signaling pathways in inflammatory breast cancer

... calmodulin and PtdIns3K In guinea pig neutrophils, it has been demonstrated that inhibition of calmodulin results in inhibition of Rac and p21 activated kinases [50] Involvement of Rac in ROS ... switch of a5b1 integrin in CHO cells, suggesting also a role for Ca2+/calmodulin-dependent molecules in regulating the affinity state of integrins on neutrophils [48] Although PtdIns3K has been ... Calcium/calmodulin-dependent protein kinase II controls alpha5beta1 integrinmediated inside-out signaling J Cell Sci 111, 657–665 Ó FEBS 2002 49 Knall, C., Worthen, G.S & Johnson, G.L (1997) Interleukin 8-stimulated...

Ngày tải lên: 08/03/2014, 10:20

... compared to the uninjured brain 15 16 Trends in Cell Signaling Pathways in Neuronal Fate Decision A major component of the brain post-injury in comparison to the uninjured brain is the inflammatory ... f, (inset in i), m, (inset in n), o, (inset in o), p, (inset in r)) 20 µm; (e, g, h, i, q, r) 50 µm Local injury to the hippocampus via saline injection produces a strong induction of activin-βA ... excitotoxic injury to the hippocampus, ablating activin signaling by infusion of the activin inhibitor follistatin potently inhibits post-injury neurogenesis and exacerbates the inflammatory...

Ngày tải lên: 16/03/2014, 20:21

... caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer Breast Cancer Res Treat 2006, 95:219-228 Mohamed MM, Sloane BF: Cysteine cathepsins: multifunctional enzymes in cancer ... Update on inflammatory breast cancer Breast Cancer Res 2005, 7:52-58 Gong Y: Pathologic aspects of inflammatory breast cancer: part Biologic insights into its aggressive phenotype Semin Oncol ... showed CTSB staining score of ++ and 65.2% showed staining score of +++ In non-IBC, CTSB staining was variable with 3.7% scoring 0, 18.5% scoring +, 25.9% scoring ++ and 51.9% scoring +++ (Table...

Ngày tải lên: 18/06/2014, 16:20

... Ras-RafMEK-ERK signaling during RV infection in RK13 cells The PI3K inhibitor LY294002 and the MEK inhibitor U0126 were used to investigate PI3K-Akt and Ras-Raf-MEK-ERK signaling respectively during RV ... blue exclusion staining Involvement of PI3K-Akt and Raf-Raf-MEK-ERK signaling in RV-induced apoptosis was also examined by expression of constitutively active Akt and MEK in RVinfected cells Results ... http://www.virologyj.com/content/2/1/1 Inhibition of PI3K results in an increase in the speed and magnitude of RV-induced apoptosis To evaluate the role of PI3K-dependent signaling during RV infection, the effects of PI3K inhibitor...

Ngày tải lên: 18/06/2014, 22:20

... Breast Neoplasm” AND “Spain” in PubMed, EMBASE and PsycINFO, with Breast Cancer also being used as a key word; “Quality of life” AND Breast cancer in Dialnet; “quality” AND “life” AND cancer ... breast in IBECS; “quality of life” and breast cancer and “Spain” as the key words in CUIDEN; cancer AND breast AND “quality” AND “life” in ISOC; and lastly, the terms “Neoplasms of breast , ... general recommendation to include HRQL as an outcome in clinical studies involving breast cancer patients [49], and the fact that HRQL questionnaires are routinely used in clinical research This reflects...

Ngày tải lên: 20/06/2014, 15:20

... recent changes in lifestyle will increase the incidence of breast cancer in carrier families In conclusion, our findings suggest that the norms of accepting breast cancer cases for BRCA analysis ... does it relate to breast cancer in African-American women? Cancer, 2005, 103(8): 1540-1550 Collaborative Group on Hormonal Factors in Breast Cancer Breast cancer and breastfeeding: collaborative ... low incidence of breast cancer in the Maghreb These factors are difficult to identify precisely, but their combined effect has serious consequences, as the clear increase in breast cancer incidence...

