... explain their wide distribution in tissues and cells [16], including stem cells [17] Increasing evidence links these noncatalytic actions with the binding of cholinesterases to several protein ... Cholinesterases inrenal carcinomas E Munoz-Delgado et al ˜ Introduction Renalcell carcinomas (RCCs), which account for 2% of adult malignancies, ... with the lectins concanavalin A, Lens culinaris agglutinin 4522 (LCA), and Ricinus communis agglutinin (RCA) (Fig 3), ruled out the blood origin and supported the renal cells themselves as the most...
... factor receptor signaling inhibits angiogenesis leading to regression of human renalcellcarcinoma growing orthotopically in nude mice Clin Cancer Res 8, 3592–3600 13 Inoue K, Kamada M, Slaton ... peptide-containing proteins inrenalcellcarcinoma tissues is associated with a decrease in tumor growth and angiogenesis Clin Cancer Res 9, 1734–1740 19 Lawler J (2002) Thrombospondin-1 as an ... expressed in HNK or RCC cells (Fig 3A,B); thus, there was no functional redundancy HNK cells expressed high levels of the calcium-binding protein, calbindin D28K [28] (Fig 3C) In normal kidney, calbindins...
... differentiation of renal tubules representing the origin of clear cellrenalcellcarcinoma (RCC) and in the regulation of the cell cycle of parietal epithelial cells of the Bowman's capsule [10,11] Since ... screening of head and neck squamous cellcarcinoma [49] as well as pancreatic carcinoma lesions and pancreatic carcinoma cells either left untreated or treated with demethylating agents [32,35] In ... ubiquitin-proteasome complex UCHL1 is involved in the control of the intracellular proteolysis, protein turnover and regulatory processes, which are important in maintaining normal cellular homeostasis [7]...
... TLR9-ligands, also induces invasion in TLR9 expressing cancer cells in vitro, the natural TLR9-ligand that might induce invasion for example in breast cancers, remains unknown [10,11] In the normal ... unspecific staining Expression of TLR9 has been previously detected in various cancer cell lines and in various clinical cancer specimens Synthetic TLR9-ligands induce cancer cell invasion in vitro ... samples were routinely fixed in 10% buffered formalin and embedded in paraffin The histological diagnosis was confirmed by reviewing the haematoxylin and eosin (H & E) stained original sections...
... ED: Tumor-Infiltrating Foxp3-CD4+CD25+ T Cells Predict Poor Survival inRenalCellCarcinoma Clin Cancer Res 2007, 13:2075-2081 Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla ... Cancer vaccines: moving beyond current paradigms Clin Cancer Res 2007, 13:3776-3782 Pantuck AJ, Belldegrun AS, Figlin RA: Nephrectomy and interleukin-2 for metastatic renal- cellcarcinoma N Engl ... Engl J Med 2001, 345:1711-1712 Diner EK, Linehan M, Walther M: Response of papillary renalcellcarcinomain a solitary kidney to high dose interleukin therapy International Journal of Urology...
... role inrenal malignancy has provided insight into the pathogenesis of sporadic clear cellrenalcarcinoma It has also provided the potential for developing novel targeted therapies, including ... de Kernion J, Figlin R, Belldegrun A: Induction of G250-targeted and T -cell- mediated antitumor activity against renalcellcarcinoma using a chimeric fusion protein consisting of G250 and granulocyte/monocyte-colony ... variability from day to day in staining or thawing The samples were tested in independent setups over days We have included internal controls in each experiment, one of those being a frozen leukapheresis...
... verified independently by reamplifying the corresponding fragment and repeating the sequencing procedure using both forward and reverse primers in the samples fixed in Bouin's solution Regarding the ... 15 ppm in screw cutting industry during c.332 G>A 58 years women no c.463+1 G>C 42 years man no Other occupational exposures identified cutting oils asbestos cutting oils in screw cutting industry ... VHL transversions in sporadic RenalCellCarcinoma Pharmacogenetics 2001, 11:521-535 La Vecchia C, Negri E, D'Avanzo B, Franceschi S: Smoking and renalcellcarcinoma Cancer Res 1990, 50:5231-5233...
... Merseburger AS, Mulders PFA, Patard JJ, Sinescu IC: European Association of Urology Guideline Group for renalcellcarcinomaRenalcellcarcinoma guideline Eur Urol 2007, 51:1502-10 12 Kulkarni ... they enter the urinary collecting system It has been shown that fibrin glue and oxidized regenerated cellulose maintain a solid form when initially placed in direct contact with urine and then assume ... matrix sealant agent, FloSeal with an infrared-sapphire coagulator (ISC), during open enucleoresection of renalcellcarcinoma (RCC), to minimize or avoid suturing and warm ischemia time Methods...
... Baum CM, Figlin RA: Sunitinib versus interferon alfa in metastatic renal- cellcarcinoma N Engl J Med 2007, 356:115-124 Gollob JA, Wilhelm S, Carter C, Kelley SL: Role of Raf kinase in cancer: therapeutic ... on T cells and antigen-presenting cells, such as dendritic cells, which play major roles in immune tumor surveillance Targeted tyrosine kinase inhibitor therapy may thus control cancer cell growth ... cause Nonetheless, in our case, CT findings were not sufficient for the diagnosis and the cause of imaging findings was unclear until laparotomy In summary, a case of an intra-abdominal abscess formation...
