self regulation in the service of conflict resolution
Báo cáo y học: " Gene expression regulation in the context of mouse interspecific mosaic genomes" pdf
Ngày tải lên :
14/08/2014, 20:22
... We therefore determined the sum of the log2 of the expression ratios of induced or repressed genes in sliding windows of 50 transcripts (Figures 5, 6, 7) In order to test whether the number of ... summary of the modes of regulation encountered in the IRCSs and their parent strains A summary of the modes of regulation encountered in the IRCSs and their parent strains Blue marks the B6 chromosome ... MMU15) In the rest of the study, we will consider the combination of the 11 segments of M spretus origin present in the three IRCSs as a whole Overall, the proportion of dysregulated genes in the...
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Role of misfolded nuclear receptor co repressor (n cor) induced transcriptional de regulation in the pathogenesis of acute monocytic leukemia (AML m5
Ngày tải lên :
09/09/2015, 18:55
... may result in changes of the folding process causing protein misfolding65 In a normal mammalian cell system, the amino acid sequence in the polypeptide chain contains all the necessary information ... importance of the transcription machinery in the regulation of hematopoiesis The transcription machinery plays a critical role in the control of normal hematopoiesis by having a major influence on the ... Okumura for his invaluable input on some of the work done in this thesis and for taking the time to vet my thesis; A/Prof Chng Wee Joo and Prof Norio Asou for their kind assistance with the patient...
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Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx
Ngày tải lên :
07/03/2014, 21:20
... maintain transcription The PHF3 protein was recovered in initial analyses and also contains a TFS2M domain showing the same architecture as the DIDO1 long isoform, although lacking the dPHD The ... from the other branches, which was indeed predicted The other main group, obtained 97% of the time in 20 740 explored trees, contained the DIDO PHD sequences clustered with the PHF and the CGBP ... To root the tree, we used inhibitor of growth protein (ING3) PHD, which is another domain involved in chromatin binding and clearly more divergent (e-value 0.019) from DIDO and the other sequences...
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POTENTIAL CONFLICT OF INTEREST IN THE PRODUCTION OF DRUG COMPENDIA doc
Ngày tải lên :
09/03/2014, 00:20
... potential sponsor conflict of interest in mind 21 Relevant information for assessing potential conflict of interest includes the identification of the sponsor, determination of whether an independent ... compendia publishers The remaining two areas – conflict of interest leading to biased selection of evidence, and bias in the interpretation of evidence – fall within the domain of the compendia publishers ... interpretation of evidence Two of these areas – conflict of interest in evidence sources, and conflict of interest in the process of making study data available – lie beyond the control of the compendia...
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Báo cáo khoa học: Transcriptional regulation of the desferrioxamine gene cluster of Streptomyces coelicolor is mediated by binding of DmdR1 to an iron box in the promoter of the desA gene doc
Ngày tải lên :
16/03/2014, 11:20
... box of desA (nucleotides 7–12 of the iron box), explaining the regulation of desA expression by binding of DmdR1 to the iron box The same overlapping was found in S pilosus DmdR1 binds to the ... Therefore, binding of the iron regulator DmdR1 will interfere with RNA polymerase interaction and expression of the desferrioxamine cluster Indeed, binding of the pure DmdR1 protein to the S coelicolor ... al A Regulation of the desferrioxamine gene cluster B Fig Binding of the DmdR1 protein to the desA promoter region of either S pilosus (left) or S coelicolor (right) at increasing protein concentrations...
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Recent Large Service Acquisitions in the Department of Defense - Lessons for the Office of the Secretary of Defense pot
Ngày tải lên :
23/03/2014, 01:20
... Large Service Acquisitions in the Department of Defense Lessons for the Office of the Secretary of Defense FRANK CAMM IRV BLICKSTEIN JOSE VENZOR Supported by the Office of the Secretary of Defense ... estimates of DoD spending on services still further Recent Large Service Acquisitions in the Department of Defense period, the largest increases came in purchases of information services (46 percent increase); ... time to determine how well they work in practice The case studies offer the best insight into the execution of the two oldest acquisitions, the Army BSC and R2CSR programs For the other four acquisitions,...
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báo cáo hóa học: " Application of a hybrid wavelet feature selection method in the design of a self-paced brain interface system" pptx
Ngày tải lên :
19/06/2014, 10:20
... did not indicate the number of NC epochs used in their study, so critical commentary on the performance of their BI system cannot be made The invasiveness of the recording technology of the BI ... from Table 2) The blue line shows the fitness of the classifier as a function of the number of top features We began by training and testing the classifier using only the feature with the highest ... divided into training, validation and test sets The training set was used to train the classifier, and the validation set was used to select the best set of features The configuration yielding the...