Ngày tải lên: 08/08/2014, 17:20

... relationship of E-cadherin, α-catenin, β-catenin and γ-catenin in breast tumours to Nottingham Prognostic Index (NPI) (E-cadherin p = 0.094, αcatenin p = 0.144, β-catenin p = 0.378, γ-catenin p = 0.131) ... e-cadherin in a high-risk breast- cancer population Int J Clin Oncol 2004, 9:154-160 Kleer CG, van Golen KL, Braun T, Merajver SD: Persistent E-cadherin expression in inflammatory breast cancer ... in breast cancer tumorigenesis and malignant progression Breast Cancer Res 2001, 3:289-293 Rimm DL, Sinard JH, Morrow JS: Reduced alpha-catenin and Ecadherin expression in breast cancer Lab Invest...

Ngày tải lên: 09/08/2014, 07:21

... tumour characteristics including stage distribution [17] are detailed in table Pathology reports revealed in 80.7% invasiv ductal and in 9.2% invasiv lobular carcinoma; in 3.7% a DCIS was found ... was also involved in the clinical patient management KE participated in the study development especially by helping to define the Page of study endpoints KE was also actively involved in the data ... Clinical assessment of breast anatomy and marking Volume, CTV) Organs at risk were the lung and the contralateral breast In nodal negative breast cancer patients the axillar region was defined...

Ngày tải lên: 09/08/2014, 09:20

... including the internal mammary chain in left-sided breast cancer: dosimetric evaluation Radiother Oncol 2009, 90(1):99-105 30 Cozzi L, Fogliata A, Nicolini G, Bernier J: Clinical experience in ... of invasive breast cancer N Engl J Med 2002, 347(16):1233-1241 Roychoudhuri R, Evans H, Robinson D, Moller H: Radiation-induced malignancies following radiotherapy for breast cancer Br J Cancer ... radiotherapy for breast cancer: a population-based study BMC Cancer 2007, 7:9 Prochazka M, Granath F, Ekbom A, Shields PG, Hall P: Lung cancer risks in women with previous breast cancer Eur J Cancer 2002,...

Ngày tải lên: 09/08/2014, 09:20

... affecting prognosis in patients with breast cancer [1] According to the current 7th edition of the American Joint Committee on Cancer staging system, N stage in breast cancer is solely determined ... nodes on survival in early breast cancer Int J Oncol 2003, 22:697-704 American Joint Committee on Cancer Chapter 32 Breast In AJCC cancer staging manual 7th edition New York: Springer; 2010:347-369 ... lymphovascular invasion (LVI), and resection margin status A close margin was defined as the presence of invasive carcinoma within mm of the surgical margin of resection Patient grouping according to...

Ngày tải lên: 09/08/2014, 09:21

... positive staining of p53 in a representative case of high-grade (G3) ductal carcinoma Immunostaining shows a clear and wide nuclear staining in an high grade (G3) invasive ductal carcinoma Original ... categories: no staining, or weak staining in fewer than 10% of the tumor cells (0); weak staining in part of the membrane in more than 10% of the tumor cells (1+); complete staining of the membrane ... of cancer and the second leading cause of cancer death in women in the USA [1] and its incidence is increasing in many countries, including Italy [2] thus representing a major health problem To...

Ngày tải lên: 10/08/2014, 10:21

... JC, Tao AD, Ma JJ, Ling LJ, Wang S: Incidence of chemotherapy-induced amenorrhea associated with epirubicin, docetaxel and navelbine in younger breast cancer patients BMC Cancer 2010, 10:281 ... randomized trials Breast Cancer Res Treat 2011, 128:625-631 Liu X, Wang Z, Yu J, Lei G, Wang S: Three polymorphisms in interleukin1beta gene and risk for breast cancer: a meta-analysis Breast Cancer Res ... Randomized clinical trials were included if they met the following criteria: (1) ZOL used in breast cancer patients in adjuvant setting; (2) ZOL used with a control group receiving no treatment or placebo,...

