signaling in the control of osteoclast activity

... with the breaking of cambial dormancy (Little and Wareing, 1981Moreover, ABA content increases again in reactivating cambium, for example, in the trunk of Pinus contorta (Savidge and Wareing, ... inactivation of auxin receptor and carrier proteins Later on, the breaking of rest may occur when the conditions of active membrane trans- port are regained Is abscisic acid (ABA) involved in the regulation ... applied to the lower and upper sides of an inclined stem, respectively Reports concerning the intervention of other phytohormones in this process are somewhat conflicting Several observations indicate...

Ngày tải lên: 09/08/2014, 02:21

... concentration Therapeutic drug monitoring of infliximab could result in a lowering of dosage in patients having higher exposure than needed, in an increasing of dosage in others, or in a discontinuation of ... Taking into account the control of disease activity, the physician selected a preliminary therapeutic decision from among four options: (a) decrease infliximab dosage, (b) maintain the same infliximab ... knowledge, this is the first study to highlight the usefulness of pharmacokinetic monitoring of infliximab concentration to control disease activity in RA Indeed, the measurement of trough infliximab...

Ngày tải lên: 12/08/2014, 11:22

... Thus, integrin-dependent cell volume sensing and signaling integrates into the overall context of insulin signaling Similarly, sensing of glutamine-induced hepatocyte swelling by integrins feeds into ... Osmosensing and signaling in mammalian cell function F Schliess et al [7] On the other hand, hyperosmotic shrinkage prevents insulin-induced hepatocyte swelling and proteolysis inhibition, indicating ... tyrosine phosphorylation, trafficking of the CD95 to the plasma membrane surface, and death inducing signaling complex formation, leading to the execution of apoptosis in this case [38] Although ineffective...

Ngày tải lên: 18/02/2014, 16:20

... with the PLC-interacting region has been found Whether the hydrolysing activity of GTP of PpTGase is related to certain cellular signalling in the slime mold remains to be determined As the production ... because of the attachment of the hexahistidine, the recombinant PpTGase protein appeared to be slightly larger These results indicate that the cDNA obtained covered the entire coding region Involvement ... terminus that is required for binding to the plasma membrane, thereby being involved in the formation of the corneum [47] Additional amino-terminal residues of TGase include the sequences that are post-translationally...

Ngày tải lên: 17/03/2014, 23:20

... pro-opiomelanocortin in the arcuate nucleus of the hypothalamus, both of which are key molecules in the control of energy balance [46] The administration of RFRPs induces Fos protein in the arcuate ... distributed within the brain [44] Expression of the main receptor for RFRP, GPR147, is broadly distributed within the brain, including the septal areas, amygdala, bed nucleus of the stria terminalis, ... be involved in the integration in the control of energy metabolism and stress responses, whereas the underlying detailed mechanisms need further investigation RFRP The mammalian members of the...

Ngày tải lên: 29/03/2014, 21:20

... describe the binding isotherms obtained previously for the b-casein 125 phosphopeptide in this pH range, and the same model was adapted to t the binding isotherm of OPN 1149 measured at pH 7.0 The ... osteopontin C Holt et al details of the model are provided in Doc S3 (see Supporting information) The Ca2+ binding isotherm of OPN 1149 was determined by measuring the concentration of free Ca ... metaPrDOS [32] According to PONDRề predictions, the positions of PC sequences in the SPs in Table were, with the exception of the globular protein riboavin-binding protein (RBP), disordered,...

Ngày tải lên: 29/03/2014, 23:20

... neurogenesis The list of these genes is reported in additional file These results support the hypothesis of a possible role of E6 and E7 in the induction of neuroendocrine differentiation of SCLC ... Evaluation of the results obtained in the two systems showed deregulation of the same pathways in human SCLC and in that induced experimentally by the E6/E7 oncoproteins of HPV16 To further highlight the ... release the E2F transcription factor, subsequently leading to progression of the cell into the S-phase [14] Furthermore, E7 binds to inhibitors of cyclin-dependent kinases (p16, p21), increasing the...

Ngày tải lên: 18/06/2014, 16:20

... neither the β3 integrin nor the CTR are expressed by osteoclast precursors The expression of these genes increases during the late stages of osteoclast differentiation [42], after induction of the ... defect in osteoclast- mediated bone resorption in mice in which either of these genes has been deleted [36,37] In humans, inactivating mutations in the cathepsin K gene are associated with an osteoclast ... activation of the osteoclast has been shown to involve several different integrins, including the vitronectin receptor αvβ3 [2,3] Expression of this integrin has served as a useful marker to identify osteoclasts...

Ngày tải lên: 09/08/2014, 07:20

... about either the composition or the stepwise construction and targeting of the mSin3a and Mi-2 co-repressor complexes or their role in disease The reduction in mSin3a expression in the lungs of cigarette ... understanding of the roles of these co-repressor complexes and thereafter their roles in disease In summary cigarette smoke exposure reduced HDAC2 activity and the expression of mSin3a and Mi-2α in the ... deacetylating of key components of the transcriptional machinery including the core histone proteins resulting in their in re-association with the DNA, thus presenting a transcriptionally closed...

Ngày tải lên: 11/08/2014, 03:20

... about either the composition or the stepwise construction and targeting of the mSin3a and Mi-2 co-repressor complexes or their role in disease The reduction in mSin3a expression in the lungs of cigarette ... understanding of the roles of these co-repressor complexes and thereafter their roles in disease In summary cigarette smoke exposure reduced HDAC2 activity and the expression of mSin3a and Mi-2α in the ... deacetylating of key components of the transcriptional machinery including the core histone proteins resulting in their in re-association with the DNA, thus presenting a transcriptionally closed...