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báo cáo hóa học:" Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter" pptx
Ngày tải lên :
20/06/2014, 07:20
... mammalian Sin3 co-repressor protein [10,11] The effectiveness of the Sin3 binding domain of Mad in silencing gene expression when fused to DNA binding proteins has been demonstrated in two studies ... POF suggesting that the expression of FoxL2 is critical in the developing eyelid as well as in the maintenance of ovarian function Foxl2 has also been implicated in the process of sex determination ... group fused the Mad SID to the c-Jun DNA binding domain and demonstrated specific inhibition of transcription mediated by binding to AP-1 binding site elements [12] Another group of investigators...
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Báo cáo toán học: " A note on the almost sure limit theorem for self-normalized partial sums of random variables in the domain of attraction of the normal law" pptx
Ngày tải lên :
20/06/2014, 21:20
... note on the almost sure limit theorem for self- normalized partial sums of random variables in the domain of attraction of the normal law Qunying Wu1,2 College of Science, Guilin University of Technology, ... removed the condition nP(|X1 | > ηn ) ≤ c(log n)ε0 , < ε0 < in theorem 1.1 of [12] Remark 1.4 If EX < ∞, then X is in the domain of attraction of the normal law Therefore, the class of random ... completes the proof of Theorem 1.1 Competing interests The author declares that she has no competing interests Acknowledgments The author was very grateful to the referees and the Editors for their...
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Báo cáo hóa học: " Enabling direct connectivity between heterogeneous objects in the internet of things through a network-service-oriented architecture" docx
Ngày tải lên :
21/06/2014, 01:20
... only delays the parameters in the waiting space of the initial node: packets are not further delayed in intermediate nodes Since the aggregation is part of the IDRA architecture, the aggregation ... are important in the context of the internet of things Memory overhead The memory overhead of the overall IDRA architecture (including queue management, the network service broker, the packet facade, ... their relevance in Page of 14 the context of the internet of things This next section describes in more detail on how IDRA can support two important internet of things use cases: (1) supporting...
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Báo cáo hóa học: " Cross-Layer Quality-of-Service Analysis and Call Admission Control in the Uplink of CDMA Cellular Networks" potx
Ngày tải lên :
22/06/2014, 22:20
... analyzed in terms of the outage probability, which refers to the probability that the achieved SINR is below the SINR requirement or the achieved BER is above the BER requirement Within the ith ... j,k Compared to the results in [6], the main contribution here is to calculate the outage probabilities in the environment with the GBN-ARQ scheme The computation of the lengthened activity factors ... to the BS, the mobile waits for an acknowledgment within a time interval of Tk The packet will be removed from the buffer upon the receipt of ACK The ratio of Tk to Tk is assumed to be an integer,...
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Báo cáo y học: "Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor" ppsx
Ngày tải lên :
12/08/2014, 12:20
... studied the effect of the presence of HLA-DR3 or DERAA-encoding alleles in combination with the SE on susceptibility to RA In the presence of one SE allele, an HLA-DR3 or DERAA-encoding allele ... reported inconsistencies may be due not only to genetic differences or the influence of other genes in linkage disequilibrium but to the interaction with environmental risk factors In summary, in a ... environmental risk factor for the development of ACPAs in the presence of SE alleles [32] but also in their absence [33] Increased ACPA levels in tobacco users have been reported, but these effects were...
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Báo cáo y học: "Universal access: the benefits and challenges in bringing integrated HIV care to isolated and conflict affected populations in the Republic of Congo" potx
Ngày tải lên :
13/08/2014, 13:21
... especially in the early phases of integration This had the effect of initially reducing the confidence of the inexperienced medical staff in managing ART, and reinforced fears around safety of ART ... sessions One of the key successes of the integration process was the institution of regular meetings between counsellors, nurses, doctors and all others involved in the HIV/AIDS activities These were ... the benefits and the means of minimising the risks of testing were required Benefits of introducing HIV/AIDS activities into medical programs 'Towards Universal Access' While there is clear international...
