells The median value of all the scores was chosen as the cut-off value to divide patients into ... received adjuvant therapy These conditions might have influenced the prognosis and could affect the results of survival analysis On the other hand, the sample size involved in the present study ... 20:705 Page of 11 Scoring of immunostained tissue sections Statistical analysis The expression of markers was quantified based on the extent of staining (by percentage of positive tumor cells: 0–100%;
Ngày tải lên: 06/08/2020, 05:57
Báo cáo y học: "Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study" pptx
... cell lung carcinoma (SCLC) NSCLC mainly consists of adenocarcinoma (AC), squamous cell carcinoma (SC) and large cell carcinoma (LCC) AC and SC are differentiated with the features of normal cells ... Background: Large cell neuroendocrine carcinoma (LCNEC) of the lung, a subtype of large cell carcinoma (LCC), is characterized by neuroendocrine differentiation that small cell lung carcinoma (SCLC) ... Abbreviations NSCLC: non-small cell lung carcinoma; LCNEC: large cell neuroendocrine carcinoma; LCC: large cell carcinoma; SCLC: small cell lung carcinoma; CSC: cancer stem cell; LC: liquid chromatography;
Ngày tải lên: 10/08/2014, 09:22
Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in squamous cell carcinoma of tongue
... However, the roles and functions of the lncRNA-miRNA-mRNA ceRNA network in squamous cell carcinoma of the tongue (SCCT) are still unclear Methods: The miRNA, mRNA and lncRNA expression profiles ... et al High expression of EPB41L5, an integral component of the Arf6-driven mesenchymal program, correlates with poor prognosis of squamous cell carcinoma of the tongue Cell Commun Signal 2016;14(1):28 ... Keywords: Squamous cell carcinoma of the tongue, Long non-coding RNAs, Competing endogenous RNAs network, The Cancer genome atlas, Overall survival Background Head and neck squamous cell carcinoma
Ngày tải lên: 17/06/2020, 17:13
Thoracoscopic and hand assisted laparoscopic esophagectomy with radical lymph node dissection for esophageal squamous cell carcinoma in the left lateral decubitus position: A single center
... the arrow indicates the right recurrent laryngeal nerve b After dissection of the left recurrent laryngeal nerve lymph nodes: arrow indicates the cardiac branch of the sympathetic nerve and the ... complications The cervical anastomosis is created with a 25 mm circular stapler using the end of the esophagus into the side of the gastric wall Three-region lymph node dissection was performed in the ... induction of general anesthesia One -lung pulmonary ventilation using an 8Fr spiral tube was used, and a blocker was placed into the tube to block the right mainstem bronchus The thoracic portion of the
Ngày tải lên: 06/08/2020, 04:47
Protein kinase C-α (PKCα) modulates cell apoptosis by stimulating nuclear translocation of NF-kappa-B p65 in urothelial cell carcinoma of the bladder
... and the sixth most diagnosed cancer in China [2, 3] Among the bladder cancers, more than 90% of the cases are urothelial cell carcinomas (UCCs) The main problems for bladder cancers are the high ... translocation of NF-κB, which enhances the transcription of a wide variety of target genes [18] PKC isozymes have been linked to the activation of NF-κB PKC θ activates NF-κB through phosphorylation of the ... University A total of 30 patients with bladder urothelial cell carcinomas (BUCCs) underwent partial cystectomies and radical cystectomies from 2013 to 2015 at the Department of Urology of the First Affiliated
Ngày tải lên: 06/08/2020, 07:30
Phase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial
... calculated from the first treatment day until the day of event occurrence (for OS the date of death or the date of termination of the trial for patients alive at the time end of the study, Caponigro ... analysis of the potential prognostic or predictive role of several biomarkers with the aim of improving the knowledge of the mechanisms by which VPA enhances chemotherapy effect and of identifying ... treatment of squamous cell carcinoma of the head and neck, the prognosis of patients with recurrent/metastatic disease remains poor The goal of V-CHANCE study is to demonstrate the feasibility
Ngày tải lên: 20/09/2020, 18:51
Pancreatic panniculitis in a patient with pancreatic-type acinar cell carcinoma of the liver – case report and review of literature
... release of pancreatic enzymes with consecutive infiltration of neutrophils We present the first case of a patient with pancreatic panniculitis caused by pancreatic-type primary acinar cell carcinoma ... Access Pancreatic panniculitis in a patient with pancreatic-type acinar cell carcinoma of the liver – case report and review of literature Sebastian Zundler1*†, Ramona Erber2†, Abbas Agaimy2, Arndt ... patient with pancreatic panniculitis caused by pancreatic-type primary acinar cell carcinoma (ACC) of the liver and without underlying pancreatic disease Case presentation: A 73-year old Caucasian
