sar mar effect on gene expression

... WEG (1998) Induction of gene ¨ expression of the chaperones 14–3)3 and HSP70 induced by PCB 118 (2,3¢,4,4¢,5-pentachlorobiphenyl) in the marine sponge Geodia cydonium: novel biomarkers for polychlorinated ... spicules The expression of this protein is not affected by a change in the concentration of silicic acid in the surrounding milieu (not shown) In contrast, as demonstrated here, the expression of the ... that morphogenesis of sponges is to a considerable extent dependent on outside inorganic factors Both elements, silicon and selenium, can be considered morphogenetic factors which control spicule...

Ngày tải lên: 30/03/2014, 20:20

... http://www.jneuroinflammation.com/content/3/1/8 effect on the constitutive NGF expression, but pre-treatment of cells by PTX completely abrogated the upregulation of NGF mRNA expression induced by anaphylatoxin agonists ... has no effect on C3aR and C5aR expression by T98G cells [31] we investigated the effects of anaphylatoxins/IL1β costimulation on NGF release We demonstrate here significant synergetic effects ... Krell T: Degenerationof rat cholinergic basal forebrain neurons and reactive changes in nerve growth factor expression after chronic neurotoxic injury I Degeneration and plastic response of basal...

Ngày tải lên: 19/06/2014, 22:20

... developmental processes, immune response, and response to stimulus and stress Gene expression data discussed in this publication have been deposited in NCBI’s Gene Expression Omnibus [GEO:GSE32014] Quantitative ... Digestion Kidney medulla-lung Cell migration Cell-matrix adhesion Cellular defense response Positive regulation of angiogenesis Positive regulation of neurotransmitter secretion Regulation of ... regulation of cell adhesion Negative regulation of enzyme activity Positive regulation of actin filament polymerization Protection from natural killer cell mediated cytotoxicity Regulation of hormone...

Ngày tải lên: 20/06/2014, 21:20

... reaction No significant difference was observed in GAPDH expression between groups over passage Gene expression with passage The gene expression abundances for primary and passaged fibrochondrocytes ... Collagen I gene expression profiles of meniscal fibrochondrocytes The x-axis refers to the passage number, and the y-axis to the gene expression fibrochondrocytes abundance (in the exponent notation ... II gene expression profiles of meniscal fibrochondrocytes The x-axis refers to the passage number, and the y-axis to the gene expression fibrochondrocytes abundance (in the exponent notation...

Ngày tải lên: 09/08/2014, 10:21

... SpA gene expression signature and the presence of novel biomarkers of disease Gene expression microarray Unfractionated whole blood collection and RNA isolation were performed using the PAXgene ... among the SpA subjects and females were more common in the control group, we took additional caution to exclude conclusions attributable to gender To identify possible gender effects on gene expression ... in which gene expression is impacted by disease state alone; (2) a model in which gender is the sole influence on gene expression; (3) a model in which, after controlling for gender effects,...

Ngày tải lên: 09/08/2014, 14:22

... on their medication history from one or two years prior to death, and compared gene expression profiles with unaffected controls We further analyzed individual AP medication effects on gene expression ... http://www.biomedcentral.com/1471-244X/9/57 Figure Effects of individual AP drugs on gene expression are shown with fold change and 95% confidence intervals Effects of individual AP drugs on gene expression are shown with fold ... order to identify potential confounding effects on gene expression We then performed the multiple regression analyses to adjust the confounding variables on a gene- by -gene level to obtain adjusted...

Ngày tải lên: 11/08/2014, 17:20

... CONTAINING PSYLLIUM HUSK ON BODY WEIGHT, PLASMA LIPIDS AND HEPATIC GENE EXPRESSION LEVELS Introduction 119 Results 120 Discussion 139 CHAPTER CONCLUSIONS AND FUTURE RECOMMENDATIONS Conclusions ... examined the effects of a typical high-fat, calorie dense diet on gene expression generated mixed findings Some demonstrated that the expression of hepatic genes involved in lipogenesis were ... Liver Reduced expression of lipogenic genes and genes involved in cholesterol metabolism Table 1.1 (continued) Review of recent literature on dietary fat and hepatic gene expression Authors Diets...

Ngày tải lên: 12/09/2015, 08:20

... real time PCR reactions, demonstrating that there was no gDNA contamination PCR reaction triplicates showed no major differences among them and expression levels of the internal control were similar ... information on the effect of antibodies on the expression of Plasmodium immunogenic molecules There are evidences that antibodies can interfere with parasite multiplication An increase on sporozoite ... histocompatibility complex class II expression by disruption of the Jak/Stat pathway J Exp Med 1998; 187: 675-683 21 Lidbury BA, Mahalingam S Specific ablation of antiviral gene expression in macrophages by...

Ngày tải lên: 02/11/2012, 10:14

... the expression of genes such as v-jun, FBJ and EGR 20-Hydroxyecdysone (20E) did not affect gene expression, but Pon A caused some changes in the expression of endogenous genes At lower ligand concentrations ... the effect of dimethylsulfoxide itself on the expression of genes in 293 cells The expressions of a total of 43 genes were modulated with P £ 0.01 with a two-fold change in expression Among the ... ligand, 20E, shows little effect on 293 cells but Pon A affects cell division Two steroid ligands Pon A and 20E were tested in 293 cells to determine their effect on gene expression 5674 using microarray...

Ngày tải lên: 30/03/2014, 03:20

... activity However, the effect on LiP expression was not mentioned in the report and details of the mechanism, including the effect on LiP and MnP transcriptions and the relationship between cAMP ... increased cAMP concentration affects the transcription of genes encoding LiPs and MnPs via regulation of CaM transcription 14 Discussion Expression of all lip and mnp isozyme genes except lipC, lipF, ... determine whether the CaM has other functions including post-transcriptional effects on the expression of LiP and MnP Additionally, lipF regulation, transcription of which was not upregulated following...

