skin lung and esophagus in murine models
Báo cáo y học: "4th meeting of the EU research network EUROME: From the identification of genes and cellular networks in murine models of arthritis to novel therapeutic intervention strategies in rheumatoid arthritis, London, UK, 9 March 2004" pot
Ngày tải lên :
09/08/2014, 01:23
... matrix) More importantly, knocking out the expression of gelsolin, an actin-binding protein with filament-severing properties found downregulated in RA, resulted in mild exacerbation of the arthritic ... expression of antiapoptotic proteins Bcl-2 and members of the inhibitor of apoptosis family (cIAP-1, XIAP and survivin, which directly bind to and inhibit caspases), was strikingly reduced Dr Brigitte ... cytosis by binding the complement inhibitor factor H (and in some cases, also the factor H-like protein 1) to its surface Binding is mediated by two types of plasmidencoded protein, class I (20...
- 4
- 288
- 0
Báo cáo y học: " T cells and post menopausal osteoporosis in murine models" doc
Ngày tải lên :
09/08/2014, 10:20
... which sex-steroids, infection and inflammation lead to bone loss by disregulating T lymphocyte function in animal models If the findings in experimental animals are confirmed in humans, it will, ... to be determined The BM levels of IL-7 are significantly elevated following ovx [6,23,24], and in vivo IL-7 blockade, using neutralizing antibodies, is effective in preventing ovx induced bone ... function and contribute to ovx induced bone loss are shown in Figure Remarkable progress has been made in elucidating the crosstalk between the immune system and bone and in uncovering the mechanism...
- 4
- 332
- 0
Báo cáo y học: " Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of b-receptor affinity in murine models of asthma" pdf
Ngày tải lên :
12/08/2014, 13:22
... manuscript writing MEP did the Bio-Plex®® cytokine analysis and assisted in data interpretation and manuscript writing LMB participated in the study design, data interpretation and manuscript writing JHTB ... data interpretation and manuscript writing CGI was involved in the study design and in the preparation of the manuscript All authors have read and approved the final manuscript Competing interests ... resulted in more exacerbations, a significant decline in baseline lung function, and an increase in airway responsiveness to methacholine, but did not alter bronchodilator responsiveness [34] As indicated...
- 12
- 300
- 0
Báo cáo y học: " Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation" pps
Ngày tải lên :
12/08/2014, 13:22
... pulmonary inflammatory diseases In murine models, cigarette smoke causes neutrophil infiltration into the lungs similar to smoke-induced inflammation in humans [19-22] Thus, murine models may ... enzymatically active and inactive chitinases, acidic mammalian chitinase (AMCase) and BRP-39 have been shown to be crucial in murine models of allergic inflammation Specifically, BRP-39 and AMCase have ... containing 0.3% bovine serum albumin (Invitrogen, Burlington, ON, Canada) or in RPMI supplemented with 10% FBS (Sigma-Aldrich, Oakville, ON, Canada), 1% L-glutamine, and 1% penicillin/streptomycin...
- 12
- 307
- 0
Báo cáo sinh học: "Histone modification enhances the effectiveness of IL-13 receptor targeted immunotoxin in murine models of human pancreatic cancer" doc
Ngày tải lên :
18/06/2014, 19:20
... Debinski W: Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 and a truncated form of Pseudomonas exotoxin ... 31 human carcinoma cells expressing receptors for interleukin 13 and interleukin J Biol Chem 1995, 270:16775-16780 Joshi BH, Kawakami K, Leland P, Puri RK: Heterogeneity in interleukin-13 receptor ... Histological finding of vital organs in SAHA and IL-13-PE treated mice Tissue specimens were obtained from mice liver, kidney, spleen, pancreas, brain and lung in each group of SAHA and IL-13-PE...
- 13
- 356
- 0
báo cáo hóa học:" Histone modification enhances the effectiveness of IL-13 receptor targeted immunotoxin in murine models of human pancreatic cancer" pot
Ngày tải lên :
20/06/2014, 03:20
... Debinski W: Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 and a truncated form of Pseudomonas exotoxin ... 31 human carcinoma cells expressing receptors for interleukin 13 and interleukin J Biol Chem 1995, 270:16775-16780 Joshi BH, Kawakami K, Leland P, Puri RK: Heterogeneity in interleukin-13 receptor ... Histological finding of vital organs in SAHA and IL-13-PE treated mice Tissue specimens were obtained from mice liver, kidney, spleen, pancreas, brain and lung in each group of SAHA and IL-13-PE...
