sensitivity analysis in the scientific discourse

... questions of the type ‘which of the uncertain input factors is more important in determining the uncertainty in the output of interest?’ or ‘if we could eliminate the uncertainty in one of the input ... replicate the example using SIMLAB All the concepts will then be revisited in the subsequent chapters In Chapter we offer another preview of the contents of the book, introducing succinctly the examples ... following) A sensitivity analysis of this model should tell us something about the relative importance of the uncertain factors in Equation (1.1) in determining the output of interest Y, the risk...

Ngày tải lên: 03/06/2014, 02:01

... taken together as a single discourse can convey meaning quite different from the meaning conveyed by each sentence taken separately The difference in meaning arises from the context they were ... development and the other on the supra sentence level appealing to the intuitive sense of the individual As a college teacher teaching observe difficulties among college student include writing effective ... material to their students Administrator The administrators will benefit from this study through insights gathered as this will guide them in what decisions they will make regarding the student’...

Ngày tải lên: 04/12/2014, 05:05

... methods described in the thesis It is interesting to develop models and algorithms according to the nature of the data, instead of trying to adjust the data to the nature of the model In an attempt ... 1.1 INTRODUCTION The subject of this thesis is multi-way analysis The problems described mostly stem from the food industry This is not coincidental as the data analytical problems arising in the ... This monograph was originally written as a Ph D thesis (see end of file for original Dutch information printed in the thesis at this page) i MULTI-WAY ANALYSIS IN THE FOOD INDUSTRY Models, Algorithms...

Ngày tải lên: 31/03/2014, 22:20

... prosecution under the German Copyright Law Springer-Verlag is a company in the BertelsmannSpringer publishing group © Springer-Verlag Berlin Heidelberg 2000 Printed in Germany The use of general ... category Our main tool is, in some sense, integration by parts, which is equivalent to the fundamental theorem of the infinitesimal calculus In our direction there are two books One of them is HSrmander's ... Microlocal Analysis" in the space of hyperfunctions ( or in a rather wider class of functions) which makes it possible to apply the methods in the C °O_ distribution category to the studies on P.D.E in...

Ngày tải lên: 01/06/2014, 08:02

... the same gait pattern (from kinematics and kinetics point of view) with the same gait speed These trials were considered for the following analysis The data were considered repeatable according ... in respect to the walking direction and is defined as the angle formed with the line of progression and the segment connecting the marker on the V metatarsal joint and the marker on external ... both to the subject's weight and to the walking velocity were calculated as kinetic parameters in order to investigate the push-off ability during the propulsive phase of the gait cycle (terminal...

Ngày tải lên: 19/06/2014, 10:20

... Institute in the Philippines and the University of Sydney The proposal for courses in the areas of marketing and policy analysis grew out of the experience in providing training as indicated above The ... used in capacity building with particular emphasis on ‘training the trainers’ Over the period of the project there has been a significant shift in the material used in teaching programs and in the ... clear indications of the benefit of the training in the work being undertaken and the level of analysis used for Ministry projects It is considered that over the period of the program there has...

Ngày tải lên: 22/06/2014, 13:20

... that includes the length of the authenticated data The integrity code is computed at the receiver side and compared with the received integrity code The CTR combines the CBC-MAC to become the ... P2 Then the adversary can obtain P1 ⊕ P2 = C1 ⊕ C2 since the counters are the same and the keys are the same although the adversary does not know the key The adversary may obtain much useful information ... (IV) and the replay counter are the same except that the last IV is used by the source device when it sends the frame, and the replay counter is used by the destination device to maintain the high...

Ngày tải lên: 22/06/2014, 22:20

... reductions of inflammatory lesions either in the SI joints or in the spine have been demonstrated for all three TNF blockers [33] Interestingly, there is still a further decrease of inflammation ... or more of the following criteria: fulfilling the clinical symptom of inflammatory back pain, being positive for HLA-B27, or showing evidence of sacroiliitis by imaging [11] Analyzing 350 referred ... decades has not clarified the functional role of the HLA-B27 molecule in the pathogenetic process In the center of the discussion about the pathogenesis of the SpA is still the interaction between...

Ngày tải lên: 09/08/2014, 01:22

... 90-amino acid N-terminal death domain, which is now classified generically as a pyrin domain (PYD) in other proteins that have homology with pyrin’s N-terminal sequence [12] Members of the death ... to major advances in their treatment, most remarkably the introduction of IL-1 inhibition in CAPS The clinical significance of low-penetrance mutations/polymorphisms in the inherited period fever ... Pucino F, Wesley RA, Papadopoulos JH, Weinstein SP, Mellis SJ, Kastner DL: A pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1...

Ngày tải lên: 09/08/2014, 01:22

... for the strikingly increased risk of atherosclerosis seen in premenopausal women with SLE These findings suggest that features of the disease itself drive this process Even in the absence of clinical ... which they are attached [13] A second explanation for the targeting of nuclear molecules in SLE relates to an increase in the exposure of the immune system in lupus to ‘dangerous’ products This increase ... with the changes in these molecules during apoptosis enhancing immunogenicity Furthermore, because cell death probably leads to the release of other immune mediators known as alarmins, the immune...