Ngày tải lên: 20/06/2014, 20:20

... the increased cAMP concentration affects the transcription of genes encoding LiPs and MnPs via regulation of CaM transcription Discussion Expression of all lip and mnp isozyme genes except lipC, ... activity However, the effect on LiP expression was not mentioned in the report and details of the mechanism, including the effect on LiP and MnP transcriptions and the relationship between cAMP ... inhibition of intracellular cAMP production via CaM inhibition, may also possibly result in reducing transcription of the isozyme genes To clarify this ambiguity, the effect of W-7 on cAMP production...

Ngày tải lên: 21/06/2014, 17:20

... the increased cAMP concentration affects the transcription of genes encoding LiPs and MnPs via regulation of CaM transcription Discussion Expression of all lip and mnp isozyme genes except lipC, ... activity However, the effect on LiP expression was not mentioned in the report and details of the mechanism, including the effect on LiP and MnP transcriptions and the relationship between cAMP ... inhibition of intracellular cAMP production via CaM inhibition, may also possibly result in reducing transcription of the isozyme genes To clarify this ambiguity, the effect of W-7 on cAMP production...

Ngày tải lên: 21/06/2014, 19:20

... the controls were found to be negative and showed only background staining Treatment with licofelone had little effect on the level of its gene expression or on the level of protein In contrast, ... autocrine regulation of 5-LOX gene expression Conclusion This study provides evidence that licofelone treatment in the OA experimental dog model markedly reduces the mRNA expression/ protein synthesis ... ADAMTS-4 and ADAMTS-5 gene expression and protein synthesis are complex and may vary based on species and culture conditions [15] The present study found the level of expression of ADAMTS-5 to be...

Ngày tải lên: 09/08/2014, 06:23

... gene expression/ replication indicated that the response is distinct from that seen upon overexpression of CLK2 or 3, as indicated by their effects on viral RNA accumulation CLK3 overexpression ... treatments on HIV-1 gene expression, replication, RNA accumulation, and splice site selection AB contributed data on the effect of chlorhexidine on Page 11 of 12 HIV-1 RNA accumulation/cell viability ... among the individual CLKs by overexpression or drug inhibition could account for the inhibitory effects on HIV-1 gene expression Subsequent evaluation of the basis for chlorhexidine suppression...

Ngày tải lên: 13/08/2014, 01:20

Ngày tải lên: 21/09/2015, 21:25

... decision analyses examined the cost-effectiveness of breast cancer gene expression assays, and overall were inconclusive Conclusions: Oncotype DX is furthest along the validation pathway, with strong ... concept is the distinction between the investigated gene expression signatures (see Glossary, Appendix B) and the actual gene expressionbased tests The gene “signature” is the collection of genes ... Questions that are presented in the Specific Aims section of Chapter (Introduction) The Key Questions apply to any gene expression profiling test, but they have been focused primarily on two gene expression...

Ngày tải lên: 06/03/2014, 01:20

... expression: rapid RT-PCR analysis of unknown SAGE tags Nucleic Acids Res 27, e17 Chen JJ, Rowley JD & Wang SM (2000) Generation of longer cDNA fragments from serial analysis of gene expression tags ... expression tags for gene identification Proc Natl Acad Sci USA 97, 349–353 Richards M, Tan SP, Chan WK & Bongso A (2006) Reverse serial analysis of gene expression (SAGE) characterization of orphan SAGE ... tags Although GLGI is more effective than RAST-PCR [17], the antisense primer in GLGI is only composed of oligo(dT), so the rigorous PCR conditions, the Mg2+ concentration, the number of PCR cycles...

Ngày tải lên: 07/03/2014, 04:20

... SOD2 expression with subsequent ROS generation in liver tissue Discussion This study demonstrates that BetA inhibits HBV replication by suppression of SOD2 expression with subsequent mitochondrial ... BetA-mediated mitochondrial redox balance We found that BetA has a strong redox effect through suppression of SOD2 expression with subsequent mitochondrial ROS generation; even though ROS generation could ... directly contribute to BetAinduced SOD2 suppression and HBV inhibition, whereas HBx translocation to mitochondria could be a consequence of BetA-induced SOD2 suppression and subsequent ROS generation...

Ngày tải lên: 16/03/2014, 01:20

... inhibition of gluconeogenic gene expression As FEBS Journal 276 (2009) 3757–3769 ª 2009 The Authors Journal compilation ª 2009 FEBS A K Pandey et al Effect of TNFa on insulin action on PEPCK expression ... Journal compilation ª 2009 FEBS A K Pandey et al Effect of TNFa on insulin action on PEPCK expression preincubated with TNFa followed by insulin treatment On termination of incubation, cells were ... experimental conditions Foxo1, another member of the forkhead family of transcription factors, is a very well-established mediator of the effects of insulin on gluconeogenic gene expression [24],...

Ngày tải lên: 16/03/2014, 02:20

... obvious effect on basal expression of Timp-1, only on induced gene expression In conclusion, this is to our knowledge, the only described instance of HDAC inhibitors having opposite effects on the ... dose–response curves of the effect of HDACi’s on either PMA- or TGF-b1-induced Timp-1 gene expression are shown in Fig 2A–C For PMA induction of Timp-1 expression, TSA superinduces this expression ... early gene induction correlates with a nucleosomal response whereby geneassociated nucleosomes are subject to both phosphorylation and acetylation on histone H3 and acetylation on histone H4...

Ngày tải lên: 16/03/2014, 18:20