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Báo cáo y học: "Animal models of copper-associated liver disease" doc
... infiltrates of inflammatory cells and prominent piecemeal necrosis (resembling chronic active hepatitis) Piecemeal necrosis has not been described in West Highland white terriers toxicosis Finally, ... development of foci of hepatocellular degeneration and necrosis with scattered inflammatory response of neutrophils, lymphocytes and plasma cells Fine fibrous septa extend from the portal areas into ... the development of fulminant hepatitis, hepatic fibrosis, and subsequent hepatocarcinogenesis in LEC rats by increasing the process of oxidative damage with copper, and a reduction in the antioxidant...
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báo cáo hóa học: " Osteoarthritis accelerates and exacerbates Alzheimer’s disease pathology in mice" ppt
... cyclooxygenase activity [38] Previous studies in our laboratory, examining the role of brain inflammation in AD pathology, revealed that chronic, low level expression of IL-1b in the brain of GFAP-IL1bXAT; ... number of chondrocyte clones in the articular cartilage (Figure 1H) Knee arthritis also induced behavioral changes including a decline in rotarod performance (Figure 1I) as well as increased grooming ... metabolism in the brain [37] However, a subset of NSAIDS have been shown to possess g-secretase modulating activity that can reduce Ab production in vitro and in vivo independently of cyclooxygenase...
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Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt
... expression of CB1 in isolated cortical neurons was affected in both strains of R6 transgenic HD mice It appeared that the amino terminus of mutant huntingtin containing an expanded polyglutamine tract ... levels of mutant huntingtin protein are lower in the R6/1 mice compared to R6/2 [10] and that neuronal intranuclear inclusions (NIIs) containing the human transgene-encoded amino terminus of human ... glycerol [26], act as modulators of dopamine neurotransmission, and abnormalities in cannabinoid signalling or modulation of dopamine signalling or both have been implicated in a number of neurodegenerative...
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Báo cáo khoa học: Amyloid-b protofibril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice docx
... (1999) Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons J Neurosci 19, 8876–8884 Walsh DM, Lomakin A, ... show prominent early pathology, with enhanced formation of Ab protofibrils and intraneuronal Ab accumulation beginning months before plaque onset [19,20] Accordingly, we found it of particular interest ... subtracted from mean escape latency at the first day of training, to measure the improvement in spatial learning Thigmotaxis, circling and floating activities, as defined by the hsv image software,...
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Báo cáo khoa học: Increased glucose metabolism and ATP level in brain tissue of Huntington’s disease transgenic mice pdf
... (wild-type) huntingtin protein and the transgene product were examined by western blotting using anti-huntingtin serum raised against the first 17 amino acids of the N-terminal part of the protein We found ... huntingtin protein One such scenario is that the interaction between polyglutamine-containing proteins and GAPDH results in a reduced activity of this energy-metabolizing enzyme, leading to cell ... Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain Science 277, 1990–1993 The Huntington’s Disease Collaborative Research Group (1993) A novel gene containing...
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Báo cáo y học: "Leptospirosis presenting in a woman with fulminant hepatic failure from Wilson’s disease: a case report" ppsx
... deterioration of our patient’s clinical condition and the biochemical findings strongly point to an underlying disease that was not obvious at the initial presentation Since other causes of FHF including ... combination of zinc, which induces a negative copper balance by blocking intestinal absorption, and trientine, which acts as a potent copper chelator Our patient showed gradual signs of improvement ... mental status deteriorated and she displayed drowsiness and flapping tremor Total serum bilirubin increased further Page of to 66.7 mg/dL, INR reached 7.7 and ammonia (NH ) rose to 95.7 μmol/L (normal...
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Báo cáo y học: "Leptospirosis presenting in a woman with fulminant hepatic failure from Wilson’s disease: a case report" pdf
... deterioration of our patient’s clinical condition and the biochemical findings strongly point to an underlying disease that was not obvious at the initial presentation Since other causes of FHF including ... combination of zinc, which induces a negative copper balance by blocking intestinal absorption, and trientine, which acts as a potent copper chelator Our patient showed gradual signs of improvement ... mental status deteriorated and she displayed drowsiness and flapping tremor Total serum bilirubin increased further Page of to 66.7 mg/dL, INR reached 7.7 and ammonia (NH ) rose to 95.7 μmol/L (normal...
