sarcomatoid dedifferentiation in renal cell carcinoma

... explain their wide distribution in tissues and cells [16], including stem cells [17] Increasing evidence links these noncatalytic actions with the binding of cholinesterases to several protein ... Cholinesterases in renal carcinomas E Munoz-Delgado et al ˜ Introduction Renal cell carcinomas (RCCs), which account for 2% of adult malignancies, ... with the lectins concanavalin A, Lens culinaris agglutinin 4522 (LCA), and Ricinus communis agglutinin (RCA) (Fig 3), ruled out the blood origin and supported the renal cells themselves as the most...

Ngày tải lên: 06/03/2014, 22:21

... factor receptor signaling inhibits angiogenesis leading to regression of human renal cell carcinoma growing orthotopically in nude mice Clin Cancer Res 8, 3592–3600 13 Inoue K, Kamada M, Slaton ... peptide-containing proteins in renal cell carcinoma tissues is associated with a decrease in tumor growth and angiogenesis Clin Cancer Res 9, 1734–1740 19 Lawler J (2002) Thrombospondin-1 as an ... expressed in HNK or RCC cells (Fig 3A,B); thus, there was no functional redundancy HNK cells expressed high levels of the calcium-binding protein, calbindin D28K [28] (Fig 3C) In normal kidney, calbindins...

Ngày tải lên: 07/03/2014, 05:20

... differentiation of renal tubules representing the origin of clear cell renal cell carcinoma (RCC) and in the regulation of the cell cycle of parietal epithelial cells of the Bowman's capsule [10,11] Since ... screening of head and neck squamous cell carcinoma [49] as well as pancreatic carcinoma lesions and pancreatic carcinoma cells either left untreated or treated with demethylating agents [32,35] In ... ubiquitin-proteasome complex UCHL1 is involved in the control of the intracellular proteolysis, protein turnover and regulatory processes, which are important in maintaining normal cellular homeostasis [7]...

Ngày tải lên: 18/06/2014, 15:20

... TLR9-ligands, also induces invasion in TLR9 expressing cancer cells in vitro, the natural TLR9-ligand that might induce invasion for example in breast cancers, remains unknown [10,11] In the normal ... unspecific staining Expression of TLR9 has been previously detected in various cancer cell lines and in various clinical cancer specimens Synthetic TLR9-ligands induce cancer cell invasion in vitro ... samples were routinely fixed in 10% buffered formalin and embedded in paraffin The histological diagnosis was confirmed by reviewing the haematoxylin and eosin (H & E) stained original sections...

Ngày tải lên: 10/08/2014, 10:21

... ED: Tumor-Infiltrating Foxp3-CD4+CD25+ T Cells Predict Poor Survival in Renal Cell Carcinoma Clin Cancer Res 2007, 13:2075-2081 Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla ... Cancer vaccines: moving beyond current paradigms Clin Cancer Res 2007, 13:3776-3782 Pantuck AJ, Belldegrun AS, Figlin RA: Nephrectomy and interleukin-2 for metastatic renal- cell carcinoma N Engl ... Engl J Med 2001, 345:1711-1712 Diner EK, Linehan M, Walther M: Response of papillary renal cell carcinoma in a solitary kidney to high dose interleukin therapy International Journal of Urology...

Ngày tải lên: 18/06/2014, 15:20

... role in renal malignancy has provided insight into the pathogenesis of sporadic clear cell renal carcinoma It has also provided the potential for developing novel targeted therapies, including ... de Kernion J, Figlin R, Belldegrun A: Induction of G250-targeted and T -cell- mediated antitumor activity against renal cell carcinoma using a chimeric fusion protein consisting of G250 and granulocyte/monocyte-colony ... variability from day to day in staining or thawing The samples were tested in independent setups over days We have included internal controls in each experiment, one of those being a frozen leukapheresis...

Ngày tải lên: 18/06/2014, 16:20

... verified independently by reamplifying the corresponding fragment and repeating the sequencing procedure using both forward and reverse primers in the samples fixed in Bouin's solution Regarding the ... 15 ppm in screw cutting industry during c.332 G>A 58 years women no c.463+1 G>C 42 years man no Other occupational exposures identified cutting oils asbestos cutting oils in screw cutting industry ... VHL transversions in sporadic Renal Cell Carcinoma Pharmacogenetics 2001, 11:521-535 La Vecchia C, Negri E, D'Avanzo B, Franceschi S: Smoking and renal cell carcinoma Cancer Res 1990, 50:5231-5233...

