seams structural and decorative elements impressions

... unstructured and highly flexible and protrudes from the oligomeric structure Both the polarity and flexibility of the C-terminal extension are important for the maintenance of sHsp solubility and for ... of polar and charged groups, as well as hydrophobic and packing effects [28] These proteins typically have a higher proportion of polar and charged residues, primarily glutamic acid and lysine, ... protein–solvent interactions: thermostability and the role of hydrophobic and electrostatic interactions Protein Sci 4, 1516–1527 Cambillau C & Claverie J-M (2000) Structural and genomic correlates of hyperthermostability

Ngày tải lên: 07/03/2014, 04:20

... proteins are likely to be Vps4 orthologues and contain all three structural elements of the Vps4 oligomerization domain (i.e b sheets and 8, the AAA domain helix and the C-terminal helix) However, the ... Hankamer1 and Alan L Munn1,2,3,4 Institute for Molecular Bioscience, The University of Queensland, Australia ARC Special Research Centre for Functional and Applied Genomics, The University of Queensland, ... ATPase domain and C-terminal helix [36] showing the location of residues that were mutated The TRP, RDF and DEL sequences are shown in green, dark blue and red, respectively The b domain and C-terminal

Ngày tải lên: 07/03/2014, 05:20

... transport, using structural indicators across Member States, plus Romania and Bulgaria; • To assess the contribution of Structural and Cohesion funds relative to the current and previous programming ... or their expected benefits; • To identify and evaluate needs in the selected fields and identify potential investment priorities of structural and cohesion funds for the programming period ... However, bordering the Baltic Sea on one side and located between its two fellow Baltic States - Estonia to the north and Lithuania to the south - and Russia and Belarus to the east, Latvia is at a

Ngày tải lên: 07/03/2014, 08:20

... resi- dues 58–61 from loop connecting b3 and a and residues 81–87 from loop connecting b4 and a3 from one subunit and the residues 114 and 128–141 from b5 and a4- and a5-helices from the neigh- bouring ... coloured in brown (A- and F-subunits), pink (B- and J-subunits), light brown (C- and I-subunits), light pink (D- and H-subunits) and beige (E- and G-subunits). The active sites, located between ... Pro51, Val53, Leu69, Leu156 and Ala158. Whereas four arginines (Arg19, Arg71, Arg154 and Arg157), two histidines (His73 and His159), two aspartates (Asp50 and Asp74) and Glu68 form ionic interactions

Ngày tải lên: 07/03/2014, 11:20

... dimers, with monomers A and B in dimer and C and D in dimer (Fig 8) The a-crystallin domain of each monomer is composed of nine b-strands (labeled b2–b10), with the b6 strand situated in a large ... formation depends upon contact of b-strand 10 from the C-terminal extensions of monomers A and D with b-strands and in the a-crystallin domain of monomers C and B, respectively (Fig 8) A more prominent ... study are situated in b-strand 7, with mutations R110G and F112R directly in the dimer–dimer interface As a result of the spatial disposition of monomers and their b-strand elements in the a-crystallin

Ngày tải lên: 07/03/2014, 12:20

... Targeting and trans- location of newly synthesized peroxisomal matrix pro- teins requires ATP and depends on peroxisomal targeting signals [10], PTS1 and PTS2, and their cognate receptors Pex5p and ... Structural and functional analysis of the interaction of the AAA-peroxins Pex1p and Pex6p Ingvild Birschmann 1, * , †, Katja Rosenkranz 2, †, Ralf Erdmann 2 and Wolf-H Kunau 1 1 ... that Pex1p and Pex6p from Saccharomyces cerevisiae do interact in vivo. We assigned their corresponding binding sites and elucidated the importance of ATP-binding and -hydrolysis of Pex1p and Pex6p

Ngày tải lên: 07/03/2014, 16:20

... and functional BMP ⁄ activin pathway in lophotrochozoans, for which a singular and promiscuous type II receptor would be the shared interface for both BMP and activin ligands Results Type I and ... bold and underlined, and the cysteine knot is boxed The second extracellular domain (C2) also contained 10 cysteines and these are also shown in bold and the cysteine knot is boxed The C1 and ... receptors This observation is congruent, structurally, with the subfamilies already defined by the ligands and suggests a concerted evolution between ligands and receptors [23] According to the phylogenetic