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Báo cáo y học: " Accidental Jorge Lobo''''s disease in a worker dealing with Lacazia loboi infected mice: a case report" doc
... characteristic of viable L loboi yeast-like cells Methenamine silver staining showed spherical to oval yeast-like cells mostly uniform in size and arranged singly or in small chains of cells linked by ... Hematoxylin-eosin stained section of the biopsied tissue Hematoxylin-eosin stained section of the biopsied tissue Numerous Lacazia loboi yeast-like cells are observed inside a granulomatous infiltrate ... (200×) and 4) In respect to treatment, it has been observed that after use of clofazimine and dapsone, which have antimicrobial as well as anti-inflammatory activity, in concomitant leprosy and...
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The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression
... and flavonols, proanthocyanidin oligomers, and triterpenoids isolated from Vaccinium inhibit the growth and proliferation of several types of tumor cells lines in vitro and may act in a complementary ... iso-quercitrin, quercitrin, I-3/II-8-biapigenin, kaempferol, myricetin Anthocyanins: cyanidin, delphinidin, malvidin, pelargonidin, petunidin, and peonidin Isoflavones: genistein, genistin, daidzein, ... was in the following order: delphinidin > petunidin > malvidin = approximately cyanidin > (+)-catechin > peonidin > pelargonidin The activity toward ONOO− was in the following order: delphinidin...
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TIỂU LUẬN CHẨN ĐOÁN AUJESZKY’S DISEASE VIRUS (ADV) BẰNG KỸ THUẬT NUÔI CẤY TẾ BÀO
... ctv: In vitro efficacy of an organic disinfectant citrex on selected swine viruses (i) Harald Granzow, Frank Weiland ctv- Journal of virology, Mar 1997, page 2072-2082: Ultrastructural analysis of ... Viruses Indigenous to Feral Swine (f) Hans Nauwynck, Sarah Glrieux ctv, 2006- review article: Cell biological and molecular characteristics of Pseudorabies virus infections in cell cultures and in ... Epidemiology and Animal HealthNational Surveillance Unit Fort Collins, CO: National Pseudorabies Surveillance Plan Final Draft (d) United States Department of Agriculter- Animal and Plant Health Inspection...
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Tài liệu THERAPEUTICS of PARKINSON’S DISEASE and OTHER MOVEMENT DISORDERS docx
... theSNc(McNaughtetal.,2002;Zhuetal.,2002).Thereisalso an increase in the content of oxidatively damaged proteins, as indicatedbyanelevationinthelevelsofproteincarbonylsand protein adducts of 4-hydroxy-2-nonenal (derived from lipid peroxidation) ... usually 30 mm in diameter, and in the SNc in PD it demonstrates an intensely stained central core with a lightly staining surrounding halo with the protein-binding dye eosin Electron microscopy demonstrates ... widespread and can be seen in noradrenergic neurons in the locus coeruleus, cholinergic neurons in the nucleus basalis of Meynert, and serotonin neurons in the median raphe, as well as in nerve cells in...
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Tài liệu Parkinson’s Disease and Related Disorders docx
... current understanding of how neurons die in sporadic and familial PD This included symposia on development of midbrain dopaminergic neurons, the role of iron in neurodegeneration, and the progress on ... degeneration of dopaminergic neurons: neuroprotective effect of Interleukin 10 367 Sawada, M., Imamura, K., Nagatsu, T.: Role of cytokines in inflammatory process in Parkinson’s disease ... computational roles of the basal ganglia and dopamine Modeling of the basal ganglia has played a major role in our understanding of the physiology and pathophysiology of this elusive group of nuclei...
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Tài liệu Alzheimer’s Disease and Other Dementias doc
... of nerve cells in Huntington’s chorea He worked at the universities of Heidelberg and Munich In 1912, he was appointed professor of psychiatry and director of the Psychiatric and Neurologic Institute ... malfunctioning of activities, which are coordinated in the prefrontal cortex of the brain They include disturbances in activities, such as planning, problem-solving, reasoning, judgment, organizing, ... symptom In a demyelinating disease, the “myelin sheaths” that cover axons of neurons get inflamed and are then stripped of myelin, or are demyelinated.12 This kind of damage to the neuron makes...
