solubility of pharmaceutical solids

Improvement of Water Quality by Removal of Suspended Solids and High-speed Biological Filtration in Closed Water Body

Ngày tải lên : 05/09/2013, 08:40

... influence of these disturbances was found Some sampling points were selected They are the outlet of plant, the outside of experimental area, points of horizontal level and 0.5, 1.0, 1.5 m of vertical ... outlet of equipment Transparency[cm] 60 out of experimental area 50 40 30 20 10 10 15 20 25 30 35 40 45 50 Time[d] Figure Variation of Transparency Variation of COD concentration Variation of COD ... system, and the removal of nitrogen should be considered, too References [1] Department of Water Environment, Ministry of the Environment, Japan July 2002 Outline of Administration of Water Environment...

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Treatment of Pharmaceutical Wastes doc

Ngày tải lên : 22/03/2014, 14:20

... 111) The addition of FeSO4 mainly produces precipitable flocs of CaCO3 and Fe(OH)3 The quantity of CaCO3 precipitated by addition of 500 mg/L of FeSO4 can be estimated as: Quantity of CaCO3 ¼ 500 ... Similarly, the quantity of Fe(OH)3 precipitated by addition of 500 mg=L of FeCl3 ¼ 500 (mg=L) Â (106:9=162) ¼ 329:94 mg=L Amount of lime consumed in formation of Fe(OH)3 flocs by addition of FeCl3 ¼ 329:94 ... treatment of 1275 m3/day of pharmaceutical wastewater with a BOD5 of 3500 mg/L Assume the following conditions are applicable: Solution (A) Effluent contains 20 mg/L biological solids of which...

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Báo cáo khoa học: Using directed evolution to improve the solubility of the C-terminal domain of Escherichia coli aminopeptidase P Implications for metal binding and protein stability pptx

Ngày tải lên : 23/03/2014, 07:20

... loss of functional activity The object of this study was to increase the solubility of the C-terminal domain of AMPP, and in so doing to determine which residues are responsible for its poor solubility ... the reduced solubility of the AMPP#3-40 mutant was due to the absence of the R166G mutation, whereas the reduced solubility of the AMPP#3-1 mutant could be attributed to a number of changes (Table ... of mutations that conferred increased solubility were noted Screening for the boundary of the C-terminal AMPP domain N-terminal deletions of AMPP were generated by exonuclease III digestion of...

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Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-speciﬁc protein over-expressed in Escherichia coli pptx

Ngày tải lên : 23/03/2014, 21:20

... central issue that solubility of fusion proteins is not necessarily indicative of either proper folding or of increased solubility of the protein of interest We propose that the success of fusion protein ... yield of Pfg27 from Pfg27A was 24 mgÆL)1 of starting culture while it was for Pfg27B–F Effect of temperature on the expression proﬁles We examined the role of temperature in enhancing the solubility ... the enhanced solubility phenomenon observed in Pfg27A, we identiﬁed three key issues: (a) the role of the N-terminal extension; (b) the role of the D to N mutation; and (c) the role of the sequence...

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handbook of conveying and handling of particulate solids

Ngày tải lên : 02/04/2014, 14:59

... the course of the development of the uniaxial tester, and to Professor Sunil de Silva for help in the preparation of the manuscript Handbook of Conveying and Handling of Particulate Solids A Levy ... devices for the handling of bulk solids and to characterize bulk solids the flow properties of these bulk solids have to be known For their measurement a great number of shear and other testers ... and Flow of Solids, Bulletin 123, Utah University 1964 J Schwedes, Testers for Measuring Flow Properties of Particulate Solids, Proceedings of the International Symposium Reliable Flow of Particulate...

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thermodynamics of pharmaceutical systems

Ngày tải lên : 11/04/2014, 06:57

... Equilibrium Constant / 116 The Ideal Solubility / 117 Temperature Dependence of the Solubility / 120 Solubility of Slightly Soluble Salts / 123 Solubilities of Nonelectrolytes: Further Issues / ... concept of the free energy to include the amounts (numbers of moles) of the chemical constituents of the system, writing G ¼ f ðT; P; n1 ; n2 ; Þ ð3:19Þ where n1 is the number of moles of chemical ... point of water (which is also the melting point of ice) at 0 C [more precisely, 0 C corresponds to the freezing point of water (called the ‘‘ice point’’) in the presence of air at a pressure of...