Ngày tải lên: 09/08/2014, 11:20

... target for therapy in these patients Cytokines, chemokines, and prostaglandins Proinflammatory cytokines, chemokines, and prostaglandins and some anti-inflammatory cytokines such as transforming growth ... is the so-called ‘endoplasmic reticulum (ER) stress response’ The folding, exporting, and processing of newly synthesised proteins, including the processing of MHC class I molecules, occur in the ... or the induction of MHC class I and ER stress) In this context, the safety and benefits of physical training are interesting and there are sufficient scientific data to advocate exercise training...

Ngày tải lên: 09/08/2014, 13:21

... LRR, and pyrin domain-containing-3) inflammasome and lead to caspase-1 processing of pro-IL-1β Activation of the endothelium by IL-1β increases trafficking of neutrophils to the inflammatory ... from the inflammatory effects of MSU [24], suggesting that the pro-inflammatory effects of IL-1 require mesenchymal cells such as the endothelium to respond to this cytokine Together, these findings ... NLR protein is NALP-3 (NACHT, LRR, and pyrin domain-containing-3), hence the NALP-3 inflammasome NALP-3 is also termed cryopyrin as this protein is mutated in patients with hereditary autoinflammatory...

Ngày tải lên: 09/08/2014, 13:22

... chondrocytes Further work is needed to determine whether leptin or other adipokines are important systemic or local factors in the link between obesity and OA Joint malalignment Whether joint malalignment ... into the basal layers of degenerating cartilage, or as a result of abnormal healing of stress fractures in the subchondral trabeculae near the joint margins [63] TGF-β, when introduced into the ... result in increased joint reactive forces in the medial compartment of the knee, thereby accelerating the degenerative process [23] Emerging data implicate a crucial role for adipocytes in regulation...

Ngày tải lên: 09/08/2014, 14:20

... deterioration in the joints These studies suggest that the Wnt signaling pathway, which is important in joint development, is also important in diseases of the joint Further understanding of the Wnt ... receiving serotonin re-uptake inhibitors have low bone mass compared with age-matched control individuals, suggesting that if circulating levels of serotonin are increased in these patients then they ... increase in dentin matrix protein-1, sclerostin, and other Wnt signaling inhibitors (DKK1 and WIF) Interestingly, atomic force microscopy and raman microscopy of the trabecular surface from the individual...

Ngày tải lên: 09/08/2014, 14:20

... areas in the central nervous system are responsible for inhibiting ascending pain transmission within the spinal cord through the activity of inhibitory neurotransmitters, which include serotonin, ... biological basis in general – and the genetic underpinning, in particular – of FM increases, we hope to gain a better understanding of the true nature of the disorder, to attain more rational therapeutic ... Polymorphisms in the serotonin 5-HT2A receptor (T/T phenotype), in the serotonin transporter, in the dopamine receptor and in the catecholamine O-methyltransferase enzyme have therefore been detected...

Ngày tải lên: 09/08/2014, 14:21

... defect in post-translational modification but a defect in inducing or maintaining peripheral tolerance, which is very much in line with the global changes in the T-cell compartment observed in patients ... engineered mice that expressed an influenza hemagglutinin antigen in combination with a transgene for hemagglutinin-reactive TCR Different strains were constructed carrying TCR with varying affinity ... proteins including fillaggrin, keratin, fibrinogen, and vimentin [73,105] These antibodies can be measured through their recognition of cyclic citrullinated peptides, now commonly used in clinical...

Ngày tải lên: 09/08/2014, 14:22

... evident in and of themselves with minimal positioning on the part of the authors The demonstrable increase in the use of adjectives with the potential to bias the reader may indicate that the interpretation ... in the following two categories: Medicine: Research and Experimental and Medicine, General and Internal The journals were chosen with the following criteria in mind; first, they reflect the informal ... be examined in conjunction with changing attitudes within the scientific community regarding the writing and submission of articles, the mounting impact of the impact factor and the pressures...

Ngày tải lên: 12/08/2014, 14:20

... brief introduction of the thesis, including: the necessity of the thesis, the research aims and objectives, the research questions, the research methodology, the scope o f the research and the ... structure of the thesis: The thesis is composed of chapters: CHAPTER 1: INTRODUCTION This Chapter gives a brief introduction to the thesis, including the necessity o f the thesis, the research ... the theories of IR activities, including: the definition, the purpose of IR, the organization of the IR divisions, models of implementing IR activities and IR tools Based on these theories, the...

Ngày tải lên: 26/03/2015, 08:55

... ‘chronotopianism’ – the imagination of acceleration as segueing into utopia – in the discourses of those who seek to expand their business scopes, they point to the fact that these discourses are ... an ‘ideal other’ that is in essence a projection of the self In “Marginality in the Teaching Machine,” Gayatri Spivak discusses how the revalidation of the West and the fantasy of the autonomous ... responsibilities The interesting ‘accident’ of the growth within the alter-globalist movement of these reciprocal annoyances and fights which each other, is then that the event of the coming together of...

Ngày tải lên: 15/09/2015, 21:10

... combining the ideas of the contingent and radial derivatives Though being different from the contingent-type derivative only at the origin, it is suitable for stating relaxed assumptions The ... expressed in terms of the contingenttype derivative This kind of derivatives is employed here for the first time in sensitivity analysis in optimization Relations between the set of minimum or weak minimum ... significantly the paper References Fiacco, A.V.: Introduction to Sensitivity and Stability Analysis in Nonlinear Programming Academic Press, New York (1983) Tanino, T.: Sensitivity analysis in multiobjective...

Ngày tải lên: 16/10/2015, 14:06