- 13
- 441
- 0
Báo cáo y học: "The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease" pot
Ngày tải lên :
09/08/2014, 01:22
... elevated in the joints of the aforementioned rat OA joint instability model, including genes encoding proteins involved in retinoic acid synthesis (Aldh1a3) and retinol transport and delivery (Lrat and ... joint four weeks post-surgery [30] Crabp2 is regulated by retinoic acid and is often induced upon activation of this pathway [33] We were interested in confirming these findings and determining ... cellular retinaldehyde binding protein J Biol Chem 2003, 278:12390-12396 Budhu AS, Noy N: Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid...
- 9
- 345
- 0
Báo cáo khoa học: "Skin invasion and prognosis in node negative breast cancer: a retrospective study" pps
Ngày tải lên :
09/08/2014, 07:21
... http://www.wjso.com/content/6/1/10 Table 2: Clinical findings in skin in the ipsilateral breast Dimpling Tumor fixing to the skin Nipple retraction Ulcer Edema Post biopsy No abnormal findings 34 30 15 (35.1%) (30.9%) ... ubiquitous use and good cost-benefit balance Sometimes skin invasion cannot be predicted preoperatively Based on our findings, dimpling alone can be a clue for skin invasion Skin invasion is important ... [14] Removal of overlying skin is necessary when skin invasion is predicted Conclusion 0.95 Our study suggests that skin invasion has no impact on survival in node negative invasive breast cancer...
- 5
- 327
- 0
Báo cáo y học: " Developmental patterns and characteristics of epicardial cell markers Tbx18 and Wt1 in murine embryonic heart" ppsx
Ngày tải lên :
10/08/2014, 10:20
... published In this study, we employed immunofluorescence staining to investigate the expression of Tbx18 and Wt1 in heart using anti-Tbx18 and Wt1 antibodies and to identify whether Tbx18 and Wt1 ... Expression of Tbx18 and Wt1 in heart Tbx18 and Wt1 were expressed in the proepicardium and epicardium Tbx18 and Wt1 were expressed early in the proepicardium, and in scattered epicardial cells ... recognized by Tbx18 and Wt1 antibodies, the staining disappeared (Supplementary Figure 2) Do Tbx-18- and Wt-1 express in the cardiomyocyte Coimmunostaining with Tbx18 or Wt1 and the cardiac transcription...
- 6
- 274
- 0
Báo cáo khoa học: "Cysteine protease activation and apoptosis in Murine norovirus infection" docx
Ngày tải lên :
12/08/2014, 04:20
... remained viable and morphologically indistinct from control cells Blebbing, swelling, and cytoplasmic leaking were evident in cells infected in the presence of the caspase inhibitor (Figure 4) In ... better understanding of the different processes that were occurring in the caspase inhibited and non-inhibited infected RAW264.7 cells, two additional stains were used Hoechst staining is commonly ... pathway for PCD using survivin and cathepsin B is involved This program is initiated within hours of infection, leading to eventual cell death 24-36 hpi In the presence of a pan-caspase inhibitor, cell...
- 11
- 222
- 0
Báo cáo sinh học: "Precision and information in linear models of genetic evaluation" ppt
Ngày tải lên :
14/08/2014, 19:22
... model and a sire model on - - BLUP AND CDs: AN OVERVIEW Let us consider a mixed model with a single random factor (and the residual effect): where b is the fixed effect vector, X the pertaining incidence ... incidence matrix, u the random effect vector, Z the pertaining incidence matrix, and e the residual vector The random factors are normally distributed with the following first and second moments: ... remarks are worth mentioning at this stage: and L’(Z’MZ)L have the same set of eigenvectors, since is a linear function of I and the inverse of a linear function of I and L’(Z’MZ)L The CDs can...
- 20
- 253
- 0
Alloreactive t cells and cytokines in murine graft versus host disease 5
Ngày tải lên :
16/09/2015, 17:13
... DJ and Boonstra A 2002 In vitro generation of interleukin 10producing regulatory CD4+ T Cells is induced by immunosuppressive drugs and inhibited by T helper type (Th1)- and Th2-inducing cytokines ... BR 1999 Dose and timing of interleukin (IL)-12 and timing and type of total-body irradiation: effects on graft-vs.-host disease inhibition and toxicity of exogenous IL-12 in murine bone marrow ... 1987 Diphtheria toxin receptor binding domain substitution with interleukin2: genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein Protein Eng.1: 493 Williamson...
- 33
- 180
- 0
Alloreactive t cells and cytokines in murine graft versus host disease 4
Ngày tải lên :
16/09/2015, 17:13
... recruitment of inflammatory cells into the liver and skin, but not into the heart, in acute GVHD The predominantly expressed chemokines MIP1α and Mig in the spleen, liver and skin recruit Th1 ... 1987) and expressing the recombinant fusion protein in E coli This genetic engineering procedure is cheaper and has the potential of optimizing the construct with respect to efficacy and minimizing ... organs involved in acute GVHD and the roles played by chemokines in directing the infiltration of donor T cells into the host target organs The inflammatory reaction in acute GVHD begins with...