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Báo cáo hóa học: " Comparison of four different methods for reliability evaluation of ecotoxicity data: a case study of non-standard test data used in environmental risk assessments of pharmaceutical substances" pdf

Ngày tải lên : 21/06/2014, 03:20

... not reported by any of the four evaluation methods: date of start of the test; method of preparation of stock solutions; the recovery efficiency of the method; the limit of quantification in ... settings of the room or chamber are stated? criteria The OECD guidelines also recommend that date of start of the test; method of preparation of stock solutions, the recovery efficiency of the ... variety of aspects are included: the chosen test system and its applicability domain, consideration of physiochemical properties and stability of test substance, number of replicates, number of concentration...

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Handbook of Pharmaceutical Granulation Technology doc

Ngày tải lên : 29/06/2014, 11:20

... manufacturing of pharmaceutical products is being evaluated by the scientists, engineers, and operational managers of pharmaceutical companies worldwide In the United States, where 49% of the world pharmaceutical ... Refs 4,5.) energies) of the powder with the help of a series of plots of both alkane and various polar probes A distinct advantage of IGC is the reproducible measurements of physical chemical ... area of a probe molecule As illup strated in Figure 16, a plot of RT ln VN vs a gD should give a straight line for a L series of alkanes, the slope of which allows p determination of the solids...

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structure and chemistry of crystalline solids

Ngày tải lên : 06/07/2014, 15:30

... interpretation of structures and assignment of notation Two appendices cover the literature, general considerations of solids, and predictions of structures Earlier books have missed the beauty of the ... great deal of insight for X-ray crystallography to follow Obviously, much of the development of crystallography predates the discovery of diffraction of X-rays by crystals Early studies of crystal ... 4.2 Metals 4.2.1 Structures of Metals Of the 109 elements 23 of these are classified as nonmetals—in the upper right corner of the long form of the periodic table Some of the elements along the...

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Pakistan journal of pharmaceutical sciences (2013) maria

Ngày tải lên : 24/07/2014, 17:46

... (Miller, 1959) The unit of alpha-amylase is defined as the amount of enzyme which liberates 1.0 μmol of maltose per minute at 50°C in phosphate buffer of pH 7.5 For the estimation of glucoamylase activity, ... discovered isolates of B licheniformis have great potential for producing high titers of different extracellular enzymes of commercial importance Optimization of growth parameters is of prime importance ... glucoamylase activity is defined as the amount of enzyme that liberates 1.0 µmole of glucose at 45°C in potassium phosphate buffer of pH 7.0 For the production of protease the cultures were grown at...

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báo cáo khoa học: " A comprehensive system of pharmaceutical care for drug misusers" ppsx

Ngày tải lên : 11/08/2014, 20:20

... population of about 900,000 covering the City of Glasgow, the whole of the local authority area of East Dumbartonshire and parts of North and South Lanarkshire and East Renfrewshire Though most of the ... approximately 80% or more of the business of a majority of pharmacies in Scotland The supervision of the consumption of methadone by patients attending the pharmacy and the provision of pharmacybased ... promote the concept of supervised consumption of methadone in community pharmacies In 1997 Scottish Office Department of Health published guidance on the planning and provision of Drug Misuse Services...

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báo cáo khoa học:" Health-Related Quality of Life after Ischemic Stroke: The Impact of Pharmaceutical Interventions on Drug Therapy (Pharmaceutical Care Concept)" docx

Ngày tải lên : 12/08/2014, 01:21

... al., Health-Related Quality of Life after Ischemic Stroke: The Impact of Pharmaceutical Interventions on Drug Therapy (Pharmaceutical Care Concept) Health and Quality of Life Outcomes 2010, 8:59 ... a valid, subjective measure of physical and mental health after stroke Two types of SF-36 scores can be generated: the SF-36 scales provide a comprehensive profile of health status, and the two ... targeting a power of 80% (2-sided test of α = 5%) to improve the patient's HRQoL after stroke on the basis of PC demonstrated that 116 patients were needed for each group The evaluation of the HRQoL...