Ngày tải lên: 07/03/2014, 21:20

... and w and were subsequently refined by varying /, w angles in intervals of 10° and setting h angle to ) 60 ± 10° and 60 ± 10° Each /, h, and w-value was fixed by applying a harmonic potential and ... protons and Ca carbons (CSDHa and CSDCa), corresponding to differences between observed chemical shifts and random coil values, are commonly used to detect secondary structures in peptides and proteins ... phosphates pathway SP, [Ala9]SP and [Pro9]SP are almost equipotent at the major binding site NK-1M (Ki between 0.64 nM and 1.6 nM and EC50 values between 4.8 and nM) [HGly9]SP and [(S)-b3-HAla9]SP are

Ngày tải lên: 08/03/2014, 08:20

... FEBS C Bottcher and S Pollmann ă for growth inhibitory effects and the development of necrotic lesions [56] Studies on flu and the flu ⁄ dde2-2 double mutant indicated that OPDA and ⁄ or dnOPDA ... of structurally related compounds and their role in cellular stress responses is a very intriguing and challenging matter of actual research The latter compounds comprise oxidized lipids and ... but also directly to enzymes and transcription factors OPDA: an independent regulator of gene expression Given the functional and structural differences between OPDA and JA, it is exciting to presume

Ngày tải lên: 16/03/2014, 02:20

... composed mainly of a helices (Figs 1 and 2). The core of Iba2 is a pair of EF-hand motifs, denoted as EF-hands 1 and 2, each consisting of two a helices (aA, aB and aC, aD, respectively) flanking ... topology of Iba2 shows structural simi- larities to classical EF-hand proteins. The second pair of EF-hands in calmodulin (PDB code 1CLL) [19] and the second pair of EF-hands in troponin C (PDB ... We investigated Ca 2+ binding and homodimerization of Iba1 and Iba2. Furthermore, F-actin binding and cross-linking assays were performed with both human Iba proteins, and their role in bacterial

Ngày tải lên: 16/03/2014, 06:20

... transport, using structural indicators across Member States, plus Romania and Bulgaria; • To assess the contribution of Structural and Cohesion funds relative to the current and previous programming ... or their expected benefits; • To identify and evaluate needs in the selected fields and identify potential investment priorities of structural and cohesion funds for the programming period ... highlighting Santander, Gijon, Ferrol, La Coruña, Algeciras, Almeria and Tarragona • The whole steel and iron sector located on the Cantabrian coast is the reason for the steel and iron

Ngày tải lên: 16/03/2014, 09:20

... chemist is concerned, are indivisible, and are known as elements Of the innumerable combinations of these elements, two general classes may be recognized, organic and inorganic bodies While it is impossible, ... decomposition, and the elements are returned again to the earth and atmosphere from which they were taken Investigation has shown that living bodies contain comparatively few elements, but these ... The nucleus is large and distinct in the larger species, and has a noticeably large and conspicuous nucleolus The most noticeable thing about the cell is the green spiral bands running around...

Ngày tải lên: 13/02/2014, 12:20

... shared Netscape and later and Internet Explorer and later define onkeypress , onkeydown, and onkeyup event handlers (note, however, that they are not yet part of the DOM standard) These handlers can ... event handlers! addhandlers(document.everything); 15.3 Scripting Form Elements The previous section listed the form elements provided by HTML and explained how to embed these elements ... "HTMLElement" in the client-side and DOM reference sections for more details on these and other event handlers that are supported by all HTML elements 15.3.7 Select and Option Elements The Select element...

Ngày tải lên: 05/10/2013, 12:20

... "Head" in English and Vietnamese language in general and in idioms in particular 15 Chapter structural and semantic features of English and Vietnamese idioms referring to head 2.1 Structural features ... groups and proverbs, we will come to the next part 1.1.4 Distinction between idioms and free word groups and proverbs 1.1.4.1 Free word groups and idioms The distinction between free word groups and ... studied and analyzed the structures of symmetrical idioms referring to Head" in Vietnamese based on the symmetry and repetition between elements A and B can be: + Identical in sound and meaning...