Ngày tải lên: 10/08/2014, 10:21

... Journal of Negative Results in BioMedicine 2008, 7:5 breast cancer families in Finland, resulting in a 4-fold increased risk to mutation carriers [6] Although predisposing PALB2 mutations generally ... mutation, 1592delT, in Icelandic breast cancer cases The mutation was not detected in 638 unselected breast cancer cases nor in any of the 111 family members of the nine high risk breast cancer families ... of breast cancer [8], mutations have also been found in strong hereditary breast cancer families [7,9] and might thus be worthwhile searching for by linkage analysis in e.g geographically confined...

Ngày tải lên: 11/08/2014, 07:20

... BCS: breast conserving surgery; DCIS: ductal carcinoma in situ; FBC: female breast cancer; FNA: fine needle aspiration; IDC: invasive ductal carcinoma; MBC: male breast cancer; SNB: sentinel ... criteria for breast conservation without radical excision in primary operable invasive breast cancer Eur J Cancer 1995, 31A:2191-2195 Giordano SH, Cohen DS, Buzdar AU, Perkins G, Hortobagyi GN: Breast ... chemotherapy in male breast cancer Cancer 1989, 64:1583-1585 Authors' contributions SL and GF collected the data and reviewed the literature and case notes and was involved in followup appointments...

Ngày tải lên: 11/08/2014, 23:21

... while TGF-β inhibits Flk-1/KDR expression through a mechanism that involves reduced binding of GATA-2 to a palindromic GATA site in the 5'-UTR [30] These findings indicate that the binding of specific ... constructs containing different deletion segments of mouse Flk-1 promoter sequence [22], including binding sites for E-Box, Sp1, AP2 and NF-κB (Fig 5A) As shown in Fig 5B and 5C, deletion binding sites ... Flk-1 expression in mouse lungs HIMF enhances Flk-1 expression in mouse lungs Recombinant HIMF protein or BSA was intratracheally instilled into adult mice (200 ng/animal in 40 μl saline, n = for...

Ngày tải lên: 12/08/2014, 16:20

... performed by heating sections in pH 6.0 citrate buffer Sections were then rinsed in PBS and incubated in blocking buffer (5% bovine serum albumin, 0.3% Triton X-100, 10% normal goat serum, in PBS) for ... between multiple signaling pathways, the ability to detect the activation status of individual pathways within a complex network of other pathways in the cell is of paramount importance In this manner, ... principal component (PC1) MTB/ TRAS mice uninduced (open triangles) or induced (filled triangles) for 48 or 96 h were used for training, while the remaining MTB/TRAS time points and MTB uninduced...

Ngày tải lên: 14/08/2014, 21:20

... polymorphisms in Asian breast cancer patients 123 ABCB1 polymorphisms and pharmacokinetics of doxorubicin and doxorubicinol in Asian breast cancer patients The influence of ABCB1 linked polymorphisms ... in Asian ethnic groups and breast cancer patients 190 Table 3.26 The influence of CBR1 polymorphisms on pharmacokinetics of doxorubicin and doxorubicinol in Asian breast cancer patients The influence ... adjuvant regimen in breast cancer chemotherapy.(30,51) Although the use of anthracyclines results in a definite survival gain in the adjuvant setting, the margin of benefit may vary in some populations.(49,52)...

Ngày tải lên: 11/09/2015, 16:04

... role in apoptotic cell death in mammalian cells Besides mediating apoptosis in the intrinsic pathway, it also amplifies the extrinsic apoptotic pathways in certain cell types, making it the point ... necessary in order for another PH domain-containing serine/threonine kinase identified as phosphoinositide-dependent kinase (PDK1) to phosphorylates Akt on Thr308 within its activation loop Binding ... Factors-Regulated Survival Signaling Pathways: PI3KAkt Pathway 27 Aberrations of PI3K-Akt Signaling in Cancer 27 PI3K-Akt Signaling 28 Akt-mediated Survival Signaling 29 Growth...

Ngày tải lên: 12/09/2015, 08:18