Ngày tải lên: 11/08/2014, 06:22

... primordia in (A), showing staining at the base of trichomes (C) Detail of an emerging later root (D) 15-day-old pVvMYB60:GUS seedling (E) Magnification of leaf primordia in (D), showing staining of ... conditions, the lines expressing the VvMYB60 gene displayed a rate of water loss indistinguishable from the one observed in the wildtype, thus demonstrating complete rescue of the stomatal defects of the ... stage, the onset of ripening and the accumulation of sugars are correlated to increasing levels of ABA in the berry [30], suggesting a possible negative effect of the hormone on the expression of...

Ngày tải lên: 11/08/2014, 11:21

... participate in inhibiting HIV-1 entry in the decidua These findings also suggest that the first trimester maternofetal interface is a relevant model for studying determinants of natural protection against ... factors) is involved in the control of HIV-1 infection at the maternofetal interface The decidua could thus serve as a mucosal model for identifying correlates of protection against HIV-1 infection ... particularly during the first months of pregnancy During the first trimester of pregnancy the maternofetal interface is composed of the placenta (the fetal part) and the maternal uterine mucosa (decidua)...

Ngày tải lên: 13/08/2014, 01:21

... represses the IRF1-mediated activation of the HIV-1 ISRE element Implication of IRF8 in the maintenance and NCoA3 in the reactivation of the viral latency may thus provide new insights into the control ... for the low level of transcription observed during post-integration latency (reviewed in [9]): the inaccessibility of the integrated provirus to the transcriptional machinery, the absence in resting ... this study, the role of the HDAC inhibitor NaB on HIV-1 latently infected cells gene expression was explored using microarrays Since chromatin remodeling is involved in the regulation of HIV-1 gene...

Ngày tải lên: 13/08/2014, 09:21

... prosthesis inserted into the portal vein and the inferior vena cava of the in vivo rabbit model Figure Diagram of silastic H-shaped prosthesis inserted into the portal vein and the inferior vena cava of ... relating the readings to the wet weight of the liver, determined at the end of each experiment The "buffering capacity" of the HA was expressed in % as: [Increase in HA flow / Decrease in PV ... cross-clamping at point "b", distal to the point of entry of the splenic vein into the portal vein perfusate significantly inhibited the HA response to 10-8 moles 100 g liver-1 intra-arterial adenosine...

Ngày tải lên: 13/08/2014, 13:20

... mutations The elucidation of genes contributing to complex-trait hearing impairment is in its infancy and is far behind the investigation of the genetics of other complex diseases Gene-environment interactions ... that the receptiveness of supporting cells to such developmental signals might depend on the mechanism of deafening and the amount of time after deafening The findings may indicate that the failure ... separately and in combination led to significant reduction in numbers of hair cells in the anterior and posterior macular epithelium of the embryonic inner ear without apparent changes in the embryonic...

Ngày tải lên: 14/08/2014, 08:20

... staining with Scott’s tap water for minutes Wash the slides in tap water for minutes Counterstain in eosin for minutes (staining time can be modified depending on desired staining intensity Rinse ... for minutes Stain the sections in hematoxylin for 2-3 minutes (staining time can be modified depending on desired staining density) Wash the slides in running tap water for minutes Identify the ... Characterization of moesin expression in the corneal fibrosis………………… 49 4.5 Role of moesin in the corneal fibrosis in vivo………………………………… 51 4.5.1 In vivo delivery of moesin siRNA into the cornea after...

Ngày tải lên: 09/09/2015, 18:51

... and the last one controls the body attitude by controlling the hip angle during the stance phase The concept NATIONAL UNIVERSITY OF SINGAPORE SINGAPORE 2.2 Overview of the Walking Algorithm 17 of ... shown in the figure NATIONAL UNIVERSITY OF SINGAPORE 72 SINGAPORE LIST OF FIGURES 4.5 xiii The sensory input to the oscillator; S i, S t and S p are the inhibition input, triggering input and ... because of the push; the dashed circle in the subplot of swing period shows the adjustment of swing period during the push 91 4.19 Simulation data: a bigger force applied on the robot; the CoP...

Ngày tải lên: 11/09/2015, 10:01

... JAK-STAT pathway in cytokine signaling The initial step of cytokine signaling involves the engagement of cytokines to their specific receptors Currently two classes of cytokine receptors have ... diagram of the Stat3β homodimer–DNA complex The N-terminal 4-helix bundle is shown in blue, the β-barrel domain in red, the connector domain in green, and the SH2 domain and phosphotyrosine-containing ... mediate the interaction with other proteins The DNA-binding domain resembles an eight-stranded β-barrel, where several loops between the β strands of this domain participate in DNA-binding Between the...

Ngày tải lên: 15/09/2015, 17:10

... occurrence of nucleation then manually start the control profiles thereafter, subject to the discretion of the operator in defining the exact point of primary nucleation Alternatively, the point of primary ... probe for inline monitoring or for the purpose of seeding The trade-off for using the port for seeds addition instead of for insertion of a probe for in- line monitoring is the loss of useful data ... PVM, the instruments of interest in this work, are then elucidated Chapters and describe the control strategies used in batch cooling crystallization in this work The benefits, or lack thereof, of...

Ngày tải lên: 05/10/2015, 22:15

... Values of q& k and q&&k are estimated from values of qk using the backward difference Training of the controller is then done with the training data sets obtained In the work done here, both the inputs ... at the outputs of the last layer of the network These are then propagated backward through the network to compute the corresponding error signals at each of the outputs of the neurons in the ... from the input signal vector to the output signal vector Learning by, or training of, a neural network is done by presenting it with training pairs of vectors of inputs and the corresponding desired...

Ngày tải lên: 26/11/2015, 22:57