Ngày tải lên: 20/12/2013, 18:33

... Agricultural Sciences and Spatial Planning (to L.W and S.E.), the 4928 Swedish Research Council (to H.E and P.N.) and the Swedish Cancer Foundation (to H.E and P.N.) The Structural Genomics Consortium ... domain is mainly built up by residues from the C-terminus and consists of a two-stranded anti-parallel b-sheet composed of b2 and b9 and an a-helix from the C-terminus (Fig 1A) The two subunits ... PRTFDC1 (A) monomer and (B) tetramer generated using symmetry-related molecules Interactions with GMP (C) GMP, phosphate and calcium ions are shown as sticks and spheres colored pink and black, respectively...

Ngày tải lên: 15/02/2014, 01:20

... Therefore a structural and cohesion policy with an orientation to growth and regional balance is needed: on the one hand, growth potentials should be promoted where they exist; on the other hand, structurally ... and training and supporting cultural and social activities in the region through sponsorships, donations and payment of foundation dividends The distribution of profits to local authorities and ... banks and their areas are investigated The paper will close with some final remarks in chapter REGIONAL STRUCTURAL POLICY BETWEEN GROWTH AGENDA AND COHESION ? Cohesion, or rather regional structural...

Ngày tải lên: 16/02/2014, 10:20

... binding and substrate oxidation to occur within the NOSoxy domain [14–16] The individual NOS domains and subdomains can be expressed separately, which has facilitated biochemical and structural ... structural studies The protein structural elements that bind heme, Arg, H4B, CaM, NADPH, FAD and FMN have been identified based on crystallography, mutagenesis and homology studies [17–22] 3960 ... NOS and related enzymes NOS includes regulatory elements that are absent in other closely related proteins (B) Structure of nNOS flavoprotein domain The FNR and FMN subdomain are shown in green and...

Ngày tải lên: 18/02/2014, 11:20

... denote H+, H• and H)) ˚ is $1 A and thus similar to a typical bond length, whereas thepffiffiffi wavelength of deuterium is shorter by a factor of $ As a consequence, the position of H (and to a lesser ... Broglie wavelength of the H or D) and DGà is the Marcus activation energy The activation energy is described by the driving force, DG0, and reorganization energy in the standard way: À Á2 DGz ¼ DG0 ... chemically modified flavins with differing redox potentials, and these authors showed that the apparent rate of H transfer obeys Eqns (1) and (2) and the reorganization energy of this reaction appears...

Ngày tải lên: 18/02/2014, 11:20

... interaction and electron transfer with PSI [53,84,88–90] Many of these Fld mutants (T12V, E16Q, T56G, W57 replaced by K, R, F, L, A and Y, I59 replaced by A and K, Y94 replaced by A and F, N97K, ... chloroplasts, phototropic and heterotrophic bacteria, apicoplasts, and animal and yeast mitochondria [139] Two unrelated families of proteins can be found in these enzymes: the plant type and the glutathione ... [126] Based on their structural and functional properties, plant-type FNRs are classified as plastidic type and bacterial type Plastidic FNRs efficiently catalyse electron transfer and hydride transfer...

Ngày tải lên: 18/02/2014, 11:20

... 218 nm (b strand signature), 202–204 nm (random coil signature) In WhiB5 and WhiB6, the structure was dominated by a helices and b strands and the proportion of these structural elements was ... of all three secondary structural elements in WhiB3 and WhiB7 appeared similar Disulfide bond formation did not affect the secondary structure, except for WhiB5 and WhiB6, and the effect was more ... WhiB6 and WhiB7 the loss was  8–10% After 48 h of air exposure, losses were as follows:  80% in WhiB1,  75% in WhiB2 and WhiB5,  65% in WhiB3,  60% in WhiB4, and  35–40% in WhiB6 and WhiB7...

Ngày tải lên: 18/02/2014, 12:20