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Báo cáo y học: "The Colombian conflict: a description of a mental health program in the Department of Tolima" pdf
Ngày tải lên :
13/08/2014, 14:20
... Similarly, as the conflict was active in the rural area, this may also help explain the higher proportion of severe cases in the rural setting Examining the correlation between the differences in the experience ... on coping mechanisms, and an explanation of the mechanisms of psychotherapy At the end of the session, the psychologist offered the possibility of an individual consultation In Ibague, the physician ... treated in both settings were affected by the same conflict, we observed differences between the urban and rural setting in the traumatic events reported, the clinical expression of the disorders, the...
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Báo cáo sinh học: "Use of relationship matrix in the evaluation of natural service Limousin bulls" pptx
Ngày tải lên :
14/08/2014, 20:20
... It was therefore decided to use these relationships in the evaluation The purpose of this investigation was to examine the impact of relationships on the ranking of sire breeding values, their ... of noting that y is < y the difference between the values reflecting the dispersion , l of solutions k The further these indexes are from 1, the larger the mean gain in connectedness resulting ... coefficients of the sires (rand r,!) were computed m relationship The overall gain in Evaluation of the accuracy gain was the ratio between the traces of both matrices: in connectedness between sires The...
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FUNCTION AND REGULATION OF CALCIUM INDEPENDENT PHOSPHOLIPASE a2 IN THE ATTENUATION OF PAIN IN MICE
Ngày tải lên :
09/09/2015, 08:15
... for the antidepressive effect of the antidepressant, maprotiline In the first part of the study, we investigated the role of prefrontal cortical iPLA2 in the antinociceptive effect of maprotiline ... 2004) Intrathecal administration of cPLA2 inhibitors significantly reduced cPLA2 activity in spinal homogenates, which suggest the involvement of cPLA2 in spinal processing of nociceptive inputs ... sometimes 2.1 Orofacial pain Orofacial pain is defined as “pain within the structures of the oral cavity and face, usually of a diffuse pattern” (Zwemer, 1998) Orofacial pain includes pain disorders...
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Identification of factors involved in the maintenance of embryonic stem cell self renewal and pluripotency 2
Ngày tải lên :
11/09/2015, 16:02
... that the regulation of Lefty1 by OCT4, KLF4 and NANOG may be part of the ES cell self renewal mechanism The role of Lefty1 in regulation of ES cell self renewal was hence dissected using loss of ... protein Hence to enable the detection of the precursor and mature forms, the V5 tag has to be incorporated at the C terminus and not the N terminus There is also the possibility that tagging at the ... suggesting the direct regulation of Lefty2 by Oct4, Sox2 and Nanog pluripotency genes in human ES cells All these observations fuelled my interest in further examining the functional role of Lefty2...
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Identification of factors involved in the maintenance of embryonic stem cell self renewal and pluripotency 3
Ngày tải lên :
11/09/2015, 16:02
... clear Conflicting roles of Nodal signaling in both the maintenance of ES cell self renewal and induction of ES cell differentiation have both previously been reported A key objective of this thesis ... Conclusion The first chapter of this thesis summarizes the current state of knowledge regarding what constitutes the fundamental mechanics governing ES cell self- renewal Much is left to be learnt The ... Nodal signaling might, as in the in vivo scenario, likewise influence ES cell fate decision in a dose dependent manner in vitro is addressed Interestingly, it was found that Nodal signaling is able...
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Identification of factors involved in the maintenance of embryonic stem cell self renewal and pluripotency 4
Ngày tải lên :
11/09/2015, 16:02
... the C-terminus of Lefty2 was chosen instead of the N-terminus because tagging at N-terminus may result in the V5 tag being cleaved off during LEFTY2 processing and secretion The insert was amplified ... for the entire duration of the experiment The E14 cells were fed daily with medium containing fresh Activin A 4.14.2 Inhibition of Nodal/Activin signaling To abolish/diminish Nodal/Activin signaling, ... overexpression The expression of the Nodal transgene was suppressed in the presence of 1µg/ml doxycyclin (Clontech,UK.) Hence to activate Nodal induction, the drug was removed from the cells by changing the...
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Identification of factors involved in the maintenance of embryonic stem cell self renewal and pluripotency 5
Ngày tải lên :
11/09/2015, 16:02
... function in patterning the mouse embryo Development 128, 1831-1843 187 Lu, C C., and Robertson, E J (2004) Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior ... Transcriptome profiling of human and murine ESCs identifies divergent paths required to maintain the stem cell state Stem Cells 23, 166-185 Wieduwilt Matthew J., (2003) SMAD3 in embryonic patterning, mesoderm ... (2003) The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells Cell 113, 631642 Moffat, J., and Sabatini, D M (2006) Building mammalian signalling pathways...
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