- 26
- 246
- 0
Alloreactive t cells and cytokines in murine graft versus host disease 3
Ngày tải lên :
16/09/2015, 17:13
... organ involvement in acute GVHD In this study, we examined T cell infiltration and chemokine expression in target and non-target organs of mice developing acute GVHD 3.1.1 T cell infiltration in ... immunohistochemical staining, that the T cell infiltration occurred in the target organs, liver, skin and intestines All these target 97 _ Results organs had intense infiltrating ... MIP-1α, MIP-2 and Mig were the predominant chemokines expressed in the spleen and liver In another target organ, the skin, MIP-1α, MIP-2, MCP-1 and MCP-3 were all highly expressed Interestingly, although...
- 62
- 145
- 0
Alloreactive t cells and cytokines in murine graft versus host disease 2
Ngày tải lên :
16/09/2015, 17:13
... different time points post-transplantation, and total body perfusion in a retrograde direction was carried out by injecting 40 ml of 1× PBS into the hepatic vein and the heart with syringe and 19-gauge ... Heart, MLN and PLN cells were obtained by mincing the tissues and the tissue debris filtered using a 41 µm mesh filter (Sefar, Switzerland) All cells were washed twice prior to staining with mAbs ... FS and SS) (Fig 1a), and cells that retained the original CFSE fluorescent intensity (non-proliferating cells) and cells that showed highly reduced CFSE fluorescent intensity (early proliferating...
- 24
- 258
- 0
Alloreactive t cells and cytokines in murine graft versus host disease 1
Ngày tải lên :
16/09/2015, 17:13
... functional domains – a cell binding domain, a translocation domain facilitating transport to the cytosol, and/ or a catalytic domain inhibiting protein synthesis Toxin engineering for therapy ... genetically fusing the toxin translocation and/ or catalytic domains to new cell-selective ligands or modifying amino acid residues in the cell binding domain and conjugating the altered toxin to the ... nitrogen intermediates, resulting in a “cytokine storm” (Ferrara, 1993; Antin et al., 1992) that produces systemic effects in inducing damage in target organs, mainly the gut, liver and skin Chronic...
- 45
- 159
- 0
Báo cáo khoa học: The heterogeneity of mast cell tryptase from human lung and skin Differences in size, charge and substrate affinity ppt
Ngày tải lên :
31/03/2014, 07:20
... tryptase in the presence and absence of heparin (j) skin tryptase, no heparin (h) skin tryptase + 100 lgặmL)1 heparin (d) lung tryptase, no heparin (s) lung tryptase + 100 lgặmL)1 heparin Km and Vmax ... represented by bands which were much larger and more intense than those for dimeric tryptase There was in all cases a corresponding reduction in band size and staining intensity with increasing degree ... amounts in the skin lysates than in lung lysates Con A, a lectin which binds to mannose of asparagine-linked oligosaccharides [45,46], also bound to Skin tryptase b Lung tryptase Detected in two...
- 14
- 438
- 0
Báo cáo y học: "Vascular Endothelial Growth Factor (VEGF) isoform expression and activity in human and murine lung injury" pps
Ngày tải lên :
12/08/2014, 14:20
... Several lines of in vitro evidence have pointed to a possible role for VEGF in lung repair and recovery following injury[19,29,35,36] In one LPSinduced murine model of lung injury, intrapulmonary ... group samples were examined for each treatment group A) Representative RT-PCR gel of VEGF isoforms in control and injured murine lung Lanes are as follows: (1–8) injured murine lung at day (24 hours ... depicting 3ng/ml and combination confirming a significant and cell number (B) following treatment for 48 hours with Bar Bar graphs depicting 3H-thymidine incorporation into ATII cells (A) and cell...
- 12
- 313
- 0
Application and Comparison of Two Biotic Ligand Models Predicting Copper Toxicity and Accumulation in Heavy Metal Tolerant Moss
Ngày tải lên :
05/09/2013, 10:15
... flux non-competitively by binding to a binding site other than BL In addition, changes in the conformation of BL caused by this binding of proton result in decreases in the number of BL The conformation ... (2007) investigated the effects of pH on short-term uptake of manganese and cadmium into Chlamydomonas reinhardtii, and they concluded that the increase in proton concentration inhibits the metal internalization ... cupric ion, and Min+ is the competing cation that inhibits copper toxicity and accumulation In this study, calcium ion and proton were assumed to be the only competing cations WHAM VI (The Windermere...
- 7
- 432
- 0