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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx
... Levels of the RAN binding protein were reduced in a-syn cells with respect to b-gal cells and RuvB-like is upregulated in a-syn cells in the absence of dopamine CRMP4, a member of a family of neuron-enriched ... overexpression of a-synuclein significantly affected the levels of four proteins [stathmin 1, glutathione S-transferase 4912 d Not applicable (GST)p, Ran binding protein and C1q binding protein], related ... plasmid containing the b-galactosidase coding sequence as control a-Synuclein-expressing cells (a-syn) and control cells (b-gal) were expanded in the presence of 200 lgÆmL)1 geneticin The cells rescued...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... is now a renewed interest in studying APP processing in sporadic AD brain, and in understanding the mechanisms of Ab truncation and modification Most transgenic models produce mainly full-length ... Zn2+ and Cu2+ play a role in Ab biology, and possibly in AD pathogenesis Both ions bind APP and Ab with high affinity, and stimulate Ab aggregation and oxidizing effects of Ab in vitro By deleting ... time-consuming and greatly in uenced by individual handlers IntelliCages are automated learning cages where animals carrying transponders are housed in groups and trained in learning corners Each individual...
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Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf
... Expression of bovine intes- Expression and purification of the amyloid b-peptide 44 45 46 47 48 49 tinal calcium binding protein from a synthetic gene in Escherichia coli and characterization of the product ... 2000 in blocking solution for 30 Cells were rinsed in NaCl ⁄ Pi several times and incubated in blocking serum containing anti-mouse IgG (Vectastain) for a further 30 Staining was developed by incubation ... HEPES, and dissociated using papain Cells were plated at · 104 cells on 48-well dishes pre-coated with poly-d-lysine (50 lgÆmL)1) and maintained in neurobasal medium containing mm glutamine and...
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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Autosomal-recessive genes in Parkinson’s disease – a common pathway? docx
... regulation of Parkin, PINK1, DJ-1 and HtrA2 activity remains to be determined Parkin can be phosphorylated by a number of kinases including casein kinase 1, protein kinase A, protein kinase C [86] and ... inactivation of Drosophila PINK1 using RNAi suggested that PINK1 maintains neuronal survival by protecting neurons against oxidative stress [79] In mammalian cell culture, PINK1 protects against ... of the ubiquitin-proteasomal system (UPS) [7] Parkin also has a proteasome-independent role and a number of putative substrates for Parkin have been described, including proteins implicated in...
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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx
... transport of cholesterol to post-lysosomal destinations Cells from NPC subjects show a decrease in acid sphingomyelinase activity, leading to the accumulation of sphingomyelin [27] Because one of the ... Regulation of intracellular cholesterol trafficking Transferase activity ATPase Dopamine transmission and synaptic vesicle dynamics Protein kinase Gaucher’s disease ⁄ Parkinson’s disease in heterozygotes ... body inclusions should have a key role in our understanding of the mechanisms of the disease We propose that pathology data will, in most cases, be more insightful than clinical data in defining...
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Tài liệu PARKINSON’S DISEASE pptx
... deaths of motor neurons in the spinal cord and brain cause profound motor weakness Again, in Parkinson’s disease, the affected neurons are located in the substantia nigra, an area of the brain that ... between aging and Parkinson’s in the actor’s mind and reinforces this association in the popular imagination The average age of onset of Parkinson’s disease is about sixty years At the beginning of ... Parkinson’s disease The loss of the dopamine-containing pigmented black cells within the substantia nigra is the landmark pathologic feature of Parkinson’s disease 10 / INTRODUCTION brains, and...
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Is Lactobacillus GG Helpful in Children With Crohn’s Disease? Results of a Preliminary, Open-Label Study docx
... index including subjective reporting of abdominal pain, general well-being, and diarrhea and physical findings, including linear growth and laboratory parameters (hematocrit, serum albumin, and ... challenge in childhood coeliac disease Scand J Gastroenterol 1994; 29:144–7 13 McKay DM Intestinal inflammation and the gut microflora Can J Gastroenterol 1999;13:509–16 14 Merger M, Croitoru K Infections ... strain indistinguishable from L rhamnosus strain GG Clin Infect Dis 1999;28:1159–60 26 Salminen S, von Wright A, Morelli L, et al Demonstration of safety of probiotics: a review Int J Food Microbiol...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25