Ngày tải lên: 21/09/2020, 11:47
A case-control study of glycemic index, glycemic load and dietary fiber intake and risk of adenocarcinomas and squamous cell carcinomas of the esophagus: The Australian Cancer
... Open Access A case-control study of glycemic index, glycemic load and dietary fiber intake and risk of adenocarcinomas and squamous cell carcinomas of the esophagus: the Australian Cancer Study Petra ... are scant This study examined the association between GI, GL, and other dietary carbohydrate components and risk of adenocarcinomas and squamous cell carcinoma of the esophagus accounting for ... consumption in the year before their diagnosis or, if their diet had changed in the last 6–12 months, their usual diet Controls were asked to report how often they consumed a specified amount of each
Ngày tải lên: 14/10/2020, 13:08
Claudin-3 inhibits lung squamous cell carcinoma cell epithelial-mesenchymal transition and invasion via suppression of the Wnt/β-catenin signaling pathway
... predicting the prognosis of lung SqCC and as a target for the treatment of lung SqCC in the future Key words: Lung squamous cell carcinoma, claudin-3, EMT, Wnt, metastasis Introduction Lung cancer ... associated with the prognosis of lung squamous cell carcinoma (SqCC) This study investigated the role of CLDN3 in inhibiting lung SqCC cell migration and invasion as well as the underlying molecular ... the lower chamber After that, the cells were grown for 24 h The cells that remained on the upper surface of the membrane were removed using a cotton swab, whereas the cells that migrated to the
Ngày tải lên: 15/01/2020, 11:10
Novel biomarkers that assist in accurate discrimination of squamous cell carcinoma from adenocarcinoma of the lung
... account for approximately 89 % of all lung cancers NSCLCs are further classified into adenocarcinoma (AD: 45 %), squamous cell carcinoma (SCC: 24 %), and large cell carcinomas (3 %), respectively ... challenging to the pathologists based solely on the morphological findings of tumors [5, 6] Cellular function is implemented with a series of molecules produced by the cell Distinct types of cells can ... Open Access Novel biomarkers that assist in accurate discrimination of squamous cell carcinoma from adenocarcinoma of the lung Kazuya Takamochi1* , Hiroko Ohmiya2, Masayoshi Itoh3, Kaoru Mogushi4,
Ngày tải lên: 20/09/2020, 18:07
More expression of BDNF associates with lung squamous cell carcinoma and is critical to the proliferation and invasion of lung cancer cells
... malignancies The purpose of this study was to explore the function of BDNF in lung squamous cell carcinoma (SCC) and adenocarcinoma (ADC) Methods: The expression of BDNF was examined in 110 samples of lung ... cells was used to indicate the relative level of BDNF expression The expression of BDNF was rare in HBE cells, and that was much higher in other lung cancer cells b The decreased expression of ... large cell neuroendocrine carcinoma [14] We previously demonstrated the involvement of the BDNF/TrkB pathway in the invasion of A549 cells [15] However, despite the considerable amount of studies
Ngày tải lên: 21/09/2020, 02:07
Distinctive roles of syntaxin binding protein 4 and its action target, TP63, in lung squamous cell carcinoma: A theranostic study for the precision medicine
... with authentication, mycoplasma test and short-tandem repeat (STR) profilings were performed in regular basis from the first culture of the cells to verify the cells to be the same as the cells ... to the development of precision medicine for LSCC patients Keywords: STXBP4, Lung squamous cell carcinoma, Drug therapy, Molecular target, Biomarker Background Despite recent advances in therapeutics, ... Background: Lung squamous cell carcinoma (LSCC) remains a challenging disease to treat, and further improvements in prognosis are dependent upon the identification of LSCC-specific therapeutic
Ngày tải lên: 05/11/2020, 08:23
Báo cáo sinh học: "The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance" doc
... oeso phageal squamous cell carcinoma . Cellular function tests further demonstrated that the presence of MTSS1 is related to the inhibition of the oesophageal squamous cell carcinoma cell aggressiveness. ... expression of MTSS1 was associated with the clinical pathology and prognosis of the patients with oesophageal squamous cell carcinoma. Cellular function tests further demonstrated that the presence of ... provided by the Beijing Cancer Hospital Ethics Committee. None of the patients received any neoadjuvant therapy prior to sur- gery. Histological types of the oesophageal squamous cell carcinoma
Ngày tải lên: 18/06/2014, 19:20