Ngày tải lên: 20/06/2014, 00:20

... Merseburger AS, Mulders PFA, Patard JJ, Sinescu IC: European Association of Urology Guideline Group for renal cell carcinoma Renal cell carcinoma guideline Eur Urol 2007, 51:1502-10 12 Kulkarni ... they enter the urinary collecting system It has been shown that fibrin glue and oxidized regenerated cellulose maintain a solid form when initially placed in direct contact with urine and then assume ... matrix sealant agent, FloSeal with an infrared-sapphire coagulator (ISC), during open enucleoresection of renal cell carcinoma (RCC), to minimize or avoid suturing and warm ischemia time Methods...

Ngày tải lên: 09/08/2014, 03:21

... Baum CM, Figlin RA: Sunitinib versus interferon alfa in metastatic renal- cell carcinoma N Engl J Med 2007, 356:115-124 Gollob JA, Wilhelm S, Carter C, Kelley SL: Role of Raf kinase in cancer: therapeutic ... on T cells and antigen-presenting cells, such as dendritic cells, which play major roles in immune tumor surveillance Targeted tyrosine kinase inhibitor therapy may thus control cancer cell growth ... cause Nonetheless, in our case, CT findings were not sufficient for the diagnosis and the cause of imaging findings was unclear until laparotomy In summary, a case of an intra-abdominal abscess formation...

Ngày tải lên: 09/08/2014, 03:21

... staining intensity and the percentage of positive tumor cells as follows [23,24]: no staining scored 0; faint or moderate staining in ≤ 25% of tumor cells scored 1; moderate or strong staining in ... PKCepsilon in renal cancer cells Int J Oncol 2004, 25:1157-1163 Engers R, Mrzyk S, Springer E, Fabbro D, Weissgerber G, Gernharz CD, Gabbert HE: Protein kinase C in human renal cell carcinomas: role in ... (Table 1) PKCε expression in renal cell cancer cell lines We detected the expression of PKCε in five RCC cell lines using Western blot PKCε was expressed in all five RCC cell lines at various levels,...

Ngày tải lên: 10/08/2014, 10:21

... L-arginine to synthesize NOHA from arginase, then increasing its inhibitory effect In contrast, it is also possible the growth of renal cell carcinoma cells is arginase II independent resulting in ... supernatants of murine renal cell carcinoma cell lines and determine their effect on cell proliferation In adult mammals, the majority of endogenous L-arginine is synthesized from citrulline in the kidney ... in arginase I expression in mononuclear immune cells [12,13], suggesting that L-arginine may have an effect on metabolic processing in the immune system In patients with renal cell carcinoma...

Ngày tải lên: 10/08/2014, 22:20

... Metastatic renal cell carcinoma involving ethmoid sinus at presentation J Postgrad Med 2003, 49:96-97 Ather MH, Masood N, Siddiqui T: Current management of advanced and metastatic renal cell carcinoma ... Maxillary sinus metastasis of renal cell carcinoma Actas Urol Esp 2006, 30:954-957 11 Lee HM, Kang HJ, Lee SH: Metastatic renal cell carcinoma presenting as epistaxis Eur Arch Otorhinolaryngol ... growth factor transcription by endothelial PAS domain protein (EPAS1) and possible involvement of EPAS1 in the angiogenesis of renal cell carcinoma Cancer 2001, 91:1429-1436 10 Torres Muros B,...

Ngày tải lên: 11/08/2014, 00:22

... Hematoxylin and eosin staining of the resected subcutaneous nodule; (b) immunostaining for CD10, (c) epithelial membrane antigen and (d) vimentin Magnification is 20 × for all images our patient declined ... first such report of this phenomenon in renal cell carcinoma, and we briefly discuss possible hypotheses here that may underpin this In the standard late dissemination model of metastasis, the metastatic ... for vimentin, CD10, focally positive for epithelial membrane antigen, melan-A and negative for TTF-1, S100, inhibin and synaptophysin (Figure 4) The positive vimentin and negative inhibin results...

Ngày tải lên: 11/08/2014, 00:23

... specially designed machine that filters blood much like a real kidney would Renal cell carcinoma Renal cell carcinoma (RCC), also known as renal cell cancer or renal cell adenocarcinoma, is by far ... Clear cell renal cell carcinoma This is the most common form of renal cell carcinoma About out of 10 people with renal cell carcinoma have this kind of cancer When seen under a microscope, the cells ... cancers in the kidney, about to 10 are transitional cell carcinomas, also known as urothelial carcinomas Transitional cell carcinomas don't start in the kidney itself, but instead begin in the lining...