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the environmental photochemistry of pharmaceutical compounds in aqueous solution and on a clay surface

Ngày tải lên : 13/11/2014, 10:10

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Cairns essentials of pharmaceutical chemistry 3e (RPS, 2008)

Ngày tải lên : 26/06/2015, 11:01

... School of Pharmacy and in 2003 moved to his present post of Associate Head of the School of Pharmacy at The Robert Gordon University in Aberdeen In 2006, he was promoted to Professor of Pharmaceutical ... 4.79 The addition of 10 mL of M alkali has only increased the pH of the buffer by a small amount By way of comparison, if 10 mL of M NaOH were added to litre of pure water, the pH of the solution ... Essentials of Pharmaceutical Chemistry Essentials of Pharmaceutical Chemistry Third edition Donald Cairns BSc, PhD, CSci, CChem, MRPharmS, MRSC Associate Head of School of Pharmacy The Robert...

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Improving the properties of pharmaceutical powders using supercritical anti solvent processing

Ngày tải lên : 09/09/2015, 10:08

... time of COM IDMC60-PVP40 versus change of VR (C10) at 50oC Figure 4.28 Aging time of SAS IDMC60-PVP40 versus change of VR (C10) at 50oC Figure 4.29 Aging time of unmilled IDMC versus change of ... interest of pharmaceutical researchers in developing new patents and novel techniques to improve oral bioavailability of APIs either in the areas of enhancing solubility and dissolution rate of poorly ... profiles for GC oven Figure 4.1 CSD of γ-IDMC Figure 4.2 CSD of α-IDMC Figure 4.3 XRDs showing the effect of SAS co-precipitation ratios on crystallinity Figure 4.4 XRDs showing the effect of...

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Novel electrostatic characterization of pharmaceutical powders

Ngày tải lên : 10/09/2015, 09:26

... ELECTROSTATIC CHARACTERIZATION OF PHARMACEUTICAL POWDERS KWEK JIN WANG (B Eng (Hons.), M Eng.), NUS A THESIS SUBMITTED FOR THE DEGREE OF PHILOSOPHY OF ENGINEERING DEPARTMENT OF CHEMICAL AND BIOMOLECULAR ... base of the aluminium sample pan (b) from the wire (a) Fig 4.2: Example plot of a surface potential verification test with applied 64 voltage of 80 V and a ramp rate of 40 V/s Fig 4.3: Effect of ... a supply voltage of 80 V Fig 4.4: Effect of agitation intensity (no of shakes per minute) on the 66 mass specific surface potential of ALM-1 powders Fig 4.5: SEM micrographs of adipic acid (AA)...

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Database development and machine learning prediction of pharmaceutical agents

Ngày tải lên : 11/09/2015, 09:57

... the cost and time of pharmaceutical research and development This work on “database development and machine learning prediction of pharmaceutical agents” is one of such kind of strategy which ... Evaluation of SVM identified MDDR virtual-hits 95 5.3.4 Evaluation of the predicted zinc binding groups of SVM virtual hits 96 5.3.5 Evaluation of the predicted tetra-peptide cap of SVM virtual ... vi List of Tables Table 1-1 Examples of well known bioinformatics databases Table 1-2 Examples of chemical databases Table 1-3 Comparison of the reported performance of different...

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Statistical learning approaches for predicting pharmacological properties of pharmaceutical agents

Ngày tải lên : 14/09/2015, 12:43

... understood because of the limited diversity of training data, quality of molecular descriptors, and the efficiency of SLMs Because of the diversity of compounds and mechanisms of toxic actions, ... success of applying SLMs in the computational study of pharmacological properties of diverse set of compounds Hence, proper representation of the structural and physicochemical features of chemical ... INTRODUCTION 1.1 Drug discovery pharmaceutical agents and pharmacological properties of Pharmacology is the study of the effects of chemical compounds on the function of living systems [Rang et al...

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Design and modeling of pharmaceutical polymorphic crystallization processes

Ngày tải lên : 14/09/2015, 14:07

... AND MODELING OF PHARMACEUTICAL POLYMORPHIC CRYSTALLIZATION PROCESSES NICHOLAS KEE CHUNG SHEN (B Eng (Hons.), NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CHEMICAL ... love i TABLE OF CONTENTS Acknowledgements i Table of Contents ii Summary iv List of Tables v List of Figures vi List of Symbols ... .6 2.1 Direct Design of Pharmaceutical Crystallization Processes ………………… 2.2 Direct Design of Pharmaceutical Polymorphic Crystallization Processes … 11 2.3 Techniques for Solubility Measurement...

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