... staining intensity and the percentage of positive tumor cells as follows [23,24]: no staining scored 0; faint or moderate staining in ≤ 25% of tumor cells scored 1; moderate or strong staining in ... PKCepsilon inrenal cancer cells Int J Oncol 2004, 25:1157-1163 Engers R, Mrzyk S, Springer E, Fabbro D, Weissgerber G, Gernharz CD, Gabbert HE: Protein kinase C in human renalcell carcinomas: role in ... (Table 1) PKCε expression inrenalcell cancer cell lines We detected the expression of PKCε in five RCC cell lines using Western blot PKCε was expressed in all five RCC cell lines at various levels,...
... L-arginine to synthesize NOHA from arginase, then increasing its inhibitory effect In contrast, it is also possible the growth of renalcellcarcinoma cells is arginase II independent resulting in ... supernatants of murine renalcellcarcinomacell lines and determine their effect on cell proliferation In adult mammals, the majority of endogenous L-arginine is synthesized from citrulline in the kidney ... in arginase I expression in mononuclear immune cells [12,13], suggesting that L-arginine may have an effect on metabolic processing in the immune system In patients with renalcell carcinoma...
... Metastatic renalcellcarcinoma involving ethmoid sinus at presentation J Postgrad Med 2003, 49:96-97 Ather MH, Masood N, Siddiqui T: Current management of advanced and metastatic renalcellcarcinoma ... Maxillary sinus metastasis of renalcellcarcinoma Actas Urol Esp 2006, 30:954-957 11 Lee HM, Kang HJ, Lee SH: Metastatic renalcellcarcinoma presenting as epistaxis Eur Arch Otorhinolaryngol ... growth factor transcription by endothelial PAS domain protein (EPAS1) and possible involvement of EPAS1 in the angiogenesis of renalcellcarcinoma Cancer 2001, 91:1429-1436 10 Torres Muros B,...
... Hematoxylin and eosin staining of the resected subcutaneous nodule; (b) immunostaining for CD10, (c) epithelial membrane antigen and (d) vimentin Magnification is 20 × for all images our patient declined ... first such report of this phenomenon inrenalcell carcinoma, and we briefly discuss possible hypotheses here that may underpin this In the standard late dissemination model of metastasis, the metastatic ... for vimentin, CD10, focally positive for epithelial membrane antigen, melan-A and negative for TTF-1, S100, inhibin and synaptophysin (Figure 4) The positive vimentin and negative inhibin results...
... specially designed machine that filters blood much like a real kidney would RenalcellcarcinomaRenalcellcarcinoma (RCC), also known as renalcell cancer or renalcell adenocarcinoma, is by far ... Clear cellrenalcellcarcinoma This is the most common form of renalcellcarcinoma About out of 10 people with renalcellcarcinoma have this kind of cancer When seen under a microscope, the cells ... cancers in the kidney, about to 10 are transitional cell carcinomas, also known as urothelial carcinomas Transitional cell carcinomas don't start in the kidney itself, but instead begin in the lining...
... have a bright prospect in future Methods Cell Lines The human CCRCC cell line OS-RC-2 and mouse macrophage cell line Ana-1 were purchased from the Institute of Cell Biology, Chinese Academy of Sciences ... (Shanghai, China) Human umbilical vein endothelial cell line (HUVEC) was ordered from ATCC All of them were maintained in RPMI-1640 media supplemented with 10% fetal bovine serum which contained 100 ... serum which contained 100 units/ml of penicillin and 100 units/ml of streptomycin All cells were routinely maintained at 37°C in humidified air containing 5% CO2 Page of 10 Reagents Dimethyl sulfoxide...
... have a bright prospect in future Methods Cell Lines The human CCRCC cell line OS-RC-2 and mouse macrophage cell line Ana-1 were purchased from the Institute of Cell Biology, Chinese Academy of Sciences ... (Shanghai, China) Human umbilical vein endothelial cell line (HUVEC) was ordered from ATCC All of them were maintained in RPMI-1640 media supplemented with 10% fetal bovine serum which contained 100 ... serum which contained 100 units/ml of penicillin and 100 units/ml of streptomycin All cells were routinely maintained at 37°C in humidified air containing 5% CO2 Page of 10 Reagents Dimethyl sulfoxide...
... high at baseline, declined some from baseline to and weeks Pain, an important clinical indicator in metastatic disease, rose slightly over time This pattern of fluctuation in the individual items ... Phase III trial of interferon alfa-2a with or without 13-cis-retinoic acid for patients with advanced renalcellcarcinoma J Clin Oncol 2000, 18:2972-2980 Yost KJ, Eton DT: Combining distribution- ... a good appetite We maintained the 5-point ordinal rating scale of the original FACT-BRM, with responses ranging from – 'not at all' to – 'very much' An aggregated symptom index score is created...
... and spindle cellcarcinoma (6-8) and tubulocystic carcinoma (5) While mucinous tubular and spindle cellcarcinoma is now recognized as a distinct subtype of renalcellcarcinoma (RCC) in the ... technique to help distinguish the different subtypes of renalcellcarcinoma [150, 151] Clear cellrenalcell carcinomas are often quite vascularized, and often 20 RenalCellCarcinoma have high Hounsfield ... renalcell carcinoma: A clinicopathological, immuno- and lectin histochemical study of nine cases APMIS; 112:183-191 [92] Skinner DG, Pfister RF, Colvin R (1972) Extension of renalcell carcinoma...