Ngày tải lên: 15/03/2014, 00:20

... have a bright prospect in future Methods Cell Lines The human CCRCC cell line OS-RC-2 and mouse macrophage cell line Ana-1 were purchased from the Institute of Cell Biology, Chinese Academy of Sciences ... (Shanghai, China) Human umbilical vein endothelial cell line (HUVEC) was ordered from ATCC All of them were maintained in RPMI-1640 media supplemented with 10% fetal bovine serum which contained 100 ... serum which contained 100 units/ml of penicillin and 100 units/ml of streptomycin All cells were routinely maintained at 37°C in humidified air containing 5% CO2 Page of 10 Reagents Dimethyl sulfoxide...

Ngày tải lên: 18/06/2014, 19:20

... pathway in renal cell carcinomas Ann Clin Lab Sci 2006, 36:283-293 Robb VA, Karbowniczek M, Klein-Szanto AJ, Henske EP: Activation of the mTOR signaling pathway in renal clear cell carcinoma J ... 6-diamidine-2-phenylindole; HIF: hypoxia-induced factor; mTOR: Mammalian target of Rapamycin; PI3K: phospahtidylinositol-3 kinase; RCC: renal cell carcinoma; RTK: receptor tyrosine kinase; and ... Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin2 and interferon in patients with metastatic renal cell carcinoma J Clin Oncol 2005, 23:133-141 Motzer RJ, Hutson...

Ngày tải lên: 18/06/2014, 22:20

... have a bright prospect in future Methods Cell Lines The human CCRCC cell line OS-RC-2 and mouse macrophage cell line Ana-1 were purchased from the Institute of Cell Biology, Chinese Academy of Sciences ... (Shanghai, China) Human umbilical vein endothelial cell line (HUVEC) was ordered from ATCC All of them were maintained in RPMI-1640 media supplemented with 10% fetal bovine serum which contained 100 ... serum which contained 100 units/ml of penicillin and 100 units/ml of streptomycin All cells were routinely maintained at 37°C in humidified air containing 5% CO2 Page of 10 Reagents Dimethyl sulfoxide...

Ngày tải lên: 20/06/2014, 03:20

... pathway in renal cell carcinomas Ann Clin Lab Sci 2006, 36:283-293 Robb VA, Karbowniczek M, Klein-Szanto AJ, Henske EP: Activation of the mTOR signaling pathway in renal clear cell carcinoma J ... 6-diamidine-2-phenylindole; HIF: hypoxia-induced factor; mTOR: Mammalian target of Rapamycin; PI3K: phospahtidylinositol-3 kinase; RCC: renal cell carcinoma; RTK: receptor tyrosine kinase; and ... Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin2 and interferon in patients with metastatic renal cell carcinoma J Clin Oncol 2005, 23:133-141 Motzer RJ, Hutson...

Ngày tải lên: 20/06/2014, 04:20

... high at baseline, declined some from baseline to and weeks Pain, an important clinical indicator in metastatic disease, rose slightly over time This pattern of fluctuation in the individual items ... Phase III trial of interferon alfa-2a with or without 13-cis-retinoic acid for patients with advanced renal cell carcinoma J Clin Oncol 2000, 18:2972-2980 Yost KJ, Eton DT: Combining distribution- ... a good appetite We maintained the 5-point ordinal rating scale of the original FACT-BRM, with responses ranging from – 'not at all' to – 'very much' An aggregated symptom index score is created...

Ngày tải lên: 20/06/2014, 16:20

... and spindle cell carcinoma (6-8) and tubulocystic carcinoma (5) While mucinous tubular and spindle cell carcinoma is now recognized as a distinct subtype of renal cell carcinoma (RCC) in the ... technique to help distinguish the different subtypes of renal cell carcinoma [150, 151] Clear cell renal cell carcinomas are often quite vascularized, and often 20 Renal Cell Carcinoma have high Hounsfield ... renal cell carcinoma: A clinicopathological, immuno- and lectin histochemical study of nine cases APMIS; 112:183-191 [92] Skinner DG, Pfister RF, Colvin R (1972) Extension of renal cell carcinoma...

Ngày tải lên: 27/06/2014, 17:20